levoleucovorin and Palatal-Neoplasms

Nasal Type T/natural killer (NK)-cell lymphomas are rare clinical entities, highly aggressive with a very poor prognosis. We present a case of a 37-year-old immunocompetent man presenting with deep palatal ulceration and a 3-month history of symptoms, which appear to have been misdiagnosed by physicians. The final diagnosis was achieved by a 15-day diagnostic algorithm, during which time the clinical status of the patient worsened severely. In this article, we also provide a succinct update on the clinical and histopathological findings of Peripheral T/NK-cell lymphomas and propose that symptoms that are consistent with these clinical entities should be considered from the early stages to inform a suitable diagnostic pathway Because of their highly aggressive behavior, we suggest that early therapy of T/NK-cell lymphomas may be started before completing the specific diagnostic investigations.

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chronic Disease; Delayed Diagnosis; Dexamethasone; Diagnostic Errors; Etoposide; Fistula; Humans; Ifosfamide; Leucovorin; Lymphoma, Extranodal NK-T-Cell; Male; Maxillary Sinusitis; Methotrexate; Mouth Diseases; Nose Diseases; Nose Neoplasms; Palatal Neoplasms; Radiotherapy

Topics: Adult; Aged; Carotid Artery, External; Catheterization; Evaluation Studies as Topic; Floxuridine; Fluorouracil; Gingival Neoplasms; Humans; Injections, Intra-Arterial; Leucovorin; Lip Neoplasms; Methotrexate; Middle Aged; Mouth Neoplasms; Palatal Neoplasms; Palliative Care

Topics: Adult; Aged; Anemia; Carcinoma, Squamous Cell; Cell Division; Drug Eruptions; Drug Synergism; Facial Neoplasms; Female; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Leucovorin; Leukopenia; Lip Neoplasms; Male; Methotrexate; Middle Aged; Mouth Neoplasms; Mucous Membrane; Palatal Neoplasms; Pharyngeal Neoplasms; Tongue Neoplasms

Topics: Carcinoma; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Geriatrics; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Laryngeal Neoplasms; Leucovorin; Maxillary Neoplasms; Methotrexate; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Orbital Neoplasms; Palatal Neoplasms; Temporal Arteries; Tongue Neoplasms; Toxicology