levoleucovorin and Myocarditis

Cardiotoxicity is a rare but serious complication of 5-fluorouracil therapy. Coronary vasospasm and, less frequently, acute myocarditis have been identified as underlying mechanisms. We report a case of severe toxicity in a relatively young and fit male patient being treated for metastatic colonic adenocarcinoma displaying characteristics that cannot be explained by either mechanism alone.

Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Cardiovascular Agents; Colonic Neoplasms; Coronary Vasospasm; Fluorouracil; Heart Diseases; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Myocarditis; Organoplatinum Compounds; Oxaliplatin; Treatment Outcome; Ventricular Dysfunction, Left

Topics: Anemia; Anemia, Macrocytic; Blood Platelets; Drug Therapy; Folic Acid; Hemoglobinometry; Humans; Leucovorin; Leukocyte Count; Metabolism; Myocarditis; Pigmentation Disorders; Purpura; Purpura, Thrombocytopenic; Pyrimethamine; Sulfonamides; Thrombocytopenia; Toxicology; Toxoplasmosis; Toxoplasmosis, Ocular