levoleucovorin and Lacrimal-Apparatus-Diseases

A 75-year-old patient with colorectal cancer was treated by FOLFOX4 therapy. When the total dose of 5-fluorouracil reached 21,200 mg and the total dose of oxaliplatin reached 880 mg after about 100 days of treatment, epiphora developed. Because the pharmacist discovered it soon, he could consult with an ophthalmologist, and the man was diagnosed with subconjunctival hemorrhage. Thereafter, the symptom improved with ofloxacin eye drops. Attention must be paid to the visual side effect in case an anticancer agent is used and when aggressive involvement of the pharmacist in medical team treatment is expected.

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Lacrimal Apparatus Diseases; Leucovorin; Liver Neoplasms; Male; Organoplatinum Compounds; Rectal Neoplasms