levoleucovorin and Hypersensitivity

Topics: Abortion, Spontaneous; Adult; Animals; Diagnosis, Differential; Eye Diseases; Female; Humans; Hypersensitivity; Infant, Newborn; Inflammation; Leucovorin; Male; Prednisone; Pregnancy; Pregnancy Complications, Infectious; Pyrimethamine; Sulfadiazine; Syphilis; Toxoplasma; Toxoplasmosis; Toxoplasmosis, Congenital; Toxoplasmosis, Ocular; Tuberculosis

Previously, we suggested that oxaliplatin (L-OHP)-related grade 3/4 hypersensitivity reactions occurred immediately after the initiation, but grade 1/2 reactions did not. This study was conducted to clarify the risk factors for L-OHP-related hypersensitivity reactions.. Clinical data from 108 Japanese patients with colorectal cancer were analyzed, who were treated with L-OHP-containing regimens, FOLFOX4 and/or mFOLFOX6. The risk factors examined included demographic data, preexisting allergies, laboratory test data, treatment regimen, treatment line of therapy, pretreatment with steroids, total number of cycles and cumulative amount of L-OHP.. The incidence of grade 1/2 and grade 3/4 hypersensitivity reactions were found at 13.0% (14/108) and 9.3% (10/108), respectively. Female (P = 0.037), preexisting allergies (P = 0.004) and lower level of lactate dehydrogenase (P = 0.003) were risk factors for grade 1/2 hypersensitivity reactions, and higher neutrophil count (P = 0.043) and lower monocyte count (P = 0.007) were for grade 3/4 reactions. Total number of cycles were larger in the patients with grade 3/4 reactions than those without reactions (P = 0.049).. Further extensive examination with a large number of patients is needed to establish a patient management strategy.

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Hypersensitivity; Female; Fluorouracil; Humans; Hypersensitivity; Japan; L-Lactate Dehydrogenase; Leucovorin; Leukocyte Count; Male; Middle Aged; Monocytes; Neutrophils; Organoplatinum Compounds; Oxaliplatin; Risk Factors; Sex Characteristics

Topics: Animals; Antibody Formation; Antigen-Antibody Complex; Dermatitis, Contact; Female; Fluorouracil; Graft Rejection; Hemolytic Plaque Technique; Hypersensitivity; Immunity, Cellular; Immunoglobulin M; Immunosuppression Therapy; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred Strains; Oxazoles; Serum Albumin, Bovine; Skin Transplantation; Transplantation, Homologous