levoleucovorin and Glaucoma--Angle-Closure

Bilateral acute angle-closure is a rare occurrence. When the central anterior chambers are shallow, it is often associated with systemic disease. We present 2 patients with atypical bilateral acute angle-closure as the presentation of systemic lymphoma. In these patients, angle closure may be caused by a uveal effusion or swelling of the ciliary body. If an atypical bilateral acute angle-closure attack cannot be attributed to a drug reaction or a bilateral iatrogenic cause, the patient should be evaluated for an associated systemic disease. In some patients, the acute angle-closure cannot be fully resolved until the underlying disease is treated. This report discusses the spectrum of presentations and the various diseases that have been associated with bilateral acute angle-closure.

Topics: Acute Disease; Aged; Antihypertensive Agents; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Bleomycin; Cyclophosphamide; Doxorubicin; Functional Laterality; Glaucoma, Angle-Closure; Glucocorticoids; Hodgkin Disease; Humans; Intraocular Pressure; Leucovorin; Lymphoma, Large-Cell, Immunoblastic; Male; Methotrexate; Middle Aged; Prednisone; Tomography, X-Ray Computed; Vincristine; Visual Acuity