levoleucovorin and Escherichia-coli-Infections

Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Infections; Drug Synergism; Escherichia coli Infections; Haemophilus Infections; Klebsiella Infections; Leucovorin; Mice; Microbial Sensitivity Tests; Pneumococcal Infections; Proteus Infections; Pseudomonas aeruginosa; Pseudomonas Infections; Salmonella Infections; Staphylococcal Infections; Sulfonamides; Thymidine; Trimethoprim

Cervical ectopic pregnancy is an uncommon form of ectopic pregnancy. The spectrum of treatment options includes systemic medical therapy, local injection with methotrexate and/or potassium chloride, surgery, or a combination of these modalities.. A 29-year-old woman, gravida 3, aborta 2, was found to have a cervical ectopic pregnancy on ultrasound at 5+6 weeks' gestation. She presented to the hospital with vaginal bleeding. Treatment was initiated with multidose methotrexate and leucovorin rescue. She subsequently developed Gram-negative septicemia, with blood cultures growing Escherichia coli. This was managed successfully by surgical removal of the ectopic pregnancy and antimicrobial therapy.. A cervical ectopic pregnancy can be complicated by E. coli septicemia.

Topics: Abortifacient Agents, Nonsteroidal; Adult; Cervix Uteri; Escherichia coli Infections; Female; Humans; Leucovorin; Methotrexate; Pregnancy; Pregnancy, Ectopic; Sepsis