levoleucovorin and Dehydration

levoleucovorin has been researched along with Dehydration* in 4 studies

Trials

2 trial(s) available for levoleucovorin and Dehydration

Article	Year
A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer. British journal of cancer, 2005, May-23, Volume: 92, Issue:10 Inhibition of epidermal growth factor receptor (EGFR) signalling contributes to the therapy of colorectal cancer. Gefitinib, an oral EGFR tyrosine kinase inhibitor, shows supra-additive growth inhibition with irinotecan and fluoropyrimidines in xenograft models. We designed a study to determine the tolerability and efficacy of gefitinib in combination with irinotecan, infusional 5-fluorouracil (5-FU) and leucovorin (LV), on a 2-week schedule. Among 13 patients with advanced colorectal cancer, 10 required dose reductions of irinotecan and 5-FU because of dehydration, diarrhoea, and neutropenia, seven of whom required hospitalisation, three with neutropenic fever. One patient achieved partial response and seven had disease stabilisation. The combination of this standard chemotherapy regimen with gefitinib is associated with excessive toxicity, suggesting an interaction at a pharmacokinetic or pharmacodynamic level. Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dehydration; Diarrhea; Drug Interactions; Female; Fluorouracil; Gefitinib; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Male; Middle Aged; Neutropenia; Quinazolines; Treatment Outcome	2005
Recovery from toxicity associated with high-dose methotrexate: prognostic factors. Cancer treatment reports, 1977, Volume: 61, Issue:5 Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dehydration; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infant; Kidney Diseases; Kidney Function Tests; Leucovorin; Liver Diseases; Liver Function Tests; Male; Methotrexate; Neoplasms; Pleural Effusion; Prognosis; Time Factors; Vomiting	1977

Article

Year

A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer.

British journal of cancer, 2005, May-23, Volume: 92, Issue:10

Inhibition of epidermal growth factor receptor (EGFR) signalling contributes to the therapy of colorectal cancer. Gefitinib, an oral EGFR tyrosine kinase inhibitor, shows supra-additive growth inhibition with irinotecan and fluoropyrimidines in xenograft models. We designed a study to determine the tolerability and efficacy of gefitinib in combination with irinotecan, infusional 5-fluorouracil (5-FU) and leucovorin (LV), on a 2-week schedule. Among 13 patients with advanced colorectal cancer, 10 required dose reductions of irinotecan and 5-FU because of dehydration, diarrhoea, and neutropenia, seven of whom required hospitalisation, three with neutropenic fever. One patient achieved partial response and seven had disease stabilisation. The combination of this standard chemotherapy regimen with gefitinib is associated with excessive toxicity, suggesting an interaction at a pharmacokinetic or pharmacodynamic level.

Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dehydration; Diarrhea; Drug Interactions; Female; Fluorouracil; Gefitinib; Humans; Infusions, Intravenous; Irinotecan; Leucovorin; Male; Middle Aged; Neutropenia; Quinazolines; Treatment Outcome

2005

Recovery from toxicity associated with high-dose methotrexate: prognostic factors.

Cancer treatment reports, 1977, Volume: 61, Issue:5

Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dehydration; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infant; Kidney Diseases; Kidney Function Tests; Leucovorin; Liver Diseases; Liver Function Tests; Male; Methotrexate; Neoplasms; Pleural Effusion; Prognosis; Time Factors; Vomiting

1977

Other Studies

2 other study(ies) available for levoleucovorin and Dehydration

Article	Year
Chemotherapy-induced mucositis: focusing on diarrhea. The journal of supportive oncology, 2007, Volume: 5, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Budesonide; Camptothecin; Dehydration; Diarrhea; Fluorouracil; Gastric Mucosa; Gastrointestinal Tract; Humans; Infusions, Intravenous; Intestinal Absorption; Intestinal Mucosa; Irinotecan; Leucovorin; Loperamide; Mice; Mucositis; Organoplatinum Compounds; Rats	2007
Pneumocystis carinii pneumonia in an adopted Vietnamese infant. A case of diffuse, fulminant disease, with recovery. JAMA, 1974, Dec-16, Volume: 230, Issue:11 Topics: Acute Disease; Adoption; Alkanesulfonates; Amidines; Antibodies; Breast Feeding; Dehydration; Female; Fluorescent Antibody Technique; Hepatomegaly; Humans; Infant; Injections, Intramuscular; Leucovorin; Lung; New Mexico; Phenyl Ethers; Pneumonia, Pneumocystis; Radiography; Scabies; Splenomegaly; Tachycardia; Vietnam	1974

Article

Year

Chemotherapy-induced mucositis: focusing on diarrhea.

The journal of supportive oncology, 2007, Volume: 5, Issue:6

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Budesonide; Camptothecin; Dehydration; Diarrhea; Fluorouracil; Gastric Mucosa; Gastrointestinal Tract; Humans; Infusions, Intravenous; Intestinal Absorption; Intestinal Mucosa; Irinotecan; Leucovorin; Loperamide; Mice; Mucositis; Organoplatinum Compounds; Rats

2007

Pneumocystis carinii pneumonia in an adopted Vietnamese infant. A case of diffuse, fulminant disease, with recovery.

JAMA, 1974, Dec-16, Volume: 230, Issue:11

Topics: Acute Disease; Adoption; Alkanesulfonates; Amidines; Antibodies; Breast Feeding; Dehydration; Female; Fluorescent Antibody Technique; Hepatomegaly; Humans; Infant; Injections, Intramuscular; Leucovorin; Lung; New Mexico; Phenyl Ethers; Pneumonia, Pneumocystis; Radiography; Scabies; Splenomegaly; Tachycardia; Vietnam

1974