levoleucovorin and Craniofacial-Abnormalities

levoleucovorin has been researched along with Craniofacial-Abnormalities* in 1 studies

Other Studies

1 other study(ies) available for levoleucovorin and Craniofacial-Abnormalities

ArticleYear
Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse.
    The British journal of nutrition, 2006, Volume: 96, Issue:3

    Prevention of retinoic acid-induced craniofacial abnormalities by folinic acid, and endothelin-1 (ET-1)/dHAND protein and mRNA expression were investigated in mouse embryos using the whole embryo culture, streptavidin-biotin peroxidase complex method, and whole-mount in situ hybridization. In the whole embryo culture, 1.0 and 0.1 mm-folinic acid dose dependently prevented branchial region malformations and decreased defects by 93 % and 77 %, respectively. Folinic acid at concentrations of 1.0 and 0.1 mm significantly increased ET-1 and dHAND protein expression levels compared to retinoic acid-exposed values in embryonic branchial areas. Folinic acid also increased ET-1 and dHAND mRNA levels in the same region. The present results suggest that folinic acid may prevent retinoic acid-induced craniofacial abnormalities via increasing ET-1 and dHAND levels in the branchial region during the organogenic period.

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Branchial Region; Craniofacial Abnormalities; Embryo Culture Techniques; Embryo, Mammalian; Endothelin-1; Female; Gene Expression Regulation; Immunohistochemistry; In Situ Hybridization; Leucovorin; Male; Mice; RNA, Messenger; Teratogens; Tretinoin; Vitamin B Complex

2006