levoleucovorin and Chest-Pain

Within diffuse large B-cell lymphomas, the Primary Mediastinal Large B-Cell Lymphoma has to be considered as a separate and well-defined clinico-pathological entity. Its tendency to target young adults makes its social impact particularly significant; hence, the General Practitioner carries the responsibility for an early diagnosis. On the contrary, the extreme complexity of the available therapies makes a quick referral to specialized Clinical Centres of outmost importance, since this remains the best way to enrol as many patients as possible in therapeutic protocols. Nowadays, good clinical results and a favourable outcome are achievable, but some questions remain open. The role of radiotherapy still has to be clarified, both as a complete remission consolidation, as well as a treatment of the residual disease. Conversely, a golden standard for the second line treatment has not been clearly established.

Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemoradiotherapy; Chest Pain; Cyclophosphamide; Diagnostic Imaging; Doxorubicin; Dyspnea; Early Diagnosis; Humans; Immunophenotyping; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Mediastinal Neoplasms; Methotrexate; Multicenter Studies as Topic; Neoplasm Staging; Prednisone; Prognosis; Randomized Controlled Trials as Topic; Rituximab; Salvage Therapy; Symptom Assessment; Vincristine