levoleucovorin and Anemia--Sideroblastic

The authors report a case of a patient who in the 24th week of a twin pregnancy became sero-positive for toxoplasmosis. This was diagnosed by cordocentesis as being infected, and the treatment was therefore started with pyrimethamine and sulfadiazine and folic acid at the 28th week of pregnancy. At 35 weeks, the patient had an acute medullary aplasia due to the absence of the folates. The mother's state was improved rapidly by giving her folinic acid and the twins were normal haematologically. In this case, the authors point out how important the folates are in a pregnancy, especially in twin pregnancies, and point out the precautions that have to be taken when treatment with pyrimethamine and sulfadiazine is started for congenital toxoplasmosis.

Topics: Adult; Anemia, Aplastic; Anemia, Sideroblastic; Cordocentesis; Female; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Second; Pregnancy, Multiple; Pyrimethamine; Spiramycin; Sulfadiazine; Toxoplasmosis; Twins

Topics: Adult; Anemia, Sideroblastic; Erythropoiesis; Folic Acid Deficiency; Hemochromatosis; Humans; Leucovorin; Male