levoleucovorin and Alcoholism

Methanol ingestion is a cause of potentially life-threatening poisoning with numerous systemic manifestations. Clinicians may overlook the possibility of acute pancreatitis in this setting. The objective of this paper is to document the incidence of this complication in a series of 22 patients and to discuss the respective role of methanol and ethanol in its pathogenesis.. A 54-year-old woman developed acute necrotizing pancreatitis following acute methanol poisoning. She was treated by hemodialysis, ethanol infusion, and folinic acid, but, despite maximal supportive therapy, she died from multiple organ failure 54 hours after the ingestion.. In a series of 22 consecutive patients admitted with a diagnosis of acute methanol poisoning, we found evidence of pancreatic damage in 11 patients. The abnormalities were present from admission and before ethanol therapy in 7 cases and developed after ethanol therapy in 4 cases. Seven patients had a history of chronic ethanol abuse, but no patient had previously suffered from acute or chronic pancreatitis. Three patients presented moderate-to-severe acute pancreatitis according to clinical and radiological criteria and required aggressive supportive therapy including peritoneal dialysis. One patient died from the direct consequences of acute necrotizing pancreatitis and 2 fully recovered from this event. Three patients evolved to brain death; autopsy revealed hemorrhagic lesions in the pancreas in only 1 case.. Clinical, biological, and radiographic signs of acute pancreatic injury may be more common than previously realized. Acute methanol poisoning appears to produce pancreatic injury, although antidotal treatment with ethanol or prior chronic ethanol abuse may be contributing factors. Because ethanol treatment may complicate the pancreatic injury, fomepizole (4-methylpyrazole) may be the preferable antidote in acute methanol poisoning.

Topics: Acute Disease; Adolescent; Adult; Aged; Alcoholism; Ethanol; Fatal Outcome; Female; Formates; Humans; Leucovorin; Male; Methanol; Middle Aged; Multiple Organ Failure; Pancreas; Pancreatitis, Acute Necrotizing; Renal Dialysis; Retrospective Studies; Risk Factors; Suicide

Topics: Alcoholic Beverages; Alcoholism; Alkaline Phosphatase; Anemia; Anemia, Macrocytic; Aspartate Aminotransferases; Bilirubin; Blood Chemical Analysis; Blood Proteins; Bone Marrow Examination; Ethanol; Folic Acid; Folic Acid Deficiency; Hematopoiesis; Humans; Iron; Leucovorin; Liver Function Tests; Pharmacology; Reticulocytes; Toxicology