levodopa has been researched along with MPTP Neurotoxicity Syndrome in 151 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (0.66) | 18.7374 |
1990's | 30 (19.87) | 18.2507 |
2000's | 46 (30.46) | 29.6817 |
2010's | 70 (46.36) | 24.3611 |
2020's | 4 (2.65) | 2.80 |
Authors | Studies |
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Bui, BV; Finkelstein, DI; Hoang, A; Lim, JKH; Nguyen, CTO; Shahandeh, A; Tran, KKN; Wong, VHY | 1 |
Beaudry, F; Bédard, D; Gaudette, F; Gourdon, JC; Hamadjida, A; Huot, P; Michaud, V; Nuara, SG; Panisset, M; Sid-Otmane, L | 1 |
Andren, PE; Bezard, E; Crossman, AR; Fridjonsdottir, E; Hulme, H; Li, Q; Nilsson, A; Pioli, E | 1 |
Asakawa, T; Kobayashi, S; Kurozumi, K; Nozaki, T; Sameshima, T; Sugiyama, K | 1 |
Pandey, S; Singh, B; Yadav, SK | 1 |
Gourdon, JC; Hamadjida, A; Huot, P; Nuara, SG | 2 |
Bourque, M; Di Paolo, T; Grégoire, L | 1 |
Feher, M; Fernandez-Villalba, E; Gaszner, B; Gil-Martinez, AL; Herrero, MT; Reglodi, D; Tamas, A | 1 |
Beck, G; Chang, PL; Maehara, S; Papa, SM | 1 |
Baufreton, J; Bessière, B; Bezard, E; Chazalon, M; Courtine, G; Farjot, G; Ko, WKD; Li, Q; McGuire, S; Milekovic, T; Milet, A; Moraud, EM; Morin, S; Normand, E; Pioli, E; Porras, G; Pype, J; Sun, S | 1 |
Beaudoin-Gobert, M; Duperrier, S; Météreau, E; Sgambato, V; Thobois, S; Tremblay, L | 1 |
Che, Y; Feng, X; Jiang, P; Lang, Q; Liu, Q; Tang, X; Yu, Q; Zhang, S; Zhu, D | 1 |
Iggena, D; Klein, C; Rasińska, J; Sparenberg, M; Steiner, B; Winter, Y | 1 |
Brotchie, JM; Fox, SH; Graef, JD; Hill, MP; Huot, P; James, JW; Johnston, TH; Jordan, KG; Koprich, JB; Letchworth, SR; Szeliga, KT | 1 |
Ly, J; Mallela, A; Quik, M; Zhang, D | 1 |
Chakraborty, J; Dhanasekaran, M; Manivasagam, T; Mohanakumar, KP; Naskar, A; Singh, R; Thomas, B | 1 |
Bagga, P; Chugani, AN; Patel, AB; Varadarajan, KS | 1 |
Jackson, MJ; Jenner, P; Pearce, RK; Swart, T | 1 |
Hurley, MJ; Jackson, MJ; Jenner, P; Rose, S; Smith, LA | 1 |
Bordia, T; Decker, MW; McGregor, M; McIntosh, JM; Quik, M; Zhang, D | 1 |
Bezard, E; Dufour, A; Facheris, MF; Ko, WK; Li, Q; McGuire, S; Pioli, E; Sherer, TB | 1 |
Georgieva, SG; Kerkerian-Le Goff, L; Khaindrava, VG; Khakimova, GR; Kozina, EA; Krasnov, AN; Kucheryanu, VG; Ugrumov, MV; Vorobyeva, NE | 1 |
Bliwise, D; Devergnas, A; Pittard, D; Wichmann, T | 1 |
Bezard, E; De Deurwaerdère, P; Engeln, M; Fernagut, PO; Li, Q | 1 |
Bezard, E; Girard, F; Keywood, C; Li, Q; Mutel, V; Pioli, EY; Poli, SM; Rascol, O; Tison, F | 1 |
Adrien, J; Arnulf, I; Belaid, H; Clark, SD; Drouot, X; François, C; Grabli, D; Hirsch, EC; Karachi, C; Laffrat, E; Tandé, D | 1 |
Decker, MW; McGregor, M; Quik, M; Zhang, D | 1 |
Di Paolo, T; Elbast, W; Feuerbach, D; Gomez-Mancilla, B; Grégoire, L; Weiss, M | 1 |
Di Paolo, T; Grégoire, L; Jourdain, VA; Morin, N; Morissette, M | 1 |
Cao, X; Kaneoke, Y; Liang, L; Papa, SM; Singh, A | 1 |
Brotchie, JM; Fox, SH; Huot, P; Johnston, TH | 1 |
Ji, C; Liu, Y; Ren, Z; Wang, T; Yang, N; Zheng, J; Zuo, P | 1 |
Bezard, E; Carta, M; Chuan, Q; Fidalgo, C; Ko, WK; Li, Q; Stancampiano, R; Tronci, E | 1 |
Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Newman-Tancredi, A | 1 |
Ballanger, B; Bars, DL; Beaudoin-Gobert, M; Bonnefoi, F; Broussolle, E; Costes, N; Duperrier, S; Epinat, J; Lavenne, F; Liger, F; Météreau, E; Neumane, S; Sgambato-Faure, V; Thobois, S; Tourvielle, C; Tremblay, L | 1 |
Andersen, JK; Kim, YH; Lazzara, CA; Rane, A; Riley, RR | 1 |
Di Paolo, T; Grégoire, L; Morin, N; Morissette, M; Rajput, A; Rajput, AH | 1 |
Jenner, P; Kanda, T; Kawai-Uchida, M; Mori, A; Okita, E; Soshiroda, K; Uchida, S | 1 |
Kim, AR; Ugryumov, MV | 1 |
Harada, N; Kakiuchi, T; Kanazawa, M; Muramatsu, S; Ohba, H; Tsukada, H | 1 |
Bernstein, AI; Chen, M; Dunn, AR; Hoffman, CA; Lohr, KM; McDaniel, MJ; Miller, GW; Stout, KA; Wang, M | 1 |
Chu, Y; Isacson, O; Kordower, JH; Redmond, DE; Vinuela, A | 1 |
Bezard, E; Camus, SM; Ko, WKD; Li, Q; McGuire, S; Pioli, EY; Yang, J | 1 |
Daniels, JS; Devergnas, A; Galvan, A; Lindsley, CW; Masilamoni, G; Morrison, RD; Pittard, D; Vuong, J; Wichmann, T | 1 |
Chan, P; Tang, R; Tao, G; Yue, F; Zeng, S | 1 |
Frouni, I; Gourdon, JC; Hamadjida, A; Harraka, MJ; Huot, P; Kwan, C; Nuara, SG; Sid-Otmane, L; Veyres, N | 1 |
Betz, AJ; Bibbiani, F; Chase, TN; Davis, RE; Kielaite, A; Salamone, JD; Vanover, KE; Weber, SM; Weiner, DM | 1 |
Desole, MS; Marchetti, B; Miele, E; Pluchino, S; Serra, PA | 1 |
Buck, K; Ferger, B; Nicholas, AP | 1 |
Belkhir, S; Di Paolo, T; Dridi, M; Grégoire, L; Meltzer, LT; Morissette, M; Ouattara, B; Samadi, P | 1 |
Brotchie, JM; de Bie, RM; Fox, SH; Johnston, TH; McCreary, AC; Visanji, NP | 1 |
Brennum, LT; Kirchhoff, J; Mørk, A; Sager, TN | 1 |
Decamp, E; Schneider, JS | 1 |
Aubert, I; Berton, O; Bezard, E; Bioulac, BH; Dileone, RJ; Gross, CE; Guigoni, C; Li, Q; Nestler, EJ | 1 |
Iravani, MM; Jackson, MJ; Jenner, P; Olanow, CW; Rose, S; Scheller, D; Smith, LA; Stockwell, KA; Tayarani-Binazir, K | 1 |
Di Paolo, T; Gilbert, F; Grégoire, L; Lévesque, D; Mahmoudi, S; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P | 1 |
Balfour, RH; Jackson, MJ; Jenner, P; Rose, S; Zeng, BY | 1 |
Andree, TH; Hansard, M; Hoffman, DC; Hurtt, MR; Jackson, MJ; Jenner, P; Kehne, JH; Pitler, TA; Smith, LA; Stack, G | 1 |
Iravani, MM; Jackson, MJ; Jenner, P; Rose, S; Scheller, DK; Smith, LA; Stockwell, KA | 1 |
Borah, A; Mohanakumar, KP | 1 |
Di Paolo, T; Lévesque, D; Morissette, M; Samadi, P | 1 |
Jackson, MJ; Jenner, P; Olanow, CW; Rose, S; Tayarani-Binazir, KA | 1 |
Di Paolo, T; Gasparini, F; Gomez-Mancilla, B; Grégoire, L; Morissette, M; Ouattara, B; Samadi, P | 1 |
Brotchie, JM; Fox, SH; Johnston, TH; McIldowie, MJ; Piggott, MJ | 1 |
Di Paolo, T; Gasparini, F; Gomez-Mancilla, B; Grégoire, L; Hoyer, D; Morissette, M; Ouattara, B | 1 |
Brotchie, JM; Fox, SH; Johnston, TH; van der Meij, A | 1 |
Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Winkelmolen, L | 1 |
Brotchie, JM; Fox, SH | 1 |
Bartolini, WP; Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Milne, GT; Pearson, JP; Sykes, KA; Wakefield, JD | 1 |
Bakay, RA; Deogaonkar, M; Lieu, CA; Subramanian, T | 1 |
Hansard, MJ; Jackson, MJ; Jenner, P; Rose, S; Smith, LA | 1 |
Brotchie, JM; Fox, SH; Huot, P; Johnston, TH; Koprich, JB; Lewis, KD; Piggott, MJ; Reyes, MG | 1 |
Brotchie, JM; Visanji, NP | 1 |
Crossman, AR; Hill, MP; Kobylecki, C; Ravenscroft, P | 1 |
Iwamuro, H; Kita, H; Nambu, A; Tachibana, Y; Takada, M | 1 |
Liang, L; Pu, X; Wang, J; Wang, X; Wu, Q; Xiang, Y; Zhang, Q; Zhang, X | 1 |
Campos-Romo, A; Carrillo-Ruiz, JD; Fernandez-Ruiz, J; Moreno-Briseño, P; Ojeda-Flores, R; Segovia, J; Vergara, P | 1 |
Bordia, T; Chin, M; Mallela, A; McIntosh, JM; Perez, XA; Quik, M | 1 |
Bankiewicz, KS; Cummins, A; Eberling, J; Kohutnicka, M; Oiwa, Y; Sanchez-Pernaute, R | 2 |
Di Paolo, T; Grégoire, L; Jourdain, VA; Morin, N; Morissette, M; Parent, M | 1 |
Hermann, A; Huehnchen, P; Klaissle, P; Lesemann, A; Steiner, B; Storch, A | 1 |
Bezard, E; Jianzhong, Y; Li, Q; Pioli, EY; Schneider, JS | 1 |
Brotchie, JM; Fox, SH; Hill, MP; Huot, P; Johnston, TH; Koprich, JB; Snoeren, T | 1 |
Brotchie, JM; Fox, SH; Huot, P; Jarvie, K; Koprich, JB; Lang, AE; Seeman, P | 1 |
Dunnett, SB; Lane, EL; Lelos, MJ | 1 |
Archer, T; Fredriksson, A | 4 |
Bankiewicz, KS; Emborg, ME; McLaughlin, WW; Moirano, J; Tetrud, JW | 1 |
Bézard, E; Boraud, T; Ferry, S; Gross, C; Leriche, L; Mach, U; Sokoloff, P; Stark, H | 1 |
Bordia, T; Fan, H; Marks, MJ; McIntosh, JM; Okihara, M; Quik, M; Whiteaker, P | 1 |
Antkiewicz-Michaluk, L; Herman, ZS; Obuchowicz, E; Romańska, I | 1 |
Bezard, E; Brotchie, JM; Crossman, AR; Grimée, R; Hill, MP; Klitgaard, H; Michel, A | 1 |
Brocco, M; Brotchie, J; Crossman, A; Di Cara, B; Gobert, A; Hill, M; Jackson, M; Jenner, P; Joyce, JN; McGuire, S; Millan, MJ; Peglion, JL; Smith, L | 1 |
Bezard, E; Brotchie, JM; Crossman, AR; Grimée, R; Hill, MP; Klitgaard, H; Michel, A; Ravenscroft, P | 1 |
Aubin, N; Barneoud, P; Burnier, P; Caille, D; Carter, C; Charieras, T; Curet, O; Gardes, A; George, P; Jegham, S; Le Kim, A; Lolivier, J; Marc, C; Pandini, M; Perron, C; Puech, F; Scatton, B; Sontag, N | 1 |
Al-Barghouthy, G; Jackson, MJ; Jenner, P; Kuoppamaki, M; Olanow, W; Rose, S; Smith, LA | 1 |
Brotchie, JM; Crossman, AR; Nicholson, SL; Silverdale, MA | 1 |
Alvarez, L; Castro, A; Gimenez-Roldan, S; Grandas, F; Hernandez, B; Jenner, P; Linazasoro, G; Luquin, MR; Macias, R; Marin, C; Obeso, JA; Pavon, N; Rodriguez, M; Rodriguez-Oroz, MC; Stochi, F; Tolosa, E; Vaamonde, J; Valldeoriola, F | 1 |
Brotchie, JM; Crossman, AR; Di Marzo, V; Fox, SH; Hill, M; Petrosino, S; van der Stelt, M | 1 |
Childs, MA; Connell, MA; Emborg, ME; Hajos-Korcsok, E; Meglasson, MD; Stephenson, DT | 1 |
Diguet, E; Fernagut, PO; Ghorayeb, I; Tison, F | 1 |
Bankiewicz, KS; Bringas, J; Cunningham, J; Daadi, M; Eberling, JL; Forsayeth, JR; Pivirotto, P; Sanftner, L | 1 |
Bédard, PJ; Di Paolo, T; Grégoire, L; Lévesque, D; Rouillard, C; Samadi, P | 1 |
Aziz, TZ; Jenkinson, N; Nandi, D; Oram, R; Stein, JF | 1 |
Carminati, P; Jackson, MJ; Jenner, P; Johnson, L; Rose, S; Smith, LA; Stockwell, K | 1 |
Brotchie, JM; Crossman, AR; Hill, MP; McGuire, SG; Millan, MJ; Ravenscroft, P; Rochat, C | 1 |
Caccia, C; Calabresi, M; Curatolo, L; Faravelli, L; Fariello, RG; Maestroni, S; Maj, R; Salvati, P | 1 |
Chalimoniuk, M; Langfort, J | 1 |
Al-Barghouthy, G; Jackson, MJ; Jenner, P; Kuoppamäki, M; Quinn, N; Smith, LA | 1 |
Hurley, MJ; Jackson, MJ; Jenner, P; Patel, PH; Rose, S; Smith, LA | 1 |
Dunnett, S; Lane, E | 1 |
Crossman, AR; Page, RD; Sambrook, MA | 1 |
Fukuda, T; Irifune, M; Nomoto, M | 1 |
Bédard, PJ; Blanchet, P; Britton, DR; Kebabian, JW | 1 |
Crossman, AR; Graham, WC; Sambrook, MA | 1 |
Dluzen, D; Jain, R; Liu, B | 1 |
Agid, Y; Augood, SJ; Emson, PC; Herrero, MT; Hirsch, EC; Javoy-Agid, F; Luquin, MR; Obeso, JA | 1 |
Dluzen, DE; Liu, B; McDermott, JL | 1 |
Agid, Y; Faucheux, B; Herrero, MT; Hirsch, EC; Levy, R; Obeso, JA; Vila, M | 1 |
Agid, Y; Asensi, H; Augood, SJ; Emson, PC; Herrero, MT; Hirsch, EC; Obeso, JA | 1 |
Agid, Y; Faucheux, B; Herrero, MT; Hirsch, EC; Levy, R; Obeso, JA; Ruberg, M; Vila, M | 1 |
Iurasov, VV; Kaplun, AP; Kryzhanovskiĭ, GN; Kucherianu, VG; Kudrin, VS; Nikushkin, EV; Podgornyĭ, GI; Sandalov, IuG; Shvets, VI; Zhigal'tsev, IV | 1 |
Blanchet, PJ; Chase, TN; Konitsiotis, S | 1 |
Bezard, E; Bioulac, B; Boraud, T; Gross, C; Guehl, D | 1 |
Domino, EF; Emborg-Knott, ME | 1 |
Domino, EF; Ni, L | 1 |
Blanchet, PJ; Chase, TN; Konitsiotis, S; Whittemore, ER; Woodward, RM; Zhou, ZL | 1 |
Andringa, G; Cools, AR; Stoof, JC | 1 |
Aigner, TG; Doudet, D; Fernández-Ruiz, J | 1 |
Bédard, PJ; Doan, VD; Grondin, R; Hadj Tahar, A; Ladure, P | 1 |
Bezard, E; Boraud, T; Gross, CE; Guitraud, S; Imbert, C | 1 |
Jenner, P | 1 |
Andringa, G; Cools, AR; Drukarch, B; Lubbers, L; Stoof, JC | 1 |
Fukuzaki, K; Kamenosono, T; Kitazumi, K; Nagata, R | 1 |
Cannizzaro, C; Costa, S; Iravani, MM; Jackson, MJ; Jenner, P; Pearce, RK; Tel, BC | 1 |
Foster, AC; Hill, RG; Iversen, L; Iversen, SD; Kemp, JA; Leeson, PD; Rupniak, NM; Saywell, K; Tricklebank, MD; Williams, BJ | 1 |
Marsden, CD | 1 |
Bédard, PJ; Blanchette, P; Di Paolo, T; Gagnon, C; Mancilla, BG | 1 |
Lieberman, A | 1 |
Gash, DM; Greenamyre, JT; Honoré, T; Klockgether, T; Kurlan, R; Turski, L; Zhang, ZM | 1 |
Bédard, PJ; Gomez-Mancilla, B | 1 |
Asanuma, M; Haba, K; Mori, A; Ogawa, N; Pongdhana, K; Sora, YH | 1 |
Boyce, S; Iversen, SD; Rupniak, NM; Steventon, MJ; Tye, S | 1 |
Bodis-Wollner, I; Chung, E; Ghilardi, MF; Glover, A; Onofrj, M; Pasik, P; Samson, Y | 1 |
Bédard, PJ; Di Paolo, T; Rouillard, C | 1 |
Boyce, S; Clarke, CE; Crossman, AR; Luquin, R; Mitchell, IJ; Peggs, D; Robertson, RG; Sambrook, MA | 1 |
Boyce, S; Crossman, AR; Luquin, MR; Peggs, D; Sambrook, MA | 1 |
9 review(s) available for levodopa and MPTP Neurotoxicity Syndrome
Article | Year |
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The MPTP mouse model: cues on DA release and neural stem cell restorative role.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Cues; Disease Models, Animal; Dopamine; Humans; Levodopa; Mice; MPTP Poisoning; Stem Cell Transplantation; Stem Cells | 2008 |
The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Basal Ganglia; Cognition Disorders; Disease Models, Animal; Dopamine; Drug Discovery; Endpoint Determination; Humans; Levodopa; Movement; MPTP Poisoning; Neurons; Neuroprotective Agents; Parkinson Disease, Secondary; Primates; Psychoses, Substance-Induced; Sleep Wake Disorders | 2010 |
[Optimization of use of levodopa in Parkinson's disease: role of levodopa-carbidopa-entacapone combination].
Topics: Akathisia, Drug-Induced; Animals; Antiparkinson Agents; Carbidopa; Catechols; Clinical Trials as Topic; Dopamine; Drug Therapy, Combination; Humans; Hyperhomocysteinemia; Levodopa; MPTP Poisoning; Neuroprotective Agents; Nitriles; Parkinson Disease; Parkinsonian Disorders; Rats; Treatment Outcome | 2005 |
Safinamide: from molecular targets to a new anti-Parkinson drug.
Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbillinae; Humans; Kainic Acid; Levodopa; Mice; MPTP Poisoning; Neurons; Rats; Veratridine | 2006 |
Animal models of Parkinson's disease and L-dopa induced dyskinesia: how close are we to the clinic?
Topics: Animals; Animals, Genetically Modified; Antiparkinson Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Humans; Levodopa; MPTP Poisoning; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Reproducibility of Results; Sympatholytics | 2008 |
Factors influencing the onset and persistence of dyskinesia in MPTP-treated primates.
Topics: Animals; Dopamine Agents; Dyskinesia, Drug-Induced; Levodopa; MPTP Poisoning; Primates | 2000 |
Neurotoxin-related research: from the laboratory to the clinic.
Topics: Animals; Antiparkinson Agents; Dopamine Agents; Humans; Levodopa; Mice; MPTP Poisoning; Nervous System; Neurotoxins; Oxazines; Parkinson Disease, Secondary; Prodrugs; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Saimiri | 1992 |
Parkinson's disease.
Topics: Dopamine; Environmental Pollutants; Humans; Levodopa; MPTP Poisoning; Parkinson Disease | 1992 |
Levodopa-induced dyskinesia: facts and fancy. What does the MPTP monkey model tell us?
Topics: Animals; Disease Models, Animal; Dyskinesia, Drug-Induced; Haplorhini; Humans; Levodopa; MPTP Poisoning | 1992 |
142 other study(ies) available for levodopa and MPTP Neurotoxicity Syndrome
Article | Year |
---|---|
Characterization of retinal function and structure in the MPTP murine model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Levodopa; Mice; Mice, Inbred C57BL; MPTP Poisoning; Parkinson Disease; Retina; Tyrosine 3-Monooxygenase | 2022 |
Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset.
Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Behavior, Animal; Callithrix; Dyskinesia, Drug-Induced; Female; GABA Modulators; Levodopa; Male; MPTP Poisoning; Parkinson Disease; Psychoses, Substance-Induced; Pyridines; Receptors, Metabotropic Glutamate; Sulfonamides | 2020 |
µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Dyskinesias; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Humans; Levodopa; Macaca fascicularis; MPTP Poisoning; Neurotransmitter Agents; Receptors, Opioid, mu | 2020 |
Development of a novel gripping test for the evaluation of the finger fine motor ability in MPTP-treated monkeys.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Deep Brain Stimulation; Disease Models, Animal; Fingers; Levodopa; Macaca fascicularis; Male; Motor Activity; Motor Skills; MPTP Poisoning; Neuropsychological Tests; Parkinson Disease; Reproducibility of Results; Subthalamic Nucleus | 2020 |
Role of estrogen and levodopa in 1-methyl-4-pheny-l-1, 2, 3, 6-tetrahydropyridine (mptp)-induced cognitive deficit in Parkinsonian ovariectomized mice model: A comparative study.
Topics: Acetylcholinesterase; Animals; Cognition Disorders; Dopaminergic Neurons; Estradiol; Levodopa; Maze Learning; Mice; MPTP Poisoning; Neuroprotective Agents; Ovariectomy; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
The effect of mianserin on the severity of psychosis and dyskinesia in the parkinsonian marmoset.
Topics: Animals; Antidepressive Agents, Second-Generation; Callithrix; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Mianserin; MPTP Poisoning; Psychotic Disorders; Severity of Illness Index; Time Factors; Treatment Outcome | 2018 |
The plasmalogen precursor analog PPI-1011 reduces the development of L-DOPA-induced dyskinesias in de novo MPTP monkeys.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; MPTP Poisoning; Ovariectomy; Plasmalogens; Time Factors | 2018 |
Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antiparkinson Agents; Basal Ganglia; Caudate Nucleus; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Phosphopyruvate Hydratase; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Tyrosine 3-Monooxygenase | 2018 |
Trazodone alleviates both dyskinesia and psychosis in the parkinsonian marmoset model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Behavior, Animal; Callithrix; Disorders of Excessive Somnolence; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; MPTP Poisoning; Parkinsonian Disorders; Serotonin Receptor Agonists; Trazodone | 2018 |
A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Organic Chemicals; Phosphodiesterase Inhibitors | 2018 |
Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental parkinsonism.
Topics: Administration, Inhalation; Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Gait Disorders, Neurologic; Green Fluorescent Proteins; Levodopa; Mice; Mice, Transgenic; MPTP Poisoning; Oxidopamine; Parkinsonian Disorders; Rats; Sensation Disorders; Sympatholytics; Time Factors; Xenon | 2018 |
Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates.
Topics: Animals; Brain; Diffusion Tensor Imaging; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Immunohistochemistry; Levodopa; Macaca fascicularis; MPTP Poisoning; Multimodal Imaging; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Fibers; Parkinson Disease, Secondary; Positron-Emission Tomography; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins | 2018 |
Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice.
Topics: Animals; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Levodopa; Mice; Mice, Inbred BALB C; MPTP Poisoning; Resveratrol | 2019 |
Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa.
Topics: Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Combinations; Female; Green Fluorescent Proteins; Hippocampus; Levodopa; Maze Learning; Memory; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; MPTP Poisoning; Neurogenesis; Random Allocation; Sedentary Behavior | 2019 |
TC-8831, a nicotinic acetylcholine receptor agonist, reduces L-DOPA-induced dyskinesia in the MPTP macaque.
Topics: Amantadine; Animals; Azabicyclo Compounds; Cyclopropanes; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; MPTP Poisoning; Nicotinic Agonists | 2013 |
Nicotine reduces established levodopa-induced dyskinesias in a monkey model of Parkinson's disease.
Topics: Animals; Anti-Dyskinesia Agents; Antiparkinson Agents; Cotinine; Data Interpretation, Statistical; Dyskinesia, Drug-Induced; Female; Levodopa; Male; MPTP Poisoning; Nicotine; Nicotinic Agonists; Parkinson Disease, Secondary; Saimiri | 2013 |
Melatonin synergizes with low doses of L-DOPA to improve dendritic spine density in the mouse striatum in experimental Parkinsonism.
Topics: Animals; Antiparkinson Agents; Central Nervous System Depressants; Corpus Striatum; Dendrites; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Melatonin; Mice; Mice, Inbred BALB C; MPTP Poisoning; Parkinson Disease, Secondary | 2013 |
In vivo NMR studies of regional cerebral energetics in MPTP model of Parkinson's disease: recovery of cerebral metabolism with acute levodopa treatment.
Topics: Acetates; Algorithms; Animals; Antiparkinson Agents; Blood Glucose; Brain Chemistry; Energy Metabolism; Glutamates; Hand Strength; Image Processing, Computer-Assisted; Levodopa; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neostriatum; Oxidation-Reduction; Parkinson Disease, Secondary; Psychomotor Performance; Radiopharmaceuticals | 2013 |
Cholinergic manipulation of motor disability and L-DOPA-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated common marmosets.
Topics: Animals; Antiparkinson Agents; Callithrix; Carbidopa; Cholinergic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; MPTP Poisoning; Statistics, Nonparametric | 2014 |
Proteomic analysis of striatum from MPTP-treated marmosets (Callithrix jacchus) with L-DOPA-induced dyskinesia of differing severity.
Topics: Animals; Callithrix; Dyskinesias; Levodopa; MPTP Poisoning; Neostriatum; Proteome | 2014 |
ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Dyskinesia, Drug-Induced; Female; Levodopa; Male; MPTP Poisoning; Nicotinic Agonists; Pyridines; Pyrrolidines; Saimiri; Treatment Outcome | 2014 |
Combined fenobam and amantadine treatment promotes robust antidyskinetic effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson's disease.
Topics: Amantadine; Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Imidazoles; Levodopa; Macaca fascicularis; MPTP Poisoning | 2014 |
Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Electrochemistry; Gene Expression Regulation; Hydrazines; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 2014 |
Relationship between oscillatory activity in the cortico-basal ganglia network and parkinsonism in MPTP-treated monkeys.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Basal Ganglia; Brain Waves; Disease Models, Animal; Electroencephalography; Fourier Analysis; Globus Pallidus; Levodopa; Macaca mulatta; Motor Activity; Motor Cortex; MPTP Poisoning; Neural Pathways; Physical Stimulation; Sleep; Subthalamic Nucleus; Time Factors; Wakefulness | 2014 |
Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca mulatta; MPTP Poisoning; Neural Pathways; Time Factors | 2015 |
The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Imidazoles; Levodopa; Macaca mulatta; Male; Motor Activity; MPTP Poisoning; Pyridines; Receptor, Metabotropic Glutamate 5; Severity of Illness Index; Time Factors | 2014 |
Sleep disorders in Parkinsonian macaques: effects of L-dopa treatment and pedunculopontine nucleus lesion.
Topics: Animals; Benserazide; Cholinergic Neurons; Diphtheria Toxin; Drug Combinations; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Muscle Tonus; Parkinsonian Disorders; Pedunculopontine Tegmental Nucleus; Polysomnography; Recombinant Fusion Proteins; Sleep Deprivation; Sleep Disorders, Intrinsic; Sleep, REM; Urotensins; Wakefulness | 2014 |
The α7 nicotinic receptor agonist ABT-107 decreases L-Dopa-induced dyskinesias in parkinsonian monkeys.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antiparkinson Agents; Dyskinesia, Drug-Induced; Female; Indoles; Levodopa; Male; MPTP Poisoning; Nicotinic Agonists; Quinuclidines; Saimiri | 2014 |
AQW051, a novel and selective nicotinic acetylcholine receptor α7 partial agonist, reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Nicotinic Agonists; Ovariectomy; Time Factors | 2014 |
Subthalamotomy-induced changes in dopamine receptors in parkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Female; Levodopa; Macaca fascicularis; MPTP Poisoning; Ovariectomy; Protein Binding; Radioligand Assay; Receptors, Dopamine; Subthalamus | 2014 |
Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates.
Topics: Action Potentials; Animals; Corpus Striatum; Dopamine; Dopamine Agents; Female; Levodopa; Macaca mulatta; MPTP Poisoning; Neurons; Receptors, Dopamine D2 | 2015 |
Pioglitazone may impair L-DOPA anti-parkinsonian efficacy in the MPTP-lesioned macaque: results of a pilot study.
Topics: Animals; Antiparkinson Agents; Drug Combinations; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; MPTP Poisoning; Pilot Projects; Pioglitazone; Thiazolidinediones | 2015 |
Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)-thiazolidinone in MPTP induced Parkinsonism model in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Animals, Newborn; Benzylidene Compounds; Cells, Cultured; Disease Models, Animal; Levodopa; Male; Membrane Potential, Mitochondrial; Mesencephalon; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; MPTP Poisoning; Neuroblastoma; Neurons; Neuroprotective Agents; Neurotoxins; Psychomotor Performance; rho GTP-Binding Proteins; Thiazolidinediones; Time Factors; Tyrosine 3-Monooxygenase | 2015 |
Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Citalopram; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Time Factors; Tyrosine 3-Monooxygenase | 2015 |
The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque.
Topics: Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Piperidines; Pyrimidines; Serotonin 5-HT1 Receptor Agonists; Severity of Illness Index | 2015 |
Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate.
Topics: Aniline Compounds; Animals; Antiparkinson Agents; Brain; Brain Mapping; Chlorocebus aethiops; Disease Models, Animal; Dopamine; Dopamine Agents; Female; Levodopa; Macaca fascicularis; Male; Mental Disorders; MPTP Poisoning; N-Methyl-3,4-methylenedioxyamphetamine; Nortropanes; Radionuclide Imaging; Serotonin; Serotonin Agents; Sulfides | 2015 |
The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy.
Topics: Animals; Antiparkinson Agents; Brain Stem; Calpain; Carbidopa; Cell Death; Cell Line; Corpus Striatum; Dopaminergic Neurons; Drug Therapy, Combination; Histone Acetyltransferases; Levodopa; Lithium Chloride; Male; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Rats; Tyrosine 3-Monooxygenase | 2015 |
Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications.
Topics: Aged; Aged, 80 and over; Animals; Antiparkinson Agents; Brain; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Humans; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Ovariectomy; Parkinson Disease; Pyridines; Receptor, Metabotropic Glutamate 5; Receptor, Serotonin, 5-HT1B | 2015 |
The adenosine A2A receptor antagonist, istradefylline enhances anti-parkinsonian activity induced by combined treatment with low doses of L-DOPA and dopamine agonists in MPTP-treated common marmosets.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; Dopamine Agonists; Drug Therapy, Combination; Female; Indoles; Levodopa; Male; Motor Activity; MPTP Poisoning; Pergolide; Purines | 2015 |
Changes in plasma catecholamines levels as preclinical biomarkers in experimental models of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Disease Progression; Dopamine; Epinephrine; Levodopa; Male; Mice, Inbred C57BL; MPTP Poisoning; Norepinephrine; Prodromal Symptoms; Severity of Illness Index | 2015 |
Evaluation of 6-11C-Methyl-m-Tyrosine as a PET Probe for Presynaptic Dopaminergic Activity: A Comparison PET Study with β-11C-l-DOPA and 18F-FDOPA in Parkinson Disease Monkeys.
Topics: Animals; Brain; Carbidopa; Dihydroxyphenylalanine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Enzyme Inhibitors; Levodopa; Macaca fascicularis; MPTP Poisoning; Parkinson Disease, Secondary; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Presynaptic; Tyrosine | 2016 |
Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals.
Topics: Animals; Corpus Striatum; Dopamine; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; MPTP Poisoning; Vesicular Monoamine Transport Proteins | 2016 |
Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias.
Topics: Animals; Antiparkinson Agents; Calbindins; Caudate Nucleus; Cerebellum; Chlorocebus aethiops; Dopamine; Dopaminergic Neurons; Dyskinesia, Drug-Induced; Fetal Tissue Transplantation; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Levodopa; Male; Mesencephalon; Microglia; MPTP Poisoning; Neurons; Putamen; Tyrosine 3-Monooxygenase | 2017 |
An evaluation of istradefylline treatment on Parkinsonian motor and cognitive deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque models.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cognition Disorders; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Hypokinesia; Levodopa; Macaca fascicularis; Motor Skills Disorders; MPTP Poisoning; Purines; Treatment Outcome | 2016 |
Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys.
Topics: Animals; Antiparkinson Agents; Arousal; Azabicyclo Compounds; Benzamides; Brain; Calcium Channel Blockers; Calcium Channels, T-Type; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Electrocorticography; Female; Heart; Levodopa; Macaca mulatta; Male; Mass Spectrometry; Motor Activity; MPTP Poisoning; Treatment Failure | 2016 |
MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Female; Levodopa; Macaca fascicularis; Male; Motor Activity; MPTP Poisoning; Severity of Illness Index; Time Factors; Treatment Outcome; Video Recording | 2017 |
The effect of mirtazapine on dopaminergic psychosis and dyskinesia in the parkinsonian marmoset.
Topics: Animals; Antidepressive Agents, Tricyclic; Antiparkinson Agents; Behavior, Animal; Callithrix; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Mianserin; Mirtazapine; Motor Activity; MPTP Poisoning; Parkinsonian Disorders; Psychoses, Substance-Induced | 2017 |
A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model.
Topics: Animals; Data Interpretation, Statistical; Dopamine Agents; Dyskinesia, Drug-Induced; Jaw; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists; Tremor; Urea | 2008 |
Effects of levodopa on striatal monoamines in mice with levodopa-induced hyperactivity.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Biogenic Monoamines; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Electrochemistry; Hyperkinesis; Levodopa; Mice; Mice, Inbred C57BL; MPTP Poisoning; Olfactory Bulb | 2008 |
Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias.
Topics: Animals; Autoradiography; Behavior, Animal; Benserazide; Benzoxazoles; Cabergoline; Corpus Striatum; Dopamine Agents; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dyskinesias; Ergolines; Female; Humans; Levodopa; Macaca fascicularis; MPTP Poisoning; Ovariectomy; Piperidines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2009 |
The nociceptin/orphanin FQ (NOP) receptor antagonist J-113397 enhances the effects of levodopa in the MPTP-lesioned nonhuman primate model of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Benzimidazoles; Callithrix; Disability Evaluation; Disease Models, Animal; Drug Synergism; Levodopa; MPTP Poisoning; Nociceptin; Opioid Peptides; Piperidines; Time Factors | 2008 |
Striatal extracellular dopamine levels and behavioural reversal in MPTP-lesioned mice.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; Dopamine Agents; Extracellular Space; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neurotoxins; Raclopride; Receptors, Dopamine D2; Tritium | 2009 |
Interaction between nicotinic and dopaminergic therapies on cognition in a chronic Parkinson model.
Topics: Animals; Attention; Cognition; Cues; Discrimination Learning; Disease Models, Animal; Dopamine Agents; Drug Combinations; Drug Interactions; Injections, Intramuscular; Injections, Intravenous; Levodopa; Macaca mulatta; Male; Memory; MPTP Poisoning; Nicotine; Nicotinic Agonists; Phenols; Pyrrolidines; Reaction Time; Task Performance and Analysis | 2009 |
Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Drug Combinations; Dyskinesia, Drug-Induced; Female; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; Humans; Iodine Radioisotopes; Levodopa; Linear Models; Macaca fascicularis; Male; MPTP Poisoning; Nortropanes; Protein Binding; Proto-Oncogene Proteins c-jun; Radionuclide Imaging; RNA, Messenger | 2009 |
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Callithrix; Disease Models, Animal; Drug Administration Schedule; Drug Delivery Systems; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; Motor Skills; MPTP Poisoning; Tetrahydronaphthalenes; Thiophenes | 2009 |
Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Antiparkinson Agents; Autoradiography; Brain; Cocaine; Disease Models, Animal; Docosahexaenoic Acids; Drug Interactions; Dyskinesia, Drug-Induced; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; MPTP Poisoning; Nuclear Receptor Subfamily 4, Group A, Member 1; Protein Binding; RNA, Messenger; Statistics as Topic | 2009 |
Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets.
Topics: Animals; Antiparkinson Agents; Brain; Callithrix; Catechol O-Methyltransferase; Cell Membrane; Cerebral Cortex; Corpus Striatum; Dyskinesia, Drug-Induced; Female; Levodopa; Liver; Male; MPTP Poisoning; Neuroglia; Neurons; RNA, Messenger | 2010 |
The dopamine D(2) receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with L-dopa.
Topics: Animals; Antiparkinson Agents; Callithrix; Disability Evaluation; Dopamine Agonists; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Indoles; Levodopa; Locomotion; Male; MPTP Poisoning; Receptors, Dopamine D2; Time Factors; Treatment Outcome | 2010 |
Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets.
Topics: Animals; Callithrix; Disability Evaluation; Disease Models, Animal; Dopamine Agents; Drug Administration Schedule; Drug Delivery Systems; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; MPTP Poisoning; Statistics, Nonparametric; Tetrahydronaphthalenes; Thiophenes; Time Factors | 2010 |
L-DOPA-induced 6-hydroxydopamine production in the striata of rodents is sensitive to the degree of denervation.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Electrochemistry; Levodopa; Male; Mice; Mice, Inbred BALB C; MPTP Poisoning; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley | 2010 |
BDNF levels are not related with levodopa-induced dyskinesias in MPTP monkeys.
Topics: Animals; Antiparkinson Agents; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dyskinesia, Drug-Induced; Enzyme-Linked Immunosorbent Assay; Female; Levodopa; Macaca fascicularis; MPTP Poisoning | 2010 |
Pramipexole combined with levodopa improves motor function but reduces dyskinesia in MPTP-treated common marmosets.
Topics: Animals; Antiparkinson Agents; Benzothiazoles; Callithrix; Carbidopa; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesias; Levodopa; Male; Motor Activity; MPTP Poisoning; Pramipexole; Time Factors | 2010 |
Effect of L-Dopa on metabotropic glutamate receptor 5 in the brain of parkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Autoradiography; Biogenic Amines; Brain Chemistry; Catecholamines; Caudate Nucleus; Data Interpretation, Statistical; Dopamine Plasma Membrane Transport Proteins; Female; In Situ Hybridization; Levodopa; Macaca fascicularis; MPTP Poisoning; Ovariectomy; Oximes; Parkinson Disease, Secondary; Putamen; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reserpine; RNA, Messenger | 2010 |
Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Male; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles | 2010 |
Changes of AMPA receptors in MPTP monkeys with levodopa-induced dyskinesias.
Topics: Animals; Antiparkinson Agents; Autoradiography; Benzoxazoles; Brain; Cabergoline; Drug Interactions; Dyskinesia, Drug-Induced; Ergolines; Female; Imidazoles; Levodopa; Ligands; Macaca fascicularis; MPTP Poisoning; Piperidines; Quinazolines; Receptors, AMPA; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 2010 |
Effect of histamine H2 receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson's disease.
Topics: Akathisia, Drug-Induced; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Famotidine; Female; Histamine H2 Antagonists; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Time Factors | 2010 |
5-HT2A receptor levels increase in MPTP-lesioned macaques treated chronically with L-DOPA.
Topics: Animals; Autoradiography; Brain; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; MPTP Poisoning; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Synaptic Transmission | 2012 |
Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease.
Topics: Amides; Amidohydrolases; Animals; Benzamides; Callithrix; Carbamates; Disease Models, Animal; Dyskinesia, Drug-Induced; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Female; Levodopa; Motor Activity; MPTP Poisoning; Oleic Acids; Palmitic Acids; Psychoses, Substance-Induced | 2011 |
Dyskinesias do not develop after chronic intermittent levodopa therapy in clinically hemiparkinsonian rhesus monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Carotid Arteries; Conditioning, Operant; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agents; Dyskinesia, Drug-Induced; Dystonia; Female; Injections, Intravenous; Levodopa; Macaca mulatta; MPTP Poisoning; Parkinson Disease, Secondary; Psychomotor Performance; Radionuclide Imaging; Radiopharmaceuticals; Substantia Nigra | 2011 |
A major metabolite of bupropion reverses motor deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets.
Topics: Animals; Bupropion; Callithrix; Dose-Response Relationship, Drug; Female; Levodopa; Male; Motor Activity; MPTP Poisoning; Stereoisomerism | 2011 |
Characterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Brain; Callithrix; Dyskinesia, Drug-Induced; Female; Levodopa; Motor Activity; MPTP Poisoning; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Stereoisomerism | 2011 |
MPTP-induced models of Parkinson's disease in mice and non-human primates.
Topics: Animals; Callithrix; Disease Models, Animal; Dyskinesia, Drug-Induced; Levodopa; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning | 2005 |
Synergistic antidyskinetic effects of topiramate and amantadine in animal models of Parkinson's disease.
Topics: Amantadine; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; Disease Models, Animal; Dopamine Agonists; Drug Synergism; Dyskinesia, Drug-Induced; Fructose; Levodopa; Male; MPTP Poisoning; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Topiramate | 2011 |
Subthalamo-pallidal interactions underlying parkinsonian neuronal oscillations in the primate basal ganglia.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Action Potentials; Animals; Antiparkinson Agents; Basal Ganglia; Biological Clocks; Brain Waves; Disease Models, Animal; Dopamine; Electric Stimulation; Functional Laterality; Globus Pallidus; Levodopa; Macaca; Male; MPTP Poisoning; Neurons; Statistics, Nonparametric; Subthalamic Nucleus | 2011 |
Chlorotoxin-modified stealth liposomes encapsulating levodopa for the targeting delivery against Parkinson's disease in the MPTP-induced mice model.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Drug Delivery Systems; Levodopa; Liposomes; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Parkinson Disease; Random Allocation; Scorpion Venoms | 2012 |
Behavioral improvement in MPTP-treated nonhuman primates in the HALLWAY task after transfer of TH cDNA to host astrocytes.
Topics: Animals; Astrocytes; Behavior, Animal; Chlorocebus aethiops; DNA, Complementary; Dopamine Agents; Gene Transfer Techniques; Genetic Vectors; Glial Fibrillary Acidic Protein; Humans; Levodopa; Magnetic Resonance Imaging; Male; MPTP Poisoning; Neostriatum; Psychomotor Performance; Tyrosine 3-Monooxygenase | 2012 |
Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Levodopa; Male; MPTP Poisoning; Nicotine; Nicotinic Agonists; Presynaptic Terminals; Receptors, Nicotinic; Saimiri | 2013 |
Preclinical models of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Levodopa; Macaca fascicularis; Macaca mulatta; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Parkinson Disease; Rats; Rats, Sprague-Dawley | 2004 |
Potentiation of response to low doses of levodopa in MPTP-injected monkeys by chemical unilateral subthalamotomy.
Topics: Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Ibotenic Acid; Levodopa; Macaca fascicularis; MPTP Poisoning; Subthalamic Nucleus | 2013 |
Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult Stem Cells; Analysis of Variance; Animals; Antigens; Bromodeoxyuridine; Calcium-Binding Proteins; Cells, Cultured; Disease Models, Animal; Dopamine; Dopamine Agents; Environment; Female; Green Fluorescent Proteins; Intermediate Filament Proteins; Levodopa; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Motor Activity; MPTP Poisoning; Nerve Tissue Proteins; Nestin; Proteoglycans; Substantia Nigra; Tyrosine 3-Monooxygenase | 2012 |
Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antiparkinson Agents; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Levodopa; Macaca fascicularis; Male; Movement; MPTP Poisoning; Photic Stimulation; Time Factors | 2013 |
Use of catechol-O-methyltransferase inhibition to minimize L-3,4-dihydroxyphenylalanine-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque.
Topics: Animals; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Nitriles | 2013 |
The effects of fast-off-D2 receptor antagonism on L-DOPA-induced dyskinesia and psychosis in parkinsonian macaques.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Butyrophenones; Cloning, Molecular; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Parkinson Disease, Secondary; Psychoses, Substance-Induced | 2013 |
What helps can also hinder: a dissociation in the acute effect of levodopa treatment on motor and cognitive functions.
Topics: Animals; Antiparkinson Agents; Cognition Disorders; Levodopa; Male; Movement; MPTP Poisoning | 2013 |
Effect of postnatal iron administration on MPTP-induced behavioral deficits and neurotoxicity: behavioral enhancement by L-Dopa-MK-801 co-administration.
Topics: Animals; Behavior, Animal; Brain Chemistry; Critical Period, Psychological; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Habituation, Psychophysiologic; Iron; Iron Overload; Levodopa; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Time | 2003 |
Rest tremor in rhesus monkeys with MPTP-induced parkinsonism.
Topics: Animals; Female; Levodopa; Macaca mulatta; Male; MPTP Poisoning; Parkinson Disease, Secondary; Tremor | 2003 |
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acrylamides; Animals; Antiparkinson Agents; Dopamine Agents; Dopamine Antagonists; Dyskinesia, Drug-Induced; Female; Haplorhini; Humans; Isoquinolines; Levodopa; Molecular Structure; Motor Activity; MPTP Poisoning; Naphthalenes; Neostriatum; Piperazines; Pyrrolidines; Rats; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2003 |
L-DOPA treatment modulates nicotinic receptors in monkey striatum.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Levodopa; Male; MPTP Poisoning; Protein Binding; Receptors, Nicotinic; Saimiri | 2003 |
Increased striatal neuropeptide Y immunoreactivity and its modulation by deprenyl, clonidine and L-dopa in MPTP-treated mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Dopamine; Homovanillic Acid; Immunohistochemistry; Levodopa; Male; Mice; MPTP Poisoning; Neuropeptide Y; Neuroprotective Agents; Selegiline; Serotonin | 2003 |
Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque.
Topics: Animals; Chorea; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Levetiracetam; Levodopa; Macaca fascicularis; MPTP Poisoning; Piracetam | 2004 |
S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole.
Topics: Acetylcholine; Animals; Callithrix; Cells, Cultured; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Interactions; Dyskinesias; Electrophysiology; Extracellular Space; Humans; Hypokinesia; Indoles; Levodopa; Male; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Oxazines; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Reserpine; Rotation | 2004 |
Levetiracetam potentiates the antidyskinetic action of amantadine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson's disease.
Topics: Amantadine; Animals; Anticonvulsants; Antiparkinson Agents; Callithrix; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Dyskinesias; Female; Levetiracetam; Levodopa; Male; MPTP Poisoning; Piracetam | 2004 |
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Levodopa; Maze Learning; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Nervous System Diseases; Nitrophenols; Oxazoles; Oxidopamine; Prefrontal Cortex; Quinolines; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior; Tolcapone; Tremor; Tyramine | 2004 |
Multiple small doses of levodopa plus entacapone produce continuous dopaminergic stimulation and reduce dyskinesia induction in MPTP-treated drug-naive primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Callithrix; Carbidopa; Catechols; Dopamine Agents; Drug Administration Schedule; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Injections, Subcutaneous; Levodopa; Locomotion; Male; MPTP Poisoning; Nitriles; Severity of Illness Index; Substantia Nigra; Time Factors | 2005 |
Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Callithrix; Disease Models, Animal; Dyskinesia, Drug-Induced; Fructose; Levodopa; MPTP Poisoning; Parkinson Disease; Topiramate | 2005 |
A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease.
Topics: Animals; Arachidonic Acids; Callithrix; Cannabinoid Receptor Modulators; Dyskinesia, Drug-Induced; Endocannabinoids; Female; gamma-Aminobutyric Acid; Glycerides; Levodopa; Male; MPTP Poisoning; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys.
Topics: Animals; Basal Ganglia; Benzimidazoles; Biogenic Monoamines; Dopamine Agonists; Levodopa; Male; Motor Activity; MPTP Poisoning; Receptors, Dopamine D2; Saimiri; Substantia Nigra | 2005 |
In vivo models of multiple system atrophy.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Corpus Striatum; Levodopa; Macaca fascicularis; Mice; MPTP Poisoning; Multiple System Atrophy; Oxidopamine; Parkinsonian Disorders; Point Mutation; Rats; Substantia Nigra | 2005 |
Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Aromatic-L-Amino-Acid Decarboxylases; Behavior, Animal; Corpus Striatum; Dependovirus; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Gene Transfer Techniques; Immunohistochemistry; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; MPTP Poisoning; Neurons; Parkinson Disease, Secondary; Positron-Emission Tomography; Time Factors | 2006 |
Influence of noradrenaline denervation on MPTP-induced deficits in mice.
Topics: Animals; Auditory Pathways; Behavior, Animal; Benzylamines; Brain Chemistry; Denervation; Dopamine Agents; Hippocampus; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neostriatum; Norepinephrine; Prefrontal Cortex; Substantia Nigra | 2006 |
Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Female; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Ovariectomy; Severity of Illness Index; Time Factors | 2006 |
Pedunculopontine nucleus electric stimulation alleviates akinesia independently of dopaminergic mechanisms.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Dopamine; Dose-Response Relationship, Radiation; Electric Stimulation; Levodopa; Macaca mulatta; Male; Motor Activity; MPTP Poisoning; Pedunculopontine Tegmental Nucleus | 2006 |
The novel adenosine A2a receptor antagonist ST1535 potentiates the effects of a threshold dose of L-DOPA in MPTP treated common marmosets.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Callithrix; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; Motor Skills; MPTP Poisoning; Triazoles | 2006 |
Postnatal iron overload destroys NA-DA functional interactions.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Benzylamines; Clonidine; Corpus Striatum; Denervation; Dopamine; Dopamine Agents; Iron Overload; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Norepinephrine | 2007 |
Antiparkinsonian effects of the novel D3/D2 dopamine receptor agonist, S32504, in MPTP-lesioned marmosets: Mediation by D2, not D3, dopamine receptors.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Indoles; Levodopa; Motor Activity; MPTP Poisoning; Oxazines; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D3; Time Factors | 2006 |
The effect of subchronic, intermittent L-DOPA treatment on neuronal nitric oxide synthase and soluble guanylyl cyclase expression and activity in the striatum and midbrain of normal and MPTP-treated mice.
Topics: Animals; Blotting, Western; Cyclic GMP; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Electrophoresis, Polyacrylamide Gel; Guanylate Cyclase; Immunohistochemistry; Levodopa; Mesencephalon; Mice; Mice, Inbred C57BL; Microdialysis; MPTP Poisoning; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Nitric Oxide Synthase Type I; Phosphoric Diester Hydrolases; RNA, Messenger; Synaptosomes | 2007 |
L-dopa dose and the duration and severity of dyskinesia in primed MPTP-treated primates.
Topics: Animals; Callithrix; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; MPTP Poisoning; Severity of Illness Index | 2007 |
Striatal leucine-rich repeat kinase 2 mRNA is increased in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned common marmosets (Callithrix jacchus) with L-3, 4-dihydroxyphenylalanine methyl ester-induced dyskinesia.
Topics: Actins; Aged; Aged, 80 and over; Animals; Antiparkinson Agents; Callithrix; Data Interpretation, Statistical; Dopamine Agents; Dyskinesia, Drug-Induced; Electrophoresis, Polyacrylamide Gel; Female; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Levodopa; Male; Middle Aged; MPTP Poisoning; Neostriatum; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra | 2007 |
Functional consequences of iron overload in catecholaminergic interactions: the Youdim factor.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Brain Chemistry; Catecholamines; Clozapine; Denervation; Dopamine; Dopamine Agents; Female; Haloperidol; Iron; Iron Overload; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Movement Disorders; MPTP Poisoning; Norepinephrine; Pregnancy; Psychotic Disorders; Signal Transduction; Weight Gain | 2007 |
Preclinical models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Injections, Intra-Arterial; Injections, Intravenous; Levodopa; Macaca fascicularis; Macaca mulatta; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Primates; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Species Specificity | 2001 |
Thalamotomy for the alleviation of levodopa-induced dyskinesia: experimental studies in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated parkinsonian monkey.
Topics: Afferent Pathways; Animals; Apomorphine; Axonal Transport; Brain Mapping; Chorea; Dyskinesia, Drug-Induced; Dystonia; Globus Pallidus; Horseradish Peroxidase; Levodopa; Macaca fascicularis; MPTP Poisoning; Parkinson Disease, Secondary; Stereotaxic Techniques; Thalamus; Wheat Germ Agglutinins | 1993 |
Antiparkinsonian activity of talipexole in MPTP-treated monkeys: in combination with L-dopa and as chronic treatment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antiparkinson Agents; Azepines; Callithrix; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Levodopa; Male; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary | 1994 |
Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- exposed monkeys.
Topics: Animals; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Parkinson Disease; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1993 |
Differential effect of chronic dopaminergic treatment on dopamine D1 and D2 receptors in the monkey brain in MPTP-induced parkinsonism.
Topics: Animals; Apomorphine; Autoradiography; Benzazepines; Brain Chemistry; Caudate Nucleus; Dopamine Agents; Female; Infusions, Intravenous; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Parkinson Disease, Secondary; Putamen; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 1993 |
Modulatory effects of testosterone on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Drug Implants; Levodopa; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MPTP Poisoning; Neurotoxins; Orchiectomy; Parkinson Disease, Secondary; Reference Values; Species Specificity; Testosterone | 1994 |
Effects of L-DOPA on preproenkephalin and preprotachykinin gene expression in the MPTP-treated monkey striatum.
Topics: Animals; Antiparkinson Agents; Caudate Nucleus; Dopamine Agents; Enkephalins; Gene Expression; In Situ Hybridization; Levodopa; Macaca fascicularis; MPTP Poisoning; Neostriatum; Oligonucleotides, Antisense; Parkinson Disease, Secondary; Protein Precursors; Putamen; RNA, Messenger; Tachykinins | 1995 |
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Estradiol; Female; Levodopa; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MPTP Poisoning; Osmolar Concentration; Ovariectomy | 1996 |
Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non-human primates: a cytochrome oxidase histochemistry study.
Topics: Aged; Aged, 80 and over; Animals; Basal Ganglia; Densitometry; Electron Transport Complex IV; Female; Histocytochemistry; Humans; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Parkinson Disease; Parkinson Disease, Secondary | 1996 |
Effects of L-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys.
Topics: Animals; Cell Count; Cell Size; Corpus Striatum; Dopamine Agents; Levodopa; Macaca fascicularis; MPTP Poisoning; Neurons; Parkinson Disease, Secondary; Receptors, Dopamine D2; RNA, Messenger | 1996 |
Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and nonhuman primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA.
Topics: Aged; Aged, 80 and over; Animals; Basal Ganglia; Corpus Striatum; Denervation; Electron Transport Complex IV; Enzyme Induction; Female; Globus Pallidus; Humans; In Situ Hybridization; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Nerve Tissue Proteins; Parkinson Disease; Parkinson Disease, Secondary; RNA, Messenger; Substantia Nigra | 1997 |
[The effect of liposomal form of L-Dopa on the level of dopamine, its metabolites, and phospholipid metabolism in the striatum of mice with experimental parkinsonian syndrome].
Topics: Animals; Blood-Brain Barrier; Corpus Striatum; Dopamine; Dopamine Agents; Levodopa; Liposomes; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Parkinson Disease, Secondary; Phospholipids | 1996 |
Motor response to a dopamine D3 receptor preferring agonist compared to apomorphine in levodopa-primed 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys.
Topics: Animals; Antiparkinson Agents; Apomorphine; Dopamine Agonists; Female; Levodopa; Macaca fascicularis; Male; Motor Activity; MPTP Poisoning; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3 | 1997 |
Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.
Topics: Animals; Dopamine Agents; Female; Globus Pallidus; Immunohistochemistry; Levodopa; Macaca mulatta; MPTP Poisoning; Neurons; Parkinson Disease, Secondary | 1998 |
MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose.
Topics: Animals; Antiparkinson Agents; Carotid Arteries; Dopamine Agents; Drug Administration Schedule; Female; Follow-Up Studies; Infusions, Intra-Arterial; Levodopa; Macaca nemestrina; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Rotation | 1998 |
Trihexyphenidyl potentiation of L-DOPA: reduced effectiveness three years later in MPTP-induced chronic hemiparkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Chronic Disease; Dopamine Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Levodopa; Macaca nemestrina; MPTP Poisoning; Parkinson Disease, Secondary; Treatment Outcome; Trihexyphenidyl | 1998 |
Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys.
Topics: Animals; Antiparkinson Agents; Dopamine Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Oocytes; Parkinson Disease, Secondary; Rats; Receptors, N-Methyl-D-Aspartate; Valine; Xenopus laevis | 1999 |
Sub-chronic administration of the dopamine D(1) antagonist SKF 83959 in bilaterally MPTP-treated rhesus monkeys: stable therapeutic effects and wearing-off dyskinesia.
Topics: Animals; Antiparkinson Agents; Dopamine Antagonists; Dyskinesia, Drug-Induced; Levodopa; Macaca mulatta; Male; MPTP Poisoning; Parkinson Disease; Receptors, Dopamine D1 | 1999 |
Spatial memory improvement by levodopa in parkinsonian MPTP-treated monkeys.
Topics: Animals; Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine Agents; Fluorine Radioisotopes; Levodopa; Macaca mulatta; Male; Memory; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Psychomotor Performance; Space Perception | 1999 |
Noradrenoceptor antagonism with idazoxan improves L-dopa-induced dyskinesias in MPTP monkeys.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Idazoxan; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Norepinephrine; Parkinson Disease | 2000 |
Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dopamine Agents; Female; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Neurologic Examination; Severity of Illness Index | 2000 |
The predictive validity of the drug-naive bilaterally MPTP-treated monkey as a model of Parkinson's disease: effects of L-DOPA and the D1 agonist SKF 82958.
Topics: Animals; Antiparkinson Agents; Arm; Behavior, Animal; Benzazepines; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Dystonia; Electroencephalography; Epilepsy; Levodopa; Macaca mulatta; Male; Motor Activity; Movement; MPTP Poisoning; Parkinson Disease, Secondary; Predictive Value of Tests; Receptors, Dopamine D1 | 1999 |
Effects of ropinirole on motor behavior in MPTP-treated common marmosets.
Topics: Animals; Antiparkinson Agents; Bromocriptine; Callithrix; Dopamine Agonists; Female; Indoles; Levodopa; Male; Motor Activity; MPTP Poisoning; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2000 |
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets.
Topics: Animals; Antiparkinson Agents; Body Weight; Callithrix; Corpus Striatum; Disease Models, Animal; Dopamine Uptake Inhibitors; Dyskinesia, Drug-Induced; Enkephalins; Female; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Levodopa; Locomotion; Male; Mazindol; MPTP Poisoning; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Protein Precursors; Recovery of Function; RNA, Messenger; Substantia Nigra; Tachykinins; Tritium; Tyrosine 3-Monooxygenase | 2001 |
Emerging perspectives in Parkinson's disease.
Topics: Animals; Humans; Levodopa; MPTP Poisoning; Neurology; Parkinson Disease; Parkinson Disease, Secondary; Selegiline | 1992 |
The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys.
Topics: Animals; Dopamine; Female; Globus Pallidus; Levodopa; Macaca mulatta; MPTP Poisoning; Parkinson Disease, Secondary; Quinoxalines; Rats; Receptors, AMPA; Receptors, Neurotransmitter; Synaptic Transmission | 1991 |
Effect of D1 and D2 agonists and antagonists on dyskinesia produced by L-dopa in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.
Topics: Animals; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Macaca fascicularis; MPTP Poisoning; Parkinson Disease, Secondary | 1991 |
Alterations of somatostatin and its modulation by levodopa in MPTP-treated mouse brain.
Topics: Animals; Brain Chemistry; Dopamine; Levodopa; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Norepinephrine; Sincalide; Somatostatin; Substance P; Thyrotropin-Releasing Hormone | 1990 |
Modulatory role for CCK-B antagonists in Parkinson's disease.
Topics: Animals; Benzodiazepinones; Carbidopa; Cholecystokinin; Devazepide; Dopamine Agents; Levodopa; Male; Motor Activity; MPTP Poisoning; Oxazines; Parkinson Disease, Secondary; Phenylurea Compounds; Receptors, Cholecystokinin; Saimiri | 1990 |
Acetyl-levo-carnitine protects against MPTP-induced parkinsonism in primates.
Topics: Acetylcarnitine; Animals; Carbidopa; Caudate Nucleus; Electroretinography; Female; Homovanillic Acid; Immunohistochemistry; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; Parkinson Disease, Secondary; Substantia Nigra | 1991 |
Effects of chronic treatment of MPTP monkeys with bromocriptine alone or in combination with SKF 38393.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Brain; Brain Chemistry; Bromocriptine; Dopamine; Female; Homovanillic Acid; Kinetics; Levodopa; Macaca fascicularis; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Receptors, Dopamine; Spiperone | 1990 |
Induction of chorea and dystonia in parkinsonian primates.
Topics: Animals; Chorea; Dystonia; Levodopa; Macaca fascicularis; MPTP Poisoning; Parkinson Disease, Secondary | 1990 |
Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Injections, Intramuscular; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; N-Methylaspartate; Parkinson Disease, Secondary | 1989 |