levetiracetam and Lymphoma

To determine whether there is a drug-drug interaction precluding the concomitant use of levetiracetam and high-dose methotrexate (HDMTX).. Retrospective analysis.. Large academic tertiary care medical center.. Adult lymphoma patients who received HDMTX as a 4-h infusion with or without concomitant levetiracetam.. Generalized estimating equations clustered on patient were used to assess each outcome. The primary outcome was the incidence of delayed MTX elimination (MTX level >1 µmol/L at 48 h). Secondary outcomes included incidence of acute kidney injury (AKI) and hospital length of stay (LOS). The 430 included patients receiving 1993 doses of HDMTX had a median (IQR) age of 66 (57.5, 72.6) years, 88 (20.5%) received concomitant levetiracetam with at least one dose of MTX, 267 (62.1%) were male, and 397 (92.3%) were Caucasian. HDMTX doses ranged from 1 to 8 g/m. High-dose methotrexate administered with concomitant levetiracetam was not associated with increased risk for delayed MTX elimination or AKI. These results support that levetiracetam and HDMTX are safe for coadministration.

Topics: Antimetabolites, Antineoplastic; Drug Interactions; Female; Humans; Levetiracetam; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies

Topics: Aged; Antineoplastic Agents; Brain Neoplasms; DNA-Binding Proteins; Female; Frontal Lobe; Humans; Immunocompetence; Levetiracetam; Lymphoma; Magnetic Resonance Imaging; Nootropic Agents; Piracetam; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcl-6; Spasm

Mediastinal lymphoma with neoplastic invasion into the heart was diagnosed in a 9-year-old castrated male domestic short hair cat. The neoplastic infiltrate was seen throughout the atria and atrial septum, surrounded the aortic root, and resulted in narrowing of the right ventricular outflow tract. Chemotherapy resulted in resolution of the echocardiographic abnormalities and the cat's clinical signs until the patient was euthanized 58 days later following development of neurologic signs. Mediastinal lymphoma with myocardial invasion and response to chemotherapy has not been documented previously in the veterinary literature.

Topics: Animals; Anticonvulsants; Antineoplastic Agents; Asparaginase; Cat Diseases; Cats; Drug Therapy, Combination; Echocardiography; Euthanasia, Animal; Fatal Outcome; Heart Neoplasms; Levetiracetam; Lomustine; Lymphoma; Male; Mediastinal Neoplasms; Neoplasm Invasiveness; Piracetam; Seizures