levetiracetam has been researched along with Carcinoma--Neuroendocrine* in 1 studies
1 other study(ies) available for levetiracetam and Carcinoma--Neuroendocrine
| Article | Year |
|---|---|
Repurposing of the Antiepileptic Drug Levetiracetam to Restrain Neuroendocrine Prostate Cancer and Inhibit Mast Cell Support to Adenocarcinoma.
A relevant fraction of castration-resistant prostate cancers (CRPC) evolve into fatal neuroendocrine (NEPC) tumors in resistance to androgen deprivation and/or inhibitors of androgen receptor pathway. Therefore, effective drugs against both CRPC and NEPC are needed. We have previously described a dual role of mast cells (MCs) in prostate cancer, being capable to promote adenocarcinoma but also to restrain NEPC. This finding suggests that a molecule targeting both MCs and NEPC cells could be effective against prostate cancer. Using an Topics: Animals; Anticonvulsants; Antineoplastic Agents; Carcinoma, Neuroendocrine; Cell Degranulation; Cell Differentiation; Cell Proliferation; Drug Repositioning; Gene Expression Regulation, Neoplastic; Humans; Levetiracetam; Male; Mast Cells; Matrix Metalloproteinase 9; Membrane Glycoproteins; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Nerve Tissue Proteins; Prostatic Neoplasms; Tumor Cells, Cultured | 2021 |