leustroducsin-b has been researched along with Escherichia-coli-Infections* in 1 studies
1 other study(ies) available for leustroducsin-b and Escherichia-coli-Infections
| Article | Year |
|---|---|
Augmentation of host resistance against bacterial infection by treatment with leustroducsin B, a new CSF inducer.
We tested the in vivo activity of leustroducsin B (LSN B), a new colony-stimulating factor (CSF) inducer isolated from the culture broth of Streptomyces platensis, with mice infected with Escherichia coli. Treatment with LSN B augmented the host resistance to lethal infection of E. coli at doses between 0.1 mg/kg and 1 mg/kg. Serum interleukin-6 (IL-6) levels were found to increase after this treatment, and superoxide anion generation of neutrophils was enhanced in vivo, suggesting that LSN B augmented the host resistance at least in part by inducing IL-6, which subsequently enhanced the bactericidal activity of the neutrophils. Topics: Animals; Anti-Bacterial Agents; Colony-Stimulating Factors; Enzyme-Linked Immunosorbent Assay; Escherichia coli Infections; Immunity; Interleukin-6; Lactones; Male; Mice; Mice, Inbred ICR; Neutrophils; Organophosphorus Compounds; Pyrones; Superoxides | 1994 |