leuprolide and Vitamin-D-Deficiency

Puberty onset and development contribute substantially to adolescents' bone mass and body composition. Our objective with this study was to examine the effects of gonadotropin-releasing hormone agonists (GnRHa) on these puberty-induced changes among youth with gender dysphoria (GD).. Medical records of the endocrine diversity clinic in an academic children's hospital were reviewed for youth with GD seen from January 2006 to April 2017 with at least 1 baseline dual-energy radiograph absorptiometry measurement.. At baseline, transgender females had lower lumbar spine (LS) and left total hip (LTH) areal bone mineral density (aBMD) and LS bone mineral apparent density (BMAD). GnRHa monotherapy negatively affected bone mineral density of youth with GD without evidence of fractures or changes in BMI

Topics: Absorptiometry, Photon; Adolescent; Body Composition; Body Mass Index; Bone Density; Female; Gender Dysphoria; Gonadotropin-Releasing Hormone; Humans; Leuprolide; Lumbar Vertebrae; Male; Pelvic Bones; Retrospective Studies; Transsexualism; Vitamin D Deficiency