leuprolide and Uterine-Cervical-Neoplasms

An unsuspected primary cervical lymphoma thought to be a cervical fibroid decreased in size dramatically after initiation of Leuprolide acetate prior to being correctly diagnosed during subsequent hysterectomy for uterine bleeding. This case represents the first reported successful use of Leuprolide acetate against a reticuloendothelial tumor.

Topics: Adult; Diagnosis, Differential; Female; Humans; Hysterectomy; Leiomyoma; Leuprolide; Lymphoma; Uterine Cervical Neoplasms; Uterine Hemorrhage

Two cases of cervical myoma were treated with combined medical/surgical therapy using a gonadotropin releasing hormone agonist (GnRH-a) and transvaginal cervical myomectomy. Patients were treated with depot GnRH-a (leuprolide acetate) for two months followed by myomectomy. This approach allowed successful treatment with short hospitalization (< 24 hours). Potential benefits of this regimen include decreased intraoperative blood loss, outpatient management, decreased morbidity, decreased hospital expense and preservation of reproductive potential by avoiding hysterectomy.

Topics: Adult; Combined Modality Therapy; Delayed-Action Preparations; Female; Humans; Leiomyoma; Length of Stay; Leuprolide; Preoperative Care; Treatment Outcome; Ultrasonography; Uterine Cervical Neoplasms

Persistent ovarian cysts are considered to be the most troublesome complication of ovarian transposition. Transabdominal drainage or surgical removal is often required. This paper reports the successful use of leuprolide acetate, a GnRH agonist, in the treatment of a symptomatic and persistent ovarian cyst which developed after ovarian transposition. The benefits of this therapy over others are discussed.

Topics: Adult; Combined Modality Therapy; Female; Gonadotropin-Releasing Hormone; Hormones; Humans; Leuprolide; Ovarian Cysts; Ovary; Postoperative Complications; Uterine Cervical Neoplasms