leuprolide and Urethral-Neoplasms

An 83 year-old male with Gleason score 4+3 prostatic adenocarcinoma status post brachytherapy developed obstructive voiding symptoms 9 years after brachytherapy. Prostate-specific antigen was 0.67. Cystoscopy noted multiple papillary urethral tumors concerning for primary urethral carcinoma. Immunophenotype of biopsies supported diagnosis of Gleason score 4+4 prostatic adenocarcinoma. Androgen deprivation therapy was started. Cystoscopy performed 4 years later, for microhematuria workup, noted complete resolution of the urethral tumors. We present a patient with little serum Prostate-specific antigen change with urethral prostatic adenocarcinoma metastasis that resolved after androgen deprivation therapy.

Topics: Adenocarcinoma; Aged, 80 and over; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Humans; Leuprolide; Male; Nitriles; Prostatic Neoplasms; Remission Induction; Tosyl Compounds; Urethral Neoplasms