leuprolide and Sarcoma--Endometrial-Stromal

Endometrial stromal nodule is a rare subtype of endometrial stromal tumor. Although such nodules are benign, hysterectomy has been considered the treatment of choice, because evaluation of the margin is required for diagnosis. The similarity between low-grade stromal sarcoma and stromal nodule suggests that stromal nodules might respond to hormonal management.. Twenty-one-year-old nulligravida, diagnosed with endometrial stromal nodule, which decreased in size with leuprolide acetate treatment, underwent local excision of the tumor with preservation of reproductive function.. Hormonal therapy was successful in decreasing the size of this stromal nodule which allowed for conservative management.

Topics: Adult; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Drug Administration Schedule; Endometrial Neoplasms; Female; Humans; Injections, Intramuscular; Leuprolide; Sarcoma, Endometrial Stromal

A 46-year-old women presented with an inoperable low-grade endometrial stromal sarcoma. Two doses of Depo-Lupron, 7.5 mg, and Megace, 160 mg/day, were given to control uterine bleeding and shrink the tumor mass. In 9 weeks, significant reduction in the tumor occurred allowing for surgical resection. Total abdominal hysterectomy with bilateral salpingo-oophorectomy is the mainstay for primary treatment. The role of chemotherapy, radiation therapy, and hormonal therapy is poorly defined. This is a case report of neoadjuvant hormonal therapy which may improve outcomes in patients with endometrial stromal sarcomas. Additional research is needed to define the exact role of these agents.

Topics: Antineoplastic Agents, Hormonal; Endometrial Neoplasms; Female; Humans; Leuprolide; Megestrol Acetate; Middle Aged; Sarcoma, Endometrial Stromal