leuprolide and Prader-Willi-Syndrome

leuprolide has been researched along with Prader-Willi-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for leuprolide and Prader-Willi-Syndrome

Article	Year
[Endocrine studies on the Prader-Labhart-Willi syndrome: puberty induction in a 19-year-old boy after long-term treatment with an LHRH analog]. Experimental and clinical endocrinology, 1983, Volume: 82, Issue:1 In two girls (14 and 16 years) and one boy (19 years) with PLW-syndrome and pronounced obesity (240, 210 and 77% overweight) endocrine function tests were carried out. Growth hormone secretion was decreased but normalized after reduction of weight. Thyroxin levels as well as basal and TRH stimulated TSH concentrations were normal. HCG application in the boy induced no rise of the normal basal testosterone levels. Oral glucose tolerance test demonstrated an increased stimulation of insulin in two cases, no other symptoms of diabetes mellitus were found. In the LHRH test an insufficient rise of gonadotropins was found. However, after two weeks of pernasal application of an LHRH analogue (D-Leu6-des-Gly10-EA) the gonadotropin stimulation was distinctly improved and onset of puberty was induced in the male patient. These results are indicative of a hypothalamic disturbance in patients with PLW-syndrome. Topics: Adolescent; Adult; Body Weight; Female; Follicle Stimulating Hormone; Glucose Tolerance Test; Gonadotropin-Releasing Hormone; Humans; Insulin; Leuprolide; Luteinizing Hormone; Male; Prader-Willi Syndrome; Puberty, Delayed; Thyrotropin; Thyrotropin-Releasing Hormone	1983

Article

Year

[Endocrine studies on the Prader-Labhart-Willi syndrome: puberty induction in a 19-year-old boy after long-term treatment with an LHRH analog].

Experimental and clinical endocrinology, 1983, Volume: 82, Issue:1

In two girls (14 and 16 years) and one boy (19 years) with PLW-syndrome and pronounced obesity (240, 210 and 77% overweight) endocrine function tests were carried out. Growth hormone secretion was decreased but normalized after reduction of weight. Thyroxin levels as well as basal and TRH stimulated TSH concentrations were normal. HCG application in the boy induced no rise of the normal basal testosterone levels. Oral glucose tolerance test demonstrated an increased stimulation of insulin in two cases, no other symptoms of diabetes mellitus were found. In the LHRH test an insufficient rise of gonadotropins was found. However, after two weeks of pernasal application of an LHRH analogue (D-Leu6-des-Gly10-EA) the gonadotropin stimulation was distinctly improved and onset of puberty was induced in the male patient. These results are indicative of a hypothalamic disturbance in patients with PLW-syndrome.

Topics: Adolescent; Adult; Body Weight; Female; Follicle Stimulating Hormone; Glucose Tolerance Test; Gonadotropin-Releasing Hormone; Humans; Insulin; Leuprolide; Luteinizing Hormone; Male; Prader-Willi Syndrome; Puberty, Delayed; Thyrotropin; Thyrotropin-Releasing Hormone

1983