leuprolide and Lymphoma

Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Hematopoietic Stem Cell Transplantation; Hormone Replacement Therapy; Humans; Leukemia; Leuprolide; Lymphoma; Middle Aged; Premenopause; Risk Factors; Uterine Hemorrhage; Vascular Diseases

To evaluate, in a pilot study, the use and efficacy of a gonadotropin-releasing hormone (GnRH)-agonist in inducing amenorrhea in women undergoing BMT.. We evaluated the use of the GnRH agonist leuprolide acetate (LA) for the induction of amenorrhea in 10 postmenarcheal women prior to BMT. If there was a contraindication to the use of the intramuscular (i.m.) formulation of LA, the subcutaneous (s.c.) formulation was given as a daily intravenous (i.v.) bolus. Once the subject's platelet count was > 50,000/microL, the LA was discontinued. Menstrual bleeding, time from initiation of therapy to amenorrhea, and liver function test results were monitored.. All subjects had induction of amenorrhea with the use of LA except for one subject with a large, myomatous uterus, who experienced light spotting. One subject who was thrombocytopenic at the prescribed time of the second dosage of i.m. LA received i.v. LA with documentation of continued pituitary/gonadal suppression. No adverse effects were determined to be directly related to either the i.m. or i.v. LA.. LA is an option for the induction of amenorrhea in postmenarcheal women undergoing BMT. In thrombocytopenic subjects, administration of the s.c. formulation of LA by an i.v. route served as an alternative to i.m. injection and was documented to maintain gonadotropin suppression.

Topics: Adolescent; Adult; Amenorrhea; Bone Marrow Transplantation; Contraindications; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Leukemia; Leuprolide; Lymphoma; Pilot Projects; Platelet Count; Uterine Hemorrhage

An unsuspected primary cervical lymphoma thought to be a cervical fibroid decreased in size dramatically after initiation of Leuprolide acetate prior to being correctly diagnosed during subsequent hysterectomy for uterine bleeding. This case represents the first reported successful use of Leuprolide acetate against a reticuloendothelial tumor.

Topics: Adult; Diagnosis, Differential; Female; Humans; Hysterectomy; Leiomyoma; Leuprolide; Lymphoma; Uterine Cervical Neoplasms; Uterine Hemorrhage