leuprolide and Lung-Diseases

To report a rare case of a patient with catamenial hemoptysis, secondary infertility, and endometriosis associated with a unicornuate uterus and noncommunicating rudimentary horn.. Case report.. University hospital.. A 29-year-old woman who developed progressive catamenial hemoptysis and secondary infertility was evaluated at the University Hospital of Crete.. The complete history, laboratory data, laparoscopic findings, and chest magnetic resonance image of this patient were analyzed. A GnRH agonist, leuprolide acetate, was successfully administered.. Diagnosis and appropriate treatment of pulmonary endometriosis in a patient with rudimentary uterine horn.. Treatment with a GnRH agonist achieved suppression of both menstruation and hemoptysis. After 6 months of normal menstrual activity, the symptoms reappeared. The patient was again treated with leuprolide acetate (3.75 mg/mo IM) for 6 months and remained asymptomatic. In fact, the patient became pregnant after cessation of therapy. Finally, the patient was treated successfully with removal of the rudimentary uterine horn during cesarean section. Three-year follow-up showed disappearance of the chest symptoms.. Pulmonary endometriosis and unicornuate uteri are rare. To our knowledge, this is the first case of catamenial hemoptysis with a congenital müllerian anomaly. We describe successful management using a combination of GnRH agonist and surgical resection of the rudimentary uterine horn.

Topics: Adult; Endometriosis; Female; Fertility Agents, Female; Gonadotropin-Releasing Hormone; Hemoptysis; Humans; Infertility, Female; Leuprolide; Lung Diseases; Pregnancy; Uterus

Endometriosis is a common disease found in reproductive age women, but pulmonary endometriosis is rare. We present a 21-year-old female with catamenial chest pain, chest tightness, severe cough, and hemoptysis. Though we could not find any definite intrapulmonary endometriotic lesion by computed tomography and bronchoscope, she was diagnosed to have pulmonary endometriosis due to the typical clinical symptoms. After 6 months of GnRH agonist application, the symptoms were completely relieved. She has been followed up and has been symptoms free for at least 6 months after administration of GnRH agonist.

Topics: Adult; Endometriosis; Female; Humans; Leuprolide; Lung Diseases

We describe a case of pulmonary lymphangiomyomatosis (LAM) with chylothorax that developed in a 46-year-old Japanese woman. This patient exhibited clinical symptoms of dyspnea and chest X-ray showed right pleural effusion. Thoracocentesis demonstrated chylous effusion. Chest computed tomography (CT) scan revealed multiple cystic lesions. Subsequent thoracoscopy revealed the chylorrhea from swelled vessels on the diaphragm. The clinical diagnosis, based on histological examinations with biopsy specimens obtained by thoracoscopy, was pulmonary LAM. Although the hormone therapy was not effective, chylous effusion was improved by the pleurodesis. Pulmonary LAM developing chylothorax is rare in Japan.

Topics: Chylothorax; Drug Therapy, Combination; Female; Humans; Leuprolide; Lung Diseases; Lymphangioleiomyomatosis; Middle Aged; Pleurodesis; Progesterone; Thoracoscopy; Tomography, X-Ray Computed

We report a case of parenchymal pulmonary endometriosis in combination with severe endometriosis genitalis externa. The difficulties on the way to final diagnosis are described, also the different possibilities of hormonal treatment that results in ovarian suppression. In our case the patient is without any symptoms since three years using a GnRH-Agonist as first line therapy and as second line therapy high-dose medroxyprogesterone acetate. Because of the very good clinical results after hormonal suppression surgical intervention might become necessary only in certain cases. This can be the case when after intolerance of hormonal treatment angiography of lung vascular system on the bases of number and localization of endometrial lesions shows good operative conditions.

Topics: Adult; Angiography; Antineoplastic Agents, Hormonal; Diagnosis, Differential; Drug Therapy, Combination; Endometriosis; Fallopian Tubes; Female; Hemoptysis; Humans; Laparoscopy; Leuprolide; Lung Diseases; Medroxyprogesterone Acetate