leuprolide and Kallmann-Syndrome

We report the case of a pregnancy in a patient with Kallmann's syndrome. The patient responded adequately to gonadotropin releasing hormone (GnRH) stimulation test, and after the third cycle of stimulation the patient became refractory to the treatment. The patient did not respond to exogenous follicle stimulating hormone (FSH) or human menopausal gonadotropins (hMG) for ovulation induction. For these reasons, we used a short course of leuprolide acetate (LUPRON) followed by hMG, which resulted in ovulation and a subsequent pregnancy which was carried to term. We present an alternate approach to ovulation induction in patients with Kallmann's syndrome and a review of the literature.

Topics: Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Infant, Newborn; Kallmann Syndrome; Leuprolide; Menotropins; Ovulation; Ovulation Induction; Pregnancy; Pregnancy Outcome