leuprolide and Fibrous-Dysplasia--Polyostotic

Topics: Anastrozole; Aromatase Inhibitors; Female; Fibrous Dysplasia, Polyostotic; Gonadotropins, Pituitary; Humans; Leuprolide; Male; Nitriles; Prognosis; Puberty, Precocious; Surgical Procedures, Operative; Triazoles

To evaluate ovarian function, especially ovulation rate, in adolescents with McCune-Albright syndrome (MAS) and a history of peripheral precocious puberty.. Prospective cross-sectional study.. Academic center.. A total of eight adolescents with MAS were compared with 15 healthy adolescents matched by age, Tanner stage and body mass index.. We determined basal gonadotropins, sex steroids, sex hormone binding globulin, anti-Müllerian hormone, glucose and insulin. A leuprolide acetate test was performed to measure luteinizing hormone (LH) and follicle stimulating hormone (FSH) (at 0 and 3 h), and 17B-estradiol, testosterone and 17-OH-progesterone (at 0 and 24 h). Salivary progesterone levels were used to assess ovulation during the 13th, 18th, 23rd and 28th days of each menstrual cycle for three to five consecutive cycles, and one pelvic ultrasound was performed during the follicular phase.. Ovulation rate in adolescents with MAS.. The proportion of ovulatory cycles was 52.6% in controls compared with 35.7% in patients with MAS.. The adolescent girls with MAS appear to have a lower ovulatory rate compared with controls.

Topics: Adolescent; Adult; Cross-Sectional Studies; Female; Fibrous Dysplasia, Polyostotic; Follicle Stimulating Hormone, Human; Follicular Phase; Gonadotropin-Releasing Hormone; Humans; Hyperandrogenism; Leuprolide; Luteinizing Hormone; Ovary; Ovulation; Prospective Studies; Puberty, Precocious; Ultrasonography; Young Adult

Adnexal torsion may occur in girls and adolescents. Often it is associated with ovarian diseases resulting in ovarian enlargement. Adnexal torsion may involve the ovary, fallopian tube or both, and the main symptom is acute pelvic pain. An 8-year-old girl complaining of acute pelvic and abdominal pain, who was previously diagnosed with precocious puberty and who received treatment with a GnRH analog, is reported. Ultrasound demonstrated a normal-sized uterus and bilaterally enlarged ovaries with multiple internal cysts. At laparotomy, we found a complete torsion in the right adnexa. The histological examination revealed massive edema associated with multiple antral follicles and reduction of the follicular reserve.

Topics: Adnexal Diseases; Child; Female; Fertility Agents, Female; Fibrous Dysplasia, Polyostotic; Humans; Leuprolide; Puberty, Precocious; Torsion Abnormality

Topics: Adolescent; Calcitriol; Diagnosis, Differential; Female; Fibrous Dysplasia, Polyostotic; Humans; Ketoconazole; Leuprolide; Male; Medroxyprogesterone Acetate; Octreotide; Ovariectomy; Propylthiouracil; Puberty, Precocious; Spironolactone; Testolactone; Thyroid Diseases