leuprolide and Ependymoma

Extraneural ependymomas are rare tumors that occur in sacrococcygeal, pelvic and extra pelvic regions. While sacrococcygeal extraneural ependymomas are equally distributed among males and females, pelvic and extra pelvic ependymomas have been exclusively reported in women, mainly of child bearing age. We present a case of extraneural, pelvic ependymoma that showed clinical response to GnRH therapy with its immunohistochemical and electron microscopic analysis, and an overview of primary extraneural ependymomas based on a review of all such cases published in English literature.

Topics: Adult; Antineoplastic Agents, Hormonal; Cadherins; Ependymoma; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Keratins; Leuprolide; Magnetic Resonance Imaging; Microscopy, Electron; Pelvis; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Tomography, X-Ray Computed; Treatment Outcome; Ultrasonography