leupeptins has been researched along with Hypoparathyroidism* in 1 studies
1 other study(ies) available for leupeptins and Hypoparathyroidism
| Article | Year |
|---|---|
The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation.
Differentiated neurons and glia are acquired from immature precursors via transcriptional controls exerted by factors such as proteins in the family of Glial Cells Missing (Gcm). Mammalian Gcm proteins mediate neural stem cell induction, placenta and parathyroid development, whereas Drosophila Gcm proteins act as a key switch to determine neuronal and glial cell fates and regulate hemocyte development. The present study reports a hypoparathyroidism-associated mutation R59L that alters Drosophila Gcm (Gcm) protein stability, rendering it unstable, and hyperubiquitinated via the ubiquitin-proteasome system (UPS). Gcm Topics: Animals; DNA; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Humans; Hypoparathyroidism; Leupeptins; Neuroglia; Nuclear Proteins; Phosphorylation; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinase C; Protein Stability; Transcription Factors; Ubiquitin; Ubiquitination | 2017 |