leupeptins has been researched along with Abortion--Habitual* in 1 studies
1 other study(ies) available for leupeptins and Abortion--Habitual
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Intracellular expression of CD69 in endometrial and peripheral T cells represents a useful marker in women with recurrent miscarriage: modulation after allogeneic leukocyte immunotherapy.
To characterize in fertile women and women with recurrent spontaneous abortions (RSA) the expression and functional status of T cells expressing the CD69 molecule.. We analyzed by flow cytometry in peripheral blood and endometrium from fertile and RSA women, the surface and cytoplasmic expression of CD69 on gated T cells. In addition, we investigated by three-color flow cytometry the expression of cytokines, and subsets of memory T cells.. In T cells, CD69 was restricted to the intracellular compartment with a higher frequency in RSA than in fertile women (68.2 +/- 12% versus 23.7 +/- 22%, P < 0.001, and 20 +/- 9.5% versus 2.1 +/- 3.8%, P < 0.005, in endometrium and peripheral blood, respectively). In contrast, the number of interferon-gamma+ (IFN-gamma+) secreting cells was higher (16 +/- 5% versus 6 +/- 1%) in fertile women. All 11 RSA women alloimmunized with parental leukocytes reached values of CD3 +/- CD69+ cells similar to those observed in fertile women.. CD69 might represent a useful marker in the diagnosis and the follow up of RSA patients. Topics: Abortion, Habitual; Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Biomarkers; CD3 Complex; Cysteine Proteinase Inhibitors; Cytokines; Endometrium; Female; Flow Cytometry; Follow-Up Studies; Humans; Immunophenotyping; Immunotherapy; Lectins, C-Type; Leupeptins; Lymphocyte Activation; Lymphocyte Transfusion; Male; Pregnancy; T-Lymphocyte Subsets; T-Lymphocytes; Transplantation, Homologous | 2003 |