leukotriene-e4 and Dysmenorrhea

leukotriene-e4 has been researched along with Dysmenorrhea* in 2 studies

Other Studies

2 other study(ies) available for leukotriene-e4 and Dysmenorrhea

ArticleYear
Urinary leukotriene (LT) E(4) in adolescents with dysmenorrhea: a pilot study.
    The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2000, Volume: 27, Issue:3

    In the present study we measured levels of urinary leukotriene (LT) E(4) as an index of LT production during the menstrual cycle in adolescents. Mean urinary LTE(4) levels in girls with dysmenorrhea was approximately threefold higher than normal laboratory values on Day 1 of the menstrual period and approximately twofold higher than normal laboratory values on Day 5 of the menstrual period. Compared with urinary LTE(4) levels in girls with eumenorrhea, urinary LTE(4) levels in girls with dysmenorrhea were higher on Day 1 [361 +/- 123 pg/mg creatinine vs. 122 +/- 37 pg/mg creatinine, p =.1; not significant (NS)] and on Day 5 (202 +/- 26 pg/mg creatinine vs. 117 +/- 26 pg/mg creatinine, p <.05) of the menstrual period, as well as on Day 10 (159 +/- 33 pg/mg creatinine vs. 88 +/- 21 pg/mg creatinine, p =.1; NS) of the menstrual cycle. Increased urinary excretion of leukotrienes, inflammatory mediators known to cause potent vasoconstriction and uterine contractions, in girls with dysmenorrhea in this pilot study, suggests that these mediators may be involved in generating dysmenorrhea symptoms in adolescents.

    Topics: Adolescent; Dysmenorrhea; Female; Humans; Leukotriene E4; Menstrual Cycle; Pilot Projects; Uterine Contraction

2000
Leukotriene release by endometrium and myometrium throughout the menstrual cycle in dysmenorrhoea and menorrhagia.
    The Journal of endocrinology, 1987, Volume: 113, Issue:2

    Endometrium and myometrium were collected at hysterectomy from 21 women with measured menstrual blood loss. Eight women complained of dysmenorrhea and the remaining 13 had pain-free periods. Specimens were obtained throughout the menstrual cycle (menstrual, n = 5; follicular, n = 4; early luteal, n = 3; mid-luteal, n = 5; late luteal, n = 4). Leukotriene C4, leukotriene D4 and leukotriene E4 release were examined using a short-term incubation technique. Endometrial leukotriene release, which was always significantly greater than myometrial release, changed throughout the menstrual cycle and the highest concentrations were found during menstruation. Endometrial, but not myometrial, leukotriene concentrations were significantly higher in tissues obtained from women with a complaint of dysmenorrhoea compared with those in tissue from pain-free women. No correlation was found between leukotriene release in either endometrium or myometrium and menstrual blood loss (range 15-457 ml).

    Topics: Adult; Dysmenorrhea; Endometrium; Female; Humans; Leukotriene E4; Menorrhagia; Menstrual Cycle; Middle Aged; Myometrium; SRS-A

1987