leukotriene-e4 has been researched along with Colitis* in 2 studies
2 other study(ies) available for leukotriene-e4 and Colitis
| Article | Year |
|---|---|
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
G-protein-coupled receptors (GPCRs) are the molecular target of 40% of marketed drugs and the most investigated structures to develop novel therapeutics. Different members of the GPCRs superfamily can modulate the same cellular process acting on diverse pathways, thus representing an attractive opportunity to achieve multitarget drugs with synergic pharmacological effects. Here, we present a series of compounds with dual activity toward cysteinyl leukotriene receptor 1 (CysLT Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Humans; Leukotriene D4; Macrophages; Mice; Molecular Docking Simulation; Protein Binding; RAW 264.7 Cells; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Structure-Activity Relationship | 2021 |
Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
The cysteinyl leukotrienes (CysLTs), i.e. LTC Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Colitis; Cyclopropanes; Disease Models, Animal; Gene Expression; Genes, Reporter; HEK293 Cells; Hep G2 Cells; Humans; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Luciferases; Mice; Mice, Knockout; Molecular Docking Simulation; Quinolines; RAW 264.7 Cells; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Recombinant Fusion Proteins; Sulfides | 2020 |