leukotriene-e4 and Bronchiolitis--Viral

We prospectively studied the levels of eicosanoids in intubated patients with severe bronchiolitis and compared them to electively intubated non-infected infants. LeukotrieneE(4) (LTE(4)), leukotrieneB(4) (LTB(4)), and prostaglandinE(2) (PGE(2)) levels were significantly increased (P <.01) from endotracheal (ET) aspirates of infants with bronchiolitis compared with controls, as were urinary LTE(4) levels (P <.001). We conclude that eicosanoids are increased in the tracheal aspirates and urine of children with bronchiolitis.

Topics: Acute Disease; Bronchiolitis, Viral; Case-Control Studies; Child, Preschool; Dinoprostone; Female; Humans; Infant; Intubation, Intratracheal; Leukotriene B4; Leukotriene E4; Male; Prospective Studies; Respiratory Syncytial Virus Infections