leukotriene-d4 has been researched along with Rhinitis--Allergic* in 2 studies
2 other study(ies) available for leukotriene-d4 and Rhinitis--Allergic
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Effects of leukotriene D
Both histamine and leukotrienes are implicated in the pathogenesis of allergic rhinitis (AR), although the pattern and severity of the nasal response to these two potent inflammatory mediators may differ, which has not been adequately studied in patients with persistent AR.. We sought to compare the differential effects of nasal challenge with leukotriene D. An open-label, crossover study was performed in 25 persistent AR patients (AR group) and 16 healthy subjects (control group). Participants randomly underwent histamine and LTD. Nasal airway resistance (NAR) increased significantly after both LTD. LTD Topics: Adult; Aged; Airway Resistance; Case-Control Studies; Chronic Disease; Cross-Over Studies; Female; Histamine; Humans; Leukotriene D4; Male; Middle Aged; Nasal Provocation Tests; Reference Values; Rhinitis, Allergic; Severity of Illness Index; Young Adult | 2018 |
Xinqin exhibits the anti-allergic effect through the JAK2/STAT5 signaling pathway.
Xinqin, a polyherbal medicine, is an important traditional Chinese herbal formula used in traditional oriental medicine for treatment of allergic rhinitis (AR). The formula is based on the Chinese Pharmacopoeia AIM OF THE STUDY: Previously, Xinqin exhibited potent anti-allergic effect in a guinea pig model of AR. In this study, we explored the molecular mechanism of the anti-allergic effect mediated by Xinqin.. AR was induced in guinea pigs (Hartley) with toluene-2, 4-diisocyanate (TDI) in vivo and in HMC-1 mast cells with A23187/phorbol 12-myristate-13-acetate (PMA) in vitro. The releases of allergic inflammatory mediators such as histamine, leukotriene (LT) D4, immunoglobulin (Ig) E, TNF-α, and IL-6 were analyzed for allergy. The mast cell degranulation was displayed in HMC-1 mast cells. The activities of janus protein kinase 2 (JAK2), signal transduction and activator of transcription 5 (STAT5) and suppressor of cytokine signaling 3 (SOCS3) were evaluated by Western blot.. Treatment with Xinqin resulted in AR symptoms and decreases in levels of histamine, LTD4, IgE, TNF-α, and IL-6 in serum of guinea pig model of AR and in A23187/PMA-stimulated HMC-1 mast cells. Treatment with Xinqin also inhibited cell degranulation in A23187/PMA-stimulated HMC-1 mast cells. The JAK2/STAT5 signaling pathway could play an important role in the anti-allergic activity mediated by Xinqin.. Xinqin exerts the anti-allergic effect by modulating mast cell-mediated allergic responses by down-regulating JAK2/STAT5 signaling pathway. Results from this study provide a mechanistic basis for the application of Xinqin in the treatment of AR. Topics: Animals; Anti-Allergic Agents; Calcimycin; Cell Degranulation; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drugs, Chinese Herbal; Guinea Pigs; Histamine; Humans; Immunoglobulin E; Interleukin-6; Janus Kinase 2; Leukotriene D4; Male; Mast Cells; Phosphorylation; Rhinitis, Allergic; Signal Transduction; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Tetradecanoylphorbol Acetate; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha | 2016 |