leukotriene-d4 and Nasal-Polyps

Eosinophils are multifunctional granulocytes capable of releasing various cytokines, chemokines, and lipid mediators. We previously reported dysregulated fatty acid metabolism in peripheral blood-derived eosinophils from patients with severe asthma. However, functional characteristics of eosinophils present in allergic inflammatory tissues remain largely uncharacterized.. We established a method for isolating CD69. Lipidomic analysis revealed impaired synthesis of prostaglandins and 15-lipoxygenase (15-LOX)-derived mediators, and selective upregulation of leukotriene D. Inflammatory tissue-derived eosinophils possess a specific phenotype with dysregulated fatty acid metabolism that may be targeted therapeutically to control eosinophilic inflammatory diseases.

Topics: Adult; Arachidonate 15-Lipoxygenase; Blood Donors; Cells, Cultured; Chronic Disease; Cytokines; Eosinophils; Fatty Acids; Female; gamma-Glutamyltransferase; Humans; Leukotriene D4; Male; Middle Aged; Nasal Polyps; Phenotype; Prostaglandin-Endoperoxide Synthases; Proteome; Rhinitis; Signal Transduction; Sinusitis; Transcriptome