leukotriene-d4 and Breast-Neoplasms

leukotriene-d4 has been researched along with Breast-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for leukotriene-d4 and Breast-Neoplasms

Article	Year
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6 A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations. Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship	2013
Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. European journal of obstetrics, gynecology, and reproductive biology, 1998, Volume: 77, Issue:1 The aim of this work was to study the action of leukotrienes on the growth of human mammary cancer cells MCF-7.. The growth of the cells was measured by incorporation of 3H-thymidine. The action of leukotriene (LT)B4, LTD4, LTC4, LTE4 or arachidonate (AA) was tested in human mammary cancer cells MCF-7 in vitro.. LTB4 or LTD4 but not LTC4 or LTE4 reduced significant incorporation of 3H-thymidine in MCF-7 cells up to 52% or 56% respectively, when administered in concentrations 0.1-1000 pM. Agents in concentrations of 0.01 pM or 10000 pM did not effect 3H-thymidine incorporation. We have shown, that MCF-7 cells synthesise LTB4 when treated with calcium ionophor A23187 (10 microM). Leukotriene-antagonist LY171883 (10 microM) lifts inhibitory effects of LTB4 or LTD4. Arachidonic acid (10 microM) inhibits 3H-thymidine incorporation up to 72%. 5-lipoxygenase inhibitor MK-886 (100 nM) lifts the inhibitory effect of arachidonate.. LTB4 or LTD4 inhibits MCF-7 breast cancer cell growth. LT-receptors mediate the growth-inhibitory effect of LTB4 or LTD4. Topics: Acetophenones; Arachidonic Acid; Breast Neoplasms; Calcimycin; Carcinoma; Cell Division; Female; Humans; Indoles; Ionophores; Leukotriene Antagonists; Leukotriene B4; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Osmolar Concentration; Tetrazoles; Thymidine; Tritium; Tumor Cells, Cultured	1998

Article

Year

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6

A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations.

Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship

2013

Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7.

European journal of obstetrics, gynecology, and reproductive biology, 1998, Volume: 77, Issue:1

The aim of this work was to study the action of leukotrienes on the growth of human mammary cancer cells MCF-7.. The growth of the cells was measured by incorporation of 3H-thymidine. The action of leukotriene (LT)B4, LTD4, LTC4, LTE4 or arachidonate (AA) was tested in human mammary cancer cells MCF-7 in vitro.. LTB4 or LTD4 but not LTC4 or LTE4 reduced significant incorporation of 3H-thymidine in MCF-7 cells up to 52% or 56% respectively, when administered in concentrations 0.1-1000 pM. Agents in concentrations of 0.01 pM or 10000 pM did not effect 3H-thymidine incorporation. We have shown, that MCF-7 cells synthesise LTB4 when treated with calcium ionophor A23187 (10 microM). Leukotriene-antagonist LY171883 (10 microM) lifts inhibitory effects of LTB4 or LTD4. Arachidonic acid (10 microM) inhibits 3H-thymidine incorporation up to 72%. 5-lipoxygenase inhibitor MK-886 (100 nM) lifts the inhibitory effect of arachidonate.. LTB4 or LTD4 inhibits MCF-7 breast cancer cell growth. LT-receptors mediate the growth-inhibitory effect of LTB4 or LTD4.

Topics: Acetophenones; Arachidonic Acid; Breast Neoplasms; Calcimycin; Carcinoma; Cell Division; Female; Humans; Indoles; Ionophores; Leukotriene Antagonists; Leukotriene B4; Leukotriene D4; Leukotrienes; Lipoxygenase Inhibitors; Osmolar Concentration; Tetrazoles; Thymidine; Tritium; Tumor Cells, Cultured

1998