leukotriene-c4 and Status-Asthmaticus

leukotriene-c4 has been researched along with Status-Asthmaticus* in 2 studies

Reviews

1 review(s) available for leukotriene-c4 and Status-Asthmaticus

Article	Year
[Leukotriene (B4, C4, D4, E4)]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8 Topics: Asthma; Biomarkers; Chromatography, High Pressure Liquid; Humans; Inflammation Mediators; Leukotriene B4; Leukotriene C4; Leukotriene D4; Leukotriene E4; Radioimmunoassay; Reference Values; Specimen Handling; Status Asthmaticus	2005

Trials

1 trial(s) available for leukotriene-c4 and Status-Asthmaticus

Article	Year
Eosinophil activation status and corticosteroid responsiveness in severe asthma. International archives of allergy and immunology, 2000, Volume: 122, Issue:3 Since eosinophils are implicated in asthma pathogenesis, we investigated whether these cells were activated in severe asthma.. Twenty-six asthmatics with different clinical responses to oral corticosteroid (CS), i.e. sensitive [change in forced expiratory volume in 1 s (DeltaFEV(1)) >/= 25% after oral methylprednisolone, 40 mg daily, for 14 days, n = 7], resistant (DeltaFEV(1) /= 20 mg oral prednisone daily for acceptable asthma control, n = 10), were studied.. Calcium ionophore-induced leukotriene (LT) C(4) release of purified blood eosinophils was similar in the three groups. Cell incubation with granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced ionophore-induced LTC(4) release, and this effect was higher in CS-sensitive (5-fold) than in CS-resistant subjects (1.7-fold) (p = 0.02). CS treatment decreased blood eosinophil counts in these two groups of subjects (p Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Cells, Cultured; Drug Resistance; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukotriene C4; Male; Status Asthmaticus	2000

Article

Year

Eosinophil activation status and corticosteroid responsiveness in severe asthma.

International archives of allergy and immunology, 2000, Volume: 122, Issue:3

Since eosinophils are implicated in asthma pathogenesis, we investigated whether these cells were activated in severe asthma.. Twenty-six asthmatics with different clinical responses to oral corticosteroid (CS), i.e. sensitive [change in forced expiratory volume in 1 s (DeltaFEV(1)) >/= 25% after oral methylprednisolone, 40 mg daily, for 14 days, n = 7], resistant (DeltaFEV(1) /= 20 mg oral prednisone daily for acceptable asthma control, n = 10), were studied.. Calcium ionophore-induced leukotriene (LT) C(4) release of purified blood eosinophils was similar in the three groups. Cell incubation with granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced ionophore-induced LTC(4) release, and this effect was higher in CS-sensitive (5-fold) than in CS-resistant subjects (1.7-fold) (p = 0.02). CS treatment decreased blood eosinophil counts in these two groups of subjects (p

Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Cells, Cultured; Drug Resistance; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukotriene C4; Male; Status Asthmaticus

2000