leukotriene-c4 and Respiratory-Sounds

leukotriene-c4 has been researched along with Respiratory-Sounds* in 1 studies

Trials

1 trial(s) available for leukotriene-c4 and Respiratory-Sounds

Article	Year
Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission. Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 58, Issue:2 To estimate the effect of prednisolone on 5-lipoxygenase activity in eosinophils obtained from asthmatic patients, cytosolic levels of 5-H(P)ETE and Ca2+ were measured in the eosinophils which were exposed to prednisolone in vitro and in vivo. The mean level of 5-H(P)ETE during a wheezing attack was significantly lower in the patients who had received intravenous prednisolone (500 mg/day). Incubation with prednisolone in vitro caused a dose-dependent decrease in the cytosolic levels of 5-H(P)ETE and Ca2+ in eosinophils obtained during the wheezing attack, but not in the eosinophils obtained from during remission. Results suggest that prednisolone inhibits the level of 5-H(P)ETE in the eosinophil cytosols of asthmatic patients during a wheezing attack, probably by inhibition of 5-lipoxygenase activity which is involved in the reduction of the influx of Ca2+. Topics: Adult; Arachidonic Acids; Asthma; Calcium; Cytosol; Dose-Response Relationship, Drug; Eosinophils; Glucocorticoids; Humans; Injections, Intravenous; Leukocyte Count; Leukotriene C4; Male; Middle Aged; Prednisolone; Remission Induction; Respiratory Sounds	1998

Article

Year

Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission.

Prostaglandins, leukotrienes, and essential fatty acids, 1998, Volume: 58, Issue:2

To estimate the effect of prednisolone on 5-lipoxygenase activity in eosinophils obtained from asthmatic patients, cytosolic levels of 5-H(P)ETE and Ca2+ were measured in the eosinophils which were exposed to prednisolone in vitro and in vivo. The mean level of 5-H(P)ETE during a wheezing attack was significantly lower in the patients who had received intravenous prednisolone (500 mg/day). Incubation with prednisolone in vitro caused a dose-dependent decrease in the cytosolic levels of 5-H(P)ETE and Ca2+ in eosinophils obtained during the wheezing attack, but not in the eosinophils obtained from during remission. Results suggest that prednisolone inhibits the level of 5-H(P)ETE in the eosinophil cytosols of asthmatic patients during a wheezing attack, probably by inhibition of 5-lipoxygenase activity which is involved in the reduction of the influx of Ca2+.

Topics: Adult; Arachidonic Acids; Asthma; Calcium; Cytosol; Dose-Response Relationship, Drug; Eosinophils; Glucocorticoids; Humans; Injections, Intravenous; Leukocyte Count; Leukotriene C4; Male; Middle Aged; Prednisolone; Remission Induction; Respiratory Sounds

1998