leukotriene-c4 and Hepatitis--Animal

The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level. The maximal effect was obtained with the dose of 1000 U (166 ng/kg) IL-1 alpha. Pretreatment with IL-1 significantly increased the synthesis of prostaglandin E2 (PGE2) in samples of liver tissue from AAP-treated mice, but had no effect on the synthesis of leukotriene C4 (LTC4). Pretreatment with indomethacin (IMC) did not abrogate significantly the protective effect of IL-1. Thus, the hepatoprotective effect of IL-1 alpha can not be entirely explained by the stimulation of prostaglandin (PG) synthesis.

Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dinoprostone; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hepatitis, Animal; Indomethacin; Interleukin-1; Leukotriene C4; Liver; Male; Mice; Mice, Inbred CBA