leukotriene-c4 and Diabetes-Mellitus

We investigated the effect of long-term administration of highly purified eicosapentaenoic acid ethyl ester (EPA-E), an n-3 polyunsaturated fatty acid, on the dysfunction of the endothelium and smooth muscle cells in male WBN/Kob rats, a model of spontaneous diabetes mellitus. After oral 8-month treatment with EPA-E, the agent significantly and dose-dependently increased the migration activity of vascular endothelial cells and also decreased 5-bromodeoxyuridine (BrdU) uptake by vascular smooth muscle cells at a dose of 0.1 g/kg or higher. In addition, there were significant correlations between the endothelial cell migration or smooth muscle cell proliferation and the 4-hour fasting glucose level. These findings suggest that EPA-E has a suppressive effect on thrombosis and atherosclerosis.

Topics: Animals; Bromodeoxyuridine; Cell Movement; Cells, Cultured; Diabetes Mellitus; Dose-Response Relationship, Drug; Eicosapentaenoic Acid; Endothelium, Vascular; Glucose Tolerance Test; Leukotriene C4; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Rats, Wistar; Time Factors