leukotriene-c4 and Candidiasis

leukotriene-c4 has been researched along with Candidiasis* in 1 studies

Other Studies

1 other study(ies) available for leukotriene-c4 and Candidiasis

ArticleYear
Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:4

    The kidney is a major target organ in generalized candidiasis. When mice were infected with C.albicans, prostaglandin E2 (PGE2)-like activity was found to be significantly decreased while leukotriene C4 (LTC4)-like activity increased in the kidneys within 10 days. The aim of this study is to investigate the effect of nordihydroguaretic (NDGA) and fluconazole on the LTC4/PGE2 ratio in the mice kidneys infected by proteinase (+) C. albicans. The LTC4/PGE2 ratio was found to be significantly decreased both in NDGA and fluconazole-pretreated groups. These results indicate that pretreatment with the lipoxygenase inhibitor NDGA and the antifungal drug fluconazole, protect the kidney against C. albicans infection. These results also indicate a possible role of arachidonic acid metabolites (increase LTC4 and decrease PGE2) in kidney damage due to C. albicans infection.

    Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Dinoprostone; Female; Fluconazole; Histocytochemistry; Kidney; Leukotriene C4; Lipoxygenase Inhibitors; Male; Masoprocol; Mice

1997