leukotriene-b4 and Spinal-Diseases

leukotriene-b4 has been researched along with Spinal-Diseases* in 1 studies

Other Studies

1 other study(ies) available for leukotriene-b4 and Spinal-Diseases

Article	Year
Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:1 The synthesis of leukotriene B4 by A23187-stimulated rat peritoneal leukocytes was studied in the presence of 0.1% normal human serum, serum from patients treated with NSAIDs for either an inflammatory (rheumatoid arthritis, RA) or a non-inflammatory condition (lumbar disc protrusion, LDP), and serum from RA patients drawn one week after withdrawal from NSAID treatment. The capacity for LTB4 synthesis was significantly lower in the presence of serum from NSAID treated patients: thirty per cent less than observed in presence of normal serum in the RA group, and fifty per cent in the LDP group. When NSAIDs were withdrawn from RA patients, the LTB4 production in presence of serum increased, but was not completely normalized after one week. These results indicate that NSAID treatment may down-regulate the capacity for leukotriene synthesis by an indirect effect. Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood; Female; Humans; Leukocytes; Leukotriene B4; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Spinal Diseases	1996

Article

Year

Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4.

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:1

The synthesis of leukotriene B4 by A23187-stimulated rat peritoneal leukocytes was studied in the presence of 0.1% normal human serum, serum from patients treated with NSAIDs for either an inflammatory (rheumatoid arthritis, RA) or a non-inflammatory condition (lumbar disc protrusion, LDP), and serum from RA patients drawn one week after withdrawal from NSAID treatment. The capacity for LTB4 synthesis was significantly lower in the presence of serum from NSAID treated patients: thirty per cent less than observed in presence of normal serum in the RA group, and fifty per cent in the LDP group. When NSAIDs were withdrawn from RA patients, the LTB4 production in presence of serum increased, but was not completely normalized after one week. These results indicate that NSAID treatment may down-regulate the capacity for leukotriene synthesis by an indirect effect.

Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood; Female; Humans; Leukocytes; Leukotriene B4; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Spinal Diseases

1996