leukotriene-b4 and Polyps

leukotriene-b4 has been researched along with Polyps* in 1 studies

Trials

1 trial(s) available for leukotriene-b4 and Polyps

Article	Year
Gene expression analysis in sinonasal polyposis before and after oral corticosteroids: a preliminary investigation. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2007, Volume: 137, Issue:1 To characterize gene expression in sinonasal polyps and to gain insight into change in expression after oral corticosteroid treatment.. Nasal polyps were obtained before and after oral corticosteroid treatment and gene expression was analyzed with a focused gene array technique.. Pretreated sinonasal polyps demonstrated high gene expression for chemokine and leukotriene receptor genes (CCR2, CCR5, CX3CL1, and LTB4R) in all patients. After treatment, the global effects of corticosteroids were evident on gene expression.. Gene array techniques hold promise as a research method in sinonasal polyposis. The potential benefits, as well as the potential challenges, in using these research methods will be discussed. Topics: Administration, Oral; Anti-Inflammatory Agents; Biopsy; Chemokine CCL2; Chemokine CX3CL1; Chemokines, CX3C; Down-Regulation; Endoscopy; Female; Gene Expression; Glucocorticoids; Humans; Leukotriene B4; Male; Membrane Proteins; Methylprednisolone; Nasal Polyps; Oligonucleotide Array Sequence Analysis; Paranasal Sinus Diseases; Polyps; Receptors, CCR2; Receptors, CCR5; Receptors, Chemokine; Receptors, Leukotriene B4	2007

Article

Year

Gene expression analysis in sinonasal polyposis before and after oral corticosteroids: a preliminary investigation.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2007, Volume: 137, Issue:1

To characterize gene expression in sinonasal polyps and to gain insight into change in expression after oral corticosteroid treatment.. Nasal polyps were obtained before and after oral corticosteroid treatment and gene expression was analyzed with a focused gene array technique.. Pretreated sinonasal polyps demonstrated high gene expression for chemokine and leukotriene receptor genes (CCR2, CCR5, CX3CL1, and LTB4R) in all patients. After treatment, the global effects of corticosteroids were evident on gene expression.. Gene array techniques hold promise as a research method in sinonasal polyposis. The potential benefits, as well as the potential challenges, in using these research methods will be discussed.

Topics: Administration, Oral; Anti-Inflammatory Agents; Biopsy; Chemokine CCL2; Chemokine CX3CL1; Chemokines, CX3C; Down-Regulation; Endoscopy; Female; Gene Expression; Glucocorticoids; Humans; Leukotriene B4; Male; Membrane Proteins; Methylprednisolone; Nasal Polyps; Oligonucleotide Array Sequence Analysis; Paranasal Sinus Diseases; Polyps; Receptors, CCR2; Receptors, CCR5; Receptors, Chemokine; Receptors, Leukotriene B4

2007