leukotriene-b4 and Hypercapnia

Hypercapnia is common in mechanically ventilated patients. Experimentally, 'therapeutic hypercapnia' can protect, but it can also cause harm, depending on the mechanism of injury. Hypercapnia suppresses multiple signalling pathways. Previous investigations have examined mechanisms that were known a priori, but only a limited number of pathways, each suppressed by CO. Because of the complexity and interdependence of processes in acute lung injury, this study sought to fill in knowledge gaps using an unbiased screen, aiming to identify a specifically upregulated pathway.. Using genome-wide gene expression analysis in a mouse model of ventilator-induced lung injury, we discovered a previously unsuspected mechanism by which CO. Inspired CO

Topics: alpha-Tocopherol; Animals; Carrier Proteins; Disease Models, Animal; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; Hypercapnia; Leukotriene B4; Lung; Male; Mice, Inbred C57BL; Oxidative Stress; RNA, Messenger; Signal Transduction; Up-Regulation; Ventilator-Induced Lung Injury