leukotriene-b4 has been researched along with Dermatomycoses* in 1 studies
1 other study(ies) available for leukotriene-b4 and Dermatomycoses
| Article | Year |
|---|---|
Involvement of leukotriene B4 in dermatophyte-related itch in mice.
Proteinase-activated receptor-2 (PAR2) is involved in dermatophyte-induced scratching and leukotriene B4 (LTB4) release from keratinocytes. We investigated whether PAR2-mediated LTB4 production is involved in dermatophyte-induced scratching.. Dermatophyte extract was injected intradermally and scratching was observed in mice. LTB4 was determined by enzyme immunoassay.. Dermatophyte extract-induced scratching was inhibited by zileuton (5-lipoxygenase inhibitor), ONO-4057 (LTB4 antagonist), FSLLRY-NH2 (PAR2 antagonist), and anti-PAR2 antibody. Dermatophyte extract injection increased the cutaneous content of LTB4, which was inhibited by zileuton and FSLLRY-NH2.. These results suggest the involvement of LTB4 in dermatophyte-associated itch. LTB4 production might be due to PAR2 stimulation in the skin. Topics: Animals; Antibodies, Monoclonal; Arthrodermataceae; Dermatomycoses; Hydroxyurea; Keratinocytes; Leukotriene Antagonists; Leukotriene B4; Male; Mice, Inbred Strains; Oligopeptides; Pruritus; Receptor, PAR-2 | 2014 |