leukotriene-b4 and Cerebral-Hemorrhage

Intracerebral hemorrhage (ICH) results from blood vessels rupture in the brain, forming a blood clot in the brain parenchyma. Leakage of blood constituents causes detrimental tissue damages, ensuing long-lasting neurological deficits; however, effective therapeutic approaches are not yet developed to date. In this study, leukotriene B

Topics: Administration, Oral; Animals; Brain; Cell Movement; Cerebral Hemorrhage; Disease Models, Animal; Drug Discovery; HL-60 Cells; Humans; Leukotriene B4; Mice; Microglia; Molecular Targeted Therapy; Neutrophil Infiltration; Phenylpropionates; Receptors, Leukotriene B4; Thrombin

Intracerebral hemorrhage (ICH) from blood vessel rupture results in parenchymal hematoma formation and neuroinflammation, ultimately leading to neurodegeneration. Several lines of evidence suggest that the severity of ICH-induced neural damage is exacerbated by infiltration of T-cells, monocytes, and especially neutrophils into the hematoma. Neutrophil migration is regulated by chemokines, formyl peptides, and leukotriene B

Topics: Animals; Brain; Cell Line; Cerebral Hemorrhage; Cytokines; Humans; Leukotriene B4; Male; Mice, Inbred C57BL; Microglia; Neutrophil Infiltration

In this study we report and compare plasma leukotriene (LT) levels in seventeen (17) patients with cerebral infarction, five (5) patients with cerebral hemorrhage and twelve (12) age-matched healthy volunteers. Plasma samples were collected at intervals of 1-7 days, 8-14 days, 15-30 days and 31 days- after cerebrovascular accident. Plasma immunoreactive LTC4, LTB4 and SRS-A (Slow Reacting Substance of Anaphylaxis or total peptido-LT's) levels were measured for each sample. Immunoreactive LTC4 (and SRS-A) levels were elevated in patients with cerebral infarction whilst LTB4 levels were raised in the patients with cerebral hemorrhage. In particular, cerebral infarcted patients exhibited significantly elevated levels in phases 1-7 days and after 15 days when compared with the age-matched healthy volunteers. In patients with cerebral hemorrhage, significant increases in LTB4 were measured in days 1-7 only. These results suggest a clinical relationship between the plasma levels of LT's and cerebrovascular disease.

Topics: Adult; Aged; Cerebral Hemorrhage; Cerebral Infarction; Chromatography, High Pressure Liquid; Female; Humans; Leukotriene B4; Male; Middle Aged; Radioimmunoassay; Reference Values; SRS-A; Time Factors