leukotriene-a4 and Metabolism--Inborn-Errors

leukotriene-a4 has been researched along with Metabolism--Inborn-Errors* in 1 studies

Other Studies

1 other study(ies) available for leukotriene-a4 and Metabolism--Inborn-Errors

Article	Year
Human genetic defect in leukotriene C4 synthesis. Biochemical and biophysical research communications, 1986, Nov-14, Volume: 140, Issue:3 Normal human platelets metabolise [3H]-LTA4 into [3H]-LTC4. Platelets from patients with glutathione synthetase deficiency possessing 10-30% of normal levels of cellular glutathione showed marked reduction in capacity to form [3H]-LTC4 (8-10% of normal) even though exogenous reduced glutathione was added to the incubation medium. To our knowledge this is the first demonstration of a genetic defect in LTC4 synthetase coupled to a defect in cellular glutathione levels. Topics: Arachidonic Acids; Blood Platelets; Child; Glutathione; Glutathione Synthase; Humans; In Vitro Techniques; Leukotriene A4; Male; Metabolism, Inborn Errors; SRS-A	1986

Article

Year

Human genetic defect in leukotriene C4 synthesis.

Biochemical and biophysical research communications, 1986, Nov-14, Volume: 140, Issue:3

Normal human platelets metabolise [3H]-LTA4 into [3H]-LTC4. Platelets from patients with glutathione synthetase deficiency possessing 10-30% of normal levels of cellular glutathione showed marked reduction in capacity to form [3H]-LTC4 (8-10% of normal) even though exogenous reduced glutathione was added to the incubation medium. To our knowledge this is the first demonstration of a genetic defect in LTC4 synthetase coupled to a defect in cellular glutathione levels.

Topics: Arachidonic Acids; Blood Platelets; Child; Glutathione; Glutathione Synthase; Humans; In Vitro Techniques; Leukotriene A4; Male; Metabolism, Inborn Errors; SRS-A

1986