leucine-hydroxamate and Brain-Ischemia

leucine-hydroxamate has been researched along with Brain-Ischemia* in 1 studies

Other Studies

1 other study(ies) available for leucine-hydroxamate and Brain-Ischemia

Article	Year
Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorganic & medicinal chemistry letters, 2003, Jul-07, Volume: 13, Issue:13 A series of hydroxamic acids has been prepared as potential inhibitors of glutamate carboxypeptidase II (GCP II). Compounds based on a P1' residue (primed-side inhibitors) were more potent than those based on a P1 group (unprimed-side inhibitors). Inhibitory potency of the primed-side GCP II inhibitors was found to be dependent on the number of methylene units between the hydroxamate group and pentanedioic acid. Succinyl hydroxamic acid derivative, 2-(hydroxycarbamoylmethyl)pentanedioic acid, is the most potent GCP II inhibitor with an IC(50) value of 220nM. The comparison of the results to those of other classes of GCP II inhibitors as well as hydroxamate-based MMP inhibitors provides further insight into the structure-activity relationships of GCP II inhibition. Topics: Aeromonas; Brain Ischemia; Crystallography, X-Ray; Dose-Response Relationship, Drug; Glutamate Carboxypeptidase II; Hydroxamic Acids; Indicators and Reagents; Protease Inhibitors; Stereoisomerism; Structure-Activity Relationship	2003

Article

Year

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.

Bioorganic & medicinal chemistry letters, 2003, Jul-07, Volume: 13, Issue:13

A series of hydroxamic acids has been prepared as potential inhibitors of glutamate carboxypeptidase II (GCP II). Compounds based on a P1' residue (primed-side inhibitors) were more potent than those based on a P1 group (unprimed-side inhibitors). Inhibitory potency of the primed-side GCP II inhibitors was found to be dependent on the number of methylene units between the hydroxamate group and pentanedioic acid. Succinyl hydroxamic acid derivative, 2-(hydroxycarbamoylmethyl)pentanedioic acid, is the most potent GCP II inhibitor with an IC(50) value of 220nM. The comparison of the results to those of other classes of GCP II inhibitors as well as hydroxamate-based MMP inhibitors provides further insight into the structure-activity relationships of GCP II inhibition.

Topics: Aeromonas; Brain Ischemia; Crystallography, X-Ray; Dose-Response Relationship, Drug; Glutamate Carboxypeptidase II; Hydroxamic Acids; Indicators and Reagents; Protease Inhibitors; Stereoisomerism; Structure-Activity Relationship

2003