leucine and Obesity

leucine has been researched along with Obesity in 185 studies

Research

Studies (185)

TimeframeStudies, this research(%)All Research%
pre-199065 (35.14)18.7374
1990's21 (11.35)18.2507
2000's30 (16.22)29.6817
2010's49 (26.49)24.3611
2020's20 (10.81)2.80

Authors

AuthorsStudies
Hu, J; Ji, L; Johnston, LJ; Liu, C; Ma, X; Zhang, X; Zhao, Y1
Bishop, CA; Grune, T; Henkel, J; Henning, T; Klaus, S; Machate, T; Püschel, G; Weber, D; Weitkunat, K1
Capparelli, R; Cuomo, P; Iannelli, A; Iannelli, D1
Chiappetta, S; Kim, M; Koschker, AC; Stein, J; Stier, C; Stier, R1
Lenart-Lipinska, M; Matyjaszek-Matuszek, B; Szmygin, H; Szydelko, J; Wozniak, S1
Achamrah, N; Bôle-Feysot, C; Castres, I; Coëffier, M; Coquard, A; Déchelotte, P; Folope, V; Grigioni, S; Guérin, C; Houivet, E; Lelandais, H; Meret, C; Petit, A; Quillard, M; Tourny, C1
He, X; Huang, X; Ji, N; Liu, M; Sun, T; Wang, J1
Barouki, R; Coumoul, X; De Bandt, JP1
Kim, J; Kwon, YH1
Han, X; Ma, Q; Shan, A; Sun, B; Sun, Y1
Han, L; Liu, X; Shi, R; Wang, B; Wang, D; Wang, L; Xia, B; Ye, J; Zhao, B; Zhao, Z1
Becetti, I; Bredella, MA; Lauze, M; Lee, H; Misra, M; Singhal, V1
Bonet, ML; Picó, C; Ribot, J1
Adams, V; Alves, PKN; Augstein, A; Barthel, P; Friedrich, J; Joachim, D; Linke, A; Männel, A; Moriscot, AS; Prieto, ME; Schauer, A1
Baum, JI; Dridi, S; Huang, Y; Wu, H1
Blouet, C; Darwish, T; Nuzzaci, D; Samudrala, H; Tsang, AH1
Bongers, A; de Vogel-van den Bosch, J; Memelink, RG; Pasman, WJ; Tromp, W; Tump, A; van Ginkel, A; Verlaan, S; Weijs, PJM; Wopereis, S1
Hu, X; Jin, H; Li, J; Shao, D; Shi, J; Yan, X1
Guo, X; Hu, W; Jiang, X; Liang, Y; Wang, B; Zhang, Y; Zheng, J; Zheng, L1
Arthur, S; Denning, K; Rahman, MM; Russell, R; Salisbury, T; Sierra-Bakhshi, C; Singh, S; Sundaram, U; Thompson, C1
López, N; Palou, A; Sánchez, J; Serra, F1
Granados-Portillo, O; Noriega, LG; Pedraza-Chaverri, J; Salinas-Rubio, D; Torre-Villalvazo, I; Torres, N; Tovar, AR1
Brunetta, HS; de Camargo, CQ; Nunes, EA1
Barritt, AS; Chalasani, N; Flores, O; Kolterman, O; Rinella, M; Siddiqui, M; Vuppalanchi, R; Zemel, MB1
Cao, W; Gu, H; Hao, L; Li, X; Liu, L; Liu, R; Liu, Z; Ma, Y; Mei, S; Sun, X; Wang, X; Yang, X; Yao, P1
Adams, SH; Hoppel, CL; Inukai, A; Kadota, Y; Kawamata, Y; Lang, CH; Lynch, CJ; Matsumoto, H; Olson, KC; Sakai, R; She, P; Shimomura, Y1
Bremner, DM; Calder, AG; Holtrop, G; Johnstone, AM; Lobley, GE; Milne, E1
Belluomo, I; Bermúdez-Silva, FJ; Binder, E; Clark, S; Cota, D; Duchampt, A; Elie, M; Leste-Lasserre, T; Mithieux, G1
Drgonova, J; Fredriksson, R; Han, JC; Jacobsson, JA; Marcus, C; Schiöth, HB; Uhl, GR; Yanovski, JA1
Barrett, PH; Chan, DC; Pang, J; Watts, GF; Wong, AT1
Adams, LA; Barrett, PH; Chan, DC; Watts, GF; Wong, AT1
Campaña, AB; Donato, J; Lima, FB; Torres-Leal, FL; Zampieri, TT1
Meininger, CJ; Wu, G; Wu, Z; Yang, Y1
Chevalier, S; Gougeon, R; Labonte, CC; Marliss, EB; Morais, JA1
Armitage, IM; Bernlohr, DA; Burrill, JS; Deng, Y; Long, EK; Reilly, B; Scherer, PE1
Mittendorfer, B; Smith, GI1
de Vogel-van den Bosch, J; Engberink, MF; Swinkels, S; Verlaan, S; Verreijen, AM; Weijs, PJ1
Baek, KJ; Kim, DS; Kim, HA; Kwon, NS; Yun, HY1
Bruckbauer, A; Cao, Q; Cui, X; Fu, L; Li, F; Shi, H; Wu, R; Xue, B; Zemel, MB2
Bernstein, AM; Golubic, M; Roizen, MF1
de Vogel-van den Bosch, J; Verlaan, S; Verreijen, AM; Weijs, PJ1
Donato, J; Pedroso, JA; Zampieri, TT1
Bojsen-Møller, KN; Dirksen, C; Holst, JJ; Jacobsen, SH; Jensen, JE; Jørgensen, NB; Kristiansen, VB; Madsbad, S; Reitelseder, S; van Hall, G1
de la Garza, AL; Etxeberria, U; Martíinez, JA; Milagro, I1
Duan, Y; Hou, Y; Li, F; Tan, B; Wu, G; Yao, K; Yin, Y1
Baum, JI; Bottje, W; Davis, G; Dridi, S; Shouse, SA; Smith, D; Washington, TA1
Larnkjær, A; Lind, MV; Michaelsen, KF; Mølgaard, C1
Beglinger, C; Doody, A; Drewe, J; Häfliger, S; Meili, J; Meyer-Gerspach, AC; Rehfeld, JF; Wölnerhanssen, B1
Babraj, J; Cuthbertson, DJ; Leese, G; Siervo, M1
Andre, A; Bailhache, E; Briand, F; Krempf, M; Magot, T; Nguyen, P; Ouguerram, K1
Jitomir, J; Willoughby, DS1
Lynch, CJ; Nairizi, A; She, P; Vary, TC1
An, W; Guan, Y; Li, S; Li, X; Li, Y; Mulholland, MW; Tang, C; Wang, N; Wang, X; Xu, G; Zhang, W; Zhu, Y1
Bedu, M; Boirie, Y; Delcourt, I; Duche, P; Giraudet, C; Guillet, C; Rance, M; Walrand, S1
Bonfleur, ML; Boschero, AC; Carneiro, EM; Collares-Buzato, CB; de França Carvalho, CP; de Gabriel Dorighello, G; de Oliveira, HC; Ribeiro, RA; Vanzela, EC1
Balage, M; Dardevet, D1
Choi, DY; Jeun, J; Kim, JH; Kim, YO; Shin, CS1
Devkota, S; Layman, DK1
Barrett, PH; Chan, DC; Chan, DT; Ooi, EM; Watts, GF; Wong, AT1
Donato, J; Pantaleão, LC; Resende, GF; Tirapegui, J; Torres-Leal, FL; Vianna, D1
Cave, MC; Frazier, TH; Hurt, RT; McClave, SA1
Mittendorfer, B; Shah, K; Smith, GI; Villareal, DT1
Kampelman, J; Magkos, F; Mittendorfer, B; Patterson, BW; Reeds, DN; Smith, GI; Wang, X1
Cotter, PD; Korpela, R; McAllan, L; Nilaweera, KN; Roche, HM1
Chen, H; Erkelens, JR; Morris, MJ; Simar, D; Ting, JH1
Bruckbauer, A; Zemel, MB1
Freudenberg, A; Klaus, S; Petzke, KJ1
Adechian, S; Balage, M; Boirie, Y; Dardevet, D; Gaudichon, C; Marset-Baglieri, A; Migné, C; Mosoni, L; Quignard-Boulangé, A; Remond, D; Rousset, S1
Clish, CB; Deik, AA; Fleischman, A; Gerszten, RE; Grinspoon, SK; McCarthy, MA; McCormack, SE; Mootha, VK; Shaham, O; Wang, TJ1
He, C; Lee, J; Li, H; Xie, Z; Xu, M1
Bassil, MS; Gougeon, R1
Huang, Z; Mao, X; Qiao, S; Wang, J; Zeng, X1
Eller, LK; Reimer, RA; Saha, DC; Shearer, J1
Duvillard, L; Florentin, E; Gambert, P; Pont, F; Vergès, B2
Buijs, MM; Burggraaf, J; Cohen, AF; De Kam, ML; Frölich, M; Meinders, AE; Pijl, H; Romijn, JA; Stellaard, F1
Layman, DK1
Corella, D; González, JI; Portolés, O; Ramírez, JB; Ruiz de la Fuente, S; Sorlí, JV1
FILLIOS, LC; SAITO, S1
Balagopal, P; Bayne, E; George, D; Patton, N; Russell, L; Sager, B1
Lambert, D; Marteau, JB; Noyer-Weidner, M; Pfister, M; Sass, C; Visvikis, S1
Aalinkeel, R; Hill, DJ; Mitrani, P; Pandya, JD; Patel, MS; Song, F; Srinivasan, M; Strutt, B1
Layman, DK; Walker, DA1
Hwang, PH; Jo, DS; Kim, SL; Kim, SY; Lee, DY; Lee, KH1
Burgess, SC; Chevalier, S; Gougeon, R; Malloy, CR; Marliss, EB; Morais, JA1
Flier, JS1
Guo, K; LeBlanc, RE; Loh, D; Schwartz, GJ; Yu, YH; Zhang, Y1
Fried, SK; Watford, M1
Bronson, SK; Hajnal, A; Hutson, SM; Lynch, CJ; Reid, TM; She, P; Vary, TC1
Cooney, RN; Hutson, SM; Lynch, CJ; Reid, T; She, P; Van Horn, C1
Bouglé, D; Clement, K; Costes, B; Dubern, B; Ersoy, B; Frelut, ML; Lubrano-Berthelier, C; Mencarelli, M; Simon, C; Tounian, P; Vaisse, C1
Anderson, SR; Gilge, DA; Previs, SF; Steiber, AL1
Autissier, N; Dumas, P; Loireau, A; Michel, R1
Ford, C; Garrow, JS; Halliday, D; Mahler, RF; Nair, KS1
Bistrian, BR; Blackburn, GL; Hoffer, LJ; Matthews, DE; Young, VR1
Tuma, DJ; Vanderhoof, JA1
Campion, DR; Hausman, GJ; Meredith, FI1
Bratusch-Marrain, P; Ferenci, P; Waldhäusl, W1
Adibi, SA; Morse, EL; Stanko, RT1
Clugston, GA; Garlick, PJ2
Adibi, SA; Hagg, SA; Morse, EL1
Clugston, GA; Garlick, PJ; Swick, RW; Waterlow, JC1
Clugston, GA; Garlick, PJ; Waterlow, JC1
Mitch, WE; Sapir, DG; Walser, M1
Gerbitz, KD; Michal, G; Rudolph, HJ; Wieland, OH1
Balba, Y; Donnelly, PV; Knutson, VP; Lopez-Reyes, M1
Boroujerdi, MA; Scobie, IN; Sönksen, PH; Umpleby, AM1
Abumrad, NN; Flakoll, PJ; Hill, JO; May, MM; Rice, DE1
Amatruda, J; Barnard, R; Statt, M; Welle, S1
Argilés, JM; Domènech, M; López-Soriano, FJ1
Haymond, MW; Jensen, MD; Kanaley, JA1
Byerley, LO; Heber, D1
Castellino, P; DeFronzo, RA; Luzi, L1
Bonadonna, R; Bonora, E; Castellino, P; DeFronzo, RA; Solini, A1
Dekker, JM; Hart, LM; Karvonen, MK; Koulu, M; Laakso, M; Niskanen, L; Pesonen, U; Rissanen, A; Uusitupa, MI; Valve, R1
Palou, A; Proenza, AM; Roca, P1
Agin, D; Albu, J; Clay-Williams, G; Gallagher, D; Heymsfield, SB; Kovera, AJ; Leone, P; Matthews, DE1
Dutra de Oliveira, JE; Ferriolli, E; Lambertini, CR; Marchini, JS1
Balagopal, P; Mauras, N; Sweeten, S1
Coppack, SW; Horowitz, JF; Klein, S; Patterson, BW; Watford, M; Wu, G1
Biourge, V; Breul, S; Diez, M; Dumon, H; Ferrier, L; Humbert, B; Martin, L; Nguyen, P; Siliart, B1
Bertilsson, L; Ding, B; Wahlestedt, C1
De Feo, P; Lucidi, P; Parlanti, N; Piccioni, F; Santeusanio, F1
Sehlin, J; Täljedal, IB1
Sherwin, RS1
Björntorp, P; Kral, JG; Lundholm, K; Scherstén, T; Sjöström, L1
Chaussain, JL; Georges, P; Job, JC; Olive, G1
Eaton, RP; Schade, S1
Herbein, JH; Martin, RJ1
Arch, JE; Stanko, RT; Tietze, DL3
Amatruda, JM; Barnard, RR; Statt, M; Welle, S1
Haymond, MW; Jensen, MD1
Caballero, B; Wurtman, RJ1
Nair, KS; Welle, S1
Forse, RA; Hoffer, LJ1
Hoffer, LJ; Kupranycz, D; Larivière, F; Wagner, DA1
Bonde, AA; Hendler, R1
Ford, GC; Garrow, JS; Halliday, D; Nair, KS1
Gylfe, E3
Herbertz, L; Langer, K; Schauder, P; Zavelberg, D1
Atkinson, S; Caro, JF; Flickinger, EG; Meelheim, D; Pories, WJ; Sehgal, NS; Sinha, MK; Taylor, LG1
Ford, GC; Garrow, JS; Halliday, D; Heels, S; Nair, KS1
Bier, DM; Matthews, DE; Staten, MA1
Fletcher, JM; Haggarty, P; Reeds, PJ; Wahle, KW1
Adibi, SA; Morse, EL; Vazquez, JA1
Gillim, SE; Harris, RA; Nagae, H; Paxton, R; Powell, SM1
Christians, J; Hasselblatt, A; Panten, U; Poser, W; von Kriegstein, E1
Hellman, B; Idahl, LA; Lernmark, A; Sehlin, J; Täljedal, IB2
Gates, RJ; Hunt, MI; Lazarus, NR1
Parmentier, J; Rubay, J1
Hellman, B; Sehlin, J; Täljedal, IB3
Gorden, P; Roth, J; Sherman, B1
Lernmark, A1
Blake, RL1
Owen, OE; Pozefsky, T; Sapir, DG; Walser, M1
Briel, G; Gylfe, E; Hellman, B; Neuhoff, V1
Kipnis, DM; Permutt, MA1
Beloff-Chain, A; Mansford, KR; Newman, ME1
Gerich, J; Grodsky, GM; Karam, J; Levin, S; Sando, H1
Sehlin, J1
Genuth, SM1
Forsham, PH; Grodsky, GM; Johnson, S; Karam, JH; Levin, SR1
Lockwood, DH; Moxley, RT; Pozefsky, T; White, JJ1
Idahl, LA; Täljedal, IB1
Hellerström, C; Schmidt, FH; Stork, H; Westman, S1
Loridan, L; Sadeghi-Nejad, A; Senior, B1
Hellman, B; Sehlin, J; Täljedal, I1
Nakanishi, S; Numa, S1
Junod, A; Lambert, AE; Letarte, J; Stauffacher, W1
Adibi, SA; Drash, AL1
Boutry, M; Christophe, J; Furnelle, J; Winand, J1
Kowalski, H; Lawecki, J; Rogala, H1
Adibi, SA1
Cahill, GF; Felig, P; Marliss, E1
Drenick, EJ; Figueroa, WS; Swendseid, ME; Villalobos, J1

Reviews

19 review(s) available for leucine and Obesity

ArticleYear
Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application.
    International journal of molecular sciences, 2021, Oct-22, Volume: 22, Issue:21

    Topics: Aging; Amino Acids; Arginine; Autophagy; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Methionine; Neoplasms; Neurodegenerative Diseases; Obesity; Signal Transduction

2021
Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease.
    International journal of molecular sciences, 2022, Apr-13, Volume: 23, Issue:8

    Topics: Amino Acids, Branched-Chain; Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Leucine; Mammals; Metabolic Diseases; Non-alcoholic Fatty Liver Disease; Obesity

2022
Branched-chain amino acids as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome - literature review.
    Ginekologia polska, 2022, Volume: 93, Issue:8

    Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Obesity; Polycystic Ovary Syndrome; Prediabetic State; Valine

2022
Branched-Chain Amino Acids and Insulin Resistance, from Protein Supply to Diet-Induced Obesity.
    Nutrients, 2022, Dec-23, Volume: 15, Issue:1

    Topics: Amino Acids, Branched-Chain; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet; Insulin; Insulin Resistance; Leucine; Obesity

2022
Does L-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review.
    Amino acids, 2018, Volume: 50, Issue:12

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Disease Models, Animal; Glucose Intolerance; Homeostasis; Humans; Insulin; Leucine; Mice, Obese; Obesity; Rodentia

2018
L-Leucine and NO-mediated cardiovascular function.
    Amino acids, 2015, Volume: 47, Issue:3

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Humans; Insulin; Insulin Resistance; Leucine; Nitric Oxide; Nitrogenous Group Transferases; Obesity; TOR Serine-Threonine Kinases

2015
Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis.
    Nutrients, 2015, May-22, Volume: 7, Issue:5

    Topics: Blood Glucose; Dietary Supplements; Eating; Energy Intake; Energy Metabolism; Homeostasis; Humans; Leucine; Obesity; TOR Serine-Threonine Kinases

2015
Leucine in Obesity: Therapeutic Prospects.
    Trends in pharmacological sciences, 2016, Volume: 37, Issue:8

    Topics: Animals; Dietary Supplements; Energy Metabolism; Humans; Leucine; Obesity

2016
Dietary protein intake and quality in early life: impact on growth and obesity.
    Current opinion in clinical nutrition and metabolic care, 2017, Volume: 20, Issue:1

    Topics: Adult; Child, Preschool; Diet, High-Protein; Dietary Proteins; Eating; Female; Growth; Humans; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Insulin-Like Growth Factor I; Leucine; Male; Obesity; Observational Studies as Topic; Randomized Controlled Trials as Topic; Risk Factors

2017
Leucine for retention of lean mass on a hypocaloric diet.
    Journal of medicinal food, 2008, Volume: 11, Issue:4

    Topics: Adipose Tissue; Anabolic Agents; Blood Glucose; Diet, Reducing; Dietary Supplements; Homeostasis; Humans; Leucine; Muscle, Skeletal; Obesity; Signal Transduction; Weight Loss

2008
Long-term effects of leucine supplementation on body composition.
    Current opinion in clinical nutrition and metabolic care, 2010, Volume: 13, Issue:3

    Topics: Amino Acids; Body Composition; Body Fluid Compartments; Dietary Supplements; Humans; Leucine; Malnutrition; Muscle Proteins; Muscle, Skeletal; Obesity; Organ Size; Resistance Training; Weight Loss

2010
Protein metabolic roles in treatment of obesity.
    Current opinion in clinical nutrition and metabolic care, 2010, Volume: 13, Issue:4

    Topics: Adipose Tissue; Diet, Reducing; Dietary Proteins; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Obesity; Patient Compliance; Treatment Outcome; Weight Loss

2010
Pharmaconutrition for the obese, critically ill patient.
    JPEN. Journal of parenteral and enteral nutrition, 2011, Volume: 35, Issue:5 Suppl

    Topics: Antioxidants; Arginine; Citrulline; Critical Care; Critical Illness; Dietary Proteins; Dietary Supplements; Enteral Nutrition; Fatty Acids, Unsaturated; Humans; Inflammatory Bowel Diseases; Intensive Care Units; Length of Stay; Leucine; Magnesium; Obesity; Oxidative Stress; Prebiotics; Probiotics; Treatment Outcome; United States; Ventilation; Zinc

2011
Impact of leucine on energy balance.
    Journal of physiology and biochemistry, 2013, Volume: 69, Issue:1

    Topics: Adipose Tissue; Body Weight; Diet; Energy Intake; Energy Metabolism; Gastrointestinal Tract; Humans; Hypothalamus; Leucine; Lipid Metabolism; Liver; Muscle, Skeletal; Obesity

2013
Muscle protein anabolism in type 2 diabetes.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:1

    Topics: Aged; Aging; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hyperglycemia; Insulin; Insulin Resistance; Leucine; Male; Motor Activity; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Sarcopenia

2013
The role of leucine in weight loss diets and glucose homeostasis.
    The Journal of nutrition, 2003, Volume: 133, Issue:1

    Topics: Amino Acids; Dietary Proteins; Glucose; Homeostasis; Humans; Leucine; Liver; Obesity; Weight Loss

2003
Potential importance of leucine in treatment of obesity and the metabolic syndrome.
    The Journal of nutrition, 2006, Volume: 136, Issue:1 Suppl

    Topics: Blood Glucose; Dietary Carbohydrates; Dietary Proteins; Humans; Leucine; Metabolic Syndrome; Muscle Proteins; Obesity

2006
Synthesis and secretion of insulin in dynamic perfusion systems.
    Advances in metabolic disorders, 1974, Volume: 7, Issue:0

    Topics: Animals; Antimetabolites; Arginine; Carbon Radioisotopes; Computers; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isotope Labeling; Leucine; Models, Biological; Obesity; Oligomycins; Pancreas; Perfusion; Rats; Time Factors; Tolbutamide

1974
Excess protein and leucine effects on food intake.
    Nutrition reviews, 1966, Volume: 24, Issue:3

    Topics: Animals; Dietary Proteins; Hypothalamus; Leucine; Obesity; Rats

1966

Trials

18 trial(s) available for leucine and Obesity

ArticleYear
Evaluation of a Supervised Adapted Physical Activity Program Associated or Not with Oral Supplementation with Arginine and Leucine in Subjects with Obesity and Metabolic Syndrome: A Randomized Controlled Trial.
    Nutrients, 2022, Sep-08, Volume: 14, Issue:18

    Topics: Arginine; Dietary Supplements; Exercise; Glucose; Humans; Leucine; Lipids; Metabolic Syndrome; Obesity; Quality of Life

2022
Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT.
    Nutrients, 2020, Dec-28, Volume: 13, Issue:1

    Topics: Absorptiometry, Photon; Aged; Anthropometry; Body Composition; Diabetes Mellitus, Type 2; Dietary Proteins; Double-Blind Method; Exercise; Female; Glucose Tolerance Test; Glycemic Control; Humans; Insulin Resistance; Leucine; Life Style; Male; Middle Aged; Muscle Strength; Muscles; Obesity; Overweight; Proteins; Vitamin D; Weight Loss

2020
Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters.
    Obesity (Silver Spring, Md.), 2019, Volume: 27, Issue:1

    Topics: Body Weight; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Leucine; Male; Metformin; Middle Aged; Obesity; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate

2019
Impact of short term consumption of diets high in either non-starch polysaccharides or resistant starch in comparison with moderate weight loss on indices of insulin sensitivity in subjects with metabolic syndrome.
    Nutrients, 2013, Jun-10, Volume: 5, Issue:6

    Topics: Blood Glucose; C-Peptide; Carbohydrate Metabolism; Cross-Over Studies; Diet, Reducing; Dietary Proteins; Energy Intake; Energy Metabolism; Fasting; Homeostasis; Humans; Insulin; Insulin Resistance; Leucine; Male; Metabolic Syndrome; Models, Biological; Obesity; Polysaccharides; Starch; Weight Loss

2013
Plasma apolipoprotein B-48 transport in obese men: a new tracer kinetic study in the postprandial state.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:1

    Topics: Aged; Apolipoprotein B-48; Blood Proteins; Humans; Isotope Labeling; Kinetics; Leucine; Male; Middle Aged; Obesity; Postprandial Period; Protein Transport; Radioactive Tracers; Thinness

2014
Effect of ω-3 fatty acid ethyl esters on apolipoprotein B-48 kinetics in obese subjects on a weight-loss diet: a new tracer kinetic study in the postprandial state.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:8

    Topics: Adolescent; Adult; Aged; Apolipoprotein B-48; Diet, Reducing; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Isotope Labeling; Kinetics; Leucine; Male; Middle Aged; Obesity; Postprandial Period; Weight Loss; Young Adult

2014
A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial.
    The American journal of clinical nutrition, 2015, Volume: 101, Issue:2

    Topics: Aged; Aged, 80 and over; Body Composition; Body Mass Index; Body Weight; Diet, Reducing; Dietary Proteins; Dietary Supplements; Double-Blind Method; Energy Intake; Female; Hand Strength; Humans; Leucine; Male; Middle Aged; Milk Proteins; Motor Activity; Muscle Strength; Muscle, Skeletal; Obesity; Resistance Training; Sarcopenia; Treatment Outcome; Vitamin D; Weight Loss; Whey Proteins

2015
Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Adult; Appetite; Cholecystokinin; Double-Blind Method; Female; Gastric Emptying; Glucagon-Like Peptide 1; Humans; Leucine; Male; Middle Aged; Obesity; Tryptophan

2016
Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese men.
    Metabolism: clinical and experimental, 2011, Volume: 60, Issue:10

    Topics: Adiponectin; Adult; Aged; Apolipoprotein A-II; Apolipoprotein B-100; Humans; Ideal Body Weight; Infusions, Intravenous; Leucine; Lipoproteins, VLDL; Male; Middle Aged; Obesity

2011
Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects.
    Nutrients, 2012, Volume: 4, Issue:6

    Topics: 3T3-L1 Cells; Adipocytes; Adult; Animals; Biomarkers; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fatty Acid Synthases; Female; Humans; Leucine; Male; Mice; Obesity; Overweight; Oxidation-Reduction; Oxidative Stress; Pyridoxal Phosphate; Triglycerides; Vitamin B Complex; Young Adult

2012
Growth hormone blunts protein oxidation and promotes protein turnover to a similar extent in abdominally obese and normal-weight women.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:12

    Topics: Abdomen; Adult; Cross-Over Studies; Double-Blind Method; Female; Growth Hormone; Hormones; Humans; Leucine; Obesity; Osmolar Concentration; Oxidation-Reduction; Reference Values; Somatostatin

2002
Effect of lifestyle changes on whole-body protein turnover in obese adolescents.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2003, Volume: 27, Issue:10

    Topics: Adolescent; Amino Acids; Blood Glucose; Body Composition; Body Mass Index; Energy Metabolism; Exercise; Fats; Female; Humans; Insulin; Leucine; Life Style; Male; Obesity; Protein Biosynthesis; Proteins

2003
Metabolic effects of very low calorie weight reduction diets.
    The Journal of clinical investigation, 1984, Volume: 73, Issue:3

    Topics: Alanine; Amino Acids; Diet, Reducing; Energy Intake; Female; Humans; Leucine; Nitrogen; Obesity

1984
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.
    Nature medicine, 1998, Volume: 4, Issue:12

    Topics: Adult; Aged; Alleles; Amino Acid Substitution; Cholesterol; Cholesterol, LDL; Female; Gene Frequency; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Proline; Protein Sorting Signals

1998
Obese women on a low energy rice and bean diet: effects of leucine, arginine or glycine supplementation on protein turnover.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2001, Volume: 34, Issue:10

    Topics: Adult; Amino Acids; Analysis of Variance; Arginine; Diet, Reducing; Dietary Proteins; Dietary Supplements; Energy Intake; Energy Metabolism; Fabaceae; Female; Glycine; Humans; Leucine; Obesity; Oryza; Proteins

2001
Short-term treatment with low doses of recombinant human GH stimulates lipolysis in visceral obese men.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:7

    Topics: Adult; Blood Glucose; C-Peptide; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fatty Acids, Nonesterified; Hormones; Human Growth Hormone; Humans; Keto Acids; Leucine; Lipid Metabolism; Lipolysis; Male; Middle Aged; Obesity; Osmolar Concentration; Recombinant Proteins; Viscera

2002
Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate.
    The American journal of clinical nutrition, 1992, Volume: 56, Issue:4

    Topics: Body Composition; Diet, Reducing; Energy Intake; Energy Metabolism; Female; Humans; Leucine; Nitrogen; Obesity; Pyruvates; Pyruvic Acid; Weight Loss

1992
Protein metabolic effects of a prolonged fast and hypocaloric refeeding.
    The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 1

    Topics: 3-Hydroxybutyric Acid; Blood Glucose; Carbon Isotopes; Diet, Reducing; Dietary Carbohydrates; Dietary Proteins; Energy Intake; Fasting; Fatty Acids, Nonesterified; Female; Humans; Hydroxybutyrates; Insulin; Isotope Labeling; Leucine; Nitrogen; Obesity; Proteins; Random Allocation; Thyroxine; Triiodothyronine, Reverse

1990

Other Studies

148 other study(ies) available for leucine and Obesity

ArticleYear
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.
    Nutrition & diabetes, 2022, 04-13, Volume: 12, Issue:1

    Topics: Amino Acids, Branched-Chain; Animals; Glucose; Insulin Resistance; Leucine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Valine

2022
Fast-track rescue weight reduction therapy to achieve rapid technical operability for emergency bariatric surgery in patients with life-threatening inoperable severe obesity - A proof of concept study.
    Clinical nutrition ESPEN, 2022, Volume: 50

    Topics: Bariatric Surgery; Diet, Reducing; Gastric Balloon; Humans; Leucine; Liraglutide; Obesity; Obesity, Morbid; Proof of Concept Study; Prospective Studies; Retrospective Studies; Weight Loss

2022
[Plasma amino acids levels in 1859 physical examination subjects in Hangzhou City in 2020].
    Wei sheng yan jiu = Journal of hygiene research, 2022, Volume: 51, Issue:6

    Topics: Alanine; Amino Acids; Chromatography, Liquid; Female; Humans; Leucine; Male; Methionine; Middle Aged; Obesity; Overweight; Tandem Mass Spectrometry

2022
Leucine supplementation in maternal high-fat diet alleviated adiposity and glucose intolerance of adult mice offspring fed a postweaning high-fat diet.
    Lipids in health and disease, 2023, Apr-15, Volume: 22, Issue:1

    Topics: Adiposity; Animals; Body Weight; Diet, High-Fat; Dietary Supplements; Female; Glucose; Glucose Intolerance; Humans; Lactation; Leucine; Male; Maternal Nutritional Physiological Phenomena; Mice; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; RNA, Messenger

2023
Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats.
    Diabetes, 2023, 10-01, Volume: 72, Issue:10

    Topics: Animals; Dietary Supplements; Female; Insulin; Lactation; Leucine; Lipids; Neuropeptide Y; Obesity; Rats; Rats, Sprague-Dawley; Rats, Wistar

2023
Leucine-Restricted Diet Ameliorates Obesity-Linked Cognitive Deficits: Involvement of the Microbiota-Gut-Brain Axis.
    Journal of agricultural and food chemistry, 2023, Jun-21, Volume: 71, Issue:24

    Topics: Animals; Bacteria; Brain-Gut Axis; Cognition; Cognitive Dysfunction; Diet; Diet, High-Fat; Fatty Acids, Volatile; Firmicutes; Humans; Leucine; Mice; Mice, Inbred C57BL; Obesity

2023
Changes in Branched-Chain Amino Acids One Year after Sleeve Gastrectomy in Youth with Obesity and Their Association with Changes in Insulin Resistance.
    Nutrients, 2023, Aug-30, Volume: 15, Issue:17

    Topics: Adolescent; Adult; Amino Acids, Branched-Chain; Female; Gastrectomy; Glucose; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Leucine; Meals; Obesity; Young Adult

2023
Decoding the Mechanisms Behind Early Weaning-Driven Obesity and the Leucine "Solution".
    Diabetes, 2023, 10-01, Volume: 72, Issue:10

    Topics: Animals; Dietary Supplements; Leucine; Obesity; Rats; Weaning

2023
Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition.
    Cells, 2023, Nov-02, Volume: 12, Issue:21

    Topics: Animals; Dietary Supplements; Female; Heart Failure; Histone Deacetylases; Leucine; Obesity; Rats; Stroke Volume

2023
Leucine decreases intramyocellular lipid deposition in an mTORC1-independent manner in palmitate-treated C2C12 myotubes.
    American journal of physiology. Endocrinology and metabolism, 2020, 02-01, Volume: 318, Issue:2

    Topics: Animals; Autophagy; Cells, Cultured; Leucine; Lipid Metabolism; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria, Muscle; Muscle Fibers, Skeletal; Myocytes, Smooth Muscle; Obesity; Organelle Biogenesis; Palmitates; Signal Transduction

2020
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.
    Molecular metabolism, 2020, Volume: 42

    Topics: Agouti-Related Protein; Animals; Appetite; Appetite Regulation; Brain; Energy Metabolism; Feeding Behavior; Hypothalamus; Leptin; Leucine; Male; Mice; Mice, Inbred C57BL; Neurons; Obesity; Solitary Nucleus

2020
The anti-obesity effects exerted by different fractions of Artemisia sphaerocephala Krasch polysaccharide in diet-induced obese mice.
    International journal of biological macromolecules, 2021, Jul-01, Volume: 182

    Topics: Animals; Anti-Obesity Agents; Artemisia; Diet, High-Fat; Gastrointestinal Microbiome; Isoleucine; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Nitrogen; Obesity; Plant Extracts; Polysaccharides; Valine

2021
Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Adiponectin; Adipose Tissue; Adiposity; AMP-Activated Protein Kinases; Animals; Diet, Fat-Restricted; Diet, High-Fat; Dietary Supplements; Dyslipidemias; Glucose Tolerance Test; Inflammation; Insulin; Insulin Resistance; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Physical Conditioning, Animal

2021
The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells.
    International journal of molecular sciences, 2021, Jun-23, Volume: 22, Issue:13

    Topics: Adipose Tissue; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Mice, Inbred C57BL; Obesity; Receptors, Estrogen; Signal Transduction; TOR Serine-Threonine Kinases

2021
Gender-Associated Impact of Early Leucine Supplementation on Adult Predisposition to Obesity in Rats.
    Nutrients, 2018, Jan-12, Volume: 10, Issue:1

    Topics: Adiponectin; Adiposity; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Blood Glucose; Body Weight; Dietary Supplements; Disease Susceptibility; Female; Hypothalamus; Insulin; Lactation; Leptin; Leucine; Male; Maternal Nutritional Physiological Phenomena; Obesity; Rats; Rats, Wistar; Sex Factors; Weaning

2018
Interaction between leucine and palmitate catabolism in 3T3-L1 adipocytes and primary adipocytes from control and obese rats.
    The Journal of nutritional biochemistry, 2018, Volume: 59

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Carnitine O-Palmitoyltransferase; Diet, High-Fat; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Leucine; Lipid Metabolism; Male; Membrane Transport Proteins; Mice; Monocarboxylic Acid Transporters; Obesity; Palmitates; Peroxisomal Bifunctional Enzyme; Rats, Inbred Strains; Rats, Sprague-Dawley

2018
Leucine facilitates insulin signaling through a Gαi protein-dependent signaling pathway in hepatocytes.
    The Journal of biological chemistry, 2013, Mar-29, Volume: 288, Issue:13

    Topics: Animals; Diabetes Mellitus; Gene Silencing; Gluconeogenesis; Glucose; GTP-Binding Protein alpha Subunits, Gi-Go; Hepatocytes; Humans; Insulin; Leucine; Mice; Models, Biological; Obesity; Phosphorylation; RNA, Small Interfering; Signal Transduction

2013
Leucine and protein metabolism in obese Zucker rats.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adipose Tissue; Amino Acids, Branched-Chain; Animals; Biomarkers; Body Weight; Carbon Radioisotopes; Carnitine; Chromatography, Liquid; Creatinine; Leucine; Liver; Male; Metabolomics; Muscle, Skeletal; Obesity; Organ Size; Proteins; Rats; Rats, Zucker; Tandem Mass Spectrometry

2013
Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice.
    Obesity (Silver Spring, Md.), 2014, Volume: 22, Issue:3

    Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; Body Composition; Calorimetry, Indirect; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Gluconeogenesis; Glucose Tolerance Test; Insulin; Intestinal Mucosa; Intestines; Leptin; Leucine; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Weight Loss

2014
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adolescent; Amino Acid Transport Systems, Neutral; Animals; Child; Child, Preschool; Eating; Female; Genotype; Humans; Leucine; Male; Mice; Mice, Knockout; Obesity; Polymorphism, Single Nucleotide; Young Adult

2013
L-leucine supplementation worsens the adiposity of already obese rats by promoting a hypothalamic pattern of gene expression that favors fat accumulation.
    Nutrients, 2014, Apr-02, Volume: 6, Issue:4

    Topics: Adiposity; Animals; Diet, High-Fat; Dietary Supplements; Energy Intake; Gene Expression; Hypothalamus; Leucine; Male; Obesity; Rats; Rats, Wistar

2014
Effect of 10% dietary protein intake on whole body protein kinetics in type 2 diabetic adults.
    Clinical nutrition (Edinburgh, Scotland), 2015, Volume: 34, Issue:6

    Topics: Amino Acids; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Diet, Protein-Restricted; Dietary Proteins; Energy Intake; Female; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Male; Mental Recall; Middle Aged; Obesity; Sex Factors; Waist Circumference

2015
Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes.
    Molecular endocrinology (Baltimore, Md.), 2015, Volume: 29, Issue:3

    Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Amino Acids, Branched-Chain; Animals; Biological Transport; Down-Regulation; Endoplasmic Reticulum Stress; Inflammation; Intracellular Space; Leucine; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Obesity; Tumor Necrosis Factor-alpha

2015
Slimming down in old age.
    The American journal of clinical nutrition, 2015, Volume: 101, Issue:2

    Topics: Dietary Supplements; Female; Humans; Leucine; Male; Milk Proteins; Muscle, Skeletal; Obesity; Vitamin D; Whey Proteins

2015
Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB.
    Cytokine, 2015, Volume: 72, Issue:2

    Topics: 3T3-L1 Cells; Adipokines; Adipose Tissue; Animals; Gene Expression Regulation; Inflammation; Leucine; Mice; Nerve Tissue Proteins; NF-kappa B; Obesity; Signal Transduction; Tumor Necrosis Factor-alpha

2015
Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.
    Metabolism: clinical and experimental, 2015, Volume: 64, Issue:7

    Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diet, High-Fat; Fasting; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Signal Transduction; Sirtuin 1

2015
The impact of protein on chronic disease risk should be considered in studies of weight loss.
    The American journal of clinical nutrition, 2015, Volume: 101, Issue:5

    Topics: Dietary Supplements; Female; Humans; Leucine; Male; Milk Proteins; Muscle, Skeletal; Obesity; Vitamin D

2015
Reply to AM Bernstein et al.
    The American journal of clinical nutrition, 2015, Volume: 101, Issue:5

    Topics: Dietary Supplements; Female; Humans; Leucine; Male; Milk Proteins; Muscle, Skeletal; Obesity; Vitamin D

2015
Accelerated protein digestion and amino acid absorption after Roux-en-Y gastric bypass.
    The American journal of clinical nutrition, 2015, Volume: 102, Issue:3

    Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Blood Glucose; Body Mass Index; Body Weight; Caseins; Dietary Proteins; Female; Gastric Bypass; Glycated Hemoglobin; Humans; Intestinal Absorption; Leucine; Male; Meals; Middle Aged; Obesity; Phenylalanine; Postprandial Period; Proteolysis; Young Adult

2015
Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice.
    Metabolism: clinical and experimental, 2015, Volume: 64, Issue:11

    Topics: Animals; Cell Line, Tumor; Diet, High-Fat; Humans; Hyperlipidemias; Leucine; Lipid Metabolism; Liver; Metformin; Mice; Obesity

2015
Biocompounds Attenuating the Development of Obesity and Insulin Resistance Produced by a High-fat Sucrose Diet.
    Natural product communications, 2015, Volume: 10, Issue:8

    Topics: Animals; Blood Glucose; Chlorogenic Acid; Coumaric Acids; Curcumin; Diet, High-Fat; Dietary Fats; Dietary Supplements; Flavanones; Humans; Insulin Resistance; Leucine; Male; Obesity; Rats; Rats, Wistar; Sucrose

2015
Leucine supplementation at the onset of high-fat feeding does not prevent weight gain or improve glycemic regulation in male Sprague-Dawley rats.
    Journal of physiology and biochemistry, 2016, Volume: 72, Issue:4

    Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Biomarkers; Blood Glucose; Body Composition; Carrier Proteins; Diet, High-Fat; Dietary Fats; Dietary Supplements; Energy Metabolism; Fatty Acids, Nonesterified; Gene Expression; Insulin; Intracellular Signaling Peptides and Proteins; Leucine; Male; Muscle, Skeletal; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoproteins; PPAR gamma; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Treatment Failure; Weight Gain

2016
Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.
    Clinical nutrition (Edinburgh, Scotland), 2017, Volume: 36, Issue:6

    Topics: Absorptiometry, Photon; Adaptor Proteins, Signal Transducing; Aged; Amino Acids, Essential; Anabolic Agents; Blood Glucose; Body Composition; Body Mass Index; Case-Control Studies; Cell Cycle Proteins; Diabetes Mellitus, Type 2; Humans; Insulin; Keto Acids; Leucine; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Postprandial Period; Protein Biosynthesis; Ribosomal Protein S6 Kinases, 70-kDa; Risk Factors; Sarcopenia; Signal Transduction; TOR Serine-Threonine Kinases

2017
The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:7

    Topics: Animals; Apolipoprotein B-100; Blood Glucose; Cholesterol; Diet; Dogs; Energy Intake; Gas Chromatography-Mass Spectrometry; Insulin; Insulin Resistance; Kinetics; Leucine; Lipoproteins, LDL; Lipoproteins, VLDL; Obesity

2008
Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice.
    The Journal of nutrition, 2009, Volume: 139, Issue:4

    Topics: Animals; Behavior, Animal; Body Composition; Body Weight; Cholesterol; Dietary Supplements; Insulin; Leucine; Mice; Mice, Inbred C57BL; Motor Activity; Obesity; Oxygen; Respiration; Triglycerides; Water

2009
Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake.
    Endocrinology, 2009, Volume: 150, Issue:8

    Topics: Animals; Blotting, Western; Eating; Fasting; Gastric Mucosa; Gene Expression Regulation; Ghrelin; Immunohistochemistry; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Kinases; Receptors, Ghrelin; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2009
Changes in basal and insulin and amino acid response of whole body and skeletal muscle proteins in obese men.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:8

    Topics: Adult; Amino Acids; Body Composition; Fatty Acids, Nonesterified; Glucose; Humans; Insulin; Insulin Resistance; Leucine; Male; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Obesity

2009
Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity.
    Biochimica et biophysica acta, 2010, Volume: 1801, Issue:2

    Topics: Animals; beta-Cyclodextrins; Cholesterol; Dietary Fats; Female; Glucose; Glucose Tolerance Test; Homeostasis; Hypercholesterolemia; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Lipids; Male; Mice; Mice, Knockout; Obesity; Oxidation-Reduction; Receptors, LDL

2010
L-Trp and L-Leu-OEt derivatives of the monascus pigment exert high anti-obesity effects on mice.
    Bioscience, biotechnology, and biochemistry, 2010, Volume: 74, Issue:2

    Topics: Animals; Anti-Obesity Agents; Body Weight; Leucine; Male; Mice; Mice, Inbred C57BL; Monascus; Obesity; Phytotherapy; Pigments, Biological; Random Allocation; Tryptophan

2010
Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats.
    Nutrition (Burbank, Los Angeles County, Calif.), 2012, Volume: 28, Issue:2

    Topics: Adipose Tissue; Age Factors; Aging; Animals; Blood Glucose; Body Composition; Body Fluid Compartments; Body Weight; Chronic Disease; Dietary Supplements; Leucine; Lipids; Male; Nutritional Status; Obesity; Proteins; Rats; Rats, Sprague-Dawley; Risk Factors

2012
Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults.
    Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Blood Glucose; Energy Intake; Energy Metabolism; Fasting; Female; Humans; Insulin; Leucine; Male; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Weight Loss

2012
Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women.
    American journal of physiology. Endocrinology and metabolism, 2012, Mar-15, Volume: 302, Issue:6

    Topics: Adipose Tissue; Administration, Cutaneous; Adult; Blood Chemical Analysis; Blood Glucose; Body Composition; Body Weight; Female; Glycerol; Humans; Kinetics; Leucine; Lipoproteins, VLDL; Magnetic Resonance Imaging; Middle Aged; Muscle Proteins; Muscle, Skeletal; Obesity; Premenopause; Stimulation, Chemical; Testosterone; Triglycerides

2012
Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake.
    Journal of neuroendocrinology, 2012, Volume: 24, Issue:10

    Topics: Animals; Appetite; Blotting, Western; Body Weight; Diet; Energy Intake; Fatty Acids, Nonesterified; Female; Glucose; Glucose Tolerance Test; Hypothalamus; Insulin; Leptin; Leucine; Lipid Metabolism; Muscle, Skeletal; Obesity; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction; TOR Serine-Threonine Kinases; Triglycerides

2012
Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity.
    Amino acids, 2013, Volume: 44, Issue:2

    Topics: Alanine; Animals; Blood Glucose; Diet, High-Fat; Dietary Proteins; Dietary Supplements; Humans; Insulin; Leucine; Male; Mice; Mice, Inbred C57BL; Obesity

2013
Protein feeding pattern, casein feeding, or milk-soluble protein feeding did not change the evolution of body composition during a short-term weight loss program.
    American journal of physiology. Endocrinology and metabolism, 2012, Oct-15, Volume: 303, Issue:8

    Topics: Adipocytes; Adipose Tissue; Adult; Algorithms; Amino Acids; Body Composition; Body Weight; Caseins; Cell Size; Diet, Carbohydrate-Restricted; Dietary Proteins; Female; Gene Expression; Humans; Hunger; Insulin; Leucine; Male; Methylhistidines; Milk Proteins; Nutritional Status; Obesity; Proteins; Weight Loss; Weight Reduction Programs

2012
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
    Pediatric obesity, 2013, Volume: 8, Issue:1

    Topics: Adolescent; Amino Acids, Branched-Chain; Biomarkers; Blood Glucose; Body Mass Index; Child; Child Nutrition Disorders; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Longitudinal Studies; Male; Massachusetts; Obesity; Predictive Value of Tests; Valine

2013
Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.
    American journal of physiology. Endocrinology and metabolism, 2012, Nov-15, Volume: 303, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Blotting, Western; Cell Cycle Proteins; Cytokines; Dietary Supplements; DNA, Mitochondrial; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Glucose Clamp Technique; Insulin Resistance; Leucine; Male; Mice; Mice, Inbred C57BL; Mitochondrial Turnover; Nicotinamide Phosphoribosyltransferase; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Sirtuin 1; Trans-Activators; Transcription Factors

2012
Leptin and leucine synergistically regulate protein metabolism in C2C12 myotubes and mouse skeletal muscles.
    The British journal of nutrition, 2013, Jul-28, Volume: 110, Issue:2

    Topics: Animals; Cell Line; Dietary Supplements; Drug Synergism; Leptin; Leucine; Mice; Mice, Knockout; Mice, Obese; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Obesity; Organ Size; Protein Biosynthesis; Proteolysis; Receptors, Leptin; Recombinant Proteins; Urea

2013
Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague-Dawley rats.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:7

    Topics: Adipose Tissue; Animals; Dairy Products; Diet; Gene Expression; Insulin Resistance; Leucine; Liver; Muscle, Skeletal; Obesity; Rats; Rats, Sprague-Dawley

2013
High-density lipoprotein apolipoprotein A-I kinetics in obese insulin resistant patients. An in vivo stable isotope study.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2002, Volume: 26, Issue:9

    Topics: Adult; Apolipoprotein A-I; Female; Gas Chromatography-Mass Spectrometry; Humans; Insulin Resistance; Isotopes; Kinetics; Leucine; Lipoproteins, HDL; Models, Statistical; Obesity; Time Factors

2002
Early kinetic abnormalities of apoB-containing lipoproteins in insulin-resistant women with abdominal obesity.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Oct-01, Volume: 22, Issue:10

    Topics: Abdomen; Adult; Apolipoproteins B; Body Mass Index; Carbon Isotopes; Fasting; Female; Humans; Injections, Intravenous; Insulin Resistance; Kinetics; Leucine; Lipids; Lipoproteins; Lipoproteins, IDL; Lipoproteins, LDL; Lipoproteins, VLDL; Obesity; Triglycerides

2002
[Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].
    Medicina clinica, 2003, Mar-15, Volume: 120, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cross-Sectional Studies; Female; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Prevalence; Proline; Protein Precursors; Spain

2003
HEPATIC PROTEIN SYNTHESIS AND LIPID METABOLISM IN GENETICALLY OBESE RATS.
    Metabolism: clinical and experimental, 1965, Volume: 14

    Topics: Amino Acids; Bile Acids and Salts; Cholesterol; Dietary Fats; DNA; Hypercholesterolemia; Leucine; Lipid Metabolism; Liver; Microsomes; Mutation; Obesity; Proteins; Rats; Research; RNA; Salts

1965
The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people.
    Journal of hypertension, 2004, Volume: 22, Issue:2

    Topics: Adult; Alleles; Blood Pressure; Body Mass Index; Cohort Studies; Diastole; E-Selectin; Female; Heterozygote; Homozygote; Humans; Leucine; Longitudinal Studies; Male; Middle Aged; Obesity; Phenylalanine; Polymorphism, Genetic; Systole

2004
Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:1

    Topics: Animals; Animals, Newborn; Arginine; Basic Helix-Loop-Helix Transcription Factors; Blood Glucose; Body Weight; Diet; Dietary Carbohydrates; Female; Fetus; Gene Expression; Glucose; Hepatocyte Nuclear Factor 3-beta; Homeodomain Proteins; Hyperinsulinism; Insulin; Islets of Langerhans; Leucine; Lipids; Male; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; Proinsulin; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trans-Activators

2006
Preproghrelin Leu72Met polymorphism in obese Korean children.
    Journal of pediatric endocrinology & metabolism : JPEM, 2005, Volume: 18, Issue:11

    Topics: Body Mass Index; Child; Cholesterol; Female; Genetic Carrier Screening; Ghrelin; Humans; Korea; Leucine; Male; Methionine; Motilin; Obesity; Polymorphism, Genetic; Triglycerides

2005
The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism.
    Diabetes, 2006, Volume: 55, Issue:3

    Topics: Adult; Female; Gluconeogenesis; Glucose; Glycogenolysis; Humans; Insulin Resistance; Leucine; Liver; Male; Obesity; Proteins

2006
Neuroscience. Regulating energy balance: the substrate strikes back.
    Science (New York, N.Y.), 2006, May-12, Volume: 312, Issue:5775

    Topics: AMP-Activated Protein Kinases; Animals; Appetite; Body Weight; Diet; Eating; Energy Metabolism; Homeostasis; Hypothalamus; Leptin; Leucine; Multienzyme Complexes; Neural Pathways; Neurons; Obesity; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Starvation; Thinness; TOR Serine-Threonine Kinases

2006
Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms.
    Diabetes, 2007, Volume: 56, Issue:6

    Topics: Adipose Tissue; Administration, Oral; Animals; Blood Glucose; Calorimetry, Indirect; Cholesterol; Diet; Glucose Tolerance Test; Leucine; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2007
Leucing weight with a futile cycle.
    Cell metabolism, 2007, Volume: 6, Issue:3

    Topics: Animals; Energy Metabolism; Humans; Leucine; Obesity; Proteins; Substrate Cycling; Weight Loss

2007
Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle.
    Cell metabolism, 2007, Volume: 6, Issue:3

    Topics: Adipose Tissue; Animals; Body Weight; Diet; Eating; Energy Metabolism; Female; Gene Targeting; Glucose Tolerance Test; Humans; Insulin; Leucine; Male; Mice; Mice, Knockout; Obesity; Organ Size; Oxygen Consumption; Protein Kinases; Proteins; Sirolimus; Substrate Cycling; Thermogenesis; TOR Serine-Threonine Kinases; Transaminases

2007
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 293, Issue:6

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adipose Tissue; Amino Acids; Amino Acids, Branched-Chain; Animals; Bariatric Surgery; Female; Food Deprivation; Humans; Keto Acids; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Minor Histocompatibility Antigens; Muscle, Skeletal; Obesity; Obesity, Morbid; Phosphorylation; Pregnancy Proteins; Rats; Rats, Zucker; Transaminases; Weight Loss

2007
Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.
    Pediatric research, 2008, Volume: 63, Issue:2

    Topics: alpha-MSH; Child; DNA Mutational Analysis; France; Gene Expression Regulation; Heterozygote; Humans; Leucine; Models, Biological; Models, Genetic; Mutation; Obesity; Phenylalanine; Pro-Opiomelanocortin; Protein Binding

2008
Diet-induced obesity alters protein synthesis: tissue-specific effects in fasted versus fed mice.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:3

    Topics: Animals; Body Weight; Deuterium Oxide; Diet; Eating; Fasting; Kinetics; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscle, Skeletal; Obesity; Proteins; Serum Albumin

2008
[Effects of 3,5,3'-triiodothyroacetic acid (TRIAC) on protein metabolism of genetically obese or non-obese Zucker rats].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1982, Volume: 176, Issue:2

    Topics: Animals; Brain; Carbon Radioisotopes; Female; Kidney; Leucine; Liver; Muscles; Myocardium; Obesity; Proteins; Radioisotope Dilution Technique; Rats; Rats, Zucker; Triiodothyronine; Tritium

1982
Effect of poor diabetic control and obesity on whole body protein metabolism in man.
    Diabetologia, 1983, Volume: 25, Issue:5

    Topics: Adult; Bicarbonates; Blood Glucose; C-Peptide; Carbon Isotopes; Diabetes Mellitus, Type 1; Female; Humans; Insulin; Leucine; Male; Obesity; Proteins; Reference Values; Sodium Bicarbonate

1983
Hepatic protein synthesis and secretion after jejunoileal bypass in the rat.
    The American journal of clinical nutrition, 1983, Volume: 37, Issue:1

    Topics: Animals; Blood Proteins; Energy Intake; Glucosamine; Glycoproteins; Ileum; In Vitro Techniques; Jejunum; Leucine; Liver; Obesity; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains; Triglycerides

1983
Skeletal muscle metabolism in neonatal lean and obese pigs.
    Journal of animal science, 1983, Volume: 57, Issue:1

    Topics: Amino Acids; Animals; Animals, Newborn; Body Weight; Glucose; Leucine; Male; Muscles; Obesity; Palmitates; Swine; Swine Diseases

1983
Leucine assimilation in patients with diabetes mellitus.
    Acta endocrinologica, 1980, Volume: 93, Issue:4

    Topics: Adult; Aged; Diabetes Mellitus; Female; Half-Life; Humans; Insulin; Leucine; Male; Middle Aged; Obesity

1980
Modulation of leucine oxidation and turnover by graded amounts of carbohydrate intake in obese subjects.
    Metabolism: clinical and experimental, 1982, Volume: 31, Issue:6

    Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Blood Glucose; Diet, Reducing; Dietary Carbohydrates; Female; Humans; Hydroxybutyrates; Insulin; Ketosis; Leucine; Methylhistidines; Nitrogen; Obesity

1982
The response of protein and energy metabolism to food intake in lean and obese man.
    Human nutrition. Clinical nutrition, 1982, Volume: 36C, Issue:1

    Topics: Adult; Aged; Body Weight; Carbon Radioisotopes; Energy Metabolism; Fasting; Female; Food; Humans; Kinetics; Leucine; Male; Middle Aged; Nitrogen; Obesity; Oxygen Consumption; Proteins

1982
Effect of exercise on rates of oxidation, turnover, and plasma clearance of leucine in human subjects.
    The American journal of physiology, 1982, Volume: 242, Issue:6

    Topics: Amino Acids; Blood Glucose; Female; Humans; Leucine; Metabolic Clearance Rate; Obesity; Oxidation-Reduction; Oxygen Consumption; Physical Exertion; Time Factors

1982
The response of whole-body protein turnover to feeding in obese subjects given a protein-free, low-energy diet for three weeks.
    Human nutrition. Clinical nutrition, 1982, Volume: 36, Issue:5

    Topics: Adaptation, Physiological; Diet; Dietary Proteins; Energy Intake; Fasting; Female; Food; Humans; Leucine; Nitrogen; Obesity; Oxidation-Reduction; Protein Biosynthesis; Proteins

1982
Diurnal pattern of protein and energy metabolism in man.
    The American journal of clinical nutrition, 1980, Volume: 33, Issue:9

    Topics: Circadian Rhythm; Energy Metabolism; Feeding Behavior; Female; Humans; Leucine; Middle Aged; Obesity; Oxidation-Reduction; Protein Biosynthesis; Proteins

1980
Influence of low-energy diets on whole-body protein turnover in obese subjects.
    The American journal of physiology, 1980, Volume: 238, Issue:3

    Topics: Adult; Aged; Diet, Reducing; Dietary Proteins; Female; Glycine; Humans; Leucine; Male; Middle Aged; Obesity; Proteins

1980
Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.
    The Journal of clinical investigation, 1981, Volume: 67, Issue:2

    Topics: Adult; Amino Acids; Fasting; Female; Humans; Infusions, Parenteral; Keto Acids; Leucine; Male; Middle Aged; Nitrogen; Obesity; Time Factors; Urea

1981
Enzymic determination of branched-chain amino acids.
    Clinical chemistry, 1981, Volume: 27, Issue:3

    Topics: Adult; Amino Acids, Branched-Chain; Fasting; Female; Glutamate Dehydrogenase; Humans; Ketoglutaric Acids; Leucine; Leucine Transaminase; Male; Methods; Middle Aged; Obesity; Sex Factors; Transaminases

1981
Insulin resistance is mediated by a proteolytic fragment of the insulin receptor.
    The Journal of biological chemistry, 1995, Oct-20, Volume: 270, Issue:42

    Topics: 3T3 Cells; Adipocytes; Animals; Female; Glycogen; Insulin; Insulin Resistance; Leucine; Mice; Obesity; Peptide Fragments; Phosphorylation; Rats; Rats, Zucker; Receptor, Insulin; Triglycerides

1995
The effect of starvation on leucine, alanine and glucose metabolism in obese subjects.
    European journal of clinical investigation, 1995, Volume: 25, Issue:8

    Topics: Adult; Alanine; Fatty Acids, Nonesterified; Female; Glucose; Humans; Insulin; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Obesity; Starvation

1995
The opposing effects of insulin and hyperglycemia in modulating amino acid metabolism during a glucose tolerance test in lean and obese subjects.
    Metabolism: clinical and experimental, 1994, Volume: 43, Issue:2

    Topics: Adult; Amino Acids; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Isoleucine; Leucine; Male; Obesity; Phenylalanine; Reference Values

1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women.
    Metabolism: clinical and experimental, 1994, Volume: 43, Issue:4

    Topics: Adult; Blood Glucose; Body Composition; Body Weight; Female; Humans; Hydrolysis; Insulin; Insulin Resistance; Kinetics; Leucine; Middle Aged; Obesity; Proteins; Weight Loss

1994
Alanine as a lipogenic precursor in isolated hepatocytes from obese Zucker rats.
    Cellular and molecular biology (Noisy-le-Grand, France), 1993, Volume: 39, Issue:6

    Topics: Acetyl Coenzyme A; Alanine; Alanine Transaminase; Animals; Cells, Cultured; Citrates; Coumaric Acids; Fatty Acids; Glucose; Lactates; Lactic Acid; Leucine; Lipids; Liver; Liver Glycogen; Male; Mitochondria, Liver; Obesity; Pyruvates; Pyruvic Acid; Rats; Rats, Zucker

1993
Effects of exercise and weight loss on leucine turnover in different types of obesity.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: Adult; Body Composition; Body Mass Index; Epinephrine; Exercise; Female; Glucagon; Growth Hormone; Hormones; Humans; Hydrocortisone; Insulin; Leucine; Norepinephrine; Obesity; Weight Loss

1993
Metabolic effects of triiodothyronine replacement during fasting in obese subjects.
    The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:3

    Topics: Adult; Blood Glucose; Fasting; Female; Humans; Leucine; Male; Middle Aged; Nitrogen; Obesity; Oxygen; Respiration; Thyroid Hormones; Triiodothyronine; Urea

1996
Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity.
    The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 1

    Topics: Adult; Amino Acids; Amino Acids, Branched-Chain; Blood Glucose; Body Composition; Female; Humans; Insulin; Keto Acids; Leucine; Lipid Metabolism; Male; Middle Aged; Obesity; Oxidation-Reduction

1996
Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:8

    Topics: Adipose Tissue; Adult; Blood Glucose; Body Composition; Calorimetry, Indirect; Fatty Acids, Nonesterified; Female; Food; Glucose; Glucose Clamp Technique; Humans; Insulin; Leucine; Lipid Peroxidation; Lipids; Obesity; Oxidation-Reduction; Proteins

1997
Sex differences in the effect of obesity on human plasma tryptophan/large neutral amino acid ratio.
    Annals of nutrition & metabolism, 1999, Volume: 43, Issue:3

    Topics: Amino Acids; Body Mass Index; Female; Humans; Leucine; Male; Obesity; Phenylalanine; Sex Characteristics; Tryptophan; Tyrosine; Valine

1999
Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:1

    Topics: Adipose Tissue; Aged; Body Composition; Body Weight; Diet, Reducing; Female; Follow-Up Studies; Humans; Kinetics; Leucine; Middle Aged; Muscle, Skeletal; Obesity; Organ Size; Postmenopause; Prospective Studies; Reference Values; Time Factors; Weight Loss

2000
Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescents.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:4

    Topics: Adolescent; Blood Glucose; Body Mass Index; Carbon Isotopes; Chromatography, Affinity; Female; Fibrinogen; Gas Chromatography-Mass Spectrometry; Humans; Insulin; Keto Acids; Kinetics; Leucine; Obesity; Serum Albumin

2002
Regional muscle and adipose tissue amino acid metabolism in lean and obese women.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:4

    Topics: Abdomen; Adipose Tissue; Adult; Alanine; Amino Acids; Arteries; Body Composition; Body Constitution; Body Mass Index; Fasting; Female; Glutamic Acid; Glutamine; Humans; Kinetics; Leucine; Muscle, Skeletal; Obesity; Proteins; Veins

2002
Weight loss does not influence energy expenditure or leucine metabolism in obese cats.
    The Journal of nutrition, 2002, Volume: 132, Issue:6 Suppl 2

    Topics: Animals; Body Composition; Cat Diseases; Cats; Diet, Protein-Restricted; Diet, Reducing; Energy Metabolism; Female; Kinetics; Leucine; Male; Obesity; Proteins; Weight Loss

2002
The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population.
    Journal of clinical pharmacy and therapeutics, 2002, Volume: 27, Issue:3

    Topics: Adult; Base Sequence; Genetics, Population; Genotype; Humans; Korea; Leucine; Neuropeptide Y; Obesity; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals

2002
45Ca2+ uptake by dispersed pancreatic islet cells: effect of D-glucose and the calcium probe, chlorotetracycline.
    Pflugers Archiv : European journal of physiology, 1979, Volume: 381, Issue:3

    Topics: Animals; Calcium; Calcium Radioisotopes; Chlortetracycline; Glucose; Islets of Langerhans; Leucine; Mannose; Methylglucosides; Mice; Mice, Mutant Strains; Obesity

1979
Effect of starvation on the turnover and metabolic response to leucine.
    The Journal of clinical investigation, 1978, Volume: 61, Issue:6

    Topics: Adult; Amino Acids; Blood Glucose; Female; Humans; Kinetics; Leucine; Male; Nitrogen; Obesity; Starvation; Time Factors

1978
Hepatic lipid metabolism in severe human obesity.
    Metabolism: clinical and experimental, 1977, Volume: 26, Issue:9

    Topics: Adult; Blood Glucose; Blood Proteins; Cholesterol; Fatty Acids, Nonesterified; Female; Fructose; Glycerol; Humans; Insulin; Leucine; Lipid Metabolism; Liver; Male; Obesity; Proteins; Triglycerides

1977
Effect of 24 hour fast in obese children.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1976, Sep-30, Volume: 25, Issue:8

    Topics: Adolescent; Alanine; Blood Glucose; Child; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Growth Hormone; Humans; Insulin; Isoleucine; Ketone Bodies; Leucine; Male; Obesity; Valine

1976
Insulin secretion by perfused islets from the obese Zucker rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 149, Issue:2

    Topics: Animals; Glucose; Hyperinsulinism; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Obesity; Perfusion; Rats; Stimulation, Chemical

1975
A comparison of the enzyme levels and the in vitro utilization of various substrates for lipogenesis in pair-fed lean and obese pigs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:1

    Topics: Acetates; Adipose Tissue; Alanine; Animals; Gluconeogenesis; Glucose; Glycerol; Glycolysis; Leucine; Lipids; Liver; Obesity; Pyruvates; Swine

1976
Body composition, nitrogen metabolism, and energy utilization with feeding of mildly restricted (4.2 MJ/d) and severely restricted (2.1 MJ/d) isonitrogenous diets.
    The American journal of clinical nutrition, 1992, Volume: 56, Issue:4

    Topics: Body Composition; Diet, Reducing; Dietary Carbohydrates; Dietary Proteins; Energy Metabolism; Female; Humans; Leucine; Nitrogen; Obesity; Weight Loss

1992
Increased protein turnover in obese women.
    Metabolism: clinical and experimental, 1992, Volume: 41, Issue:9

    Topics: Abdomen; Adult; Body Mass Index; Body Weight; Female; Glucose Tolerance Test; Hip; Humans; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Magnetic Resonance Imaging; Middle Aged; Obesity; Proteins

1992
Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate.
    The American journal of clinical nutrition, 1992, Volume: 55, Issue:4

    Topics: Adult; Basal Metabolism; Body Composition; Diet, Reducing; Dihydroxyacetone; Energy Metabolism; Female; Humans; Leucine; Middle Aged; Nitrogen; Obesity; Pyruvates; Pyruvic Acid; Weight Loss

1992
Protein metabolism in obesity: effects of body fat distribution and hyperinsulinemia on leucine turnover.
    The American journal of clinical nutrition, 1991, Volume: 53, Issue:1

    Topics: Adipose Tissue; Body Mass Index; Caproates; Female; Humans; Insulin; Keto Acids; Leucine; Obesity; Proteins

1991
Differential effects of insulin resistance on leucine and glucose kinetics in obesity.
    Metabolism: clinical and experimental, 1991, Volume: 40, Issue:1

    Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Carbon Isotopes; Female; Glucose; Humans; Hyperinsulinism; Insulin Resistance; Kinetics; Leucine; Obesity

1991
Failure of glyburide and insulin treatment to decrease leucine flux in obese type II diabetic patients.
    International journal of obesity, 1990, Volume: 14, Issue:8

    Topics: Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Insulin; Leucine; Middle Aged; Obesity

1990
Prolonged fasting as conditioned by prior protein depletion: effect on urinary nitrogen excretion and whole-body protein turnover.
    Metabolism: clinical and experimental, 1990, Volume: 39, Issue:12

    Topics: Fasting; Female; Humans; Kinetics; Leucine; Male; Methylhistidines; Nitrogen; Obesity; Protein Deficiency; Reference Values; Time Factors

1990
Effects of sucrose on resting metabolic rate, nitrogen balance, leucine turnover and oxidation during weight loss with low calorie diets.
    International journal of obesity, 1990, Volume: 14, Issue:11

    Topics: Adult; Blood Glucose; Body Temperature Regulation; Diet, Reducing; Dietary Fats; Dietary Proteins; Energy Intake; Energy Metabolism; Female; Humans; Insulin; Leucine; Middle Aged; Nitrogen; Obesity; Sucrose; Thyroxine; Triiodothyronine; Weight Loss

1990
Effect of triiodothyronine on leucine kinetics, metabolic rate, glucose concentration and insulin secretion rate during two weeks of fasting in obese women.
    International journal of obesity, 1989, Volume: 13, Issue:4

    Topics: Adult; Blood Glucose; Fasting; Female; Humans; Insulin; Insulin Secretion; Leucine; Obesity; Triiodothyronine

1989
Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse beta-cells.
    The Journal of biological chemistry, 1988, Sep-25, Volume: 263, Issue:27

    Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arginine; Calcium; Cytoplasm; Dose-Response Relationship, Drug; Glucose; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Leucine; Mice; Mice, Obese; Obesity

1988
Sex-specific differences in plasma branched-chain keto acid levels in obesity.
    The American journal of clinical nutrition, 1987, Volume: 46, Issue:1

    Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Obesity; Sex Characteristics; Valine

1987
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:4

    Topics: Adipose Tissue; Adult; Binding, Competitive; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glucose; Humans; Insulin; Insulin Resistance; Leucine; Male; Obesity

1987
Failure of carbohydrate to spare leucine oxidation in obese subjects.
    International journal of obesity, 1987, Volume: 11, Issue:5

    Topics: Administration, Oral; Adult; Blood Glucose; Female; Glucagon; Glucose; Humans; Insulin; Leucine; Male; Middle Aged; Obesity

1987
Leucine metabolism in type II diabetes mellitus.
    Diabetes, 1986, Volume: 35, Issue:11

    Topics: Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Leucine; Middle Aged; Obesity

1986
The fate of 14C derived from radioactively labelled dietary precursors in young rats of the Zucker strain (Fa/- and fa/fa).
    The Biochemical journal, 1986, Apr-15, Volume: 235, Issue:2

    Topics: Animals; Carbon Radioisotopes; Glucose; Lactates; Lactic Acid; Leucine; Obesity; Palmitic Acid; Palmitic Acids; Rats; Rats, Zucker; Valine

1986
Effect of dietary fat, carbohydrate, and protein on branched-chain amino acid catabolism during caloric restriction.
    The Journal of clinical investigation, 1985, Volume: 76, Issue:2

    Topics: 3-Hydroxybutyric Acid; Amino Acids, Branched-Chain; Blood Glucose; Diet, Reducing; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Female; Humans; Hydroxybutyrates; Insulin; Leucine; Obesity

1985
Physiological covalent regulation of rat liver branched-chain alpha-ketoacid dehydrogenase.
    Archives of biochemistry and biophysics, 1985, Volume: 243, Issue:2

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Dietary Proteins; Female; Ketone Oxidoreductases; Leucine; Liver; Male; Multienzyme Complexes; Obesity; Radiochemistry; Rats; Rats, Inbred Strains; Rats, Zucker; Starvation; Temperature

1985
Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets.
    Diabetologia, 1974, Volume: 10, Issue:2

    Topics: Animals; Caproates; Chemical Phenomena; Chemistry; Female; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Leucine; Male; Mice; NADP; Obesity; Spectrometry, Fluorescence; Structure-Activity Relationship; Valerates

1974
Iodoacetamide-induced sensitization of the pancreatic beta-cells to glucose stimulation.
    The Biochemical journal, 1973, Volume: 132, Issue:4

    Topics: Amides; Animals; Calcium; Carbon Isotopes; Dithiothreitol; Epinephrine; Female; Fructosephosphates; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Iodine Isotopes; Iodoacetates; Islets of Langerhans; Leucine; Male; Mice; Obesity; Radioimmunoassay; Theophylline; Tritium

1973
The pancreatic beta-cell recognition of insulin secretagogues. Comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone.
    Archives of biochemistry and biophysics, 1974, Volume: 162, Issue:2

    Topics: Acetone; Animals; Arginine; Calcium; Carbon Radioisotopes; Dinitrophenols; Epinephrine; Female; Glucosamine; Glucose; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Iodoacetates; Islets of Langerhans; Isomerism; Leucine; Male; Obesity; Phlorhizin; Theophylline; Time Factors

1974
Further studies on the amelioration of the characteristics of New Zealand Obese (NZO) mice following implantation of islets of Langerhans.
    Diabetologia, 1974, Volume: 10, Issue:5

    Topics: Animals; Blood Glucose; Body Weight; Cytological Techniques; Diffusion; Hyperglycemia; Hyperinsulinism; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Leucine; Male; Mice; Mice, Inbred Strains; Micropore Filters; Obesity; Peritoneal Cavity; Proinsulin; Streptozocin; Time Factors; Transplantation, Homologous; Tritium

1974
[2 cases of Langerhans adenoma].
    Acta chirurgica Belgica, 1969, Volume: 68, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adult; Aged; Angiography; Celiac Artery; Female; Gastrointestinal Hemorrhage; Glucagon; Humans; Hypoglycemia; Insulin; Intracranial Arteriosclerosis; Leucine; Mesenteric Arteries; Obesity; Pancreatectomy; Pancreatic Neoplasms; Pregnancy; Pregnancy Complications; Prognosis; Tolbutamide

1969
Transport of -aminoisobutyric acid in mammalian pancretic -cells.
    Diabetologia, 1971, Volume: 7, Issue:4

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Butyrates; Cyclic AMP; Diazoxide; Galactose; Glucose; Hyperglycemia; Hypoxia; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Methionine; Mice; Monosaccharides; Obesity; Sodium

1971
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.
    The Journal of clinical investigation, 1971, Volume: 50, Issue:10

    Topics: Acromegaly; Adenoma, Islet Cell; Adolescent; Adult; Animals; Child; Chromatography, Gel; Cricetinae; Cushing Syndrome; Diazoxide; Disease Models, Animal; Female; Glucagon; Glucose Tolerance Test; Half-Life; Humans; Hypoglycemia; Hypokalemia; Insulin; Iodine Isotopes; Leucine; Male; Middle Aged; Myotonic Dystrophy; Neoplasms, Experimental; Obesity; Proinsulin; Radioimmunoassay; Stimulation, Chemical; Tolbutamide

1971
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets.
    The Biochemical journal, 1971, Volume: 123, Issue:4

    Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Citrates; Cyclic AMP; Depression, Chemical; Diazoxide; Epinephrine; Glucose; Glyburide; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Iodoacetates; Islets of Langerhans; Leucine; Male; Mice; Monosaccharides; Obesity; Oxidation-Reduction; Pyruvates; Stimulation, Chemical; Succinates

1971
Specificity of leucine stimulation of insulin release.
    Hormones, 1972, Volume: 3, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Dose-Response Relationship, Drug; Female; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Antibodies; Insulin Secretion; Iodine Isotopes; Islets of Langerhans; Isoleucine; Leucine; Mice; Obesity; Radioimmunoassay; Receptors, Cell Surface

1972
Control of liver tyrosine aminotransferase expression: enzyme regulatory studies on inbred strains and mutant mice.
    Biochemical genetics, 1970, Volume: 4, Issue:1

    Topics: Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Electrophoresis, Disc; Enzyme Induction; Fasting; Female; Flumethasone; Genes, Regulator; Glucocorticoids; Glucose; Hot Temperature; Hydrocortisone; Isoenzymes; Kinetics; Leucine; Liver; Male; Mice; Mutation; Obesity; Protein Denaturation; Species Specificity; Starvation; Tyrosine Transaminase

1970
Nitrogen sparing induced by a mixture of essential amino acids given chiefly as their keto-analogues during prolonged starvation in obese subjects.
    The Journal of clinical investigation, 1974, Volume: 54, Issue:4

    Topics: Amino Acids; Female; Humans; Infusions, Parenteral; Isoleucine; Keto Acids; Leucine; Methionine; Nitrogen; Obesity; Phenylalanine; Starvation; Urea; Valine

1974
Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic mice.
    Acta physiologica Scandinavica, 1972, Volume: 84, Issue:2

    Topics: Amino Acids; Animals; Binding Sites; Carbon Isotopes; Chromatography, Thin Layer; Dansyl Compounds; Fatty Acids, Nonesterified; Hyperglycemia; Islets of Langerhans; Leucine; Mice; Obesity; Taurine; Valine

1972
Inductive effects of glucose on the insulin secretory and synthetic apparatus of the pancreatic -cell.
    Israel journal of medical sciences, 1972, Volume: 8, Issue:3

    Topics: Administration, Oral; Animals; Cell Fractionation; Dactinomycin; Diabetes Mellitus; Dietary Carbohydrates; Fasting; Glucose; Humans; Injections, Intraperitoneal; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Obesity; Pancreas; Peptide Chain Initiation, Translational; Rats; Receptors, Drug; Ribosomes; RNA; Tritium; Uridine

1972
In vitro studies on insulin in the genetically obese mouse.
    Diabetologia, 1973, Volume: 9, Issue:6

    Topics: Animals; Arginine; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Mice; Obesity; Stimulation, Chemical

1973
Changes of free amino acids in pancreatic beta-cells after starvation and substrate deprivation.
    Acta endocrinologica, 1974, Volume: 75, Issue:1

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, Thin Layer; Dansyl Compounds; Diabetes Mellitus; Fasting; Female; Freeze Drying; Glutamates; Glycine; Islets of Langerhans; Leucine; Lysine; Mice; Obesity; Ornithine; Phenylalanine; Proline; Taurine; Tritium; Valine

1974
Glucose oxidation and contents of free amino acids in pancreatic beta-cells stimulated by a non-metabolizable leucine analogue.
    Biochimica et biophysica acta, 1974, May-24, Volume: 343, Issue:3

    Topics: Amino Acids; Animals; Carbon Radioisotopes; Dansyl Compounds; Glucose; In Vitro Techniques; Islets of Langerhans; Isomerism; Leucine; Obesity; Structure-Activity Relationship; Tritium

1974
Transport of L-leucine and D-leucine into pancreatic -cells with reference to the mechanisms of amino acid-induced insulin release.
    Biochimica et biophysica acta, 1972, May-09, Volume: 266, Issue:2

    Topics: Amino Acids; Animals; Biological Transport; Carbon Isotopes; Cells; Extracellular Space; Glyburide; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Mice; Mice, Inbred Strains; Obesity; Protein Biosynthesis; Receptors, Drug; Stereoisomerism; Sucrose; Tritium

1972
Uptake and oxidation of glutamic acid in mammalian pancreatic islets.
    Hormones, 1972, Volume: 3, Issue:3

    Topics: Alanine; Animals; Arginine; Carbon Isotopes; Female; Galactose; Glucose; Glutamates; Glyburide; Hyperglycemia; Insulin; Iodine Isotopes; Islets of Langerhans; Leucine; Male; Mice; Obesity; Oxidation-Reduction; Sucrose; Time Factors; Tritium

1972
Effects of oral alanine administration in fasting obese subjects.
    Metabolism: clinical and experimental, 1973, Volume: 22, Issue:7

    Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Female; Gluconeogenesis; Humans; Hydroxybutyrates; Insulin; Isoleucine; Leucine; Male; Middle Aged; Nitrogen; Obesity; Phosphorus; Potassium; Urea; Uric Acid; Valine

1973
Hyperinsulin response to oral leucine in obesity and acromegaly.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:3

    Topics: Acromegaly; Blood Glucose; Fatty Acids, Nonesterified; Glucose Tolerance Test; Growth Hormone; Humans; Hyperinsulinism; Insulin; Leucine; Male; Obesity

1973
Transient kwaskiorkor: A cause of fatty liver following small bowel bypass.
    Surgery, 1974, Volume: 75, Issue:6

    Topics: Adult; Amino Acids; Body Weight; Dietary Carbohydrates; Dietary Proteins; Fatty Liver; Female; Glycine; Humans; Ileum; Intestinal Absorption; Intestine, Small; Kwashiorkor; Leucine; Lipid Metabolism; Liver; Lysine; Malabsorption Syndromes; Male; Obesity

1974
Leucyl-beta-naphthylamide-splitting enzymes in the mammalian endocrine pancreas.
    The Biochemical journal, 1968, Volume: 106, Issue:1

    Topics: Aminopeptidases; Animals; Electrophoresis, Disc; Female; Hydrogen-Ion Concentration; Hyperglycemia; Insulin; Islets of Langerhans; Kinetics; Leucine; Liver; Male; Mice; Naphthalenes; Obesity; Pancreas; Spectrophotometry; Starvation

1968
[Effect of blood sugar decreasing sulfonylureas on the in vitro metabolism of glucose and amino acids in the beta-cells of the pancreas in mice].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:8

    Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Depression, Chemical; Female; Glucose; Hyperglycemia; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Male; Mice; Obesity; Oxidation-Reduction; Oxygen Consumption; Pancreas; Stimulation, Chemical; Tolbutamide; Urea; Valine

1969
Hypersecretion of insulin after the administration of L-leucine to obese children.
    The Journal of pediatrics, 1971, Volume: 78, Issue:1

    Topics: Abnormalities, Multiple; Administration, Oral; Adolescent; Blood Glucose; Child; Child, Preschool; Female; Glucose Tolerance Test; Humans; Hypogonadism; Insulin; Insulin Secretion; Intellectual Disability; Islets of Langerhans; Laurence-Moon Syndrome; Leucine; Male; Obesity; Stimulation, Chemical

1971
Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells.
    Endocrinology, 1971, Volume: 89, Issue:6

    Topics: Alanine; Animals; Arginine; Carbon Isotopes; Diazoxide; Fructose; Glucose; Glyburide; Hyperglycemia; Islets of Langerhans; Leucine; Mice; Obesity; Pancreas; Pyruvates; Sodium; Stereoisomerism; Succinates; Time Factors

1971
Synthesis and degradation of liver acetyl coenzyme A carboxylase in genetically obese mice.
    Proceedings of the National Academy of Sciences of the United States of America, 1971, Volume: 68, Issue:9

    Topics: Animals; Autoradiography; Body Weight; Coenzyme A; Half-Life; Hot Temperature; Immunochemistry; Immunodiffusion; Kinetics; Leucine; Ligases; Liver; Mice; Obesity; Organ Size; Palmitic Acids; Precipitin Tests; Tritium

1971
Studies in spiny mice (Acomys cahirinus): metabolic state and pancreatic insulin release in vitro.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1969, Volume: 1, Issue:2

    Topics: Age Factors; Animals; Antigens; Arginine; Blood Glucose; Caffeine; Calcium; Diabetes Mellitus; Glucagon; Glycosuria; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Leucine; Mice; Mice, Inbred Strains; Obesity; Pancreas; Tolbutamide

1969
Hormone and amino acid levels in altered nutritional states.
    The Journal of laboratory and clinical medicine, 1970, Volume: 76, Issue:5

    Topics: Adult; Alanine; Amino Acids; Aminobutyrates; Female; Growth Hormone; Humans; Insulin; Isoleucine; Leucine; Male; Nutritional Physiological Phenomena; Obesity; Protein Deficiency; Starvation; Valine

1970
[Quality of lipids and quantity of proteins synthesized in vivo by the normal mouse and the obese-hyperglycemic mouse from Bar Harbor].
    Bulletin de la Societe de chimie biologique, 1970, Apr-17, Volume: 52, Issue:3

    Topics: Acetates; Adipose Tissue; Aminoisobutyric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Fatty Acids; Fatty Acids, Nonesterified; Female; Glycerides; Hyperglycemia; Leucine; Lipids; Liver; Mice; Muscles; Obesity; Phospholipids; Protein Biosynthesis; Rodent Diseases; Triglycerides

1970
Studies on the radioimmunological determination of blood insulin by means of 125-I-insulin of high specific activity.
    Polish medical journal, 1970, Volume: 9, Issue:6

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Fasting; Female; Glucagon; Glucose; Humans; Infant; Insulin; Iodine Isotopes; Leucine; Methods; Obesity; Radioimmunoassay; Swine; Tolbutamide

1970
Alteration in the urinary excretion rate of amino acids and nitrogen by dietary means in obese and normal human subjects.
    The Journal of laboratory and clinical medicine, 1971, Volume: 77, Issue:2

    Topics: Adult; Alanine; Amino Acids; Creatinine; Female; Humans; Isoleucine; Leucine; Male; Nitrogen; Obesity; Protein Deficiency; Renal Aminoacidurias; Starvation; Taurine; Urea; Valine

1971
Plasma amino acid levels and insulin secretion in obesity.
    The New England journal of medicine, 1969, Oct-09, Volume: 281, Issue:15

    Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Middle Aged; Obesity; Pancreas; Phenylalanine; Tyrosine; Valine

1969
The effects of test doses of leucine, isoleucine or valine on plasma amino acid levels. The unique effect of leucine.
    The American journal of clinical nutrition, 1965, Volume: 17, Issue:5

    Topics: Amino Acids; Blood; Fasting; Humans; Isoleucine; Leucine; Male; Obesity; Valine

1965
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