leucine and Obesity
leucine has been researched along with Obesity in 185 studies
Research
Studies (185)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 65 (35.14) | 18.7374 |
1990's | 21 (11.35) | 18.2507 |
2000's | 30 (16.22) | 29.6817 |
2010's | 49 (26.49) | 24.3611 |
2020's | 20 (10.81) | 2.80 |
Authors
Authors | Studies |
---|---|
Hu, J; Ji, L; Johnston, LJ; Liu, C; Ma, X; Zhang, X; Zhao, Y | 1 |
Bishop, CA; Grune, T; Henkel, J; Henning, T; Klaus, S; Machate, T; Püschel, G; Weber, D; Weitkunat, K | 1 |
Capparelli, R; Cuomo, P; Iannelli, A; Iannelli, D | 1 |
Chiappetta, S; Kim, M; Koschker, AC; Stein, J; Stier, C; Stier, R | 1 |
Lenart-Lipinska, M; Matyjaszek-Matuszek, B; Szmygin, H; Szydelko, J; Wozniak, S | 1 |
Achamrah, N; Bôle-Feysot, C; Castres, I; Coëffier, M; Coquard, A; Déchelotte, P; Folope, V; Grigioni, S; Guérin, C; Houivet, E; Lelandais, H; Meret, C; Petit, A; Quillard, M; Tourny, C | 1 |
He, X; Huang, X; Ji, N; Liu, M; Sun, T; Wang, J | 1 |
Barouki, R; Coumoul, X; De Bandt, JP | 1 |
Kim, J; Kwon, YH | 1 |
Han, X; Ma, Q; Shan, A; Sun, B; Sun, Y | 1 |
Han, L; Liu, X; Shi, R; Wang, B; Wang, D; Wang, L; Xia, B; Ye, J; Zhao, B; Zhao, Z | 1 |
Becetti, I; Bredella, MA; Lauze, M; Lee, H; Misra, M; Singhal, V | 1 |
Bonet, ML; Picó, C; Ribot, J | 1 |
Adams, V; Alves, PKN; Augstein, A; Barthel, P; Friedrich, J; Joachim, D; Linke, A; Männel, A; Moriscot, AS; Prieto, ME; Schauer, A | 1 |
Baum, JI; Dridi, S; Huang, Y; Wu, H | 1 |
Blouet, C; Darwish, T; Nuzzaci, D; Samudrala, H; Tsang, AH | 1 |
Bongers, A; de Vogel-van den Bosch, J; Memelink, RG; Pasman, WJ; Tromp, W; Tump, A; van Ginkel, A; Verlaan, S; Weijs, PJM; Wopereis, S | 1 |
Hu, X; Jin, H; Li, J; Shao, D; Shi, J; Yan, X | 1 |
Guo, X; Hu, W; Jiang, X; Liang, Y; Wang, B; Zhang, Y; Zheng, J; Zheng, L | 1 |
Arthur, S; Denning, K; Rahman, MM; Russell, R; Salisbury, T; Sierra-Bakhshi, C; Singh, S; Sundaram, U; Thompson, C | 1 |
López, N; Palou, A; Sánchez, J; Serra, F | 1 |
Granados-Portillo, O; Noriega, LG; Pedraza-Chaverri, J; Salinas-Rubio, D; Torre-Villalvazo, I; Torres, N; Tovar, AR | 1 |
Brunetta, HS; de Camargo, CQ; Nunes, EA | 1 |
Barritt, AS; Chalasani, N; Flores, O; Kolterman, O; Rinella, M; Siddiqui, M; Vuppalanchi, R; Zemel, MB | 1 |
Cao, W; Gu, H; Hao, L; Li, X; Liu, L; Liu, R; Liu, Z; Ma, Y; Mei, S; Sun, X; Wang, X; Yang, X; Yao, P | 1 |
Adams, SH; Hoppel, CL; Inukai, A; Kadota, Y; Kawamata, Y; Lang, CH; Lynch, CJ; Matsumoto, H; Olson, KC; Sakai, R; She, P; Shimomura, Y | 1 |
Bremner, DM; Calder, AG; Holtrop, G; Johnstone, AM; Lobley, GE; Milne, E | 1 |
Belluomo, I; Bermúdez-Silva, FJ; Binder, E; Clark, S; Cota, D; Duchampt, A; Elie, M; Leste-Lasserre, T; Mithieux, G | 1 |
Drgonova, J; Fredriksson, R; Han, JC; Jacobsson, JA; Marcus, C; Schiöth, HB; Uhl, GR; Yanovski, JA | 1 |
Barrett, PH; Chan, DC; Pang, J; Watts, GF; Wong, AT | 1 |
Adams, LA; Barrett, PH; Chan, DC; Watts, GF; Wong, AT | 1 |
Campaña, AB; Donato, J; Lima, FB; Torres-Leal, FL; Zampieri, TT | 1 |
Meininger, CJ; Wu, G; Wu, Z; Yang, Y | 1 |
Chevalier, S; Gougeon, R; Labonte, CC; Marliss, EB; Morais, JA | 1 |
Armitage, IM; Bernlohr, DA; Burrill, JS; Deng, Y; Long, EK; Reilly, B; Scherer, PE | 1 |
Mittendorfer, B; Smith, GI | 1 |
de Vogel-van den Bosch, J; Engberink, MF; Swinkels, S; Verlaan, S; Verreijen, AM; Weijs, PJ | 1 |
Baek, KJ; Kim, DS; Kim, HA; Kwon, NS; Yun, HY | 1 |
Bruckbauer, A; Cao, Q; Cui, X; Fu, L; Li, F; Shi, H; Wu, R; Xue, B; Zemel, MB | 2 |
Bernstein, AM; Golubic, M; Roizen, MF | 1 |
de Vogel-van den Bosch, J; Verlaan, S; Verreijen, AM; Weijs, PJ | 1 |
Donato, J; Pedroso, JA; Zampieri, TT | 1 |
Bojsen-Møller, KN; Dirksen, C; Holst, JJ; Jacobsen, SH; Jensen, JE; Jørgensen, NB; Kristiansen, VB; Madsbad, S; Reitelseder, S; van Hall, G | 1 |
de la Garza, AL; Etxeberria, U; Martíinez, JA; Milagro, I | 1 |
Duan, Y; Hou, Y; Li, F; Tan, B; Wu, G; Yao, K; Yin, Y | 1 |
Baum, JI; Bottje, W; Davis, G; Dridi, S; Shouse, SA; Smith, D; Washington, TA | 1 |
Larnkjær, A; Lind, MV; Michaelsen, KF; Mølgaard, C | 1 |
Beglinger, C; Doody, A; Drewe, J; Häfliger, S; Meili, J; Meyer-Gerspach, AC; Rehfeld, JF; Wölnerhanssen, B | 1 |
Babraj, J; Cuthbertson, DJ; Leese, G; Siervo, M | 1 |
Andre, A; Bailhache, E; Briand, F; Krempf, M; Magot, T; Nguyen, P; Ouguerram, K | 1 |
Jitomir, J; Willoughby, DS | 1 |
Lynch, CJ; Nairizi, A; She, P; Vary, TC | 1 |
An, W; Guan, Y; Li, S; Li, X; Li, Y; Mulholland, MW; Tang, C; Wang, N; Wang, X; Xu, G; Zhang, W; Zhu, Y | 1 |
Bedu, M; Boirie, Y; Delcourt, I; Duche, P; Giraudet, C; Guillet, C; Rance, M; Walrand, S | 1 |
Bonfleur, ML; Boschero, AC; Carneiro, EM; Collares-Buzato, CB; de França Carvalho, CP; de Gabriel Dorighello, G; de Oliveira, HC; Ribeiro, RA; Vanzela, EC | 1 |
Balage, M; Dardevet, D | 1 |
Choi, DY; Jeun, J; Kim, JH; Kim, YO; Shin, CS | 1 |
Devkota, S; Layman, DK | 1 |
Barrett, PH; Chan, DC; Chan, DT; Ooi, EM; Watts, GF; Wong, AT | 1 |
Donato, J; Pantaleão, LC; Resende, GF; Tirapegui, J; Torres-Leal, FL; Vianna, D | 1 |
Cave, MC; Frazier, TH; Hurt, RT; McClave, SA | 1 |
Mittendorfer, B; Shah, K; Smith, GI; Villareal, DT | 1 |
Kampelman, J; Magkos, F; Mittendorfer, B; Patterson, BW; Reeds, DN; Smith, GI; Wang, X | 1 |
Cotter, PD; Korpela, R; McAllan, L; Nilaweera, KN; Roche, HM | 1 |
Chen, H; Erkelens, JR; Morris, MJ; Simar, D; Ting, JH | 1 |
Bruckbauer, A; Zemel, MB | 1 |
Freudenberg, A; Klaus, S; Petzke, KJ | 1 |
Adechian, S; Balage, M; Boirie, Y; Dardevet, D; Gaudichon, C; Marset-Baglieri, A; Migné, C; Mosoni, L; Quignard-Boulangé, A; Remond, D; Rousset, S | 1 |
Clish, CB; Deik, AA; Fleischman, A; Gerszten, RE; Grinspoon, SK; McCarthy, MA; McCormack, SE; Mootha, VK; Shaham, O; Wang, TJ | 1 |
He, C; Lee, J; Li, H; Xie, Z; Xu, M | 1 |
Bassil, MS; Gougeon, R | 1 |
Huang, Z; Mao, X; Qiao, S; Wang, J; Zeng, X | 1 |
Eller, LK; Reimer, RA; Saha, DC; Shearer, J | 1 |
Duvillard, L; Florentin, E; Gambert, P; Pont, F; Vergès, B | 2 |
Buijs, MM; Burggraaf, J; Cohen, AF; De Kam, ML; Frölich, M; Meinders, AE; Pijl, H; Romijn, JA; Stellaard, F | 1 |
Layman, DK | 1 |
Corella, D; González, JI; Portolés, O; Ramírez, JB; Ruiz de la Fuente, S; Sorlí, JV | 1 |
FILLIOS, LC; SAITO, S | 1 |
Balagopal, P; Bayne, E; George, D; Patton, N; Russell, L; Sager, B | 1 |
Lambert, D; Marteau, JB; Noyer-Weidner, M; Pfister, M; Sass, C; Visvikis, S | 1 |
Aalinkeel, R; Hill, DJ; Mitrani, P; Pandya, JD; Patel, MS; Song, F; Srinivasan, M; Strutt, B | 1 |
Layman, DK; Walker, DA | 1 |
Hwang, PH; Jo, DS; Kim, SL; Kim, SY; Lee, DY; Lee, KH | 1 |
Burgess, SC; Chevalier, S; Gougeon, R; Malloy, CR; Marliss, EB; Morais, JA | 1 |
Flier, JS | 1 |
Guo, K; LeBlanc, RE; Loh, D; Schwartz, GJ; Yu, YH; Zhang, Y | 1 |
Fried, SK; Watford, M | 1 |
Bronson, SK; Hajnal, A; Hutson, SM; Lynch, CJ; Reid, TM; She, P; Vary, TC | 1 |
Cooney, RN; Hutson, SM; Lynch, CJ; Reid, T; She, P; Van Horn, C | 1 |
Bouglé, D; Clement, K; Costes, B; Dubern, B; Ersoy, B; Frelut, ML; Lubrano-Berthelier, C; Mencarelli, M; Simon, C; Tounian, P; Vaisse, C | 1 |
Anderson, SR; Gilge, DA; Previs, SF; Steiber, AL | 1 |
Autissier, N; Dumas, P; Loireau, A; Michel, R | 1 |
Ford, C; Garrow, JS; Halliday, D; Mahler, RF; Nair, KS | 1 |
Bistrian, BR; Blackburn, GL; Hoffer, LJ; Matthews, DE; Young, VR | 1 |
Tuma, DJ; Vanderhoof, JA | 1 |
Campion, DR; Hausman, GJ; Meredith, FI | 1 |
Bratusch-Marrain, P; Ferenci, P; Waldhäusl, W | 1 |
Adibi, SA; Morse, EL; Stanko, RT | 1 |
Clugston, GA; Garlick, PJ | 2 |
Adibi, SA; Hagg, SA; Morse, EL | 1 |
Clugston, GA; Garlick, PJ; Swick, RW; Waterlow, JC | 1 |
Clugston, GA; Garlick, PJ; Waterlow, JC | 1 |
Mitch, WE; Sapir, DG; Walser, M | 1 |
Gerbitz, KD; Michal, G; Rudolph, HJ; Wieland, OH | 1 |
Balba, Y; Donnelly, PV; Knutson, VP; Lopez-Reyes, M | 1 |
Boroujerdi, MA; Scobie, IN; Sönksen, PH; Umpleby, AM | 1 |
Abumrad, NN; Flakoll, PJ; Hill, JO; May, MM; Rice, DE | 1 |
Amatruda, J; Barnard, R; Statt, M; Welle, S | 1 |
Argilés, JM; Domènech, M; López-Soriano, FJ | 1 |
Haymond, MW; Jensen, MD; Kanaley, JA | 1 |
Byerley, LO; Heber, D | 1 |
Castellino, P; DeFronzo, RA; Luzi, L | 1 |
Bonadonna, R; Bonora, E; Castellino, P; DeFronzo, RA; Solini, A | 1 |
Dekker, JM; Hart, LM; Karvonen, MK; Koulu, M; Laakso, M; Niskanen, L; Pesonen, U; Rissanen, A; Uusitupa, MI; Valve, R | 1 |
Palou, A; Proenza, AM; Roca, P | 1 |
Agin, D; Albu, J; Clay-Williams, G; Gallagher, D; Heymsfield, SB; Kovera, AJ; Leone, P; Matthews, DE | 1 |
Dutra de Oliveira, JE; Ferriolli, E; Lambertini, CR; Marchini, JS | 1 |
Balagopal, P; Mauras, N; Sweeten, S | 1 |
Coppack, SW; Horowitz, JF; Klein, S; Patterson, BW; Watford, M; Wu, G | 1 |
Biourge, V; Breul, S; Diez, M; Dumon, H; Ferrier, L; Humbert, B; Martin, L; Nguyen, P; Siliart, B | 1 |
Bertilsson, L; Ding, B; Wahlestedt, C | 1 |
De Feo, P; Lucidi, P; Parlanti, N; Piccioni, F; Santeusanio, F | 1 |
Sehlin, J; Täljedal, IB | 1 |
Sherwin, RS | 1 |
Björntorp, P; Kral, JG; Lundholm, K; Scherstén, T; Sjöström, L | 1 |
Chaussain, JL; Georges, P; Job, JC; Olive, G | 1 |
Eaton, RP; Schade, S | 1 |
Herbein, JH; Martin, RJ | 1 |
Arch, JE; Stanko, RT; Tietze, DL | 3 |
Amatruda, JM; Barnard, RR; Statt, M; Welle, S | 1 |
Haymond, MW; Jensen, MD | 1 |
Caballero, B; Wurtman, RJ | 1 |
Nair, KS; Welle, S | 1 |
Forse, RA; Hoffer, LJ | 1 |
Hoffer, LJ; Kupranycz, D; Larivière, F; Wagner, DA | 1 |
Bonde, AA; Hendler, R | 1 |
Ford, GC; Garrow, JS; Halliday, D; Nair, KS | 1 |
Gylfe, E | 3 |
Herbertz, L; Langer, K; Schauder, P; Zavelberg, D | 1 |
Atkinson, S; Caro, JF; Flickinger, EG; Meelheim, D; Pories, WJ; Sehgal, NS; Sinha, MK; Taylor, LG | 1 |
Ford, GC; Garrow, JS; Halliday, D; Heels, S; Nair, KS | 1 |
Bier, DM; Matthews, DE; Staten, MA | 1 |
Fletcher, JM; Haggarty, P; Reeds, PJ; Wahle, KW | 1 |
Adibi, SA; Morse, EL; Vazquez, JA | 1 |
Gillim, SE; Harris, RA; Nagae, H; Paxton, R; Powell, SM | 1 |
Christians, J; Hasselblatt, A; Panten, U; Poser, W; von Kriegstein, E | 1 |
Hellman, B; Idahl, LA; Lernmark, A; Sehlin, J; Täljedal, IB | 2 |
Gates, RJ; Hunt, MI; Lazarus, NR | 1 |
Parmentier, J; Rubay, J | 1 |
Hellman, B; Sehlin, J; Täljedal, IB | 3 |
Gorden, P; Roth, J; Sherman, B | 1 |
Lernmark, A | 1 |
Blake, RL | 1 |
Owen, OE; Pozefsky, T; Sapir, DG; Walser, M | 1 |
Briel, G; Gylfe, E; Hellman, B; Neuhoff, V | 1 |
Kipnis, DM; Permutt, MA | 1 |
Beloff-Chain, A; Mansford, KR; Newman, ME | 1 |
Gerich, J; Grodsky, GM; Karam, J; Levin, S; Sando, H | 1 |
Sehlin, J | 1 |
Genuth, SM | 1 |
Forsham, PH; Grodsky, GM; Johnson, S; Karam, JH; Levin, SR | 1 |
Lockwood, DH; Moxley, RT; Pozefsky, T; White, JJ | 1 |
Idahl, LA; Täljedal, IB | 1 |
Hellerström, C; Schmidt, FH; Stork, H; Westman, S | 1 |
Loridan, L; Sadeghi-Nejad, A; Senior, B | 1 |
Hellman, B; Sehlin, J; Täljedal, I | 1 |
Nakanishi, S; Numa, S | 1 |
Junod, A; Lambert, AE; Letarte, J; Stauffacher, W | 1 |
Adibi, SA; Drash, AL | 1 |
Boutry, M; Christophe, J; Furnelle, J; Winand, J | 1 |
Kowalski, H; Lawecki, J; Rogala, H | 1 |
Adibi, SA | 1 |
Cahill, GF; Felig, P; Marliss, E | 1 |
Drenick, EJ; Figueroa, WS; Swendseid, ME; Villalobos, J | 1 |
Reviews
19 review(s) available for leucine and Obesity
Article | Year |
---|---|
Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application.
Topics: Aging; Amino Acids; Arginine; Autophagy; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Methionine; Neoplasms; Neurodegenerative Diseases; Obesity; Signal Transduction | 2021 |
Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease.
Topics: Amino Acids, Branched-Chain; Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Leucine; Mammals; Metabolic Diseases; Non-alcoholic Fatty Liver Disease; Obesity | 2022 |
Branched-chain amino acids as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome - literature review.
Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Obesity; Polycystic Ovary Syndrome; Prediabetic State; Valine | 2022 |
Branched-Chain Amino Acids and Insulin Resistance, from Protein Supply to Diet-Induced Obesity.
Topics: Amino Acids, Branched-Chain; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet; Insulin; Insulin Resistance; Leucine; Obesity | 2022 |
Does L-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Disease Models, Animal; Glucose Intolerance; Homeostasis; Humans; Insulin; Leucine; Mice, Obese; Obesity; Rodentia | 2018 |
L-Leucine and NO-mediated cardiovascular function.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Humans; Insulin; Insulin Resistance; Leucine; Nitric Oxide; Nitrogenous Group Transferases; Obesity; TOR Serine-Threonine Kinases | 2015 |
Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis.
Topics: Blood Glucose; Dietary Supplements; Eating; Energy Intake; Energy Metabolism; Homeostasis; Humans; Leucine; Obesity; TOR Serine-Threonine Kinases | 2015 |
Leucine in Obesity: Therapeutic Prospects.
Topics: Animals; Dietary Supplements; Energy Metabolism; Humans; Leucine; Obesity | 2016 |
Dietary protein intake and quality in early life: impact on growth and obesity.
Topics: Adult; Child, Preschool; Diet, High-Protein; Dietary Proteins; Eating; Female; Growth; Humans; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Insulin-Like Growth Factor I; Leucine; Male; Obesity; Observational Studies as Topic; Randomized Controlled Trials as Topic; Risk Factors | 2017 |
Leucine for retention of lean mass on a hypocaloric diet.
Topics: Adipose Tissue; Anabolic Agents; Blood Glucose; Diet, Reducing; Dietary Supplements; Homeostasis; Humans; Leucine; Muscle, Skeletal; Obesity; Signal Transduction; Weight Loss | 2008 |
Long-term effects of leucine supplementation on body composition.
Topics: Amino Acids; Body Composition; Body Fluid Compartments; Dietary Supplements; Humans; Leucine; Malnutrition; Muscle Proteins; Muscle, Skeletal; Obesity; Organ Size; Resistance Training; Weight Loss | 2010 |
Protein metabolic roles in treatment of obesity.
Topics: Adipose Tissue; Diet, Reducing; Dietary Proteins; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Obesity; Patient Compliance; Treatment Outcome; Weight Loss | 2010 |
Pharmaconutrition for the obese, critically ill patient.
Topics: Antioxidants; Arginine; Citrulline; Critical Care; Critical Illness; Dietary Proteins; Dietary Supplements; Enteral Nutrition; Fatty Acids, Unsaturated; Humans; Inflammatory Bowel Diseases; Intensive Care Units; Length of Stay; Leucine; Magnesium; Obesity; Oxidative Stress; Prebiotics; Probiotics; Treatment Outcome; United States; Ventilation; Zinc | 2011 |
Impact of leucine on energy balance.
Topics: Adipose Tissue; Body Weight; Diet; Energy Intake; Energy Metabolism; Gastrointestinal Tract; Humans; Hypothalamus; Leucine; Lipid Metabolism; Liver; Muscle, Skeletal; Obesity | 2013 |
Muscle protein anabolism in type 2 diabetes.
Topics: Aged; Aging; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hyperglycemia; Insulin; Insulin Resistance; Leucine; Male; Motor Activity; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Sarcopenia | 2013 |
The role of leucine in weight loss diets and glucose homeostasis.
Topics: Amino Acids; Dietary Proteins; Glucose; Homeostasis; Humans; Leucine; Liver; Obesity; Weight Loss | 2003 |
Potential importance of leucine in treatment of obesity and the metabolic syndrome.
Topics: Blood Glucose; Dietary Carbohydrates; Dietary Proteins; Humans; Leucine; Metabolic Syndrome; Muscle Proteins; Obesity | 2006 |
Synthesis and secretion of insulin in dynamic perfusion systems.
Topics: Animals; Antimetabolites; Arginine; Carbon Radioisotopes; Computers; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isotope Labeling; Leucine; Models, Biological; Obesity; Oligomycins; Pancreas; Perfusion; Rats; Time Factors; Tolbutamide | 1974 |
Excess protein and leucine effects on food intake.
Topics: Animals; Dietary Proteins; Hypothalamus; Leucine; Obesity; Rats | 1966 |
Trials
18 trial(s) available for leucine and Obesity
Article | Year |
---|---|
Evaluation of a Supervised Adapted Physical Activity Program Associated or Not with Oral Supplementation with Arginine and Leucine in Subjects with Obesity and Metabolic Syndrome: A Randomized Controlled Trial.
Topics: Arginine; Dietary Supplements; Exercise; Glucose; Humans; Leucine; Lipids; Metabolic Syndrome; Obesity; Quality of Life | 2022 |
Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT.
Topics: Absorptiometry, Photon; Aged; Anthropometry; Body Composition; Diabetes Mellitus, Type 2; Dietary Proteins; Double-Blind Method; Exercise; Female; Glucose Tolerance Test; Glycemic Control; Humans; Insulin Resistance; Leucine; Life Style; Male; Middle Aged; Muscle Strength; Muscles; Obesity; Overweight; Proteins; Vitamin D; Weight Loss | 2020 |
Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters.
Topics: Body Weight; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Leucine; Male; Metformin; Middle Aged; Obesity; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate | 2019 |
Impact of short term consumption of diets high in either non-starch polysaccharides or resistant starch in comparison with moderate weight loss on indices of insulin sensitivity in subjects with metabolic syndrome.
Topics: Blood Glucose; C-Peptide; Carbohydrate Metabolism; Cross-Over Studies; Diet, Reducing; Dietary Proteins; Energy Intake; Energy Metabolism; Fasting; Homeostasis; Humans; Insulin; Insulin Resistance; Leucine; Male; Metabolic Syndrome; Models, Biological; Obesity; Polysaccharides; Starch; Weight Loss | 2013 |
Plasma apolipoprotein B-48 transport in obese men: a new tracer kinetic study in the postprandial state.
Topics: Aged; Apolipoprotein B-48; Blood Proteins; Humans; Isotope Labeling; Kinetics; Leucine; Male; Middle Aged; Obesity; Postprandial Period; Protein Transport; Radioactive Tracers; Thinness | 2014 |
Effect of ω-3 fatty acid ethyl esters on apolipoprotein B-48 kinetics in obese subjects on a weight-loss diet: a new tracer kinetic study in the postprandial state.
Topics: Adolescent; Adult; Aged; Apolipoprotein B-48; Diet, Reducing; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Isotope Labeling; Kinetics; Leucine; Male; Middle Aged; Obesity; Postprandial Period; Weight Loss; Young Adult | 2014 |
A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial.
Topics: Aged; Aged, 80 and over; Body Composition; Body Mass Index; Body Weight; Diet, Reducing; Dietary Proteins; Dietary Supplements; Double-Blind Method; Energy Intake; Female; Hand Strength; Humans; Leucine; Male; Middle Aged; Milk Proteins; Motor Activity; Muscle Strength; Muscle, Skeletal; Obesity; Resistance Training; Sarcopenia; Treatment Outcome; Vitamin D; Weight Loss; Whey Proteins | 2015 |
Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial.
Topics: Adult; Appetite; Cholecystokinin; Double-Blind Method; Female; Gastric Emptying; Glucagon-Like Peptide 1; Humans; Leucine; Male; Middle Aged; Obesity; Tryptophan | 2016 |
Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese men.
Topics: Adiponectin; Adult; Aged; Apolipoprotein A-II; Apolipoprotein B-100; Humans; Ideal Body Weight; Infusions, Intravenous; Leucine; Lipoproteins, VLDL; Male; Middle Aged; Obesity | 2011 |
Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects.
Topics: 3T3-L1 Cells; Adipocytes; Adult; Animals; Biomarkers; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fatty Acid Synthases; Female; Humans; Leucine; Male; Mice; Obesity; Overweight; Oxidation-Reduction; Oxidative Stress; Pyridoxal Phosphate; Triglycerides; Vitamin B Complex; Young Adult | 2012 |
Growth hormone blunts protein oxidation and promotes protein turnover to a similar extent in abdominally obese and normal-weight women.
Topics: Abdomen; Adult; Cross-Over Studies; Double-Blind Method; Female; Growth Hormone; Hormones; Humans; Leucine; Obesity; Osmolar Concentration; Oxidation-Reduction; Reference Values; Somatostatin | 2002 |
Effect of lifestyle changes on whole-body protein turnover in obese adolescents.
Topics: Adolescent; Amino Acids; Blood Glucose; Body Composition; Body Mass Index; Energy Metabolism; Exercise; Fats; Female; Humans; Insulin; Leucine; Life Style; Male; Obesity; Protein Biosynthesis; Proteins | 2003 |
Metabolic effects of very low calorie weight reduction diets.
Topics: Alanine; Amino Acids; Diet, Reducing; Energy Intake; Female; Humans; Leucine; Nitrogen; Obesity | 1984 |
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.
Topics: Adult; Aged; Alleles; Amino Acid Substitution; Cholesterol; Cholesterol, LDL; Female; Gene Frequency; Genotype; Humans; Leucine; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Proline; Protein Sorting Signals | 1998 |
Obese women on a low energy rice and bean diet: effects of leucine, arginine or glycine supplementation on protein turnover.
Topics: Adult; Amino Acids; Analysis of Variance; Arginine; Diet, Reducing; Dietary Proteins; Dietary Supplements; Energy Intake; Energy Metabolism; Fabaceae; Female; Glycine; Humans; Leucine; Obesity; Oryza; Proteins | 2001 |
Short-term treatment with low doses of recombinant human GH stimulates lipolysis in visceral obese men.
Topics: Adult; Blood Glucose; C-Peptide; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fatty Acids, Nonesterified; Hormones; Human Growth Hormone; Humans; Keto Acids; Leucine; Lipid Metabolism; Lipolysis; Male; Middle Aged; Obesity; Osmolar Concentration; Recombinant Proteins; Viscera | 2002 |
Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate.
Topics: Body Composition; Diet, Reducing; Energy Intake; Energy Metabolism; Female; Humans; Leucine; Nitrogen; Obesity; Pyruvates; Pyruvic Acid; Weight Loss | 1992 |
Protein metabolic effects of a prolonged fast and hypocaloric refeeding.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Carbon Isotopes; Diet, Reducing; Dietary Carbohydrates; Dietary Proteins; Energy Intake; Fasting; Fatty Acids, Nonesterified; Female; Humans; Hydroxybutyrates; Insulin; Isotope Labeling; Leucine; Nitrogen; Obesity; Proteins; Random Allocation; Thyroxine; Triiodothyronine, Reverse | 1990 |
Other Studies
148 other study(ies) available for leucine and Obesity
Article | Year |
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Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.
Topics: Amino Acids, Branched-Chain; Animals; Glucose; Insulin Resistance; Leucine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Valine | 2022 |
Fast-track rescue weight reduction therapy to achieve rapid technical operability for emergency bariatric surgery in patients with life-threatening inoperable severe obesity - A proof of concept study.
Topics: Bariatric Surgery; Diet, Reducing; Gastric Balloon; Humans; Leucine; Liraglutide; Obesity; Obesity, Morbid; Proof of Concept Study; Prospective Studies; Retrospective Studies; Weight Loss | 2022 |
[Plasma amino acids levels in 1859 physical examination subjects in Hangzhou City in 2020].
Topics: Alanine; Amino Acids; Chromatography, Liquid; Female; Humans; Leucine; Male; Methionine; Middle Aged; Obesity; Overweight; Tandem Mass Spectrometry | 2022 |
Leucine supplementation in maternal high-fat diet alleviated adiposity and glucose intolerance of adult mice offspring fed a postweaning high-fat diet.
Topics: Adiposity; Animals; Body Weight; Diet, High-Fat; Dietary Supplements; Female; Glucose; Glucose Intolerance; Humans; Lactation; Leucine; Male; Maternal Nutritional Physiological Phenomena; Mice; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; RNA, Messenger | 2023 |
Leucine Supplementation Ameliorates Early-Life Programming of Obesity in Rats.
Topics: Animals; Dietary Supplements; Female; Insulin; Lactation; Leucine; Lipids; Neuropeptide Y; Obesity; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2023 |
Leucine-Restricted Diet Ameliorates Obesity-Linked Cognitive Deficits: Involvement of the Microbiota-Gut-Brain Axis.
Topics: Animals; Bacteria; Brain-Gut Axis; Cognition; Cognitive Dysfunction; Diet; Diet, High-Fat; Fatty Acids, Volatile; Firmicutes; Humans; Leucine; Mice; Mice, Inbred C57BL; Obesity | 2023 |
Changes in Branched-Chain Amino Acids One Year after Sleeve Gastrectomy in Youth with Obesity and Their Association with Changes in Insulin Resistance.
Topics: Adolescent; Adult; Amino Acids, Branched-Chain; Female; Gastrectomy; Glucose; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Leucine; Meals; Obesity; Young Adult | 2023 |
Decoding the Mechanisms Behind Early Weaning-Driven Obesity and the Leucine "Solution".
Topics: Animals; Dietary Supplements; Leucine; Obesity; Rats; Weaning | 2023 |
Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition.
Topics: Animals; Dietary Supplements; Female; Heart Failure; Histone Deacetylases; Leucine; Obesity; Rats; Stroke Volume | 2023 |
Leucine decreases intramyocellular lipid deposition in an mTORC1-independent manner in palmitate-treated C2C12 myotubes.
Topics: Animals; Autophagy; Cells, Cultured; Leucine; Lipid Metabolism; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria, Muscle; Muscle Fibers, Skeletal; Myocytes, Smooth Muscle; Obesity; Organelle Biogenesis; Palmitates; Signal Transduction | 2020 |
Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.
Topics: Agouti-Related Protein; Animals; Appetite; Appetite Regulation; Brain; Energy Metabolism; Feeding Behavior; Hypothalamus; Leptin; Leucine; Male; Mice; Mice, Inbred C57BL; Neurons; Obesity; Solitary Nucleus | 2020 |
The anti-obesity effects exerted by different fractions of Artemisia sphaerocephala Krasch polysaccharide in diet-induced obese mice.
Topics: Animals; Anti-Obesity Agents; Artemisia; Diet, High-Fat; Gastrointestinal Microbiome; Isoleucine; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Nitrogen; Obesity; Plant Extracts; Polysaccharides; Valine | 2021 |
Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice.
Topics: Adiponectin; Adipose Tissue; Adiposity; AMP-Activated Protein Kinases; Animals; Diet, Fat-Restricted; Diet, High-Fat; Dietary Supplements; Dyslipidemias; Glucose Tolerance Test; Inflammation; Insulin; Insulin Resistance; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Physical Conditioning, Animal | 2021 |
The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells.
Topics: Adipose Tissue; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Mice, Inbred C57BL; Obesity; Receptors, Estrogen; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Gender-Associated Impact of Early Leucine Supplementation on Adult Predisposition to Obesity in Rats.
Topics: Adiponectin; Adiposity; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Blood Glucose; Body Weight; Dietary Supplements; Disease Susceptibility; Female; Hypothalamus; Insulin; Lactation; Leptin; Leucine; Male; Maternal Nutritional Physiological Phenomena; Obesity; Rats; Rats, Wistar; Sex Factors; Weaning | 2018 |
Interaction between leucine and palmitate catabolism in 3T3-L1 adipocytes and primary adipocytes from control and obese rats.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carnitine O-Palmitoyltransferase; Diet, High-Fat; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Leucine; Lipid Metabolism; Male; Membrane Transport Proteins; Mice; Monocarboxylic Acid Transporters; Obesity; Palmitates; Peroxisomal Bifunctional Enzyme; Rats, Inbred Strains; Rats, Sprague-Dawley | 2018 |
Leucine facilitates insulin signaling through a Gαi protein-dependent signaling pathway in hepatocytes.
Topics: Animals; Diabetes Mellitus; Gene Silencing; Gluconeogenesis; Glucose; GTP-Binding Protein alpha Subunits, Gi-Go; Hepatocytes; Humans; Insulin; Leucine; Mice; Models, Biological; Obesity; Phosphorylation; RNA, Small Interfering; Signal Transduction | 2013 |
Leucine and protein metabolism in obese Zucker rats.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adipose Tissue; Amino Acids, Branched-Chain; Animals; Biomarkers; Body Weight; Carbon Radioisotopes; Carnitine; Chromatography, Liquid; Creatinine; Leucine; Liver; Male; Metabolomics; Muscle, Skeletal; Obesity; Organ Size; Proteins; Rats; Rats, Zucker; Tandem Mass Spectrometry | 2013 |
Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; Body Composition; Calorimetry, Indirect; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Gluconeogenesis; Glucose Tolerance Test; Insulin; Intestinal Mucosa; Intestines; Leptin; Leucine; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Weight Loss | 2014 |
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes.
Topics: Adolescent; Amino Acid Transport Systems, Neutral; Animals; Child; Child, Preschool; Eating; Female; Genotype; Humans; Leucine; Male; Mice; Mice, Knockout; Obesity; Polymorphism, Single Nucleotide; Young Adult | 2013 |
L-leucine supplementation worsens the adiposity of already obese rats by promoting a hypothalamic pattern of gene expression that favors fat accumulation.
Topics: Adiposity; Animals; Diet, High-Fat; Dietary Supplements; Energy Intake; Gene Expression; Hypothalamus; Leucine; Male; Obesity; Rats; Rats, Wistar | 2014 |
Effect of 10% dietary protein intake on whole body protein kinetics in type 2 diabetic adults.
Topics: Amino Acids; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Diet, Protein-Restricted; Dietary Proteins; Energy Intake; Female; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Male; Mental Recall; Middle Aged; Obesity; Sex Factors; Waist Circumference | 2015 |
Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Amino Acids, Branched-Chain; Animals; Biological Transport; Down-Regulation; Endoplasmic Reticulum Stress; Inflammation; Intracellular Space; Leucine; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Obesity; Tumor Necrosis Factor-alpha | 2015 |
Slimming down in old age.
Topics: Dietary Supplements; Female; Humans; Leucine; Male; Milk Proteins; Muscle, Skeletal; Obesity; Vitamin D; Whey Proteins | 2015 |
Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB.
Topics: 3T3-L1 Cells; Adipokines; Adipose Tissue; Animals; Gene Expression Regulation; Inflammation; Leucine; Mice; Nerve Tissue Proteins; NF-kappa B; Obesity; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.
Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diet, High-Fat; Fasting; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Signal Transduction; Sirtuin 1 | 2015 |
The impact of protein on chronic disease risk should be considered in studies of weight loss.
Topics: Dietary Supplements; Female; Humans; Leucine; Male; Milk Proteins; Muscle, Skeletal; Obesity; Vitamin D | 2015 |
Reply to AM Bernstein et al.
Topics: Dietary Supplements; Female; Humans; Leucine; Male; Milk Proteins; Muscle, Skeletal; Obesity; Vitamin D | 2015 |
Accelerated protein digestion and amino acid absorption after Roux-en-Y gastric bypass.
Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Blood Glucose; Body Mass Index; Body Weight; Caseins; Dietary Proteins; Female; Gastric Bypass; Glycated Hemoglobin; Humans; Intestinal Absorption; Leucine; Male; Meals; Middle Aged; Obesity; Phenylalanine; Postprandial Period; Proteolysis; Young Adult | 2015 |
Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice.
Topics: Animals; Cell Line, Tumor; Diet, High-Fat; Humans; Hyperlipidemias; Leucine; Lipid Metabolism; Liver; Metformin; Mice; Obesity | 2015 |
Biocompounds Attenuating the Development of Obesity and Insulin Resistance Produced by a High-fat Sucrose Diet.
Topics: Animals; Blood Glucose; Chlorogenic Acid; Coumaric Acids; Curcumin; Diet, High-Fat; Dietary Fats; Dietary Supplements; Flavanones; Humans; Insulin Resistance; Leucine; Male; Obesity; Rats; Rats, Wistar; Sucrose | 2015 |
Leucine supplementation at the onset of high-fat feeding does not prevent weight gain or improve glycemic regulation in male Sprague-Dawley rats.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Biomarkers; Blood Glucose; Body Composition; Carrier Proteins; Diet, High-Fat; Dietary Fats; Dietary Supplements; Energy Metabolism; Fatty Acids, Nonesterified; Gene Expression; Insulin; Intracellular Signaling Peptides and Proteins; Leucine; Male; Muscle, Skeletal; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoproteins; PPAR gamma; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Treatment Failure; Weight Gain | 2016 |
Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.
Topics: Absorptiometry, Photon; Adaptor Proteins, Signal Transducing; Aged; Amino Acids, Essential; Anabolic Agents; Blood Glucose; Body Composition; Body Mass Index; Case-Control Studies; Cell Cycle Proteins; Diabetes Mellitus, Type 2; Humans; Insulin; Keto Acids; Leucine; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Postprandial Period; Protein Biosynthesis; Ribosomal Protein S6 Kinases, 70-kDa; Risk Factors; Sarcopenia; Signal Transduction; TOR Serine-Threonine Kinases | 2017 |
The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes.
Topics: Animals; Apolipoprotein B-100; Blood Glucose; Cholesterol; Diet; Dogs; Energy Intake; Gas Chromatography-Mass Spectrometry; Insulin; Insulin Resistance; Kinetics; Leucine; Lipoproteins, LDL; Lipoproteins, VLDL; Obesity | 2008 |
Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice.
Topics: Animals; Behavior, Animal; Body Composition; Body Weight; Cholesterol; Dietary Supplements; Insulin; Leucine; Mice; Mice, Inbred C57BL; Motor Activity; Obesity; Oxygen; Respiration; Triglycerides; Water | 2009 |
Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake.
Topics: Animals; Blotting, Western; Eating; Fasting; Gastric Mucosa; Gene Expression Regulation; Ghrelin; Immunohistochemistry; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Kinases; Receptors, Ghrelin; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2009 |
Changes in basal and insulin and amino acid response of whole body and skeletal muscle proteins in obese men.
Topics: Adult; Amino Acids; Body Composition; Fatty Acids, Nonesterified; Glucose; Humans; Insulin; Insulin Resistance; Leucine; Male; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Obesity | 2009 |
Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity.
Topics: Animals; beta-Cyclodextrins; Cholesterol; Dietary Fats; Female; Glucose; Glucose Tolerance Test; Homeostasis; Hypercholesterolemia; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Lipids; Male; Mice; Mice, Knockout; Obesity; Oxidation-Reduction; Receptors, LDL | 2010 |
L-Trp and L-Leu-OEt derivatives of the monascus pigment exert high anti-obesity effects on mice.
Topics: Animals; Anti-Obesity Agents; Body Weight; Leucine; Male; Mice; Mice, Inbred C57BL; Monascus; Obesity; Phytotherapy; Pigments, Biological; Random Allocation; Tryptophan | 2010 |
Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats.
Topics: Adipose Tissue; Age Factors; Aging; Animals; Blood Glucose; Body Composition; Body Fluid Compartments; Body Weight; Chronic Disease; Dietary Supplements; Leucine; Lipids; Male; Nutritional Status; Obesity; Proteins; Rats; Rats, Sprague-Dawley; Risk Factors | 2012 |
Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults.
Topics: Aged; Aged, 80 and over; Aging; Blood Glucose; Energy Intake; Energy Metabolism; Fasting; Female; Humans; Insulin; Leucine; Male; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Weight Loss | 2012 |
Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women.
Topics: Adipose Tissue; Administration, Cutaneous; Adult; Blood Chemical Analysis; Blood Glucose; Body Composition; Body Weight; Female; Glycerol; Humans; Kinetics; Leucine; Lipoproteins, VLDL; Magnetic Resonance Imaging; Middle Aged; Muscle Proteins; Muscle, Skeletal; Obesity; Premenopause; Stimulation, Chemical; Testosterone; Triglycerides | 2012 |
Leucine improves glucose and lipid status in offspring from obese dams, dependent on diet type, but not caloric intake.
Topics: Animals; Appetite; Blotting, Western; Body Weight; Diet; Energy Intake; Fatty Acids, Nonesterified; Female; Glucose; Glucose Tolerance Test; Hypothalamus; Insulin; Leptin; Leucine; Lipid Metabolism; Muscle, Skeletal; Obesity; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Signal Transduction; TOR Serine-Threonine Kinases; Triglycerides | 2012 |
Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity.
Topics: Alanine; Animals; Blood Glucose; Diet, High-Fat; Dietary Proteins; Dietary Supplements; Humans; Insulin; Leucine; Male; Mice; Mice, Inbred C57BL; Obesity | 2013 |
Protein feeding pattern, casein feeding, or milk-soluble protein feeding did not change the evolution of body composition during a short-term weight loss program.
Topics: Adipocytes; Adipose Tissue; Adult; Algorithms; Amino Acids; Body Composition; Body Weight; Caseins; Cell Size; Diet, Carbohydrate-Restricted; Dietary Proteins; Female; Gene Expression; Humans; Hunger; Insulin; Leucine; Male; Methylhistidines; Milk Proteins; Nutritional Status; Obesity; Proteins; Weight Loss; Weight Reduction Programs | 2012 |
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
Topics: Adolescent; Amino Acids, Branched-Chain; Biomarkers; Blood Glucose; Body Mass Index; Child; Child Nutrition Disorders; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Longitudinal Studies; Male; Massachusetts; Obesity; Predictive Value of Tests; Valine | 2013 |
Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.
Topics: AMP-Activated Protein Kinases; Animals; Blotting, Western; Cell Cycle Proteins; Cytokines; Dietary Supplements; DNA, Mitochondrial; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Glucose Clamp Technique; Insulin Resistance; Leucine; Male; Mice; Mice, Inbred C57BL; Mitochondrial Turnover; Nicotinamide Phosphoribosyltransferase; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Sirtuin 1; Trans-Activators; Transcription Factors | 2012 |
Leptin and leucine synergistically regulate protein metabolism in C2C12 myotubes and mouse skeletal muscles.
Topics: Animals; Cell Line; Dietary Supplements; Drug Synergism; Leptin; Leucine; Mice; Mice, Knockout; Mice, Obese; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Obesity; Organ Size; Protein Biosynthesis; Proteolysis; Receptors, Leptin; Recombinant Proteins; Urea | 2013 |
Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague-Dawley rats.
Topics: Adipose Tissue; Animals; Dairy Products; Diet; Gene Expression; Insulin Resistance; Leucine; Liver; Muscle, Skeletal; Obesity; Rats; Rats, Sprague-Dawley | 2013 |
High-density lipoprotein apolipoprotein A-I kinetics in obese insulin resistant patients. An in vivo stable isotope study.
Topics: Adult; Apolipoprotein A-I; Female; Gas Chromatography-Mass Spectrometry; Humans; Insulin Resistance; Isotopes; Kinetics; Leucine; Lipoproteins, HDL; Models, Statistical; Obesity; Time Factors | 2002 |
Early kinetic abnormalities of apoB-containing lipoproteins in insulin-resistant women with abdominal obesity.
Topics: Abdomen; Adult; Apolipoproteins B; Body Mass Index; Carbon Isotopes; Fasting; Female; Humans; Injections, Intravenous; Insulin Resistance; Kinetics; Leucine; Lipids; Lipoproteins; Lipoproteins, IDL; Lipoproteins, LDL; Lipoproteins, VLDL; Obesity; Triglycerides | 2002 |
[Low prevalence of the Leu7/Pro polymorphism in the signal peptide of preproneuropeptide Y in the Spanish Mediterranean population].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cross-Sectional Studies; Female; Humans; Leucine; Lipids; Male; Middle Aged; Neuropeptide Y; Obesity; Polymorphism, Genetic; Prevalence; Proline; Protein Precursors; Spain | 2003 |
HEPATIC PROTEIN SYNTHESIS AND LIPID METABOLISM IN GENETICALLY OBESE RATS.
Topics: Amino Acids; Bile Acids and Salts; Cholesterol; Dietary Fats; DNA; Hypercholesterolemia; Leucine; Lipid Metabolism; Liver; Microsomes; Mutation; Obesity; Proteins; Rats; Research; RNA; Salts | 1965 |
The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people.
Topics: Adult; Alleles; Blood Pressure; Body Mass Index; Cohort Studies; Diastole; E-Selectin; Female; Heterozygote; Homozygote; Humans; Leucine; Longitudinal Studies; Male; Middle Aged; Obesity; Phenylalanine; Polymorphism, Genetic; Systole | 2004 |
Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype.
Topics: Animals; Animals, Newborn; Arginine; Basic Helix-Loop-Helix Transcription Factors; Blood Glucose; Body Weight; Diet; Dietary Carbohydrates; Female; Fetus; Gene Expression; Glucose; Hepatocyte Nuclear Factor 3-beta; Homeodomain Proteins; Hyperinsulinism; Insulin; Islets of Langerhans; Leucine; Lipids; Male; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; Proinsulin; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trans-Activators | 2006 |
Preproghrelin Leu72Met polymorphism in obese Korean children.
Topics: Body Mass Index; Child; Cholesterol; Female; Genetic Carrier Screening; Ghrelin; Humans; Korea; Leucine; Male; Methionine; Motilin; Obesity; Polymorphism, Genetic; Triglycerides | 2005 |
The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism.
Topics: Adult; Female; Gluconeogenesis; Glucose; Glycogenolysis; Humans; Insulin Resistance; Leucine; Liver; Male; Obesity; Proteins | 2006 |
Neuroscience. Regulating energy balance: the substrate strikes back.
Topics: AMP-Activated Protein Kinases; Animals; Appetite; Body Weight; Diet; Eating; Energy Metabolism; Homeostasis; Hypothalamus; Leptin; Leucine; Multienzyme Complexes; Neural Pathways; Neurons; Obesity; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Starvation; Thinness; TOR Serine-Threonine Kinases | 2006 |
Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms.
Topics: Adipose Tissue; Administration, Oral; Animals; Blood Glucose; Calorimetry, Indirect; Cholesterol; Diet; Glucose Tolerance Test; Leucine; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Leucing weight with a futile cycle.
Topics: Animals; Energy Metabolism; Humans; Leucine; Obesity; Proteins; Substrate Cycling; Weight Loss | 2007 |
Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle.
Topics: Adipose Tissue; Animals; Body Weight; Diet; Eating; Energy Metabolism; Female; Gene Targeting; Glucose Tolerance Test; Humans; Insulin; Leucine; Male; Mice; Mice, Knockout; Obesity; Organ Size; Oxygen Consumption; Protein Kinases; Proteins; Sirolimus; Substrate Cycling; Thermogenesis; TOR Serine-Threonine Kinases; Transaminases | 2007 |
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adipose Tissue; Amino Acids; Amino Acids, Branched-Chain; Animals; Bariatric Surgery; Female; Food Deprivation; Humans; Keto Acids; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Minor Histocompatibility Antigens; Muscle, Skeletal; Obesity; Obesity, Morbid; Phosphorylation; Pregnancy Proteins; Rats; Rats, Zucker; Transaminases; Weight Loss | 2007 |
Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.
Topics: alpha-MSH; Child; DNA Mutational Analysis; France; Gene Expression Regulation; Heterozygote; Humans; Leucine; Models, Biological; Models, Genetic; Mutation; Obesity; Phenylalanine; Pro-Opiomelanocortin; Protein Binding | 2008 |
Diet-induced obesity alters protein synthesis: tissue-specific effects in fasted versus fed mice.
Topics: Animals; Body Weight; Deuterium Oxide; Diet; Eating; Fasting; Kinetics; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscle, Skeletal; Obesity; Proteins; Serum Albumin | 2008 |
[Effects of 3,5,3'-triiodothyroacetic acid (TRIAC) on protein metabolism of genetically obese or non-obese Zucker rats].
Topics: Animals; Brain; Carbon Radioisotopes; Female; Kidney; Leucine; Liver; Muscles; Myocardium; Obesity; Proteins; Radioisotope Dilution Technique; Rats; Rats, Zucker; Triiodothyronine; Tritium | 1982 |
Effect of poor diabetic control and obesity on whole body protein metabolism in man.
Topics: Adult; Bicarbonates; Blood Glucose; C-Peptide; Carbon Isotopes; Diabetes Mellitus, Type 1; Female; Humans; Insulin; Leucine; Male; Obesity; Proteins; Reference Values; Sodium Bicarbonate | 1983 |
Hepatic protein synthesis and secretion after jejunoileal bypass in the rat.
Topics: Animals; Blood Proteins; Energy Intake; Glucosamine; Glycoproteins; Ileum; In Vitro Techniques; Jejunum; Leucine; Liver; Obesity; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains; Triglycerides | 1983 |
Skeletal muscle metabolism in neonatal lean and obese pigs.
Topics: Amino Acids; Animals; Animals, Newborn; Body Weight; Glucose; Leucine; Male; Muscles; Obesity; Palmitates; Swine; Swine Diseases | 1983 |
Leucine assimilation in patients with diabetes mellitus.
Topics: Adult; Aged; Diabetes Mellitus; Female; Half-Life; Humans; Insulin; Leucine; Male; Middle Aged; Obesity | 1980 |
Modulation of leucine oxidation and turnover by graded amounts of carbohydrate intake in obese subjects.
Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Blood Glucose; Diet, Reducing; Dietary Carbohydrates; Female; Humans; Hydroxybutyrates; Insulin; Ketosis; Leucine; Methylhistidines; Nitrogen; Obesity | 1982 |
The response of protein and energy metabolism to food intake in lean and obese man.
Topics: Adult; Aged; Body Weight; Carbon Radioisotopes; Energy Metabolism; Fasting; Female; Food; Humans; Kinetics; Leucine; Male; Middle Aged; Nitrogen; Obesity; Oxygen Consumption; Proteins | 1982 |
Effect of exercise on rates of oxidation, turnover, and plasma clearance of leucine in human subjects.
Topics: Amino Acids; Blood Glucose; Female; Humans; Leucine; Metabolic Clearance Rate; Obesity; Oxidation-Reduction; Oxygen Consumption; Physical Exertion; Time Factors | 1982 |
The response of whole-body protein turnover to feeding in obese subjects given a protein-free, low-energy diet for three weeks.
Topics: Adaptation, Physiological; Diet; Dietary Proteins; Energy Intake; Fasting; Female; Food; Humans; Leucine; Nitrogen; Obesity; Oxidation-Reduction; Protein Biosynthesis; Proteins | 1982 |
Diurnal pattern of protein and energy metabolism in man.
Topics: Circadian Rhythm; Energy Metabolism; Feeding Behavior; Female; Humans; Leucine; Middle Aged; Obesity; Oxidation-Reduction; Protein Biosynthesis; Proteins | 1980 |
Influence of low-energy diets on whole-body protein turnover in obese subjects.
Topics: Adult; Aged; Diet, Reducing; Dietary Proteins; Female; Glycine; Humans; Leucine; Male; Middle Aged; Obesity; Proteins | 1980 |
Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.
Topics: Adult; Amino Acids; Fasting; Female; Humans; Infusions, Parenteral; Keto Acids; Leucine; Male; Middle Aged; Nitrogen; Obesity; Time Factors; Urea | 1981 |
Enzymic determination of branched-chain amino acids.
Topics: Adult; Amino Acids, Branched-Chain; Fasting; Female; Glutamate Dehydrogenase; Humans; Ketoglutaric Acids; Leucine; Leucine Transaminase; Male; Methods; Middle Aged; Obesity; Sex Factors; Transaminases | 1981 |
Insulin resistance is mediated by a proteolytic fragment of the insulin receptor.
Topics: 3T3 Cells; Adipocytes; Animals; Female; Glycogen; Insulin; Insulin Resistance; Leucine; Mice; Obesity; Peptide Fragments; Phosphorylation; Rats; Rats, Zucker; Receptor, Insulin; Triglycerides | 1995 |
The effect of starvation on leucine, alanine and glucose metabolism in obese subjects.
Topics: Adult; Alanine; Fatty Acids, Nonesterified; Female; Glucose; Humans; Insulin; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Obesity; Starvation | 1995 |
The opposing effects of insulin and hyperglycemia in modulating amino acid metabolism during a glucose tolerance test in lean and obese subjects.
Topics: Adult; Amino Acids; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Isoleucine; Leucine; Male; Obesity; Phenylalanine; Reference Values | 1994 |
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women.
Topics: Adult; Blood Glucose; Body Composition; Body Weight; Female; Humans; Hydrolysis; Insulin; Insulin Resistance; Kinetics; Leucine; Middle Aged; Obesity; Proteins; Weight Loss | 1994 |
Alanine as a lipogenic precursor in isolated hepatocytes from obese Zucker rats.
Topics: Acetyl Coenzyme A; Alanine; Alanine Transaminase; Animals; Cells, Cultured; Citrates; Coumaric Acids; Fatty Acids; Glucose; Lactates; Lactic Acid; Leucine; Lipids; Liver; Liver Glycogen; Male; Mitochondria, Liver; Obesity; Pyruvates; Pyruvic Acid; Rats; Rats, Zucker | 1993 |
Effects of exercise and weight loss on leucine turnover in different types of obesity.
Topics: Adult; Body Composition; Body Mass Index; Epinephrine; Exercise; Female; Glucagon; Growth Hormone; Hormones; Humans; Hydrocortisone; Insulin; Leucine; Norepinephrine; Obesity; Weight Loss | 1993 |
Metabolic effects of triiodothyronine replacement during fasting in obese subjects.
Topics: Adult; Blood Glucose; Fasting; Female; Humans; Leucine; Male; Middle Aged; Nitrogen; Obesity; Oxygen; Respiration; Thyroid Hormones; Triiodothyronine; Urea | 1996 |
Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity.
Topics: Adult; Amino Acids; Amino Acids, Branched-Chain; Blood Glucose; Body Composition; Female; Humans; Insulin; Keto Acids; Leucine; Lipid Metabolism; Male; Middle Aged; Obesity; Oxidation-Reduction | 1996 |
Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue.
Topics: Adipose Tissue; Adult; Blood Glucose; Body Composition; Calorimetry, Indirect; Fatty Acids, Nonesterified; Female; Food; Glucose; Glucose Clamp Technique; Humans; Insulin; Leucine; Lipid Peroxidation; Lipids; Obesity; Oxidation-Reduction; Proteins | 1997 |
Sex differences in the effect of obesity on human plasma tryptophan/large neutral amino acid ratio.
Topics: Amino Acids; Body Mass Index; Female; Humans; Leucine; Male; Obesity; Phenylalanine; Sex Characteristics; Tryptophan; Tyrosine; Valine | 1999 |
Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism.
Topics: Adipose Tissue; Aged; Body Composition; Body Weight; Diet, Reducing; Female; Follow-Up Studies; Humans; Kinetics; Leucine; Middle Aged; Muscle, Skeletal; Obesity; Organ Size; Postmenopause; Prospective Studies; Reference Values; Time Factors; Weight Loss | 2000 |
Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescents.
Topics: Adolescent; Blood Glucose; Body Mass Index; Carbon Isotopes; Chromatography, Affinity; Female; Fibrinogen; Gas Chromatography-Mass Spectrometry; Humans; Insulin; Keto Acids; Kinetics; Leucine; Obesity; Serum Albumin | 2002 |
Regional muscle and adipose tissue amino acid metabolism in lean and obese women.
Topics: Abdomen; Adipose Tissue; Adult; Alanine; Amino Acids; Arteries; Body Composition; Body Constitution; Body Mass Index; Fasting; Female; Glutamic Acid; Glutamine; Humans; Kinetics; Leucine; Muscle, Skeletal; Obesity; Proteins; Veins | 2002 |
Weight loss does not influence energy expenditure or leucine metabolism in obese cats.
Topics: Animals; Body Composition; Cat Diseases; Cats; Diet, Protein-Restricted; Diet, Reducing; Energy Metabolism; Female; Kinetics; Leucine; Male; Obesity; Proteins; Weight Loss | 2002 |
The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population.
Topics: Adult; Base Sequence; Genetics, Population; Genotype; Humans; Korea; Leucine; Neuropeptide Y; Obesity; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals | 2002 |
45Ca2+ uptake by dispersed pancreatic islet cells: effect of D-glucose and the calcium probe, chlorotetracycline.
Topics: Animals; Calcium; Calcium Radioisotopes; Chlortetracycline; Glucose; Islets of Langerhans; Leucine; Mannose; Methylglucosides; Mice; Mice, Mutant Strains; Obesity | 1979 |
Effect of starvation on the turnover and metabolic response to leucine.
Topics: Adult; Amino Acids; Blood Glucose; Female; Humans; Kinetics; Leucine; Male; Nitrogen; Obesity; Starvation; Time Factors | 1978 |
Hepatic lipid metabolism in severe human obesity.
Topics: Adult; Blood Glucose; Blood Proteins; Cholesterol; Fatty Acids, Nonesterified; Female; Fructose; Glycerol; Humans; Insulin; Leucine; Lipid Metabolism; Liver; Male; Obesity; Proteins; Triglycerides | 1977 |
Effect of 24 hour fast in obese children.
Topics: Adolescent; Alanine; Blood Glucose; Child; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Growth Hormone; Humans; Insulin; Isoleucine; Ketone Bodies; Leucine; Male; Obesity; Valine | 1976 |
Insulin secretion by perfused islets from the obese Zucker rat.
Topics: Animals; Glucose; Hyperinsulinism; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Obesity; Perfusion; Rats; Stimulation, Chemical | 1975 |
A comparison of the enzyme levels and the in vitro utilization of various substrates for lipogenesis in pair-fed lean and obese pigs.
Topics: Acetates; Adipose Tissue; Alanine; Animals; Gluconeogenesis; Glucose; Glycerol; Glycolysis; Leucine; Lipids; Liver; Obesity; Pyruvates; Swine | 1976 |
Body composition, nitrogen metabolism, and energy utilization with feeding of mildly restricted (4.2 MJ/d) and severely restricted (2.1 MJ/d) isonitrogenous diets.
Topics: Body Composition; Diet, Reducing; Dietary Carbohydrates; Dietary Proteins; Energy Metabolism; Female; Humans; Leucine; Nitrogen; Obesity; Weight Loss | 1992 |
Increased protein turnover in obese women.
Topics: Abdomen; Adult; Body Mass Index; Body Weight; Female; Glucose Tolerance Test; Hip; Humans; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Magnetic Resonance Imaging; Middle Aged; Obesity; Proteins | 1992 |
Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate.
Topics: Adult; Basal Metabolism; Body Composition; Diet, Reducing; Dihydroxyacetone; Energy Metabolism; Female; Humans; Leucine; Middle Aged; Nitrogen; Obesity; Pyruvates; Pyruvic Acid; Weight Loss | 1992 |
Protein metabolism in obesity: effects of body fat distribution and hyperinsulinemia on leucine turnover.
Topics: Adipose Tissue; Body Mass Index; Caproates; Female; Humans; Insulin; Keto Acids; Leucine; Obesity; Proteins | 1991 |
Differential effects of insulin resistance on leucine and glucose kinetics in obesity.
Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Carbon Isotopes; Female; Glucose; Humans; Hyperinsulinism; Insulin Resistance; Kinetics; Leucine; Obesity | 1991 |
Failure of glyburide and insulin treatment to decrease leucine flux in obese type II diabetic patients.
Topics: Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Insulin; Leucine; Middle Aged; Obesity | 1990 |
Prolonged fasting as conditioned by prior protein depletion: effect on urinary nitrogen excretion and whole-body protein turnover.
Topics: Fasting; Female; Humans; Kinetics; Leucine; Male; Methylhistidines; Nitrogen; Obesity; Protein Deficiency; Reference Values; Time Factors | 1990 |
Effects of sucrose on resting metabolic rate, nitrogen balance, leucine turnover and oxidation during weight loss with low calorie diets.
Topics: Adult; Blood Glucose; Body Temperature Regulation; Diet, Reducing; Dietary Fats; Dietary Proteins; Energy Intake; Energy Metabolism; Female; Humans; Insulin; Leucine; Middle Aged; Nitrogen; Obesity; Sucrose; Thyroxine; Triiodothyronine; Weight Loss | 1990 |
Effect of triiodothyronine on leucine kinetics, metabolic rate, glucose concentration and insulin secretion rate during two weeks of fasting in obese women.
Topics: Adult; Blood Glucose; Fasting; Female; Humans; Insulin; Insulin Secretion; Leucine; Obesity; Triiodothyronine | 1989 |
Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse beta-cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arginine; Calcium; Cytoplasm; Dose-Response Relationship, Drug; Glucose; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Leucine; Mice; Mice, Obese; Obesity | 1988 |
Sex-specific differences in plasma branched-chain keto acid levels in obesity.
Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Obesity; Sex Characteristics; Valine | 1987 |
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
Topics: Adipose Tissue; Adult; Binding, Competitive; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glucose; Humans; Insulin; Insulin Resistance; Leucine; Male; Obesity | 1987 |
Failure of carbohydrate to spare leucine oxidation in obese subjects.
Topics: Administration, Oral; Adult; Blood Glucose; Female; Glucagon; Glucose; Humans; Insulin; Leucine; Male; Middle Aged; Obesity | 1987 |
Leucine metabolism in type II diabetes mellitus.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Leucine; Middle Aged; Obesity | 1986 |
The fate of 14C derived from radioactively labelled dietary precursors in young rats of the Zucker strain (Fa/- and fa/fa).
Topics: Animals; Carbon Radioisotopes; Glucose; Lactates; Lactic Acid; Leucine; Obesity; Palmitic Acid; Palmitic Acids; Rats; Rats, Zucker; Valine | 1986 |
Effect of dietary fat, carbohydrate, and protein on branched-chain amino acid catabolism during caloric restriction.
Topics: 3-Hydroxybutyric Acid; Amino Acids, Branched-Chain; Blood Glucose; Diet, Reducing; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Female; Humans; Hydroxybutyrates; Insulin; Leucine; Obesity | 1985 |
Physiological covalent regulation of rat liver branched-chain alpha-ketoacid dehydrogenase.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Dietary Proteins; Female; Ketone Oxidoreductases; Leucine; Liver; Male; Multienzyme Complexes; Obesity; Radiochemistry; Rats; Rats, Inbred Strains; Rats, Zucker; Starvation; Temperature | 1985 |
Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets.
Topics: Animals; Caproates; Chemical Phenomena; Chemistry; Female; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Leucine; Male; Mice; NADP; Obesity; Spectrometry, Fluorescence; Structure-Activity Relationship; Valerates | 1974 |
Iodoacetamide-induced sensitization of the pancreatic beta-cells to glucose stimulation.
Topics: Amides; Animals; Calcium; Carbon Isotopes; Dithiothreitol; Epinephrine; Female; Fructosephosphates; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Iodine Isotopes; Iodoacetates; Islets of Langerhans; Leucine; Male; Mice; Obesity; Radioimmunoassay; Theophylline; Tritium | 1973 |
The pancreatic beta-cell recognition of insulin secretagogues. Comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone.
Topics: Acetone; Animals; Arginine; Calcium; Carbon Radioisotopes; Dinitrophenols; Epinephrine; Female; Glucosamine; Glucose; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Iodoacetates; Islets of Langerhans; Isomerism; Leucine; Male; Obesity; Phlorhizin; Theophylline; Time Factors | 1974 |
Further studies on the amelioration of the characteristics of New Zealand Obese (NZO) mice following implantation of islets of Langerhans.
Topics: Animals; Blood Glucose; Body Weight; Cytological Techniques; Diffusion; Hyperglycemia; Hyperinsulinism; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Leucine; Male; Mice; Mice, Inbred Strains; Micropore Filters; Obesity; Peritoneal Cavity; Proinsulin; Streptozocin; Time Factors; Transplantation, Homologous; Tritium | 1974 |
[2 cases of Langerhans adenoma].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adult; Aged; Angiography; Celiac Artery; Female; Gastrointestinal Hemorrhage; Glucagon; Humans; Hypoglycemia; Insulin; Intracranial Arteriosclerosis; Leucine; Mesenteric Arteries; Obesity; Pancreatectomy; Pancreatic Neoplasms; Pregnancy; Pregnancy Complications; Prognosis; Tolbutamide | 1969 |
Transport of -aminoisobutyric acid in mammalian pancretic -cells.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Butyrates; Cyclic AMP; Diazoxide; Galactose; Glucose; Hyperglycemia; Hypoxia; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Methionine; Mice; Monosaccharides; Obesity; Sodium | 1971 |
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.
Topics: Acromegaly; Adenoma, Islet Cell; Adolescent; Adult; Animals; Child; Chromatography, Gel; Cricetinae; Cushing Syndrome; Diazoxide; Disease Models, Animal; Female; Glucagon; Glucose Tolerance Test; Half-Life; Humans; Hypoglycemia; Hypokalemia; Insulin; Iodine Isotopes; Leucine; Male; Middle Aged; Myotonic Dystrophy; Neoplasms, Experimental; Obesity; Proinsulin; Radioimmunoassay; Stimulation, Chemical; Tolbutamide | 1971 |
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets.
Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Citrates; Cyclic AMP; Depression, Chemical; Diazoxide; Epinephrine; Glucose; Glyburide; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Iodoacetates; Islets of Langerhans; Leucine; Male; Mice; Monosaccharides; Obesity; Oxidation-Reduction; Pyruvates; Stimulation, Chemical; Succinates | 1971 |
Specificity of leucine stimulation of insulin release.
Topics: Amino Acids; Animals; Biological Transport; Dose-Response Relationship, Drug; Female; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Antibodies; Insulin Secretion; Iodine Isotopes; Islets of Langerhans; Isoleucine; Leucine; Mice; Obesity; Radioimmunoassay; Receptors, Cell Surface | 1972 |
Control of liver tyrosine aminotransferase expression: enzyme regulatory studies on inbred strains and mutant mice.
Topics: Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Electrophoresis, Disc; Enzyme Induction; Fasting; Female; Flumethasone; Genes, Regulator; Glucocorticoids; Glucose; Hot Temperature; Hydrocortisone; Isoenzymes; Kinetics; Leucine; Liver; Male; Mice; Mutation; Obesity; Protein Denaturation; Species Specificity; Starvation; Tyrosine Transaminase | 1970 |
Nitrogen sparing induced by a mixture of essential amino acids given chiefly as their keto-analogues during prolonged starvation in obese subjects.
Topics: Amino Acids; Female; Humans; Infusions, Parenteral; Isoleucine; Keto Acids; Leucine; Methionine; Nitrogen; Obesity; Phenylalanine; Starvation; Urea; Valine | 1974 |
Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic mice.
Topics: Amino Acids; Animals; Binding Sites; Carbon Isotopes; Chromatography, Thin Layer; Dansyl Compounds; Fatty Acids, Nonesterified; Hyperglycemia; Islets of Langerhans; Leucine; Mice; Obesity; Taurine; Valine | 1972 |
Inductive effects of glucose on the insulin secretory and synthetic apparatus of the pancreatic -cell.
Topics: Administration, Oral; Animals; Cell Fractionation; Dactinomycin; Diabetes Mellitus; Dietary Carbohydrates; Fasting; Glucose; Humans; Injections, Intraperitoneal; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Obesity; Pancreas; Peptide Chain Initiation, Translational; Rats; Receptors, Drug; Ribosomes; RNA; Tritium; Uridine | 1972 |
In vitro studies on insulin in the genetically obese mouse.
Topics: Animals; Arginine; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Mice; Obesity; Stimulation, Chemical | 1973 |
Changes of free amino acids in pancreatic beta-cells after starvation and substrate deprivation.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, Thin Layer; Dansyl Compounds; Diabetes Mellitus; Fasting; Female; Freeze Drying; Glutamates; Glycine; Islets of Langerhans; Leucine; Lysine; Mice; Obesity; Ornithine; Phenylalanine; Proline; Taurine; Tritium; Valine | 1974 |
Glucose oxidation and contents of free amino acids in pancreatic beta-cells stimulated by a non-metabolizable leucine analogue.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Dansyl Compounds; Glucose; In Vitro Techniques; Islets of Langerhans; Isomerism; Leucine; Obesity; Structure-Activity Relationship; Tritium | 1974 |
Transport of L-leucine and D-leucine into pancreatic -cells with reference to the mechanisms of amino acid-induced insulin release.
Topics: Amino Acids; Animals; Biological Transport; Carbon Isotopes; Cells; Extracellular Space; Glyburide; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Mice; Mice, Inbred Strains; Obesity; Protein Biosynthesis; Receptors, Drug; Stereoisomerism; Sucrose; Tritium | 1972 |
Uptake and oxidation of glutamic acid in mammalian pancreatic islets.
Topics: Alanine; Animals; Arginine; Carbon Isotopes; Female; Galactose; Glucose; Glutamates; Glyburide; Hyperglycemia; Insulin; Iodine Isotopes; Islets of Langerhans; Leucine; Male; Mice; Obesity; Oxidation-Reduction; Sucrose; Time Factors; Tritium | 1972 |
Effects of oral alanine administration in fasting obese subjects.
Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Female; Gluconeogenesis; Humans; Hydroxybutyrates; Insulin; Isoleucine; Leucine; Male; Middle Aged; Nitrogen; Obesity; Phosphorus; Potassium; Urea; Uric Acid; Valine | 1973 |
Hyperinsulin response to oral leucine in obesity and acromegaly.
Topics: Acromegaly; Blood Glucose; Fatty Acids, Nonesterified; Glucose Tolerance Test; Growth Hormone; Humans; Hyperinsulinism; Insulin; Leucine; Male; Obesity | 1973 |
Transient kwaskiorkor: A cause of fatty liver following small bowel bypass.
Topics: Adult; Amino Acids; Body Weight; Dietary Carbohydrates; Dietary Proteins; Fatty Liver; Female; Glycine; Humans; Ileum; Intestinal Absorption; Intestine, Small; Kwashiorkor; Leucine; Lipid Metabolism; Liver; Lysine; Malabsorption Syndromes; Male; Obesity | 1974 |
Leucyl-beta-naphthylamide-splitting enzymes in the mammalian endocrine pancreas.
Topics: Aminopeptidases; Animals; Electrophoresis, Disc; Female; Hydrogen-Ion Concentration; Hyperglycemia; Insulin; Islets of Langerhans; Kinetics; Leucine; Liver; Male; Mice; Naphthalenes; Obesity; Pancreas; Spectrophotometry; Starvation | 1968 |
[Effect of blood sugar decreasing sulfonylureas on the in vitro metabolism of glucose and amino acids in the beta-cells of the pancreas in mice].
Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Depression, Chemical; Female; Glucose; Hyperglycemia; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Male; Mice; Obesity; Oxidation-Reduction; Oxygen Consumption; Pancreas; Stimulation, Chemical; Tolbutamide; Urea; Valine | 1969 |
Hypersecretion of insulin after the administration of L-leucine to obese children.
Topics: Abnormalities, Multiple; Administration, Oral; Adolescent; Blood Glucose; Child; Child, Preschool; Female; Glucose Tolerance Test; Humans; Hypogonadism; Insulin; Insulin Secretion; Intellectual Disability; Islets of Langerhans; Laurence-Moon Syndrome; Leucine; Male; Obesity; Stimulation, Chemical | 1971 |
Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells.
Topics: Alanine; Animals; Arginine; Carbon Isotopes; Diazoxide; Fructose; Glucose; Glyburide; Hyperglycemia; Islets of Langerhans; Leucine; Mice; Obesity; Pancreas; Pyruvates; Sodium; Stereoisomerism; Succinates; Time Factors | 1971 |
Synthesis and degradation of liver acetyl coenzyme A carboxylase in genetically obese mice.
Topics: Animals; Autoradiography; Body Weight; Coenzyme A; Half-Life; Hot Temperature; Immunochemistry; Immunodiffusion; Kinetics; Leucine; Ligases; Liver; Mice; Obesity; Organ Size; Palmitic Acids; Precipitin Tests; Tritium | 1971 |
Studies in spiny mice (Acomys cahirinus): metabolic state and pancreatic insulin release in vitro.
Topics: Age Factors; Animals; Antigens; Arginine; Blood Glucose; Caffeine; Calcium; Diabetes Mellitus; Glucagon; Glycosuria; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Leucine; Mice; Mice, Inbred Strains; Obesity; Pancreas; Tolbutamide | 1969 |
Hormone and amino acid levels in altered nutritional states.
Topics: Adult; Alanine; Amino Acids; Aminobutyrates; Female; Growth Hormone; Humans; Insulin; Isoleucine; Leucine; Male; Nutritional Physiological Phenomena; Obesity; Protein Deficiency; Starvation; Valine | 1970 |
[Quality of lipids and quantity of proteins synthesized in vivo by the normal mouse and the obese-hyperglycemic mouse from Bar Harbor].
Topics: Acetates; Adipose Tissue; Aminoisobutyric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Fatty Acids; Fatty Acids, Nonesterified; Female; Glycerides; Hyperglycemia; Leucine; Lipids; Liver; Mice; Muscles; Obesity; Phospholipids; Protein Biosynthesis; Rodent Diseases; Triglycerides | 1970 |
Studies on the radioimmunological determination of blood insulin by means of 125-I-insulin of high specific activity.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Fasting; Female; Glucagon; Glucose; Humans; Infant; Insulin; Iodine Isotopes; Leucine; Methods; Obesity; Radioimmunoassay; Swine; Tolbutamide | 1970 |
Alteration in the urinary excretion rate of amino acids and nitrogen by dietary means in obese and normal human subjects.
Topics: Adult; Alanine; Amino Acids; Creatinine; Female; Humans; Isoleucine; Leucine; Male; Nitrogen; Obesity; Protein Deficiency; Renal Aminoacidurias; Starvation; Taurine; Urea; Valine | 1971 |
Plasma amino acid levels and insulin secretion in obesity.
Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Middle Aged; Obesity; Pancreas; Phenylalanine; Tyrosine; Valine | 1969 |
The effects of test doses of leucine, isoleucine or valine on plasma amino acid levels. The unique effect of leucine.
Topics: Amino Acids; Blood; Fasting; Humans; Isoleucine; Leucine; Male; Obesity; Valine | 1965 |