leucine and Muscular Atrophy

leucine has been researched along with Muscular Atrophy in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (12.73)	18.7374
1990's	1 (1.82)	18.2507
2000's	11 (20.00)	29.6817
2010's	25 (45.45)	24.3611
2020's	11 (20.00)	2.80

Authors

Authors	Studies
Bear, DE; Rooyackers, O	1
Busanello, ENB; Castelucci, BG; Chiocchetti, GME; Consonni, SR; de Oliveira, ALR; de Sousa, LM; Gomes-Marcondes, MCC; Marques, AC; Oroy, L; Salgado, CM; Suarez, PS; Vercesi, AE; Viana, LR; Vieira, AS; Vieira, WF	1
Chen, KY; Chen, PD; Hou, YC; Lee, PC; Lin, MT; Wu, JM; Wu, MH; Yang, PJ; Yeh, SL	1
Chaix, A; de Hart, NMMP; Drummond, MJ; Ferrara, PJ; Fix, DK; Funai, K; Lang, MJ; Petrocelli, JJ; Yee, EM	1
Hsu, TH; Huang, CS; Liao, JW; Tai, YA; Wu, TJ; Yeh, SL	1
Breen, L; Edwards, SJ; Joanisse, S; Luo, D; Marshall, RN; Mckendry, J; Nishimura, Y; Perkins, M; Philp, A; Ramsay, J; Smeuninx, B	1
Abo-Ismail, M; Boutry-Regard, C; Canovas, A; Davis, TA; Fiorotto, ML; Maj, M; Manjarín, R; Nguyen, HV; Piccolo, BD; Suryawan, A	1
Arentson-Lantz, EJ; Bhattarai, N; Fry, CS; Lamon, S; Mikovic, J; Paddon-Jones, D; Porter, C	1
Allen, SL; Breen, L; Edwards, SJ; Lavery, GG; Lord, JM; Marshall, RN	1
de Hart, NM; Drummond, MJ; Eshima, H; Ferrara, PJ; Fix, DK; Funai, K; Kelley, JJ; Mahmassani, ZS; McKenzie, AI; Montgomery, JA; Petrocelli, JJ; Reidy, PT	1
Baptista, IL; Labeit, S; Moriscot, AS; Silva, WJ; Silvestre, JG	1
Cruz-Jentoft, AJ	1
Dardevet, D; Hafnaoui, N; Jarzaguet, M; Migné, C; Mosoni, L; Papet, I; Peyron, MA; Polakof, S; Rémond, D; Revel, A; Savary-Auzeloux, I	1
Backx, EMP; de Groot, LCPGM; Fuchs, CJ; Horstman, AMH; Janssen, AAW; Marzuca-Nassr, GN; Smeets, JS; Snijders, T; van Kranenburg, J; van Loon, LJC; Verdijk, LB	1
Boland, M; Franssen, FME; Gosker, HR; Kremers, SPJ; Rutten-van Mölken, MPMH; Schols, AMWJ; van Beers, M; van de Bool, C; van Helvoort, A; Wouters, EF	1
Huang, S; Lin, W; Xu, H; Zheng, R; Zheng, X; Zhu, J	1
Tipton, KD	1
Combaret, L; Dardevet, D; Magne, H; Migné, C; Peyron, MA; Rémond, D; Savary-Auzeloux, I	2
Chevalier, S; Winter, A	1
Brett, SJ; Frost, G; Hickson, M; Wandrag, L	1
Caldow, MK; Ham, DJ; Koopman, R; Lynch, GS	1
Bai, K; Dong, L; He, J; Su, W; Wang, T; Xu, W; Zhang, L	1
Antunes, HKM; Dáttilo, M; de Campos Giampa, SQ; de Mello, MT; de Sá Souza, H; Lee, KS; Mônico-Neto, M; Phillips, SM; Tufik, S	1
Arentson-Lantz, E; Ellison, JB; English, KL; Mamerow, MM; Mettler, JA; Paddon-Jones, D; Pattarini, JM; Ploutz-Snyder, R; Sheffield-Moore, M	1
Caldow, MK; Chee, A; Chhen, V; Ham, DJ; Koopman, R; Lynch, GS; Proud, CG; Wang, X	1
Arentson-Lantz, E; Galvan, E; Lamon, S; Paddon-Jones, D	1
Chen, D; He, J; Luo, J; Luo, Y; Mao, X; Wan, J; Yu, B; Yu, J; Zheng, P	1
Bönnemann, C; Brockmann, K; Gärtner, J; Huebner, A; Kind, B; Koehler, K; Krumbholz, M	1
Paddon-Jones, D; Rasmussen, BB	1
Haus, JM; Lemoine, JK; Trappe, SW; Trappe, TA	1
Huber, D; Jiao, Q; Lang, CH; Pruznak, AM; Vary, TC	1
Aoki, MS; Artioli, GG; Baptista, IL; Curi, R; Fiamoncini, J; Leal, ML; Miyabara, EH; Moriscot, AS; Turri, AO	1
Artioli, GG; Blachier, F; Costa, Ados S; da Luz, CR; Lancha, AH; Nicastro, H; Solis, MY	1
Brum, PC; Chaves, DF; da Luz, CR; Dardevet, D; de Moraes, WM; de Siqueira Filho, MA; Lancha, AH; Medeiros, A; Nicastro, H; Ramona, P; Zanchi, NE	1
Breen, L; Phillips, SM	1
Breen, L; Churchward-Venne, TA	1
Knuiman, P; Kramer, IF	1
Chihara, K; Iguchi, G; Iida, K; Kaji, H; Maki, T; Nakanishi, S; Okimura, Y; Takahashi, Y; Yamamoto, D	1
Blachier, F; Bueno, C; Campos-Ferraz, P; de Oliveira Carvalho, CR; de Siqueira-Filho, MA; Felitti, V; Guimarães-Ferreira, L; Lancha, AH; Lira, FS; Naimo, MA; Nicastro, H; Nunes, MT; Seelaender, M; Zanchi, NE	1
Dardevet, D; Grizard, J; Rieu, I; Sornet, C	1
Espeillac, C; Klumperman, J; Mieulet, V; Ohanna, M; Oorschot, V; Pende, M; Roceri, M; Sandri, M; Sotiropoulos, A	1
Eley, HL; Russell, ST; Tisdale, MJ	1
Burd, NA; Lee, GA; Louis, ES; Trappe, SW; Trappe, TA	1
Ito, Y; Nagasawa, T; Nishizawa, N; Sugawara, T	1
Drac, H; Hausmanowa-Petrusewicz, I; Kabzińska, D; Kochański, A; Lupski, JR; Rowińska-Marcińska, K; Saifi, GM	1
Ku, Z; Menon, V; Thomason, DB; Yang, J	1
Baldwin, KM; Ikemoto, M; Izumi, R; Kishi, K; Kitano, T; Nikawa, T; Nonaka, I; Rokutan, K; Takeda, S; Teshima, S; Towatari, T; Watanabe, C	1
Marusyk, H; Monckton, G	2
Bolander, P; Carlsson, CA; Sjöstrand, J	1
Bradley, WG; Day, MJ; Murchison, D	1
Ionescu, V; Killyen, I; Radu, H; Roşu, AM; Tanase-Mogoş, I	1
Gorevic, P; Samuels, AJ	1
Goldberg, AL	1

Reviews

10 review(s) available for leucine and Muscular Atrophy

Article	Year
HMB and leucine supplementation during critical illness and recovery. Current opinion in clinical nutrition and metabolic care, 2022, 03-01, Volume: 25, Issue:2 Topics: Critical Illness; Dietary Supplements; Humans; Leucine; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Valerates	2022
Beta-Hydroxy-Beta-Methyl Butyrate (HMB): From Experimental Data to Clinical Evidence in Sarcopenia. Current protein & peptide science, 2018, Volume: 19, Issue:7 Topics: Aged; Aged, 80 and over; Aging; Apoptosis; Cell Survival; Dietary Supplements; Frailty; Humans; Leucine; Middle Aged; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Sarcopenia; Valerates	2018
Dietary strategies to attenuate muscle loss during recovery from injury. Nestle Nutrition Institute workshop series, 2013, Volume: 75 Topics: Diet; Dietary Supplements; Energy Metabolism; Exercise; Fatty Acids, Omega-3; Humans; Inflammation; Leucine; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Nutritional Requirements; Nutritional Status; Wound Healing	2013
Do patients with advanced cancer have any potential for protein anabolism in response to amino acid therapy? Current opinion in clinical nutrition and metabolic care, 2014, Volume: 17, Issue:3 Topics: Amino Acids; Amino Acids, Branched-Chain; Anabolic Agents; Cachexia; Dietary Proteins; Dietary Supplements; Humans; Inflammation; Leucine; Muscular Atrophy; Neoplasms; Proteins	2014
Impact of supplementation with amino acids or their metabolites on muscle wasting in patients with critical illness or other muscle wasting illness: a systematic review. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2015, Volume: 28, Issue:4 Topics: Aged; Amino Acids; Amino Acids, Essential; Body Composition; Creatine; Critical Illness; Diet; Dietary Supplements; Enteral Nutrition; Female; Humans; Intensive Care Units; Leucine; Male; MEDLINE; Muscular Atrophy; Nutritional Status; Valerates	2015
Leucine as a treatment for muscle wasting: a critical review. Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:6 Topics: Aging; Animals; Dietary Supplements; Disease Models, Animal; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Protein Biosynthesis; TOR Serine-Threonine Kinases	2014
Protecting Skeletal Muscle with Protein and Amino Acid during Periods of Disuse. Nutrients, 2016, Jul-01, Volume: 8, Issue:7 Topics: Amino Acids; Bed Rest; Diet; Dietary Proteins; Dietary Supplements; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Protein Biosynthesis; Quality of Life; Sedentary Behavior; TOR Serine-Threonine Kinases	2016
Dietary protein recommendations and the prevention of sarcopenia. Current opinion in clinical nutrition and metabolic care, 2009, Volume: 12, Issue:1 Topics: Aged; Aging; Dietary Proteins; Dietary Supplements; Exercise; Humans; Leucine; Muscle Proteins; Muscular Atrophy; Nutrition Policy; Protein Deficiency	2009
An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino acids, 2011, Volume: 40, Issue:2 Topics: Clinical Trials as Topic; Dietary Supplements; Humans; Leucine; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Neoplasms	2011
Nutrient interaction for optimal protein anabolism in resistance exercise. Current opinion in clinical nutrition and metabolic care, 2012, Volume: 15, Issue:3 Topics: Cachexia; Dietary Proteins; Humans; Hypertrophy; Leucine; Muscle Proteins; Muscular Atrophy; Protein Biosynthesis; Resistance Training	2012

Trials

4 trial(s) available for leucine and Muscular Atrophy

Article	Year
High-dose leucine supplementation does not prevent muscle atrophy or strength loss over 7 days of immobilization in healthy young males. The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5 Topics: Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Immobilization; Leucine; Male; Muscle Strength; Muscular Atrophy; Young Adult	2020
Clinical outcome and cost-effectiveness of a 1-year nutritional intervention programme in COPD patients with low muscle mass: The randomized controlled NUTRAIN trial. Clinical nutrition (Edinburgh, Scotland), 2020, Volume: 39, Issue:2 Topics: Cost-Benefit Analysis; Counseling; Dietary Supplements; Fatty Acids, Unsaturated; Female; Humans; Leucine; Male; Middle Aged; Motivational Interviewing; Muscular Atrophy; Netherlands; Nutrition Therapy; Program Evaluation; Pulmonary Disease, Chronic Obstructive; Treatment Outcome; Vitamin D	2020
Leucine partially protects muscle mass and function during bed rest in middle-aged adults. The American journal of clinical nutrition, 2016, Volume: 103, Issue:2 Topics: Absorptiometry, Photon; Bed Rest; Biopsy, Needle; Body Composition; Carbon Isotopes; Dietary Supplements; Double-Blind Method; Exercise Test; Female; Humans; Leucine; Male; Middle Aged; Muscle Development; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Oxygen Consumption; Signal Transduction; Whole Body Imaging	2016
Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women. Acta physiologica (Oxford, England), 2007, Volume: 191, Issue:2 Topics: Adult; Analysis of Variance; Bed Rest; Dietary Proteins; Ergometry; Exercise Therapy; Female; Head-Down Tilt; Humans; Isometric Contraction; Leg; Leucine; Muscle, Skeletal; Muscular Atrophy; Nutritional Physiological Phenomena; Space Flight; Thigh; Time Factors; Weightlessness Simulation	2007

Other Studies

41 other study(ies) available for leucine and Muscular Atrophy

Article	Year
Leucine-Rich Diet Improved Muscle Function in Cachectic Walker 256 Tumour-Bearing Wistar Rats. Cells, 2021, 11-23, Volume: 10, Issue:12 Topics: Animals; Cachexia; Dietary Supplements; Forkhead Box Protein O1; Humans; Inflammation; Leucine; Muscle Proteins; Muscular Atrophy; Neoplasms; Proteolysis; Quality of Life; Rats; Tripartite Motif Proteins; Ubiquitin-Protein Ligases	2021
Glutamine and leucine administration attenuates muscle atrophy in sepsis. Life sciences, 2023, Feb-01, Volume: 314 Topics: Amino Acids, Branched-Chain; Animals; Glutamine; Leucine; Mammals; Mice; Muscle, Skeletal; Muscular Atrophy; Sepsis	2023
Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail. Aging, 2023, 03-20, Volume: 15, Issue:6 Topics: Aged; Animals; Cellular Senescence; Humans; Leucine; Metformin; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Proteostasis	2023
The combination of quercetin and leucine synergistically improves grip strength by attenuating muscle atrophy by multiple mechanisms in mice exposed to cisplatin. PloS one, 2023, Volume: 18, Issue:9 Topics: Animals; Cisplatin; Fatigue; Glycogen; Leucine; Male; Mice; Muscular Atrophy; Quercetin	2023
Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs. Amino acids, 2020, Volume: 52, Issue:9 Topics: Animals; Animals, Newborn; Dietary Supplements; Female; Leucine; Metabolome; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Phosphorylation; Swine; Transcriptome	2020
Leucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults. Journal of applied physiology (Bethesda, Md. : 1985), 2021, 05-01, Volume: 130, Issue:5 Topics: Aged; Bed Rest; Humans; Leucine; Mitochondria; Muscle, Skeletal; Muscular Atrophy; Sedentary Behavior	2021
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging. American journal of physiology. Cell physiology, 2021, 07-01, Volume: 321, Issue:1 Topics: Adult; Aged; Aging; Animals; C-Reactive Protein; Cell Line; Culture Media; Humans; Insulin Resistance; Interleukin-6; Leucine; Male; Mice; Models, Biological; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Peptide Elongation Factor 2; Protein Biosynthesis; Proteolysis; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction	2021
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:9 Topics: Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Collagen; Fibrosis; Hindlimb Suspension; Immunoglobulin G; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Muscle Development; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Organ Size; RNA-Seq; Satellite Cells, Skeletal Muscle; Signal Transduction	2021
FoxO3a suppression and VPS34 activity are essential to anti-atrophic effects of leucine in skeletal muscle. Cell and tissue research, 2017, Volume: 369, Issue:2 Topics: Animals; Cell Nucleus; Class III Phosphatidylinositol 3-Kinases; Dexamethasone; Forkhead Box Protein O3; Leucine; Male; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Proto-Oncogene Proteins c-akt; Rats, Wistar; Ubiquitination	2017
At same leucine intake, a whey/plant protein blend is not as effective as whey to initiate a transient post prandial muscle anabolic response during a catabolic state in mini pigs. PloS one, 2017, Volume: 12, Issue:10 Topics: Anabolic Agents; Animals; Caseins; Eating; Glucocorticoids; Leucine; Metabolism; Muscle, Skeletal; Muscular Atrophy; Plant Proteins, Dietary; Postprandial Period; Swine; Swine, Miniature; Whey	2017
Leucine Supplementation Does Not Attenuate Skeletal Muscle Loss during Leg Immobilization in Healthy, Young Men. Nutrients, 2018, May-17, Volume: 10, Issue:5 Topics: Diet; Dietary Supplements; Humans; Immobilization; Knee; Leg; Leucine; Male; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Quadriceps Muscle; Young Adult	2018
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears. Cell and tissue research, 2019, Volume: 378, Issue:1 Topics: Animals; Autophagosomes; Autophagy-Related Proteins; Leucine; Male; Muscular Atrophy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rotator Cuff Injuries; Signal Transduction; TOR Serine-Threonine Kinases	2019
Unilateral hindlimb casting induced a delayed generalized muscle atrophy during rehabilitation that is prevented by a whey or a high protein diet but not a free leucine-enriched diet. PloS one, 2013, Volume: 8, Issue:8 Topics: Animals; Hindlimb; Immobilization; Leucine; Male; Milk Proteins; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Postprandial Period; Proteasome Endopeptidase Complex; Protein Biosynthesis; Proteolysis; Rats; Rats, Wistar; Signal Transduction; Ubiquitination; Whey Proteins	2013
Leucine improves growth performance of intrauterine growth retardation piglets by modifying gene and protein expression related to protein synthesis. Nutrition (Burbank, Los Angeles County, Calif.), 2016, Volume: 32, Issue:1 Topics: Animals; Animals, Newborn; Birth Weight; Dietary Supplements; Fetal Growth Retardation; Gene Expression; Growth; Leucine; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Phosphorylation; Protein Biosynthesis; Protein Processing, Post-Translational; Ribosomal Protein S6; RNA, Messenger; Signal Transduction; Swine; TOR Serine-Threonine Kinases; Weaning; Weight Gain	2016
Leucine supplementation is anti-atrophic during paradoxical sleep deprivation in rats. Amino acids, 2016, Volume: 48, Issue:4 Topics: Administration, Oral; Animals; Carrier Proteins; Corticosterone; Dietary Supplements; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Microtubule-Associated Proteins; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscular Atrophy; Myosins; Phosphoproteins; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Sequestosome-1 Protein; Signal Transduction; Sleep Deprivation; Testosterone; TOR Serine-Threonine Kinases	2016
Glycine restores the anabolic response to leucine in a mouse model of acute inflammation. American journal of physiology. Endocrinology and metabolism, 2016, 06-01, Volume: 310, Issue:11 Topics: Acute Disease; Anabolic Agents; Animals; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Glycine; Leucine; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscular Atrophy; Myositis; Treatment Outcome	2016
Leucine Protects Against Skeletal Muscle Atrophy in Lipopolysaccharide-Challenged Rats. Journal of medicinal food, 2017, Volume: 20, Issue:1 Topics: Animals; C-Reactive Protein; Dietary Supplements; Humans; Interleukin-1; Leucine; Lipopolysaccharides; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; NF-kappa B; Protective Agents; Rats; Rats, Sprague-Dawley; SKP Cullin F-Box Protein Ligases	2017
Axonal neuropathy with unusual pattern of amyotrophy and alacrima associated with a novel AAAS mutation p.Leu430Phe. European journal of human genetics : EJHG, 2008, Volume: 16, Issue:12 Topics: Amino Acid Substitution; DNA Mutational Analysis; Female; HeLa Cells; Humans; Lacrimal Apparatus Diseases; Leucine; Muscular Atrophy; Musculoskeletal Abnormalities; Nerve Tissue Proteins; Nuclear Pore Complex Proteins; Peripheral Nervous System Diseases; Phenylalanine; Point Mutation; Syndrome; Transfection	2008
Muscle proteins during 60-day bedrest in women: impact of exercise or nutrition. Muscle & nerve, 2009, Volume: 39, Issue:4 Topics: Actins; Adult; Astronauts; Bed Rest; Biopsy; Collagen; Dietary Proteins; Exercise; Female; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Myofibrils; Myosins; Quadriceps Muscle; Sarcoplasmic Reticulum; Weightlessness Simulation	2009
Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue. American journal of physiology. Endocrinology and metabolism, 2009, Volume: 297, Issue:5 Topics: Adipose Tissue; Animals; Blood Proteins; Blotting, Western; Body Composition; Body Weight; Carbon Dioxide; Cytokines; Eating; Energy Metabolism; Glucose Intolerance; Heart; Hormones; Insulin-Like Growth Factor I; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Nuclease Protection Assays; Orchiectomy; Organ Size; Oxygen Consumption; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Stimulation, Chemical	2009
Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases. Muscle & nerve, 2010, Volume: 41, Issue:6 Topics: Administration, Oral; Animals; Cyclophilin A; Dietary Supplements; Gene Expression Regulation, Enzymologic; Hindlimb Suspension; Histocytochemistry; Insulin; Leucine; Male; Muscle, Skeletal; Muscular Atrophy; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; Ubiquitin-Protein Ligases	2010
Effects of leucine supplementation and resistance exercise on dexamethasone-induced muscle atrophy and insulin resistance in rats. Nutrition (Burbank, Los Angeles County, Calif.), 2012, Volume: 28, Issue:4 Topics: Animals; Blood Glucose; Dexamethasone; Dietary Supplements; Glucose Transporter Type 4; Hyperglycemia; Insulin Resistance; Leucine; Male; Movement; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Wistar; Resistance Training; Ribosomal Protein S6 Kinases, 70-kDa	2012
Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing. The Journal of physiology, 2012, Apr-15, Volume: 590, Issue:8 Topics: Aging; Amino Acids; Animals; Diet; Dietary Supplements; Hindlimb Suspension; Leucine; Male; Milk Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Ubiquitin; Whey Proteins	2012
Leucine: a nutrient 'trigger' for muscle anabolism, but what more? The Journal of physiology, 2012, May-01, Volume: 590, Issue:9 Topics: Aging; Animals; Leucine; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy	2012
Contributions to the understanding of the anabolic properties of different dietary proteins. The Journal of physiology, 2012, Jun-15, Volume: 590, Issue:12 Topics: Aging; Animals; Leucine; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy	2012
Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats. Nutrition research (New York, N.Y.), 2012, Volume: 32, Issue:9 Topics: Amino Acids, Branched-Chain; Animals; Blotting, Western; Hindlimb Suspension; Isoleucine; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Muscular Disorders, Atrophic; Organ Size; Rats; Rats, Sprague-Dawley; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Valine	2012
Dose and latency effects of leucine supplementation in modulating glucose homeostasis: opposite effects in healthy and glucocorticoid-induced insulin-resistance states. Nutrients, 2012, Nov-27, Volume: 4, Issue:12 Topics: Animals; Blood Glucose; Dexamethasone; Dietary Supplements; Dose-Response Relationship, Drug; Drug Administration Routes; Glucocorticoids; Homeostasis; Insulin; Insulin Resistance; Leucine; Male; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Rats; Rats, Wistar	2012
Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats. Experimental gerontology, 2004, Volume: 39, Issue:9 Topics: Aging; Animals; Dexamethasone; Dose-Response Relationship, Drug; Drug Resistance; Eating; Glucocorticoids; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Rats; Rats, Wistar; Tissue Culture Techniques	2004
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover. American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:2 Topics: Animals; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Elongation Factor 2 Kinase; Eukaryotic Initiation Factors; Hepatocytes; Insulin; Leucine; Liver; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Atrophy; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Biosynthesis; Protein Kinases; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin-Protein Ligases	2007
Effect of branched-chain amino acids on muscle atrophy in cancer cachexia. The Biochemical journal, 2007, Oct-01, Volume: 407, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Amino Acids, Branched-Chain; Animals; Cachexia; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Eukaryotic Initiation Factors; Leucine; Mice; Mice, Inbred Strains; Muscular Atrophy; Myoblasts; Neoplasms; Phosphoproteins; Phosphorylation; Protein Kinases; Proteoglycans; Time Factors; Valine	2007
Supplementation with dietary leucine to a protein-deficient diet suppresses myofibrillar protein degradation in rats. Journal of nutritional science and vitaminology, 2007, Volume: 53, Issue:6 Topics: Animal Feed; Animals; Body Weight; Diet, Protein-Restricted; Dietary Proteins; Dietary Supplements; Leucine; Muscle Proteins; Muscular Atrophy; Myofibrils; Protein-Energy Malnutrition; Rats; Rats, Wistar	2007
Charcot-Marie-Tooth disease type 4C4 caused by a novel Pro153Leu substitution in the GDAP1 gene. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2007, Volume: 26, Issue:2 Topics: Adult; Amino Acid Sequence; Charcot-Marie-Tooth Disease; Genotype; GTP Phosphohydrolases; Humans; Leucine; Male; Membrane Proteins; Membrane Transport Proteins; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Muscular Atrophy; Mutation; Nerve Tissue Proteins; Phenotype; Poland; Proline	2007
Decreased polysomal HSP-70 may slow polypeptide elongation during skeletal muscle atrophy. The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1 Topics: Adenosine Triphosphate; Animals; Female; Hindlimb; HSP70 Heat-Shock Proteins; Kinetics; Leucine; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Peptide Chain Elongation, Translational; Phosphorylation; Phosphothreonine; Polyribosomes; Rats; Rats, Sprague-Dawley; Reference Values; Regression Analysis	1995
Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:7 Topics: Animals; Calpain; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Precursors; Hindlimb Suspension; Leucine; Ligases; Models, Biological; Multienzyme Complexes; Muscle, Skeletal; Muscular Atrophy; Myosin Heavy Chains; Proteasome Endopeptidase Complex; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Space Flight; Ubiquitins; Weightlessness; Weightlessness Simulation	2001
The incorporation of 3H (G) L-leucine into single muscle fibers in Duchenne dystrophy and Charcot-Marie Tooth disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1979, Volume: 6, Issue:1 Topics: Adolescent; Adult; Biopsy; Charcot-Marie-Tooth Disease; Humans; In Vitro Techniques; Leucine; Middle Aged; Muscles; Muscular Atrophy; Muscular Dystrophies	1979
The uptake of 3H(G)L leucine into single muscle fibers in Charcot-Marine-Tooth disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1978, Volume: 5, Issue:2 Topics: Charcot-Marie-Tooth Disease; Histocytochemistry; Humans; Leg; Leucine; Motor Neurons; Muscles; Muscular Atrophy; Neuromuscular Diseases	1978
Changes in axonal transport during regeneration of feline ventral roots. Journal of the neurological sciences, 1971, Volume: 14, Issue:1 Topics: Acetylcholinesterase; Acyltransferases; Animals; Axonal Transport; Axons; Cats; Electromyography; Leucine; Locomotion; Muscle Denervation; Muscular Atrophy; Nerve Regeneration; Nerve Tissue Proteins; Organ Size; Sciatic Nerve; Spinal Nerve Roots; Spinal Nerves; Time Factors; Tritium	1971
The range of velocities of axoplasmic flow. A new approach, and its application to mice with genetically inherited spinal muscular atrophy. Brain research, 1971, Dec-10, Volume: 35, Issue:1 Topics: Animals; Axonal Transport; Leucine; Mice; Muscular Atrophy; Neurons; Peripheral Nerves; Sciatic Nerve; Spinal Cord; Tritium	1971
A new polygenic disturbance: cystinuria, leucinuria and spinal muscular atrophy. Journal of neurology, 1974, Volume: 207, Issue:1 Topics: Acromegaly; Adolescent; Amino Acid Metabolism, Inborn Errors; Biopsy; Child; Creatine Kinase; Cystinuria; Electromyography; Female; Humans; Leucine; Microscopy, Electron; Muscles; Muscular Atrophy; Pedigree; Spinal Cord Diseases; Syndrome	1974
Evidence suggesting a retardation of denervation atrophy upon injection of trophic brain proteolipids. Life sciences, 1968, Nov-15, Volume: 7, Issue:22 Topics: Animals; Brain Chemistry; Carbon Isotopes; Female; Growth Substances; Injections, Intramuscular; Leucine; Lipids; Male; Muscle Denervation; Muscle Proteins; Muscles; Muscular Atrophy; Rats	1968
Protein turnover in skeletal muscle. II. Effects of denervation and cortisone on protein catabolism in skeletal muscle. The Journal of biological chemistry, 1969, Jun-25, Volume: 244, Issue:12 Topics: Animals; Cortisone; Depression, Chemical; Leucine; Muscle Denervation; Muscle Proteins; Muscles; Muscular Atrophy; Myofibrils; Pituitary Gland; Rats; Sciatic Nerve; Solubility; Time Factors; Tritium	1969