leucine has been researched along with Lung Neoplasms in 79 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 26 (32.91) | 18.7374 |
1990's | 14 (17.72) | 18.2507 |
2000's | 15 (18.99) | 29.6817 |
2010's | 12 (15.19) | 24.3611 |
2020's | 12 (15.19) | 2.80 |
Authors | Studies |
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Kovács, A; Kurucz, I; Lázár, J; Takács, L; Tornyi, I | 1 |
He, KM; Pu, JT; Teng, ZY; Wu, YF; Zhang, DG; Zhang, T | 1 |
Chen, W; Hou, R; Li, Q; Liang, H; Yang, Y; Zhang, Y | 1 |
Chen, Q; Chen, X; Ge, P; Wu, B; Zhang, P | 1 |
Liang, L; Wang, X; Yin, W | 1 |
Ma, X; Wei, Y; Yang, Z; Zhang, W; Zhou, F | 1 |
Dang, K; Li, Y; Liu, L; Wang, X; Xu, H; Xu, X; Yan, X; Zhang, Y | 1 |
Fan, K; Huang, A; Li, C; Li, J; Wan, L; Xing, S; Zhai, W | 1 |
Ding, GG; Ling, XA; Wan, J; Wang, J; Wang, X | 1 |
Hu, X; Huang, S; Mao, T; Su, T; Xiong, H; Yang, L | 1 |
Chingin, K; Feng, S; Huang, K; Li, Y; Lu, H; Wei, Y; Zhang, H | 1 |
Chen, J; Chen, PR; Guan, J; Li, Y; Liu, Y; Luo, R; Ou, Y; Wang, D; Wang, J; Xia, P | 1 |
Cao, J; Ding, Q; Gao, Q; Gao, S; Kong, X; Liang, X; Ma, C; Wang, B; Xu, W; Yan, Y; Zang, J; Zhang, Y; Zhao, C | 1 |
Creighton, CJ; Fradette, JJ; Gibbons, DL; Gibson, LA; Grzeskowiak, CL; Kundu, ST; Rodriguez, LB; Scott, KL | 1 |
Hu, Y; Liang, Z; Liu, J; Shan, Y; Sui, Z; Zhang, L; Zhang, Y; Zhao, B; Zhou, Y | 1 |
Allegra, M; Bahadoran, P; Ballotti, R; Giacchero, D; Hofman, P; Lacour, JP; Le Duff, F; Long-Mira, E; Passeron, T | 1 |
Bogdanovic, G; De Rosa, S; Iodice, C; Kojic, V; Pejin, B; Tommonaro, G | 1 |
Cui, DX; Gao, ZQ; Guo, XX; Liu, SM; Ma, WQ; Wang, B; Wang, XJ; Zhang, XR; Zhao, TK | 1 |
Li, Y; Liu, XJ; Wu, SY; Zhen, YS; Zheng, YB | 1 |
Cao, J; Huang, Y; Li, Y; Liang, X; Ma, C; Wu, P; Xu, W; Zhang, Y | 1 |
Amighi, K; Langer, I; Mathieu, V; Mathivet, T; Rosière, R; Van Woensel, M; Vermeersch, M; Wauthoz, N | 1 |
Lin, R; Ling, YH; Perez-Soler, R | 1 |
Glinskii, AB; Glinskii, OV; Glinsky, GV; Glinsky, VV; Huxley, VH; Kiriakova, G; Mawhinney, TP; Mossine, VV; Price, JE; Turk, JR | 1 |
Ito, S; Miyahara, R; Nagai, S; Takahashi, R; Takenaka, K; Tanaka, F; Wada, H | 1 |
Chen, B; Li, Y; Qiu, LX; Wang, XL; Wu, JQ; Xu, W; Zhao, WH | 1 |
Imai, H; Ishizuka, T; Kaira, K; Kanai, Y; Mori, M; Nagamori, S; Nakajima, T; Oriuchi, N; Promchan, K; Shimizu, K; Sunaga, N; Tominaga, H; Yamamoto, N; Yanagitani, N | 1 |
Bird, SP; Keogh, JW; MacLeod, RD; Rogers, ES; Stewart, J | 1 |
Genka, K; Ichinose, Y; Iioka, S; Kato, H; Koike, T; Mori, T; Ohta, M; Sakuma, A; Watanabe, Y | 1 |
LORINCZ, AB; RYAN, WL | 1 |
Golouh, R; Jeras, M; Kos, J; Langerholc, T; Premzl, A; Repnik, U; Sekirnik, A; Turk, B; Turk, V; Werle, B; Zavasnik Bergant, V | 1 |
Glinskii, OV; Glinsky, GV; Glinsky, VV; Huxley, VH; Pienta, KJ; Raz, A | 1 |
Abe, F; Ichimura, E; Nakajima, T; Nishikawa, K; Yamada, M | 1 |
Degani, H; Eshhar, Z; Kalchenko, V; Makovitzki, A; Papo, N; Seger, D; Shai, Y | 1 |
Fukuhara, T; Inoue, A; Kimura, Y; Maemondo, M; Morikawa, N; Nukiwa, T; Saijo, Y; Suzuki, T; Watanabe, H | 1 |
Frederiksen, K; Hansen, RD; Overvad, K; Raaschou-Nielsen, O; Sørensen, M; Tjønneland, A; Vogel, U | 1 |
Asahina, H; Dosaka-Akita, H; Kinoshita, I; Nishimura, M; Yamazaki, K; Yokouchi, H | 1 |
Agulnik, JS; Batist, G; Chong, G; Cohen, V; Jarry, J; Kreisman, H; Miller, WH; Small, D; Tejada, NA | 1 |
Fukui, T; Furuta, K; Kunitoh, H; Matsuno, Y; Nokihara, H; Ohe, Y; Sakamoto, H; Sekine, I; Takano, T; Tamura, T; Tateishi, U; Tsuta, K; Yamamoto, N; Yoshida, T | 1 |
Edwards, RH; Emery, PW; Halliday, D; Rennie, MJ; Souhami, RL | 1 |
Banks, WL; Chan, W; Kaplan, AM; McElhanon, S | 1 |
Ashida, C; Gose, K; Hamada, F; Ichiyanagi, A; Imajo, Y; Imanaka, K; Inomata, Y; Kimura, S; Ogawa, Y; Takada, Y | 1 |
Aaronson, SA; Dunn, CY; Reddy, EP; Rhim, JS; Srivastava, SK; Yuasa, Y | 1 |
Leibovici, J; Susskind-Brudner, G; Wolman, M | 1 |
Umezawa, H | 1 |
Fukuoka, M; Furuse, K; Genka, K; Ishikawa, S; Kato, H; Kinuwaki, E; Nakai, H; Nakano, M; Ohta, M; Tsubura, E | 1 |
Lauber, B; Mórocz, IA; Schmitter, D; Stahel, RA | 1 |
Dobashi, K; Ezawa, K; Minato, K | 1 |
Glinsky, GV; Glinsky, VV; Kiriakova, G; Metcalf, JB; Mossine, VV; Price, JE | 1 |
Ebert, W; Jülke, B; Lah, T; Spiess, E; Werle, B | 1 |
Houlston, RS | 1 |
Richardson, AP; Tayek, JA | 1 |
Kanno, T; Oh-Uchi, A; Sudo, K | 1 |
Bourrillon, R; Jouanneau, J; Le François, D; Vilarem, MJ | 1 |
Grimm, EA; Morton, DL; Roth, JA | 1 |
Feldman, M; Schechter, B; Treves, AJ | 1 |
Arima, T; Fujii, S; Niinobe, M; Okuda, H; Tamura, Y | 1 |
Boddie, AW; Holmes, EC; Morton, DL; Roth, JA | 1 |
Jani, JP; Lazo, JS; Mistry, JS; Morris, G; Sebti, SM | 1 |
Korchinskiĭ, AG; Kusen', SI; Stoĭka, RS | 1 |
Brennan, MF; Heslin, MJ; Newman, E; Pisters, PW; Wolf, RF | 1 |
Cordell, GA; Pezzuto, JM; Shieh, HL | 1 |
Mouritzen, C | 1 |
Fukuoka, M; Kudo, S; Kusunoki, Y; Masuda, N; Matsui, K; Negoro, S; Ryu, S; Sakai, N; Takada, M; Takifuji, N | 1 |
Kotake, Y; Nakano, N; Ohshima, S; Tominaga, S; Yasumitsu, T | 1 |
Abe, F; Black, PL; Pelus, LM; Talmadge, JE | 1 |
Calder, AG; Garlick, PJ; McNurlan, MA; Melville, S | 1 |
Aquino, S; Young, ME; Young, MR | 1 |
Cotelingam, JD; Funa, K; Gazdar, AF; Linnoila, RI; Matthews, MJ; Mulshine, JL; Steinberg, SM | 1 |
Abe, F; Alvord, G; Koyama, M; Matsuda, A; Talmadge, JE | 1 |
Newby, M; Wepsic, HT; Young, MR | 1 |
Ahsan, A; Bain, DL; Ostrowski, LE; Pagast, P; Patel, A; Schultz, RM; Suthar, BP; Wong, C | 1 |
Schirrmacher, V; Schwartz, R; Toomes, H; Walk, A | 1 |
Beck, C; Burger, HG; Greenberg, PB; Martin, TJ | 1 |
Greenwood, FC; Howorth, PJ; Marks, V; Samols, E | 1 |
Lombardini, JB; Talalay, P | 1 |
Ludueña, MA; Rabson, AS; Sussman, HH | 1 |
Beckman, L; Lundgren, E; Rydelius, PA | 1 |
Klein, LA; Rabson, AS; Worksman, J | 1 |
Bojan, O; Mustea, I; Preda, N | 1 |
3 review(s) available for leucine and Lung Neoplasms
Article | Year |
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Efficacy of Standardised Treatments Combined with Ubenimex in Patients with Malignant Tumors.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Leucine; Lung Neoplasms; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Survival Rate | 2021 |
The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: evidence from 6501 subjects.
Topics: Adenocarcinoma; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1B1; Ethnicity; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Lung Neoplasms; Penetrance; Polymorphism, Genetic; Risk; Smoking; Valine | 2010 |
CYP1A1 polymorphisms and lung cancer risk: a meta-analysis.
Topics: Adult; Aged; Aged, 80 and over; Cytochrome P-450 CYP1A2; Deoxyribonuclease HpaII; Female; Genetic Predisposition to Disease; Humans; Isoleucine; Leucine; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Risk Factors | 2000 |
7 trial(s) available for leucine and Lung Neoplasms
Article | Year |
---|---|
A randomised feasibility study of EPA and Cox-2 inhibitor (Celebrex) versus EPA, Cox-2 inhibitor (Celebrex), resistance training followed by ingestion of essential amino acids high in leucine in NSCLC cachectic patients--ACCeRT study.
Topics: Adult; Amino Acids, Essential; Cachexia; Carcinoma, Non-Small-Cell Lung; Celecoxib; Combined Modality Therapy; Cyclooxygenase 2 Inhibitors; Dietary Supplements; Eicosapentaenoic Acid; Feasibility Studies; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; New Zealand; Patient Satisfaction; Prospective Studies; Pyrazoles; Resistance Training; Sulfonamides | 2011 |
Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Confidence Intervals; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Protease Inhibitors; Survival Analysis; Time Factors; Treatment Failure; Treatment Outcome | 2003 |
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Arginine; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Feasibility Studies; Female; Gefitinib; Glutamic Acid; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Neoplasm Staging; Positron-Emission Tomography; Prospective Studies; Quinazolines; Treatment Outcome | 2006 |
[Double blind controlled study of ubenimex (Bestatin) against squamous cell lung cancer--a multicenter cooperative study].
Topics: Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Double-Blind Method; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Radiotherapy Dosage; Survival Rate | 1993 |
Bestatin as adjuvant treatment in operated stage I and stage II non-small cell lung cancer. European Lung Cancer Study Group.
Topics: Aged; Antibiotics, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Humans; Leucine; Lung Neoplasms; Lymph Nodes; Neoplasm Staging; Survival Analysis | 1990 |
Combination therapy with bestatin in inoperable lung cancer. A randomized trial.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Survival Analysis | 1990 |
Bestatin in resected lung cancer. A randomized clinical trial.
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Survival Analysis | 1990 |
69 other study(ies) available for leucine and Lung Neoplasms
Article | Year |
---|---|
Detection of leucine-rich alpha-2-glycoprotein 1 containing immunocomplexes in the plasma of lung cancer patients with epitope-specific mAbs.
Topics: Antibodies, Monoclonal; Autoantibodies; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Enzyme-Linked Immunosorbent Assay; Epitopes; Glycoproteins; Humans; Immunoglobulin G; Leucine; Lung Neoplasms | 2022 |
Transient receptor potential vanilloid 4 promotes the growth of non-small cell lung cancer by regulating Foxp3.
Topics: A549 Cells; Aged; Apoptosis; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Female; Forkhead Transcription Factors; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Morpholines; Pyrroles; Sulfonamides; TRPV Cation Channels | 2022 |
An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer.
Topics: Animals; Arginine; Breast Neoplasms; Choline; Female; Glutamic Acid; Histidine; Humans; Isoleucine; Lactic Acid; Leucine; Lung Neoplasms; Metabolomics; Mice; Taurine; Valine | 2022 |
Ubenimex Combined with Pemetrexed Upregulates SOCS1 to Inhibit Lung Adenocarcinoma Progression via the JAK2-STAT3 Signaling Pathway.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Humans; Janus Kinase 2; Leucine; Lung Neoplasms; Mice; Mice, Nude; Pemetrexed; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein | 2022 |
PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins; CTLA-4 Antigen; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Glutamates; Humans; Leucine; Lung Neoplasms; Proline; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Transcription Factors | 2022 |
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19.
Topics: Adenocarcinoma of Lung; Computational Biology; COVID-19; COVID-19 Drug Treatment; Drug Combinations; Humans; Interleukin-17; Interleukin-6; Lactams; Leucine; Lung Neoplasms; Molecular Docking Simulation; Network Pharmacology; Nitriles; Proline; Receptors, Cytokine; Ritonavir; SARS-CoV-2; United States | 2022 |
Association of plasma branched-chain amino acid with multiple cancers: A mendelian randomization analysis.
Topics: Amino Acids, Branched-Chain; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Genome-Wide Association Study; Humans; Isoleucine; Leucine; Lung Neoplasms; Mendelian Randomization Analysis; Valine | 2023 |
MicroRNA-125a attenuates the chemoresistance against ubenimex in non-small cell lung carcinoma via targeting the aminopeptidase N signaling pathway.
Topics: Antibiotics, Antineoplastic; Apoptosis; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; CD13 Antigens; Cell Cycle; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; MicroRNAs; Prognosis; Tumor Cells, Cultured | 2020 |
Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P-glycoprotein expression level in non-small lung cancer.
Topics: A549 Cells; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; Mice, Inbred C57BL; Mice, Nude; RNA, Messenger | 2020 |
Direct quantitative profiling of amino acids in tissues for the assessment of lung cancer.
Topics: Alanine; Amino Acids; Humans; Isoleucine; Leucine; Lung Neoplasms; Lysine | 2021 |
SAR1B senses leucine levels to regulate mTORC1 signalling.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Conserved Sequence; GTP Phosphohydrolases; HEK293 Cells; Humans; Leucine; Longevity; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mice; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Nuclear Proteins; Protein Binding; Signal Transduction; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2021 |
Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry.
Topics: Animals; Antineoplastic Agents; Binding Sites; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Docking Simulation; Neovascularization, Physiologic; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship | 2018 |
TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
Topics: Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Calcium; Cathepsins; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Exocytosis; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lung Neoplasms; Lysosomes; Membrane Proteins; Mice; Neoplasm Metastasis; Nerve Tissue Proteins; Prognosis; Protein Isoforms; Proteolysis; Signal Transduction; Survival Analysis; Xenograft Model Antitumor Assays | 2018 |
A Multiplex Fragment-Ion-Based Method for Accurate Proteome Quantification.
Topics: A549 Cells; Adenocarcinoma of Lung; Epithelial-Mesenchymal Transition; Escherichia coli; Escherichia coli Proteins; Humans; Isotope Labeling; Leucine; Lung Neoplasms; Neoplasm Proteins; Peptide Fragments; Proteome; Transforming Growth Factor beta | 2019 |
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
Topics: Aged; Antineoplastic Agents; Arginine; Back; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Indoles; Leucine; Lung Neoplasms; MAP Kinase Signaling System; Melanoma; Niacinamide; Oximes; Phenylurea Compounds; Point Mutation; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sorafenib; Sulfonamides; Vemurafenib | 2013 |
Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone.
Topics: Animals; Antineoplastic Agents; Biological Products; Cyclohexenes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Leucine; Lung Neoplasms; Male; Molecular Structure; Porifera; Quinones; Sesquiterpenes | 2014 |
Preliminary detection of the anti‑tumour activity of indoline‑2,3‑dione derivative DH‑12a targeting aminopeptidase N.
Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Hydroxamic Acids; Indoles; Inhibitory Concentration 50; Leucine; Lung Neoplasms; Mice; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Dexamethasone; Dipyridamole; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Tumor Microenvironment; Vasodilator Agents; Xenograft Model Antitumor Assays | 2014 |
Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.
Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship | 2016 |
Development and evaluation of well-tolerated and tumor-penetrating polymeric micelle-based dry powders for inhaled anti-cancer chemotherapy.
Topics: Administration, Inhalation; Animals; Antineoplastic Agents, Phytogenic; Bronchoalveolar Lavage Fluid; Cell Count; Cell Line, Tumor; Cell Survival; Cytokines; Dextrans; Drug Liberation; Female; Folic Acid; Humans; Leucine; Lung Neoplasms; Mannitol; Mice; Mice, Inbred BALB C; Micelles; Paclitaxel; Polyethylene Glycols; Powders | 2016 |
Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK.
Topics: Amino Acid Substitution; Apoptosis; Arginine; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Cell Line, Tumor; Down-Regulation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Humans; Leucine; Lung Neoplasms; Mitochondria; Mutation; Oxidative Phosphorylation; Protein Structure, Quaternary; Protein Transport; Quinazolines; Reactive Oxygen Species; RNA, Small Interfering | 2008 |
Synthetic galectin-3 inhibitor increases metastatic cancer cell sensitivity to taxol-induced apoptosis in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Breast Neoplasms; Drug Combinations; Galactosides; Galectin 3; Humans; In Vitro Techniques; Leucine; Lung Neoplasms; Membrane Potential, Mitochondrial; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2009 |
Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; CD13 Antigens; Chemotherapy, Adjuvant; Female; Fibroblasts; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Leucine; Lung Neoplasms; Lymph Node Excision; Male; Microvessels; Middle Aged; Neovascularization, Pathologic; Pneumonectomy; Retrospective Studies; Time Factors; Treatment Outcome | 2009 |
Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Cyclic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; ErbB Receptors; Fusion Regulatory Protein-1; Gefitinib; Humans; Immunohistochemistry; Large Neutral Amino Acid-Transporter 1; Leucine; Lung Neoplasms; Middle Aged; Mutation; Quinazolines; RNA, Messenger; TOR Serine-Threonine Kinases | 2010 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.
Topics: Antibodies, Monoclonal; Antibody Specificity; Carboxypeptidases; Cathepsin B; Cathepsin K; Cathepsins; Cell Line, Tumor; Cell Movement; Collagen; Cysteine Proteinase Inhibitors; Cytosol; Dendritic Cells; Drug Combinations; Flow Cytometry; Humans; Immunohistochemistry; Laminin; Leucine; Lung; Lung Neoplasms; Lymph Nodes; Monocytes; Neoplasm Invasiveness; Proteoglycans; U937 Cells | 2005 |
Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Bone Neoplasms; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Citrus; Female; Galectin 3; Humans; Leucine; Lung Neoplasms; Male; Mice; Mice, Inbred ICR; Mice, SCID; Neoplasm Metastasis; Neoplasm Transplantation; Pectins; Prostatic Neoplasms | 2005 |
Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; CD13 Antigens; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Leucine; Lung Neoplasms; Male; Middle Aged; Tissue Array Analysis | 2006 |
Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Female; Humans; Leucine; Lung Neoplasms; Lysine; Male; Membrane Potentials; Mice; Mice, SCID; Neoplasm Metastasis; Peptides; Phosphatidylserines; Prostate-Specific Antigen; Prostatic Neoplasms; Xenograft Model Antitumor Assays | 2006 |
GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer.
Topics: Alcohol Drinking; Cohort Studies; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Lung Neoplasms; Middle Aged; Polymorphism, Genetic; Proline; Risk Factors; Smoking | 2007 |
Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
Topics: Adenocarcinoma; DNA, Neoplasm; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Isoleucine; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Quinazolines; Serine; Valine | 2006 |
Evaluation of denaturing high-performance liquid chromatography as a rapid detection method for identification of epidermal growth factor receptor mutations in nonsmall-cell lung cancer.
Topics: Arginine; Carcinoma, Non-Small-Cell Lung; Chromatography, High Pressure Liquid; DNA Mutational Analysis; ErbB Receptors; Humans; Leucine; Lung Neoplasms; Mutation; Nucleic Acid Denaturation; Sensitivity and Specificity | 2006 |
Epidermal growth factor receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non small cell lung cancer treated with gefitinib.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antineoplastic Agents; Arginine; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; DNA Mutational Analysis; ErbB Receptors; Female; Gefitinib; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Mutation; Prognosis; Quinazolines; Survival Analysis; Treatment Outcome | 2007 |
Protein synthesis in muscle measured in vivo in cachectic patients with cancer.
Topics: Aged; Cachexia; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Humans; Kidney Neoplasms; Leucine; Lung Neoplasms; Male; Middle Aged; Muscle Proteins; Neoplasms; Protein Biosynthesis; Wilms Tumor | 1984 |
Effects of three feeding schedules on tumor and host of Lewis lung carcinoma-bearing mice.
Topics: Animals; Body Weight; DNA, Neoplasm; Eating; Energy Intake; Female; Leucine; Liver; Lung Neoplasms; Mice; Mice, Inbred C57BL; Muscles; Neoplasm Proteins; RNA, Neoplasm; Time Factors | 1984 |
[Clinical evaluation of bestatin (NK-421) supplementing radiotherapy in the treatment of lung cancer].
Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Leucine; Lung Neoplasms; Male; Middle Aged; Radiotherapy Dosage | 1983 |
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.
Topics: Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cloning, Molecular; Glutamine; Humans; Leucine; Lung Neoplasms; Mutation; Oncogenes; Proto-Oncogene Mas; Urinary Bladder Neoplasms | 1983 |
Direct antitumor effect of high-molecular-weight levan on Lewis lung carcinoma cells in mice.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Survival; Cells, Cultured; DNA, Neoplasm; Fructans; Leucine; Lung Neoplasms; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Polysaccharides; Thymidine; Transplantation, Isogeneic; Uridine | 1980 |
Recent studies on antibiotics and small molecular immunomodulators with potential usefulness in treating lung cancer: Part II - Small molecular weight immunomodulators produced by microorganisms.
Topics: Adjuvants, Immunologic; Aminopeptidases; Animals; Antibiotics, Antineoplastic; Drug Evaluation, Preclinical; Humans; Immunity, Cellular; Leucine; Lung Neoplasms; Mice; Molecular Weight; Neoplasms, Experimental | 1982 |
In vitro effect of suramin on lung tumour cells.
Topics: DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Leucine; Lung Neoplasms; Suramin; Thymidine; Time Factors; Tumor Cells, Cultured | 1993 |
Induction of apoptosis by ubenimex (Bestatin) in human non-small-cell lung cancer cell lines.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Squamous Cell; Cell Division; DNA Fragmentation; Humans; Leucine; Lung Neoplasms; Tumor Cells, Cultured | 1996 |
Inhibition of human breast cancer metastasis in nude mice by synthetic glycoamines.
Topics: Amino Acids; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Drug Screening Assays, Antitumor; Female; Glycoconjugates; Humans; Lectins; Leucine; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Peanut Agglutinin; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cathepsin B; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leucine; Lung; Lung Neoplasms; Middle Aged; Prognosis; Substrate Specificity; Survival Analysis | 1997 |
Type 2 diabetic patients may have a mild form of an injury response: a clinical research center study.
Topics: Acute-Phase Reaction; Adult; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Glucagon; Gluconeogenesis; Humans; Hydrocortisone; Insulin; Interleukin-6; Leucine; Lung Neoplasms; Middle Aged; Triiodothyronine; Tumor Necrosis Factor-alpha | 2002 |
[Properties of alkaline phosphatase found in the pleural fluid of the patient with lung cancer: its L-leucine sensitivity and differences of electrophoretic mobility in the broad beta regions (author's transl)].
Topics: Alkaline Phosphatase; Electrophoresis; Female; Humans; Leucine; Lung Neoplasms; Middle Aged; Pleural Effusion | 1979 |
Differential effects of lectins on the in vitro growth of normal mouse lung cells and low- and high-cancer-derived cell lines.
Topics: Animals; Cell Division; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Concanavalin A; Lectins; Leucine; Lung; Lung Neoplasms; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Thymidine; Time Factors; Transplantation, Isogeneic | 1978 |
A rapid assay for stimulation of human lymphocytes by tumor-associated antigens.
Topics: Antigens, Neoplasm; Carcinoma; Female; Hemagglutination Tests; Hemocyanins; Humans; Leucine; Lung; Lung Neoplasms; Lymphocyte Activation; Lymphocytes; Male; Melanoma; Neoplasm Proteins; Neoplasms; Protein Biosynthesis; Sarcoma; Skin Tests; Thymidine | 1976 |
Specific cytotoxicity in vitro of lymphocytes sensitized in culture against tumor cells.
Topics: Animals; Antigens, Neoplasm; Carcinoma; Cell Survival; Cytotoxicity Tests, Immunologic; DNA, Neoplasm; Leucine; Lung Neoplasms; Lymphocytes; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Experimental; Spleen | 1976 |
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Topics: Alanine; Amides; Aminopeptidases; Colon; Digestive System; Humans; Ileum; Kidney; Leucine; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Methionine; Naphthalenes; Neoplasms; Phenylalanine; Rectum; Stomach; Stomach Neoplasms | 1975 |
Lymphocyte responses of lung cancer patients to tumor-associated antigen measured by leucine incorporation.
Topics: Adenocarcinoma; Antigens, Neoplasm; Carcinoma, Squamous Cell; Humans; Leucine; Lung Neoplasms; Lymphocytes; Male; Neoplasm Proteins; Potassium Chloride; Tissue Extracts | 1975 |
In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64.
Topics: Animals; Bleomycin; Cell Line; Cysteine Proteinase Inhibitors; Drug Administration Schedule; Drug Resistance; Female; Humans; Leucine; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 1992 |
[Heat shock modulates the ability of A-549 cell line from human lung adenocarcinoma to regulate the intensity of DNA and protein biosynthesis by an autocrine mechanism].
Topics: Adenocarcinoma; DNA, Neoplasm; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; Hormones; Hot Temperature; Humans; Leucine; Lung Neoplasms; Neoplasm Proteins; Thymidine; Tumor Cells, Cultured | 1992 |
Effect of systemic hyperinsulinemia in cancer patients.
Topics: Body Weight; Female; Gastrointestinal Neoplasms; Glucose; Humans; Hyperinsulinism; Leucine; Lung Neoplasms; Male; Middle Aged; Proteins | 1992 |
Evaluation of the cytotoxic mechanisms mediated by the broad-spectrum antitumor alkaloid acronycine and selected semisynthetic derivatives.
Topics: Acronine; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line; Cell Nucleus; Cell Survival; DNA Replication; DNA-Directed RNA Polymerases; Drug Screening Assays, Antitumor; Female; Humans; Kinetics; Leucine; Lung Neoplasms; Male; Melanoma; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; RNA, Neoplasm; Thymidine; Tumor Stem Cell Assay; Uridine | 1992 |
Hematopoietic and hematologic properties of bestatin in normal and cyclophosphamide myelosuppressed mice.
Topics: Aminopeptidases; Animals; Bone Marrow; Cell Count; Cyclophosphamide; Drug Therapy, Combination; Hematopoietic Stem Cells; Immune Tolerance; Leucine; Lung Neoplasms; Melanoma, Experimental; Mice | 1990 |
Increased protein turnover despite normal energy metabolism and responses to feeding in patients with lung cancer.
Topics: Aged; Carbohydrate Metabolism; Energy Intake; Energy Metabolism; Female; Humans; Leucine; Lipid Metabolism; Lung Neoplasms; Male; Middle Aged; Proteins; Weight Loss | 1990 |
Differential induction of hematopoiesis and immune suppressor cells in the bone marrow versus in the spleen by Lewis lung carcinoma variants.
Topics: Animals; Antibodies, Anti-Idiotypic; Bone Marrow; Cell Adhesion; Cell Division; Hematopoiesis; Indomethacin; Leucine; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Spleen; T-Lymphocytes, Regulatory | 1989 |
Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas.
Topics: Adenocarcinoma; Biomarkers, Tumor; Carcinoembryonic Antigen; Carcinoid Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Chromogranin A; Chromogranins; Humans; Leucine; Lung Neoplasms; Phosphopyruvate Hydratase | 1988 |
Pharmacokinetics of bestatin and oral activity for treatment of experimental metastases.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Drug Administration Schedule; Injections, Intravenous; Leucine; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL | 1989 |
Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors.
Topics: Animals; Bone Marrow; Cell Adhesion; Cells, Cultured; Colony-Stimulating Factors; Complement System Proteins; Hematopoiesis; Hematopoietic Stem Cells; Immune Tolerance; Indomethacin; Isoantibodies; Leucine; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes, Regulatory | 1987 |
Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis.
Topics: Animals; Cathepsin B; Cathepsins; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endopeptidases; Female; Fibrinolysis; Leucine; Leupeptins; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Peptide Hydrolases; Plasminogen Activators; Plasminogen Inactivators; Protease Inhibitors; Serine Endopeptidases; Thrombin; Thrombosis | 1986 |
Assay for the determination of human carcinoma cells in circulating blood.
Topics: Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Cell Line; Centrifugation, Density Gradient; Colonic Neoplasms; Female; Galactose; Humans; Leucine; Leukocytes; Lung Neoplasms; Male; Middle Aged; Neoplastic Cells, Circulating; Thymidine; Tritium | 1985 |
Synthesis and release of human growth hormone from lung carcinoma in cell culture.
Topics: Aged; Blood Glucose; Carbon Isotopes; Carcinoma; Cells, Cultured; Chromatography, Gel; Chromatography, Paper; Culture Media; Female; Growth Hormone; Hormones, Ectopic; Humans; Leucine; Lung; Lung Neoplasms; Osteoarthropathy, Secondary Hypertrophic; Radioimmunoassay | 1972 |
Plasma growth hormone levels in spontaneous hypoglycemia.
Topics: Adenoma, Islet Cell; Adrenal Gland Diseases; Adult; Aged; Carcinoma; Cholangitis; Deficiency Diseases; Fasting; Female; Fluorometry; Glucose; Glucose Tolerance Test; Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Immunoassay; Insulin; Leucine; Lung Neoplasms; Male; Middle Aged; Pancreatitis; Sertoli-Leydig Cell Tumor; Stomach Neoplasms; Tolbutamide | 1967 |
Effect of inhibitors of adenosine triphosphate: L-methionine S-adenosyltransferase on levels of S-adenosyl-L-methionine and L-methionine in normal and malignant mammalian tissues.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Caproates; Carbon Isotopes; Carcinoma 256, Walker; Female; Leucine; Leukemia L1210; Lung Neoplasms; Male; Melanoma; Methionine; Mice; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Rats; S-Adenosylmethionine; Time Factors; Transferases; Tritium | 1973 |
Synthesis of human placental alkaline phosphatase in vitro by the ChaGo cell line.
Topics: Alkaline Phosphatase; Cell Line; Cells, Cultured; Chorionic Gonadotropin; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Hormones, Ectopic; Hot Temperature; Humans; Immunoassay; Leucine; Lung Neoplasms; Molecular Weight; Phenylalanine; Placenta | 1974 |
Amino acid naphthylamidase isozymes in cancer cells and normal cells.
Topics: Aged; Aminopeptidases; Autopsy; Cell Line; Cells, Cultured; Copper; Electrophoresis; Female; Gels; Humans; Isoenzymes; Leucine; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Middle Aged; Naphthalenes; Neoplasm Metastasis; Neoplasms; Starch; Tissue Extracts | 1971 |
In vitro synthesis of vasopressin by lung tumor cells.
Topics: Carbon Isotopes; Carcinoma, Bronchogenic; Humans; Hyperaldosteronism; Leucine; Lung Neoplasms; Male; Middle Aged; Radioimmunoassay; Tritium; Tyrosine; Vasopressins | 1969 |
[Modification of some free amino acids in the serum of cancer patients under the influence of glucose on tumoral metabolism].
Topics: Alanine; Amino Acids; Breast Neoplasms; Chromatography, Paper; Dietary Carbohydrates; Dietary Proteins; Female; Gastrointestinal Neoplasms; Glucose; Glycolysis; Leucine; Lung Neoplasms; Lysine; Neoplasm Metastasis; Perfusion; Stimulation, Chemical; Uterine Neoplasms; Valine | 1969 |