leucine has been researched along with Disease Models, Animal in 218 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (16.06) | 18.7374 |
| 1990's | 21 (9.63) | 18.2507 |
| 2000's | 45 (20.64) | 29.6817 |
| 2010's | 95 (43.58) | 24.3611 |
| 2020's | 22 (10.09) | 2.80 |
| Authors | Studies |
|---|---|
| Avdeef, A; Tam, KY | 1 |
| Allerton, C; Anderson, AS; Anson, BJ; Arenson, D; Aschenbrenner, L; Bakowski, MA; Beutler, N; Binder, J; Boras, B; Chatterjee, AK; Chen, E; Eng, H; Frieman, MB; García-Sastre, A; Hammond, H; Hammond, J; Haupt, RE; Hoffman, R; Jones, RM; Kadar, EP; Kania, R; Kimoto, E; Kirkpatrick, MG; Lanyon, L; Lendy, EK; Lillis, JR; Logue, J; Luthra, SA; Ma, C; Mason, SW; McGrath, ME; Mesecar, AD; Noell, S; O' Brien, MN; O'Connor, R; Obach, RS; Ogilvie, K; Owen, D; Pettersson, M; Reese, MR; Rogers, TF; Rosales, R; Rossulek, MI; Sathish, JG; Shirai, N; Steppan, C; Ticehurst, M; Updyke, LW; Wang, J; Weston, S; White, KM; Zhu, Y | 1 |
| Allerton, CMN; Anderson, AS; Aschenbrenner, L; Avery, M; Berritt, S; Boras, B; Cardin, RD; Carlo, A; Coffman, KJ; Dantonio, A; Di, L; Eng, H; Ferre, R; Gajiwala, KS; Gibson, SA; Greasley, SE; Hurst, BL; Kadar, EP; Kalgutkar, AS; Lee, J; Lee, JC; Liu, W; Mason, SW; Noell, S; Novak, JJ; Obach, RS; Ogilvie, K; Owen, DR; Patel, NC; Pettersson, M; Rai, DK; Reese, MR; Sammons, MF; Sathish, JG; Singh, RSP; Steppan, CM; Stewart, AE; Tuttle, JB; Updyke, L; Verhoest, PR; Wei, L; Yang, Q; Zhu, Y | 1 |
| Abdelnabi, R; Augustijns, P; Chatelain, E; De Jonghe, S; Escudié, F; Foo, CS; Hoglund, RM; Jochmans, D; Mols, R; Mowbray, CE; Neyts, J; Scandale, I; Sjö, P; Tarning, J; Vangeel, L; Wattanakul, T; Weynand, B | 1 |
| Burlin, TV; Loutaev, I; Schmidt, KC; Sheeler, C; Smith, CB; Thurm, A | 1 |
| Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X | 1 |
| Hossain, MZ; Mohammed Alabsi, A; Mohd Bakri, M; Ramanathan, A; Syed Abdul Rahman, SN; Yahya, F | 1 |
| Du, X; Geng, M; Huang, L; Wang, N; Wang, W; Zhang, T; Zhang, Y; Zhao, C; Zhu, C | 1 |
| Abraham, SJK; Dedeepiya, VD; Ikewaki, N; Iwasaki, M; Levy, GA; Preethy, S; Raghavan, K; Ranganathan, N; Senthilkumar, R; Srinivasan, S; Yamamoto, N | 1 |
| Abbas, A; Baldassano, RN; Bushman, FD; Bustin, KA; Di, C; Dunny, GM; Erlichman, J; Evans, DR; Furth, EE; Gaddy, JA; Green, J; Hart, JL; Jenior, ML; Keenan, O; Kelly, BJ; Laut, C; Matthews, ML; Nicholson, MR; Papin, JA; Prentice, BM; Rangel, PC; Silverman, MA; Skaar, EP; Smith, AB; Specker, J; Van Tyne, D; Zackular, JP | 1 |
| Bochicchio, D; Boutin, H; Christie, L; Herholz, K; Hinz, R; Lawrence, CB; Parker, CA | 1 |
| He, Q; Liu, S; Liu, T; Shi, K; Wei, P; Zhang, J | 1 |
| Basten, AM; Bijwadia, SR; Call, JA; Greising, SM; Lentz, MT; Lillquist, TJ; Raymond-Pope, CJ | 1 |
| Chang, YS; Chu, TH; Shih, C; Wu, SY | 1 |
| Candiotto, G; de Oliveira, J; Dos Santos, PCL; Farias, HR; Rico, EP; Ronsani, JF; Streck, EL; Wessler, LB | 1 |
| Argilès, J; Faber, J; Laviano, A; Meijerink, J; Plas, RLC; Poland, M; van Dijk, M; van Helvoort, A; van Norren, K; Witkamp, RF | 1 |
| Alcorn, JF; Fulton, WB; Hackam, DJ; Holtzman, MJ; Jia, H; Kovler, ML; Ladd, MR; Lazartigues, ED; Lu, P; Nguyen, J; Prindle, T; Sodhi, CP; Wang, S; Werts, AD; Yamaguchi, Y; Zhang, Y | 1 |
| Blaauw, B; Breen, L; Carmeliet, P; D'Hulst, G; De Bock, K; Deldicque, L; Fitzgerald, G; Kim, S; Koivunen, P; Masschelein, E; Smeuninx, B; Soro-Arnaiz, I; Veys, K; Zhao, SM | 1 |
| Picklo, MJ; Rust, BM; Yan, L | 1 |
| Crozier, SJ; D'Alecy, LG; Sans, MD; Vogel, NL; Williams, JA | 1 |
| Asao, Y; Kakae, M; Kaneko, S; Nagayasu, K; Shibasaki, K; Shirakawa, H; Tobori, S | 1 |
| Brosien, M; Chao, YK; Dietrich, A; Grimm, C; Gudermann, T; Kannler, M; Krasteva-Christ, G; Rajan, S; Schredelseker, J; Schremmer, C; Weber, J; Weissmann, N; Yildirim, AÖ | 1 |
| Loutaev, I; Saré, RM; Smith, CB; Torossian, A | 1 |
| Broersen, LM; Dyall, SC; Feichtinger, RG; Hageman, RJ; Kofler, B; Lotstra, S; Michael-Titus, AT; Paredes-Esquivel, U; Priestley, JV; Rhodes, M; Silva, JP; Svendsen, L; Thau-Zuchman, O; Tremoleda, JL; van Wijk, N; Verkuyl, JM | 1 |
| Aksentijević, D; Bridges, HR; Burger, N; Grba, DN; Hirst, J; James, AM; Krieg, T; Kula-Alwar, D; Mottahedin, A; Murphy, MP; Prag, HA; Viscomi, C; Yin, Z | 1 |
| Cribb, MT; Dixon, JB; Nicolls, MR; Rockson, SG; Sestito, LF; Thomas, SN | 1 |
| Hegdekar, N; Lipinski, MM; Sarkar, C | 1 |
| Han, L; Liang, X; Liu, S; Ma, Z; Wang, A; Wang, X; Zhang, Z; Zhao, M; Zhao, Q | 1 |
| Caldow, MK; Chee, A; Ham, DJ; Koopman, R; Lynch, GS; Naim, T; Stapleton, DI; Swiderski, K; Trieu, J | 1 |
| Dong, S; Gong, X; Huang, L; Shang, D; Wang, C; Wang, H; Zhang, L; Zhao, Y | 1 |
| Akiba, C; Arai, H; Inoue, R; Kanai, F; Kondo, A; Kunichika, M; Miura, M; Miyajima, M; Nakajima, M; Nakamura, E; Nishimura, K; Ogino, I; Sugano, H; Tada, N; Yoshida, M | 1 |
| Abudu, H; Ahemaiti, A; Aximujiang, K; Wu, G; Yunusi, K; Zhang, J | 1 |
| Kan, H; Li, H; Ma, X; Mao, A; Sun, C; Tang, C; Yang, Z; Zhang, P | 1 |
| Hartman, AL; Holden, K | 1 |
| Li, G; Liu, Y; Yan, D; Zhang, H; Zhang, Y; Zhao, L | 1 |
| Aida, T; Akiyama, Y; Arii, S; Ban, D; Kudo, A; Mitsunori, Y; Mizuno, Y; Ogawa, K; Ono, H; Shimada, S; Tanabe, M; Tanaka, S; Watanabe, S; Yamaoka, S | 1 |
| Ding, C; Do, E; Jung, WH; Kronstad, JW; Li, MH; Park, S; Wang, JM | 1 |
| Fukuda, I; Hasegawa, M; Higashino, K; Hinata, M; Horita, N; Ikeda, M; Imai, M; Imai, S; Kanemasa, T; Minami, M; Morioka, Y; Morita, A; Sakaguchi, G; Sanaki, T; Soga, M; Tsuchida, J; Yamamoto, M; Yamane, S; Yoshioka, T | 1 |
| Antoun, S; Raynard, B | 1 |
| Amat, R; Bahri, M; Barceló-Coblijn, G; Campbell, M; Carobbio, S; Dias, AR; Gray, SL; Prieur, X; Relat, J; Rodriguez-Cuenca, S; Vidal-Puig, A | 1 |
| Cao, J; Ding, Q; Gao, Q; Gao, S; Kong, X; Liang, X; Ma, C; Wang, B; Xu, W; Yan, Y; Zang, J; Zhang, Y; Zhao, C | 1 |
| Albersen, M; De Ridder, D; Deruyver, Y; Dewulf, K; Everaerts, W; Franken, J; Gevaert, T; Pinto, S; Rietjens, R; Van Ranst, N; Vanneste, M; Vennekens, R; Voets, T; Weyne, E | 1 |
| Chen, QF; Hao, H; Huang, YH; Kuang, XD; Yuan, QF; Zhang, T; Zhou, XY | 1 |
| Banks, WA; Dantzer, R; Walker, AK; Wing, EE | 1 |
| Chermansky, CJ; Kurobe, M; Kwon, J; Nishiyama, H; Okada, H; Shimizu, N; Suzuki, T; Takai, S; Takaoka, EI; Yoshimura, N | 1 |
| Ahmadieh, H; Hafezi-Moghadam, A; Ishibashi, T; Ishikawa, K; Kanavi, MR; Koga, T; Nakama, T; Nakao, S; Ohba, M; Okuno, T; Penninger, JM; Saeki, K; Sasaki, F; Sonoda, KH; Yokomizo, T; Yoshida, S | 1 |
| Brunetta, HS; de Camargo, CQ; Nunes, EA | 1 |
| Chuang, DT; Hackett, EP; Luo, W; Park, JM; Sherry, AD; Suh, EH; Wynn, RM; Zhang, B | 1 |
| Fang, S; He, H; Hua, Y; Huang, Y; Li, R; Liang, S; Liu, P; Tian, Y; Xu, F; Yang, X; Yuan, Y; Zhang, Z | 1 |
| Ding, J; Fu, K; Gan, W; Han, R; Han, X; Jiang, K; Li, D; Wu, J; Zhang, L | 1 |
| Li, XJ; Ma, L; Mou, Y; Tian, Y; Trinh, J; Wang, Y; Xu, C; Zhang, B; Zhang, X; Zhou, S | 1 |
| Ashok, A; Bajpai, S; Bieberich, CJ; De Marzo, AM; Greer, T; Hao, L; Li, L; Ricke, WA; Thomas, S; Vezina, CM | 1 |
| Bai, R; Bode, AM; Chen, H; Dong, Z; Guo, Z; Jin, G; Li, D; Liu, K; Shin, SH; Wang, G; Wu, Q; Yan, M; Yao, K; Zhao, S | 1 |
| Rehni, AK; Singh, TG | 1 |
| da Silveira, CK; de Assis, AM; Farina, M; Longoni, A; Müller, AP; Perry, ML; Souza, DO | 1 |
| Chen, Y; McIntire, KL; Rabkin, R; Sood, S | 1 |
| Raju, AB; Suresh, P | 1 |
| Bartholomae, CC; Gui, T; Hu, G; Kafri, T; Kutschera, I; Monahan, PE; Schmidt, M; Suwanmanee, T; von Kalle, C | 1 |
| Ceballos, C; Dickson, DW; Hyman, BT; Lin, WL; Polydoro, M; Ren, Y; Sahara, N; Sanchez, L; Spires-Jones, TL | 1 |
| Bannon, AW; Bespalov, A; Bitner, RS; Chu, KL; Cole, EE; Gauvin, D; Jarvis, MF; Joshi, SK; Lee, CH; Lewis, LG; McGaraughty, S; Mikusa, J; Milicic, I; Neelands, T; Niforatos, W; Pai, M; Roderwald, V; Scott, VE; Searle, XB; Swensen, AM; Vortherms, TA; Xu, J; Zhan, C; Zhang, M; Zhong, C; Zhu, CZ | 1 |
| Batlle, D; Haber, PK; Haque, SK; Maier, C; Wysocki, J; Ye, M | 1 |
| Li, Z; Ni, GX; Zhou, YZ | 1 |
| Merrill, L; Vizzard, MA | 1 |
| Han, S; Li, W; Qin, LQ; Tong, X; Xu, JY | 1 |
| Ear, J; Lin, S; Morimoto, K; Yang, Z; Zhang, B; Zhang, Y | 1 |
| Abayasekara, N; Berliner, N; Ebert, BL; Hurst, SN; Khanna-Gupta, A; Look, AT; Narla, A; Payne, EM; Raiser, DM | 1 |
| Becchetti, A; Casari, G; Gullo, F; Lecchi, M; Manfredi, I; Wanke, E | 1 |
| Goellner, JJ; Lee, SM; O'Brien, CA; Pike, JW | 1 |
| Acker, C; Azose, M; Buthorn, J; D'Abramo, C; Davies, P; Greenwald, BS; Jimenez, H; Koppel, J; Lesser, M; Lewis, J; Liu, Z | 1 |
| Cardenas, ME; Gerton, JL; Sowa, N; Xu, B | 1 |
| Caldow, MK; Ham, DJ; Koopman, R; Lynch, GS | 1 |
| Caza, M; Do, E; Hu, G; Jung, WH; Kronstad, JW; Oliveira, D | 1 |
| Chai, J; Chi, Y; Luo, H; Xu, C; Zhang, Q | 1 |
| Gao, X; Li, J; Li, N; Tian, F; Wan, X; Wang, X; Wu, C; Zhang, L; Zhao, J | 1 |
| Bennion, DM; Donnangelo, LL; Haltigan, EA; Irwin, AJ; Pioquinto, DJ; Purich, DL; Regenhardt, RW; Sumners, C | 1 |
| Amani, M; Kolahian, S; Mazadeh, A; Mirani, M; Sadri, H; Shahbazfar, AA | 1 |
| Bunnett, NW; Cygankiewicz, AI; Fichna, J; Krajewska, WM; Liedtke, W; MacEachern, SJ; Małecka-Panas, E; Mokrowiecka, A; Poole, DP; Saur, D; Sharkey, KA; Steinhoff, MS; Storr, MA; Timmermans, JP; Veldhuis, N; Zakrzewski, PK | 1 |
| Abe, H; Aikata, H; Chayama, K; Ellis, JD; Hayes, CN; Hiraga, N; Imamura, M; Ishida, Y; Kan, H; Miyaki, E; Tateno, C; Tsuge, M; Uchida, T; Yoshimi, S | 1 |
| Krag, TO; Vissing, J | 1 |
| Gaudenz, K; Gerton, JL; Gogol, M; Xu, B | 1 |
| Cruz, BL; da Silva, PC; Gomes-Marcondes, MC; Oliveira, AG; Salomao, EM; Tomasin, R; Viana, LR | 1 |
| Aereas, MA; Ferreira Ramos, LA; Gomes-Marcondes, MC; Salomão, EM; Tomasin, R; Toneto, AT | 1 |
| A Gutierrez, M; Hsu, Y; J Lopez, A; K Kennedy, B; M Nguyen, S; Mateen, S; N O'Leary, M; P Mitchell, K; Ramanathan, A; S Sonnet, D; Vockley, J | 1 |
| Gigliucci, V; Harkin, A; Sherwin, E | 1 |
| Arnér, K; Ghosh, F; Taylor, L | 1 |
| Arancio, O; Fa', M; Hidalgo, A; Liu, S; Mathews, PM; Nixon, RA; Schmidt, SD; Trinchese, F; Yamaguchi, H; Yoshii, N; Zhang, H | 1 |
| Becker, AK; Bogyo, M; Gajda, M; Peters, C; Reinheckel, T; Schurigt, U; Schwinde, A; Sevenich, L; Stahl, A; Vannier, C; von Elverfeldt, D; Werner, F | 1 |
| Biczó, G; Hegyi, P; Rakonczay, Z; Szabolcs, A; Takács, T | 1 |
| Crowley, VE; DeLong, C; Hand, E; Hatunic, M; Nolan, JJ; Stapleton, M | 1 |
| Byrnes, JJ; Connolly, K; Donahue, S; Ellard, C; Gross, S; Picarella, D | 1 |
| Hirotsune, S; Kengaku, M; Miyakawa, T; Mori, D; Sato, M; Sorimachi, H; Takao, K; Takitoh, T; Umeshima, H; Wynshaw-Boris, A; Yamada, M; Yoshida, Y | 1 |
| Darmaun, D; Marchini, JS; Oliveira, JE; Ribas, DF; Tannus, AF | 1 |
| Bradley, WG; Escala, W; Papapetropoulos, S; Zhai, RG; Zhou, X | 1 |
| Adegoke, OA; Chevalier, S; Fraser, KG; Harding, SV; Jefferson, LS; Kimball, SR; Marliss, EB; Wykes, LJ | 1 |
| Coughlin, L; Foecking, EM; Jones, KJ; Marzo, SJ; Porter, RG; Sharma, N; Tanzer, L; Wurster, RD | 1 |
| Alkam, T; Furukawa-Hibi, Y; Mizoguchi, H; Nabeshima, T; Nitta, A; Niwa, M; Yamada, K | 1 |
| Burns, KD; Dilauro, M; Genest, D; Robertson, SJ; Zimpelmann, J | 1 |
| Banales, JM; Gradilone, SA; Huang, BQ; LaRusso, NF; Lehmann, GL; Masyuk, AI; Masyuk, TV; Radtke, BN; Splinter, PL; Stroope, A | 1 |
| Chun, J; Nagai, J; Uchida, H; Ueda, H; Ueda, M; Xie, W | 1 |
| Dalrymple, SA; Elie, BT; Gocheva, V; Holsinger, LJ; Joyce, JA; Shree, T | 1 |
| MacLachlan, JN; Matushewski, B; McCallum, JD; Richardson, BS; Smith, N | 1 |
| Chan, CC; Chan, JF; Chan, KH; Chen, H; Jin, DY; Leung, VH; Poon, VK; To, KK; Woo, PC; Yuen, KY; Zhang, AJ; Zhang, K; Zheng, B; Zhou, J | 1 |
| Gardner, PD; Hendrickson, LM; Pang, X; Tapper, AR; Zhao-Shea, R | 1 |
| Carneiro, EM; de Mello, MA; de Oliveira, CA; Latorraca, MQ | 1 |
| Bartnik, E; Caglič, D; Globisch, A; Jeske, V; Juretschke, HP; Kindermann, M; Lim, NH; Nagase, H; Turk, B; Weithmann, KU; Wendt, KU | 1 |
| Boyle, SM; Rajasekaran, P; Schurig, GG; Seleem, MN; Sriranganathan, N; Surendran, N | 1 |
| Balage, M; Dardevet, D; Dupont, J; Hébuterne, X; Mothe-Satney, I; Schneider, SM; Zeanandin, G | 1 |
| Bloom, BR; Carville, A; Hondalus, MK; Howerth, EW; Magee, DM; Mansfield, KG; Quitugua, T; Sampson, SL | 1 |
| Faber, J; Garssen, J; Kegler, D; Knol, J; Luiking, Y; van Helvoort, A; van Limpt, K; Vos, AP | 1 |
| Hook, G; Hook, V; Kindy, M | 1 |
| Adamowicz, DH; Carlson, GA; Fox, LM; Hyman, BT; Pitstick, R; Spires-Jones, TL; William, CM | 1 |
| Abdul, HM; Butterfield, DA; Cai, J; Di Domenico, F; Markesbery, WR; Pierce, WM; Robinson, RA; St Clair, DK; Sultana, R | 1 |
| Chen, A; Diaz-Ruiz, C; Ho, L; Ksiezak-Reding, H; Pasinetti, GM; Santa-Maria, I; Wang, J | 1 |
| Borghgraef, P; Demedts, D; Devijver, H; Kremer, A; Maurin, H; Van Leuven, F | 1 |
| Chen, T; Corcoran, NM; Grundy, R; Hovens, CM; Jones, NC; Nguyen, T; O'Brien, TJ; Velakoulis, D | 1 |
| Baker, A; Bredesen, DE; Butterfield, DA; Cai, J; Fiorini, A; Fombonne, J; Galvan, V; Gorostiza, O; Lange, MB; Pierce, WM; Robinson, RA; Sultana, R; Zhang, J | 1 |
| Chung, BC; Haque, MM; Im, HY; Jung, BH; Kandagaddala, LD; Kang, MJ; Kwon, OS; Patterson, TA; Seo, JE | 1 |
| Brown, LD; Friedman, JE; Hay, WW; Rozance, PJ; Thorn, SR | 1 |
| Berliner, N; Ebert, BL; Khanna-Gupta, A; Levine, M; Look, AT; Narla, A; Paw, BH; Payne, EM; Sun, H; Virgilio, M | 1 |
| Aoki, H; Imaizumi, T; Kyogoku, S; Minami, T; Nagata, T; Oba, T; Ohmura, H; Ohshima, H; Sugi, Y; Yasukawa, H | 1 |
| Batlle, D; Evora, K; Garcia-Halpin, L; Gonzalez-Pacheco, FR; Poglitsch, M; Salem, M; Schuster, M; Wysocki, J; Ye, M | 1 |
| Bryder, D; Debnath, S; Flygare, J; Jaako, P; Karlsson, S; Olsson, K | 1 |
| Imagawa, T; Matahira, Y; Minami, S; Ohnishi, A; Okamoto, Y; Osaki, T; Tsuka, T | 1 |
| Britschgi, M; Johns, H; Masliah, E; Rockenstein, E; Takeda-Uchimura, Y; Wyss-Coray, T | 1 |
| Fletcher, PJ; Lee, FH; Lipina, TV; Roder, JC; Wong, AH | 1 |
| Feng, X; Ni, H; Ren, SY; Sun, Q; Tian, T; Zhang, LL | 1 |
| Allen, DA; Chesser, AM; Harwood, SM; New, DI; Raftery, MJ; Yaqoob, MM | 1 |
| DuBois, RN | 1 |
| Beer, DG; Chen, X; Hong, J; Jiao, X; Krasna, MJ; Li, N; Wang, S; Wu, N; Yang, CS | 1 |
| Itakura, A; Kuno, N; Mizutani, S; Murata, Y; Nakashima, Y; Ohno, Y; Takeuchi, M | 1 |
| Barbot, L; Gobert, JG; Huneau, JF; Kapel, N; Rome, S; Tomé, D; Topouchian, A | 1 |
| Arancio, O; Battaglia, F; Liu, S; Nixon, RA; Trinchese, F; Walter, S | 1 |
| Aleksandrova, IY; Borisova, GY; Kulikova, OG; Reikhardt, BA; Sapronov, NS | 1 |
| Kraft, M; Lerch, MM; Mayerle, J; Meister, T; Simon, P | 1 |
| Horta, MF; Ramalho-Pinto, FJ; Silva-Jardim, I | 1 |
| Fujitani, S; Nishitani, S; Sonaka, I; Takehana, K | 1 |
| Ghetti, B; Harris, DA; Piccardo, P; Stewart, RS | 1 |
| Braum, CA; Bridi, R; Dutra-Filho, CS; Latini, A; Lissi, E; Moacir, W; Zorzi, GK | 1 |
| Burlin, TV; Jiang, C; Kang, J; Qin, M; Smith, CB | 1 |
| Alberti-Navarro, A; Alcalá-Canto, Y; Gracia-Mora, J; Ibarra-Velarde, F; Sumano-Lopez, H | 1 |
| Grimm, C; Naash, M; Remé, CE; Samardzija, M; Wenzel, A | 1 |
| Ben Yaou, R; Bonne, G; Decostre, V | 1 |
| Brunini, TM; Ellory, JC; Mann, GE; Mendes Ribeiro, AC; Moss, MB; Roberts, NB; Siqueira, MA; Yaqoob, MM | 1 |
| Averill, DB; Chappell, MC; Ferrario, CM; Ganten, D; Trask, AJ | 1 |
| Gomes-Marcondes, MC; Mello, MA; Ventrucci, G | 1 |
| Doi, K; Fukada, Y; Kitayama, M; Nakano, T; Nakashima, K; Watanabe, Y; Yasui, K | 1 |
| Alberti, A; Bierne, H; Brinster, S; Makhzami, S; Posteraro, B; Sanguinetti, M; Serror, P | 1 |
| Asuni, AA; Boutajangout, A; Quartermain, D; Sigurdsson, EM | 1 |
| Coksaygan, T; McCallum, J; Nathanielsz, P; Reinhardt, B; Richardson, BS; Schwab, M; Smith, N | 1 |
| Brüning, JC; Chang, L; Chen, YE; Cui, T; Day, SM; Ilany, J; Kahn, CR; Sun, Z; Tseng, YH; Xie, CQ; Yang, Q; Youker, KA; Zhang, J; Zhu, X | 1 |
| Doi, K; Fukada, Y; Inoué, T; Kaidoh, T; Kitayama, M; Morino, S; Nakano, T; Nakashima, K; Watanabe, Y; Yasui, K | 1 |
| Hook, G; Hook, VY; Kindy, M | 1 |
| Arantes, VC; Boschero, AC; Carneiro, EM; Ferreira, F; Filiputti, E; Souza, KL; Stoppiglia, LF | 1 |
| Behl, C; Clement, AB; Endres, K; Fahrenholz, F; Hanstein, R; Nagel, H; Schröder, A | 1 |
| Gieselmann, V | 1 |
| Dickneite, G; Schorlemmer, HU; Sedlacek, HH | 2 |
| Lipovac, K; Zanić-Grubisić, T | 1 |
| Orunesu, G; Pau, A; Sehrbundt Viale, E; Turtas, S; Viale, GL | 1 |
| Długosz, JW; Korsten, MA | 1 |
| Cope, BK; McCoy, JR; Smith, SB | 1 |
| Burch, RM; Lowe, VC; Noronha-Blob, L; Otterbein, L; Steranka, L | 1 |
| Kyle, DJ; Lowe, VC; Noronha-Blob, L; Otterbein, L | 1 |
| Lowe, VC; Noronha-Blob, L | 1 |
| Ebisui, C; Homma, T; Iijima, S; Kan, K; Kido, Y; Mori, T; Tsujinaka, T; Yano, M | 1 |
| Ishiwata, K; Kubota, K; Kubota, R; Murakami, M; Senda, M | 1 |
| Skop, B; Zak, I | 1 |
| Chotinaruemol, S; Clark, DA; McIntyre, JA; Miller, MJ; Sadowska-Krowikca, H; Zhang, XJ | 1 |
| Burrin, DG; Del Rosario, M; Fiorotto, M; Frazer, ME; Jahoor, F; Pond, WG; Wykes, LJ | 1 |
| Dijkhuizen, S; Grool, TA; Hommes, DW; Meenan, J; ten Kate, FJ; Tytgat, GN; van Deventer, SJ; Whittaker, M; Wood, M | 1 |
| Edenbaum, LR; Gurbel, PA; Herzog, WR; Serebruany, VL; Solomon, SR | 1 |
| Bittar, GD; Collins, ME; Gurbel, PA; Komiathy, SF; Mergner, W; Schlossberg, ML; Serebruany, VL | 1 |
| Burke, JF; Costa, D; Hu, RH; Ryan, CM; Tompkins, RG; Young, VR; Yu, YM | 1 |
| Brusque, AM; Feksa, L; Mello, CF; Wajner, M; Wannmacher, CM | 1 |
| Gearing, A; Gendelman, HE; Limoges, J; Persidsky, Y; Rasmussen, J; Zheng, J | 1 |
| Holecek, M; Sprongl, L; Tichý, M; Tilser, I | 1 |
| Grenier, D; Labbé, S; Mayrand, D; Plamondon, P; Uitto, VJ | 1 |
| Ashley, SW; Chandler, CF; Gloor, B; Kau, AW; Lane, JS; McFadden, DW; Reber, HA; Todd, KE | 1 |
| Barbot, L; Gobert, JG; Huneau, JF; Kapel, N; Magne, D; Tomé, D; Topouchian, A | 1 |
| Dufour, F; Nalecz, KA; Nalecz, MJ; Nehlig, A | 1 |
| Chen, X; Didier, ES; Kwong, CD; Maddry, JA; Millership, JJ; Okhuysen, PC; Snowden, KF | 1 |
| Antonas, KN; Coulson, WF | 1 |
| Mello, NK; Mendelson, JH | 1 |
| Hara, Y; Tomizawa, S | 1 |
| Cummings, MG; Fischer, JE; James, JH; Kean, JM; Soeters, PB | 1 |
| Marusyk, H; Monckton, G | 1 |
| Bonnekoh, P; Hossmann, KA; Schlenker, M; Weber, C; Widmann, R | 1 |
| Bailey, JW; DeMichele, SJ; Karlstad, MD; Killeffer, JA | 1 |
| Fischer, JE; Hasselgren, PO; Li, SJ; von Allmen, D | 1 |
| Azuma, M; David, LL; Shearer, TR | 1 |
| DeArmond, SJ; Foster, D; Groth, DF; Hsiao, KK; Prusiner, SB; Scott, M | 1 |
| Shimizu, H | 1 |
| Eto, Y; Ida, H; Matsui, K | 1 |
| Ishida, E; Ito, M; Sato, A; Shigeta, S; Takami, Y; Tanabe, F | 1 |
| Braig, HR; Diringer, H | 1 |
| Chow, IZ; Inoue, A; Isshiki, G; Okano, Y; Oura, T | 1 |
| Borson, DB; Jacoby, DB; Nadel, JA; Tamaoki, J | 1 |
| Baricos, WH; Cortez, SL; O'Connor, SE; Shah, SV; Wu, LT | 1 |
| Birkhahn, RH; Okuno, M | 1 |
| Bird, MT; Koestner, A; Reinglass, J; Shuttleworth, E | 1 |
| Bradley, WG; Williams, MH | 1 |
| Nagy, F | 1 |
| Gorden, P; Roth, J; Sherman, B | 1 |
| Bolmey, S; Kaltenbach, JP | 1 |
| Norton, AL; Pihlaja, DJ | 1 |
| Wajgt, A; Wender, M; Zgorzalewicz, B | 1 |
| Anderson, MS; Kastin, AJ; Plotnikoff, NP; Schally, AV | 1 |
| Brennan, E; Herron, WL; Riegel, BW; Rubin, ML | 1 |
| Sidransky, H; Verney, E | 2 |
| Murty, CN; Sidransky, H; Verney, E | 1 |
| Blomstrand, C; Lundborg, H | 1 |
| Wasterlain, CG | 1 |
| Chang, AY; Schneider, DI | 1 |
| Aguirre, A; Katsh, GF; Katsh, S; Willson, JT | 1 |
| Kozik, M | 1 |
| Jesdinsky, HJ; Lesch, R; Oehlert, W; Schreiber, G | 1 |
| Massaro, D; Weiss, H; White, G | 1 |
7 review(s) available for leucine and Disease Models, Animal
| Article | Year |
|---|---|
Does L-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Disease Models, Animal; Glucose Intolerance; Homeostasis; Humans; Insulin; Leucine; Mice, Obese; Obesity; Rodentia | 2018 |
The role of small leucine-rich proteoglycans in osteoarthritis pathogenesis.
Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Leucine; Mice; Osteoarthritis; Proteoglycans; Signal Transduction; Transforming Growth Factor beta | 2014 |
Leucine as a treatment for muscle wasting: a critical review.
Topics: Aging; Animals; Dietary Supplements; Disease Models, Animal; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Protein Biosynthesis; TOR Serine-Threonine Kinases | 2014 |
[The clinical relevance of experimental acute pancreatitis models].
Topics: Animals; Disease Models, Animal; Enteral Nutrition; Gastrointestinal Agents; Humans; Imidazoles; Leucine; Octreotide; Pancreatitis, Acute Necrotizing; Protease Inhibitors; Somatostatin | 2008 |
Mechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent models.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Diabetes Mellitus, Type 2; Dietary Supplements; Disease Models, Animal; Gene Expression Regulation; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Leucine; Malnutrition; Mice; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Rodentia; Taurine; TOR Serine-Threonine Kinases | 2011 |
[Conservative treatment of acute pancreatitis].
Topics: Acute Disease; Adjuvants, Immunologic; Analgesics; Animals; Anti-Bacterial Agents; APACHE; C-Reactive Protein; Cholangiography; Cholangiopancreatography, Endoscopic Retrograde; Clinical Trials as Topic; Disease Models, Animal; Double-Blind Method; Enteral Nutrition; Humans; Imidazoles; Leucine; Multicenter Studies as Topic; Multiple Organ Failure; Pancreatitis; Pancreatitis, Acute Necrotizing; Placebos; Platelet Activating Factor; Prognosis; Protease Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Tomography, X-Ray Computed | 2003 |
Laminopathies affecting skeletal and cardiac muscles: clinical and pathophysiological aspects.
Topics: Animals; Cardiomyopathy, Dilated; Disease Models, Animal; Humans; Lamin Type A; Lamins; Leucine; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Muscular Dystrophy, Emery-Dreifuss; Myocardium; Nuclear Envelope; Proline | 2005 |
211 other study(ies) available for leucine and Disease Models, Animal
| Article | Year |
|---|---|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Topics: Adenosine Monophosphate; Alanine; Animals; Chlorocebus aethiops; Coronavirus 229E, Human; Coronavirus 3C Proteases; Coronavirus Protease Inhibitors; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Design; Drug Synergism; Drug Therapy, Combination; HeLa Cells; Humans; Indoles; Infusions, Intravenous; Leucine; Mice; Pyrrolidinones; SARS-CoV-2; Severe acute respiratory syndrome-related coronavirus; Vero Cells | 2021 |
An oral SARS-CoV-2 M
Topics: Administration, Oral; Animals; Clinical Trials, Phase I as Topic; Coronavirus; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Therapy, Combination; Humans; Lactams; Leucine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Nitriles; Proline; Randomized Controlled Trials as Topic; Ritonavir; SARS-CoV-2; Viral Protease Inhibitors; Virus Replication | 2021 |
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
Topics: A549 Cells; Administration, Oral; Animals; Chlorocebus aethiops; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Humans; Lactams; Leucine; Mesocricetus; Nitriles; Proline; Respiratory Mucosa; SARS-CoV-2; Vero Cells; Viral Protease Inhibitors; Virus Replication | 2022 |
Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1-
Topics: Animals; Cerebrum; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Leucine; Male; Mice; Mice, Knockout; Positron-Emission Tomography; Protein Biosynthesis; Young Adult | 2022 |
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Animal; Epilepsy; Glucose; Glutamates; Isoleucine; Ketone Bodies; Lactates; Leucine; Pentylenetetrazole; Pyruvates; Rats; Seizures; Succinates; Valine | 2022 |
Combination Treatment of TRPV4 Agonist with Cisplatin Promotes Vessel Normalization in an Animal Model of Oral Squamous Cell Carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Disease Models, Animal; Head and Neck Neoplasms; Leucine; Mouth Neoplasms; Neovascularization, Pathologic; Nitroquinolines; Oxides; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; Squamous Cell Carcinoma of Head and Neck; Sulfonamides; TRPV Cation Channels | 2022 |
Protective Effects and Mechanism of a Novel Probiotic Strain
Topics: Animals; Caco-2 Cells; Cronobacter sakazakii; Cytokines; Disease Models, Animal; Enterocolitis, Necrotizing; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Mucosa; Leucine; Ligilactobacillus salivarius; Mice; Mucin-2; Occludin; Probiotics; RNA, Messenger | 2022 |
Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential applications in human health and disease.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Firmicutes; Fructose; Gastrointestinal Microbiome; Glucans; Humans; Isoleucine; Leucine; Metabolome; Mice; Non-alcoholic Fatty Liver Disease; Ornithine; RNA, Ribosomal, 16S; Spermidine; Succinic Acid; Telmisartan; Tryptophan; Water | 2022 |
Enterococci enhance Clostridioides difficile pathogenesis.
Topics: Animals; Anti-Bacterial Agents; Arginine; Clostridioides difficile; Disease Models, Animal; Disease Susceptibility; Drug Resistance, Bacterial; Enterococcus; Gastrointestinal Microbiome; Humans; Intestines; Leucine; Mice; Microbial Interactions; Ornithine; Virulence | 2022 |
Measurement of Protein Synthesis Rate in Rat by [
Topics: Alzheimer Disease; Animals; Anisomycin; Cross-Sectional Studies; Disease Models, Animal; Leucine; Longitudinal Studies; Positron-Emission Tomography; Rats; Rats, Inbred F344; Rats, Wistar | 2023 |
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Humans; Leucine; Mice; Mice, Inbred C57BL; Oxidative Stress | 2023 |
Exploring skeletal muscle tolerance and whole-body metabolic effects of FDA-approved drugs in a volumetric muscle loss model.
Topics: Animals; Disease Models, Animal; Leucine; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Muscular Diseases; Pharmaceutical Preparations; Regeneration | 2023 |
Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model.
Topics: Animals; Disease Models, Animal; DNA, Viral; Genome, Viral; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Isoleucine; Leucine; Male; Mice; Mice, Inbred BALB C; Mutation; Phenotype; Viral Core Proteins; Virion; Virus Assembly; Virus Replication | 2019 |
Acute exposure to leucine modifies behavioral parameters and cholinergic activity in zebrafish.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Choline O-Acetyltransferase; Disease Models, Animal; Leucine; Maple Syrup Urine Disease; Zebrafish | 2019 |
A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice.
Topics: Animals; Cachexia; Calcium; Diet; Dinoprostone; Disease Models, Animal; Fish Oils; Hypercalcemia; Leucine; Male; Mice; Muscle, Skeletal; Neoplasms; Parathyroid Hormone-Related Protein | 2019 |
A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to
Topics: Angiotensin-Converting Enzyme 2; Animals; Disease Models, Animal; Female; Imidazoles; Immunity, Innate; Inflammation; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Neutrophils; Peptidyl-Dipeptidase A; Pseudomonas aeruginosa; Pseudomonas Infections | 2019 |
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
Topics: Adult; Aged; Aging; Amino Acids; Animals; Disease Models, Animal; Female; HEK293 Cells; Humans; Hydroxylation; Hypoxia-Inducible Factor-Proline Dioxygenases; Leucine; Leucine-tRNA Ligase; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Development; Muscles; Oxygen; Procollagen-Proline Dioxygenase; Signal Transduction | 2020 |
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma.
Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease Models, Animal; Docosahexaenoic Acids; Fasting; Humans; Insulin; Isoleucine; Lactic Acid; Leucine; Metabolomics; Mice; Neoplasm Metastasis; Phenylalanine; Pyruvic Acid | 2020 |
Dietary Protein and Amino Acid Deficiency Inhibit Pancreatic Digestive Enzyme mRNA Translation by Multiple Mechanisms.
Topics: Animals; Diet, Protein-Restricted; Disease Models, Animal; Eukaryotic Initiation Factor-2; Exocrine Pancreatic Insufficiency; Humans; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Pancreas; Phosphorylation; Postprandial Period; Protein Biosynthesis; Protein Deficiency | 2021 |
Transient receptor potential vanilloid 4 agonist GSK1016790A improves neurological outcomes after intracerebral hemorrhage in mice.
Topics: Animals; Brain; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Gene Expression; Leucine; Male; Mice, Inbred C57BL; Mice, Knockout; Motor Disorders; Nervous System Diseases; Proto-Oncogene Proteins c-fos; Sulfonamides; TRPV Cation Channels | 2020 |
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
Topics: Alveolar Epithelial Cells; Animals; Aquaporin 5; Bronchi; Cell Movement; Disease Models, Animal; Edema; Humans; Leucine; Lung Diseases; Lung Transplantation; Mice; Mice, Knockout; Reperfusion Injury; Sulfonamides; TRPV Cation Channels | 2020 |
Increased rates of cerebral protein synthesis in Shank3 knockout mice: Implications for a link between synaptic protein deficit and dysregulated protein synthesis in autism spectrum disorder/intellectual disability.
Topics: Animals; Autism Spectrum Disorder; Autoradiography; Brain; Carbon Radioisotopes; Chromosome Deletion; Chromosome Disorders; Chromosomes, Human, Pair 22; Disease Models, Animal; Intellectual Disability; Leucine; Mice; Mice, Knockout; Microfilament Proteins; Nerve Tissue Proteins; Protein Biosynthesis; Synaptosomes | 2021 |
A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice.
Topics: 3-Hydroxybutyric Acid; Acetylation; Animals; Ataxia; Brain; Brain Injuries, Traumatic; Diet, Ketogenic; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Dietary Proteins; Disease Models, Animal; Docosahexaenoic Acids; Epigenesis, Genetic; Glycemic Index; Histone Code; Inflammation; Lameness, Animal; Leucine; Male; Methylation; Mice; Morris Water Maze Test; Oligodendroglia; Paresis; Postural Balance; Rotarod Performance Test; Sensation Disorders; Signal Transduction; Spatial Memory; TOR Serine-Threonine Kinases; Triglycerides | 2021 |
Structural basis for a complex I mutation that blocks pathological ROS production.
Topics: Amino Acid Substitution; Animals; Cryoelectron Microscopy; Disease Models, Animal; Disease Resistance; DNA, Mitochondrial; Electron Transport; Electron Transport Complex I; Humans; Isolated Heart Preparation; Leucine; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membranes; Myocardial Reperfusion Injury; NAD; NADH Dehydrogenase; Oxidation-Reduction; Point Mutation; Proline; Reactive Oxygen Species | 2021 |
The Kinetics of Lymphatic Dysfunction and Leukocyte Expansion in the Draining Lymph Node during LTB
Topics: Animals; Disease Models, Animal; Female; Kinetics; Leucine; Leukocytes; Leukotriene B4; Lymph Nodes; Lymphatic Vessels; Lymphedema; Male; Mice; Mice, Inbred C57BL; Protease Inhibitors | 2021 |
N-Acetyl-L-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice.
Topics: Animals; Autophagy; Brain Injuries, Traumatic; Cell Death; Cerebral Cortex; Disease Models, Animal; Hippocampus; Inflammation; Leucine; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Recovery of Function | 2021 |
Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagosomes; Autophagy; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Knockdown Techniques; Glioma; Humans; Leucine; Mice; Models, Biological; Nuclear Proteins; Proto-Oncogene Proteins c-akt; RNA-Binding Proteins; Signal Transduction; Transcription Factors; Xenograft Model Antitumor Assays | 2017 |
Muscle-specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation.
Topics: Anabolic Agents; Animals; Chemokine CCL2; Disease Models, Animal; Inflammation; Interleukin-6; Leucine; Lipopolysaccharides; Male; Mice; Mice, Knockout; Muscle, Skeletal; Phosphorylation; Protein Biosynthesis; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Tumor Necrosis Factor-alpha | 2017 |
Cell surface binding, uptaking and anticancer activity of L-K6, a lysine/leucine-rich peptide, on human breast cancer MCF-7 cells.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Calcium; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Endocytosis; Female; Humans; Hydrophobic and Hydrophilic Interactions; Leucine; Lysine; MCF-7 Cells; Membrane Potential, Mitochondrial; Mice; Peptides; Permeability; Protein Binding; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2017 |
Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment.
Topics: Aging; Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Glycoproteins; Hippocampus; Leucine; Long-Term Potentiation; Memory Disorders; Mice, Transgenic; Synaptic Vesicles | 2017 |
[Metabonomic analysis of the urine from rat model with abnormal sapra syndrome].
Topics: Amino Acids; Animals; Citric Acid; Creatine; Disease Models, Animal; Energy Metabolism; Glutamine; Glycoproteins; Isoleucine; Leucine; Metabolomics; Phenylalanine; Rats; Rats, Wistar; Syndrome | 2017 |
TRPV4 (Transient Receptor Potential Vanilloid 4) Mediates Endothelium-Dependent Contractions in the Aortas of Hypertensive Mice.
Topics: Acetylcholine; Animals; Aorta; Cyclooxygenase 2; Dinoprost; Disease Models, Animal; Endothelium, Vascular; Hypertension; Leucine; Mice; Myography; Osmotic Pressure; Phospholipase A2 Inhibitors; Phospholipases A2; Sulfonamides; TRPV Cation Channels; Vasoconstriction | 2018 |
d-Leucine: Evaluation in an epilepsy model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Leucine; Male; Mice; Photoperiod; Status Epilepticus | 2018 |
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Endothelium, Vascular; Enzyme Activators; Humans; Hypertension, Pulmonary; Imidazoles; Leucine; Lung; Male; Monocrotaline; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Phosphorylation; Pulmonary Artery; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Specific Pathogen-Free Organisms; Spiro Compounds; Xanthenes | 2017 |
DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma.
Topics: Animals; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Female; Gene Knockout Techniques; GTPase-Activating Proteins; Humans; Leucine; Liver Neoplasms; Male; Mice; Oxidative Stress; Reactive Oxygen Species; Repressor Proteins; RNA-Binding Proteins; Signal Transduction; Starvation; Tumor Suppressor Proteins | 2018 |
The mitochondrial ABC transporter Atm1 plays a role in iron metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.
Topics: Animals; ATP-Binding Cassette Transporters; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Female; Fungal Proteins; Gene Expression Regulation, Fungal; Humans; Iron; Iron-Sulfur Proteins; Leucine; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Saccharomyces cerevisiae; Sequence Deletion; Superoxide Dismutase; Virulence | 2018 |
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic Acid; Leucine; Male; Morpholines; Neurons; Osteoarthritis; Pain; Pain Measurement; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels | 2018 |
Muscle protein anabolism in advanced cancer patients: response to protein and amino acids support, and to physical activity.
Topics: Animals; Antineoplastic Agents; Cachexia; Combined Modality Therapy; Dietary Proteins; Dietary Supplements; Disease Models, Animal; Exercise; Exercise Therapy; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Neoplasm Staging; Neoplasms; Physical Conditioning, Animal; Postoperative Complications; Protein Biosynthesis | 2018 |
P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.
Topics: Amino Acid Substitution; Animals; Disease Models, Animal; Drug Resistance; Fatty Liver; Fibric Acids; Hyperlipidemias; Hypolipidemic Agents; Leucine; Mice; Mice, Transgenic; Mutation, Missense; PPAR gamma; Proline | 2018 |
Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry.
Topics: Animals; Antineoplastic Agents; Binding Sites; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Molecular Docking Simulation; Neovascularization, Physiologic; Protease Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship | 2018 |
Intravesical Activation of the Cation Channel TRPV4 Improves Bladder Function in a Rat Model for Detrusor Underactivity.
Topics: Animals; Disease Models, Animal; Female; Leucine; Rats, Sprague-Dawley; Rats, Transgenic; Recovery of Function; Sulfonamides; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Underactive; Urodynamics; Urological Agents | 2018 |
Lipoxin A
Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Cell Line, Tumor; Disease Models, Animal; Humans; Imidazoles; Leucine; Lipopolysaccharides; Lipoxins; Male; Mice; NF-kappa B; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Signal Transduction | 2018 |
Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice.
Topics: Amino Acid Transport System y+L; Animals; Antidepressive Agents; Behavior, Animal; Blood-Brain Barrier; Brain; Depression; Depressive Disorder; Disease Models, Animal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Leucine; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL | 2019 |
Effect of TRPV4 activation in a rat model of detrusor underactivity induced by bilateral pelvic nerve crush injury.
Topics: Animals; Disease Models, Animal; Female; Hypogastric Plexus; Leucine; Muscle Contraction; Nerve Crush; Rats; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels; Urinary Bladder, Underactive | 2018 |
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.
Topics: Animals; Benzopyrans; Carboxylic Acids; Choroidal Neovascularization; Disease Models, Animal; Eye; Eye Injuries; Hydroxyurea; Indoles; Lasers; Leucine; Leukotriene B4; Macrophages; Macular Degeneration; Male; Mice; Mice, Knockout; Neovascularization, Pathologic; Receptors, Leukotriene B4; Signal Transduction | 2018 |
In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma.
Topics: Amino Acids, Branched-Chain; Animals; Cell Line, Tumor; Disease Models, Animal; Glioblastoma; Histocytochemistry; Isotope Labeling; Leucine; Magnetic Resonance Imaging; Neoplasm Transplantation; Oxidation-Reduction; Rats | 2019 |
Time Series Characteristics of Serum Branched-Chain Amino Acids for Early Diagnosis of Chronic Heart Failure.
Topics: Animals; Area Under Curve; Biomarkers; Disease Models, Animal; Disease Progression; Early Diagnosis; Heart Failure; Leucine; Machine Learning; Male; Metabolome; Metabolomics; Myocardial Infarction; Rats; Rats, Sprague-Dawley; ROC Curve; Valine | 2019 |
piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine.
Topics: Animals; Arginine; Argonaute Proteins; Bacterial Toxins; Cell Line, Tumor; Cyanobacteria Toxins; Disease Models, Animal; Drinking Water; Epithelial Cells; Female; Fresh Water; Hyperplasia; Leucine; Male; Marine Toxins; Maternal Exposure; Mice; Mice, Inbred BALB C; Microarray Analysis; Microcystins; Phosphatidylinositol 3-Kinases; Pregnancy; Prostate; Prostatic Neoplasms; Protein Isoforms; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Water Pollution | 2019 |
Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology.
Topics: Animals; Blood-Brain Barrier; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Genes, Reporter; HEK293 Cells; Humans; Ketones; Leucine; Mice; Mitochondria; Motor Neurons; Muscular Atrophy, Spinal; Protective Agents; Protein Stability; Proteolysis; Signal Transduction; Survival of Motor Neuron 2 Protein; Transfection; Treatment Outcome | 2019 |
Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Disease Models, Animal; High-Throughput Screening Assays; Inflammation Mediators; Isotope Labeling; Leucine; Male; Mice, Transgenic; Prostate; Prostatitis; Proteome; Proteomics; Tandem Mass Spectrometry; Time Factors; Urinalysis; Workflow | 2019 |
Inhibition of LTA4H by bestatin in human and mouse colorectal cancer.
Topics: Adult; Aged; Animals; Antibiotics, Antineoplastic; Biomarkers; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Epoxide Hydrolases; Female; Gene Expression; Humans; Immunohistochemistry; Leucine; Male; Mice; Mice, Knockout; Middle Aged; Models, Biological; Neoplasm Staging; Prognosis; Receptors, Leukotriene B4; Signal Transduction; Xenograft Model Antitumor Assays | 2019 |
Pharmacological modulation of geranylgeranyltransferase and farnesyltransferase attenuates opioid withdrawal in vivo and in vitro.
Topics: Alkyl and Aryl Transferases; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Female; Ileum; Imidazoles; In Vitro Techniques; Leucine; Male; Methionine; Mice; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Naphthalenes; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2013 |
Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices.
Topics: Animals; Carbon Dioxide; Cerebellum; Disease Models, Animal; Female; Glucose; Hypothyroidism; Lactation; Lactic Acid; Leucine; Mannose; Oxidation-Reduction; Pregnancy; Propylthiouracil; Rats; Rats, Wistar | 2013 |
Acute uremia suppresses leucine-induced signal transduction in skeletal muscle.
Topics: Acute Disease; Acute Kidney Injury; Animals; Carrier Proteins; Disease Models, Animal; Down-Regulation; Insulin-Like Growth Factor I; Interleukin-6; Intracellular Signaling Peptides and Proteins; Leucine; Ligation; Male; Microtubule-Associated Proteins; Muscle, Skeletal; Nutritional Status; Phosphoproteins; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Uremia; Ureter | 2014 |
Antidopaminergic effects of leucine and genistein on shizophrenic rat models.
Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dopaminergic Neurons; Genistein; Leucine; Motor Activity; Protein Kinase Inhibitors; Rats; Rats, Wistar; Schizophrenia; Stereotyped Behavior | 2013 |
Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice.
Topics: Animals; Arginine; Codon; Disease Models, Animal; Factor IX; Genetic Therapy; Genetic Vectors; Hemophilia B; Hep G2 Cells; Humans; Lentivirus; Leucine; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout | 2014 |
Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.
Topics: Analysis of Variance; Animals; Antibodies; Brain; Disease Models, Animal; Gene Expression Regulation; Humans; Leucine; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Molecular Weight; Mutation; Oligodendroglia; Proline; Rats; tau Proteins; Tauopathies | 2014 |
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
Topics: Analgesics; Animals; Azabicyclo Compounds; Calcium Channel Blockers; Disease Models, Animal; Immunohistochemistry; Leucine; Male; Neurons; Nociception; Pain; Patch-Clamp Techniques; Rats, Sprague-Dawley; Spinal Cord | 2014 |
Angiotensin-converting enzyme 2-independent action of presumed angiotensin-converting enzyme 2 activators: studies in vivo, ex vivo, and in vitro.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Diminazene; Disease Models, Animal; Glutamyl Aminopeptidase; Hypertension; Imidazoles; In Vitro Techniques; Kidney; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Xanthones | 2014 |
Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats.
Topics: Administration, Intravesical; Animals; Disease Models, Animal; Gene Expression Regulation; Leucine; Male; Morpholines; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Time Factors; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Neurogenic; Urinary Incontinence, Stress; Urodynamics; Urological Agents | 2014 |
Effects of whey protein and leucine supplementation on insulin resistance in non-obese insulin-resistant model rats.
Topics: Animals; Antioxidants; Area Under Curve; Blood Glucose; Cholesterol, HDL; Dietary Supplements; Disease Models, Animal; Fasting; Glucose Tolerance Test; Glutathione; Insulin; Insulin Resistance; Leucine; Male; Malondialdehyde; Milk Proteins; Oxidative Stress; Rats, Wistar; Superoxide Dismutase; Whey Proteins | 2014 |
Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19.
Topics: Anemia, Diamond-Blackfan; Animals; Disease Models, Animal; Erythroid Cells; Humans; Leucine; Mutation; Ribosomal Proteins; Zebrafish; Zebrafish Proteins | 2014 |
L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way.
Topics: Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Chromosome Deletion; Chromosomes, Human, Pair 5; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Humans; Leucine; Ribosomal Proteins; Tumor Suppressor Protein p53; Zebrafish Proteins | 2014 |
Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cells, Cultured; Disease Models, Animal; Epilepsy, Frontal Lobe; Leucine; Mice; Mice, Transgenic; Mutation; Nerve Net; Neurons; Receptors, Nicotinic; Transfection; Valine | 2014 |
A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.
Topics: Alopecia; Amino Acid Substitution; Animals; Disease Models, Animal; Drug Resistance; Familial Hypophosphatemic Rickets; Humans; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Calcitriol; Serine; Vitamin D | 2014 |
Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.
Topics: Acoustic Stimulation; Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; Humans; Inhibition, Psychological; Leucine; Mice; Mice, Transgenic; Mutation; Phenotype; Proline; Psychotic Disorders; Reflex, Startle; tau Proteins | 2014 |
L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome.
Topics: Animals; Cell Cycle Proteins; De Lange Syndrome; Disease Models, Animal; Leucine; Mutation; Phosphorylation; Protein Biosynthesis; TOR Serine-Threonine Kinases; Zebrafish; Zebrafish Proteins | 2015 |
Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans.
Topics: Animals; Cell Membrane; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Fungal Capsules; Fungal Proteins; Gene Expression Regulation, Fungal; Homeostasis; Hydro-Lyases; Iron; Iron-Sulfur Proteins; Leucine; Mice; Mitochondria; Oxidative Stress; Saccharomyces cerevisiae; Virulence | 2015 |
Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats.
Topics: Analysis of Variance; Animals; Apelin; Binding Sites; Burns; Carrier Proteins; Cytokines; Cytoskeletal Proteins; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glucose Tolerance Test; Inflammasomes; Injury Severity Score; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Leucine; Male; NG-Nitroarginine Methyl Ester; NLR Family, Pyrin Domain-Containing 3 Protein; Pyrin; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate | 2015 |
Leucine supplementation improves acquired growth hormone resistance in rats with protein-energy malnutrition.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Growth Hormone; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Leucine; Liver; Male; Muscle, Skeletal; Protein-Energy Malnutrition; Rats; Rats, Sprague-Dawley; Receptors, Somatotropin; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Corpus Striatum; Diminazene; Disease Models, Animal; Endothelin-1; Enzyme Activation; Imidazoles; Infarction, Middle Cerebral Artery; Infusions, Intraventricular; Leucine; Male; Neuroprotective Agents; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Renin-Angiotensin System; RNA, Messenger | 2015 |
The Effects of Leucine, Zinc, and Chromium Supplements on Inflammatory Events of the Respiratory System in Type 2 Diabetic Rats.
Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Chromium; Diabetes Mellitus, Type 2; Dietary Supplements; Disease Models, Animal; Insulin; Leucine; Lung; Male; Oxidative Stress; Pneumonia; Rats, Wistar; Trachea; Zinc | 2015 |
Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission.
Topics: Adult; Aged; Aged, 80 and over; Animals; Case-Control Studies; Colon; Disease Models, Animal; Female; Gastrointestinal Motility; Gene Expression; Guanylate Cyclase; Humans; Irritable Bowel Syndrome; Leucine; Male; Mice; Mice, Knockout; Middle Aged; Models, Biological; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Sulfonamides; Synaptic Transmission; TRPV Cation Channels | 2015 |
Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice.
Topics: Animals; Antiviral Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Gene Expression Profiling; Hepacivirus; Hepatitis C; Hepatocytes; High-Throughput Nucleotide Sequencing; Humans; Indoles; Isoindoles; Lactams, Macrocyclic; Leucine; Mice; Mice, Transgenic; Mutation, Missense; Proline; RNA, Viral; Sulfonamides; Treatment Outcome; Virus Replication | 2016 |
A New Mouse Model of Limb-Girdle Muscular Dystrophy Type 2I Homozygous for the Common L276I Mutation Mimicking the Mild Phenotype in Humans.
Topics: Age Factors; Animals; Autoantigens; Disease Models, Animal; Genotype; Golgi Matrix Proteins; Humans; Isoleucine; Leucine; Mice; Mice, Transgenic; Muscular Dystrophies, Limb-Girdle; Mutation; Pentosyltransferases; Phenotype; Proteins; RNA, Untranslated | 2015 |
Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome.
Topics: Acetyltransferases; Animals; Chromosomal Proteins, Non-Histone; Craniofacial Abnormalities; Disease Models, Animal; Ectromelia; Humans; Hypertelorism; Leucine; Mutation; Protein Biosynthesis; Ribosomes; TOR Serine-Threonine Kinases; Transcription, Genetic; Zebrafish | 2016 |
Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats.
Topics: Animals; Carcinoma 256, Walker; Dietary Supplements; Disease Models, Animal; Female; Humans; Leucine; Malondialdehyde; Neoplasm Proteins; Placenta; Pregnancy; Pregnancy Complications, Neoplastic; Rats | 2016 |
Nutritional leucine supplementation attenuates cardiac failure in tumour-bearing cachectic animals.
Topics: Animals; Apoptosis; Biomarkers; Body Weight; Cachexia; Dietary Supplements; Disease Models, Animal; Electrocardiography; Heart Failure; Leucine; Male; Neoplasms; Nutrition Therapy; Rats | 2016 |
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
Topics: Amino Acids, Branched-Chain; Animals; Chromatography, Liquid; Disease Models, Animal; Female; Fibroblasts; Homeostasis; Homozygote; Keto Acids; Ketoglutaric Acids; Ketosis; Leucine; Male; Maple Syrup Urine Disease; Mass Spectrometry; Metformin; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation | 2016 |
Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity.
Topics: Analysis of Variance; Animals; Brain; Cell Count; Depression; Disease Models, Animal; Enzyme Inhibitors; Leucine; Male; Nitroarginine; Polymethacrylic Acids; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Restraint, Physical; Serotonin; Statistics, Nonparametric; Swimming | 2017 |
Specific inhibition of TRPV4 enhances retinal ganglion cell survival in adult porcine retinal explants.
Topics: Animals; Cell Survival; Disease Models, Animal; Female; Gliosis; Leucine; Neuroglia; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction; Sulfonamides; Swine; Tissue Culture Techniques; TRPV Cation Channels | 2017 |
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Calpain; Cells, Cultured; Disease Models, Animal; Glycoproteins; Hippocampus; Homozygote; Immunohistochemistry; Leucine; Memory; Mice; Mice, Transgenic; Models, Neurological; Synaptic Transmission | 2008 |
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.
Topics: Animals; Breast Neoplasms; Cathepsins; Cysteine Proteinase Inhibitors; Disease Models, Animal; Disease Progression; Female; Leucine; Magnetic Resonance Imaging; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Neoplasm Staging | 2008 |
The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population.
Topics: Age of Onset; Albuminuria; Amino Acid Substitution; Animals; Case-Control Studies; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Disease Models, Animal; Genetic Variation; Gerbillinae; Humans; Hyperinsulinism; Ireland; Leucine; Metalloproteases; Mitochondrial Proteins; Polymorphism, Single Nucleotide; Reference Values; Valine | 2009 |
Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice.
Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Humans; Imidazoles; Inflammatory Bowel Diseases; Leucine; Mice; Mice, Inbred BALB C; Peptidyl-Dipeptidase A; Peroxidase; Random Allocation | 2009 |
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Calpain; Cell Movement; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dyneins; Embryo, Mammalian; Female; Fibroblasts; Gene Expression Regulation, Developmental; Leucine; Leupeptins; Lissencephaly; Mice; Mice, Knockout; Microtubule-Associated Proteins; Models, Neurological; Neurons; Phenotype; Pregnancy | 2009 |
Glutamine supplementation does not improve protein synthesis rate by the jejunal mucosa of the malnourished rat.
Topics: Amino Acids; Animals; Body Weight; Carbon Isotopes; Dietary Supplements; Disease Models, Animal; Glutamine; Intestinal Mucosa; Jejunum; Leucine; Male; Nitrogen; Protein Biosynthesis; Protein-Energy Malnutrition; Random Allocation; Rats; Rats, Wistar; Reference Values | 2009 |
BMAA neurotoxicity in Drosophila.
Topics: Alanine; Amino Acids, Diamino; Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cyanobacteria Toxins; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Glutamic Acid; Leucine; Longevity; Lysine; Male; Neurotoxicity Syndromes; Neurotoxins | 2009 |
Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Blood Glucose; Body Size; Colitis; Dextran Sulfate; Disease Models, Animal; Enteral Nutrition; Eukaryotic Initiation Factor-4E; Growth Disorders; Hydrocortisone; Insulin; Intracellular Signaling Peptides and Proteins; Leucine; Muscle Proteins; Muscle, Skeletal; Nutritional Status; Phosphorylation; Probiotics; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Swine; TOR Serine-Threonine Kinases; Ubiquitination; Weight Gain | 2010 |
Effects of electrical stimulation and gonadal steroids on rat facial nerve regenerative properties.
Topics: Animals; Axotomy; Dihydrotestosterone; Disease Models, Animal; Electric Stimulation; Estradiol; Facial Nerve Diseases; Leucine; Lysine; Male; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Steroids; Testosterone Propionate; Time Factors; Tritium | 2009 |
Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase.
Topics: Administration, Oral; Aminoacetonitrile; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hippocampus; Isoleucine; Leucine; Male; Memory Disorders; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Oligopeptides; Peptide Fragments; Phosphorylation; Recognition, Psychology; Time Factors | 2010 |
Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease.
Topics: Albuminuria; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Chronic Disease; Disease Models, Animal; Glomerular Filtration Rate; Hematocrit; Imidazoles; Infusion Pumps; Injections, Subcutaneous; Inulin; Kidney; Kidney Diseases; Leucine; Losartan; Male; Mice; Nephrectomy; Organ Size; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Time Factors | 2010 |
Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.
Topics: Animals; Bile Ducts; Calcium; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Humans; Leucine; Phenotype; Phorbol Esters; Polycystic Kidney, Autosomal Recessive; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; TRPV Cation Channels | 2010 |
Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Demyelinating Diseases; Disease Models, Animal; Enzyme Activation; Leucine; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin-Associated Glycoprotein; Neurotoxins; Peripheral Nervous System Diseases; Receptors, Lysophosphatidic Acid; Sciatic Neuropathy; Sensory Receptor Cells; Spinal Nerve Roots | 2010 |
Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Availability; Cathepsins; Cell Proliferation; Cyclopropanes; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrocarbons, Fluorinated; Leucine; Mice; Neoplasm Invasiveness; Neovascularization, Pathologic; Pancreatic Neoplasms; Protease Inhibitors; Sulfones; Tumor Burden | 2010 |
Cerebral protein synthesis in the ovine fetus near term with amino acid infusion and insulin-induced hypoaminoacidemia.
Topics: Amino Acids; Animals; Cerebral Cortex; Disease Models, Animal; Drug Therapy, Combination; Fetal Proteins; Fetus; Glucose; Glucose Clamp Technique; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Leucine; Protein Biosynthesis; Sheep | 2010 |
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Cytokines; Disease Models, Animal; Disease Outbreaks; Female; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Inflammation Mediators; Influenza A Virus, H1N1 Subtype; Influenza, Human; Leucine; Lung; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; N-Acetylneuraminic Acid; Receptors, Virus; Time Factors; Virulence | 2010 |
Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption.
Topics: Alanine; Alcohol Drinking; Analysis of Variance; Animals; Benzazepines; Central Nervous System Depressants; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drinking Behavior; Drug Combinations; Ethanol; Gene Expression Regulation; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Quinoxalines; Receptors, Nicotinic; Tyrosine 3-Monooxygenase; Varenicline; Ventral Tegmental Area | 2010 |
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cathepsins; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dexamethasone; Disease Models, Animal; Fluorescent Dyes; Indoles; Inflammation; Leucine; Male; Mice; Phenazines; Zymosan | 2011 |
Over-expression of homologous antigens in a leucine auxotroph of Brucella abortus strain RB51 protects mice against a virulent B. suis challenge.
Topics: Animals; Antigens, Bacterial; Bacterial Load; Brucella abortus; Brucella suis; Brucella Vaccine; Brucellosis; Disease Models, Animal; Female; Gene Expression; Glucosyltransferases; Leucine; Mice; Mice, Inbred BALB C; Ribosomal Proteins; Spleen; Superoxide Dismutase; Vaccines, Attenuated | 2011 |
Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach.
Topics: Adipose Tissue; Aging; Animals; Biological Transport; Blotting, Western; Dietary Supplements; Disease Models, Animal; Follow-Up Studies; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Muscle, Skeletal; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA; Sarcopenia; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases | 2012 |
Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate.
Topics: Animals; Biosynthetic Pathways; Disease Models, Animal; Female; Gene Deletion; Guinea Pigs; Leucine; Macaca mulatta; Male; Mycobacterium tuberculosis; Pantothenic Acid; Primate Diseases; Rodent Diseases; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Analysis; Tuberculosis; Tuberculosis Vaccines; Vaccines, Attenuated | 2011 |
Bacterial translocation is reduced by a specific nutritional combination in mice with chemotherapy-induced neutropenia.
Topics: Animals; Antineoplastic Agents; Bacterial Translocation; Cyclophosphamide; Cytokines; Dietary Proteins; Dietary Supplements; Dinoprostone; Disease Models, Animal; Feces; Female; Fish Oils; Hydrogen-Ion Concentration; Leucine; Mice; Mice, Inbred C3H; Neutropenia; Oligosaccharides; Pseudomonas aeruginosa; Pseudomonas Infections | 2011 |
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cathepsin B; Cysteine Proteinase Inhibitors; Disease Models, Animal; Guinea Pigs; Leucine; Memory; Mice; Mice, Transgenic | 2011 |
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.
Topics: Animals; Animals, Genetically Modified; Cell Count; Cytoskeletal Proteins; Disease Models, Animal; Doxycycline; Environment; Gene Expression Regulation; Hippocampus; Indoles; Leucine; Mice; Mutation; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurons; Proline; RNA, Messenger; tau Proteins; Tauopathies | 2011 |
Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
Topics: Age Factors; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Brain Chemistry; Disease Models, Animal; Gene Knock-In Techniques; Humans; Leucine; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Presenilin-1; Proline; Protein Carbonylation; Protein Structure, Tertiary; Proteomics | 2011 |
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy.
Topics: Analysis of Variance; Animals; Antioxidants; Brain; Disease Models, Animal; Grape Seed Extract; Humans; Leucine; Male; Mice; Mice, Transgenic; Molecular Weight; Mutation; Polyphenols; Proline; Psychomotor Performance; Spinal Cord; tau Proteins; Tauopathies | 2012 |
Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice.
Topics: Age Factors; Animals; Bacterial Proteins; Brain; Cells, Cultured; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Female; Humans; Leucine; Luminescent Proteins; Male; Mice; Mice, Transgenic; Neurons; Phosphorylation; Proline; Synaptosomes; tau Proteins | 2011 |
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Cell Line, Tumor; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leucine; Male; Mutation; Neuroblastoma; Okadaic Acid; Pentylenetetrazole; Phosphorylation; Proline; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Selenic Acid; Selenium Compounds; tau Proteins; Time Factors; Transfection | 2012 |
Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alz
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Humans; Leucine; Methionine; Mice; Mice, Transgenic; Molecular Sequence Data; Oxidative Stress; Proteins; Proteomics | 2012 |
In vitro screening of NADPH oxidase inhibitors and in vivo effects of L-leucinethiol on experimental autoimmune encephalomyelitis-induced mice.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Female; Leucine; Mice; Mice, Inbred C57BL; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Random Allocation; Sulfhydryl Compounds | 2012 |
Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep.
Topics: Amino Acids; Animals; Carbon Isotopes; Dietary Supplements; Disease Models, Animal; Female; Fetal Growth Retardation; Insulin; Leucine; Pregnancy; Protein Biosynthesis; Proteins; Proteolysis; Random Allocation; Sheep; Time Factors | 2012 |
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.
Topics: Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Animals, Genetically Modified; Cells, Cultured; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Models, Animal; Embryo, Nonmammalian; Embryonic Development; Hematinics; Hematopoiesis; Hematopoietic Stem Cells; Humans; Leucine; Myelodysplastic Syndromes; Ribosomal Proteins; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation; Zebrafish; Zebrafish Proteins | 2012 |
Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice.
Topics: Amino Acid Oxidoreductases; Aminopropionitrile; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Echocardiography; Endothelin-1; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Rats; Rats, Wistar | 2012 |
Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Disease Models, Animal; Humans; Hydrolysis; Hypertension; Imidazoles; In Vitro Techniques; Kidney; Leucine; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Peptides; Peptidyl-Dipeptidase A; Recombinant Proteins | 2012 |
Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.
Topics: Anemia, Diamond-Blackfan; Animals; Bone Marrow Cells; Dietary Supplements; Disease Models, Animal; Down-Regulation; Erythrocyte Count; Gene Knockdown Techniques; Hematinics; Hematopoiesis; Hematopoietic Stem Cells; Hemoglobins; Leucine; Mice; Mice, Transgenic; Molecular Targeted Therapy; Ribosomal Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Correlation of plasma amino acid concentrations and chondroprotective effects of glucosamine and fish collagen peptide on the development of osteoarthritis.
Topics: Alanine; Animals; Cartilage, Articular; Collagen; Disease Models, Animal; Female; Glucosamine; Histocytochemistry; Leucine; Methionine; Osteoarthritis; Rabbits; Statistics, Nonparametric | 2013 |
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Topics: Animals; Brain; CD59 Antigens; Disease Models, Animal; Green Fluorescent Proteins; Humans; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Phosphorylation; Proline; Receptors, Complement; Signal Transduction; tau Proteins; Tauopathies | 2012 |
Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Arrestins; beta-Arrestin 1; beta-Arrestins; Biogenic Monoamines; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Glutamine; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nucleus Accumbens; Polymorphism, Genetic; Signal Transduction | 2013 |
Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Annexins; Cathepsins; Cation Transport Proteins; Clusterin; Cysteine Proteinase Inhibitors; Disease Models, Animal; Gene Expression Regulation; Leucine; Male; Metallothionein 3; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Seizures | 2013 |
Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury?
Topics: Acrylates; Animals; Calcium-Binding Proteins; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Humans; Hypertrophy, Left Ventricular; Leucine; Male; Nephrectomy; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Uremia | 2003 |
Leukotriene A4 signaling, inflammation, and cancer.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Arachidonate 5-Lipoxygenase; Cell Transformation, Neoplastic; Cyclooxygenase Inhibitors; Disease Models, Animal; Epoxide Hydrolases; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Leucine; Leukotriene A4; Neoplasms; Signal Transduction; Up-Regulation | 2003 |
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
Topics: Adenocarcinoma; Anastomosis, Surgical; Animals; Antibiotics, Antineoplastic; Blotting, Western; Chemoprevention; Disease Models, Animal; Duodenum; Epoxide Hydrolases; Esophageal Neoplasms; Esophagus; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Incidence; Inflammation; Leucine; Leukotriene A4; Rats; Stomach; Treatment Outcome; Up-Regulation | 2003 |
Bestatin results in pathophysiological changes similar to preeclampsia in rats via induction of placental apoptosis.
Topics: Animals; Apoptosis; Birth Weight; Blood Pressure; Disease Models, Animal; Female; Gestational Age; In Situ Nick-End Labeling; Leucine; Organ Size; Placenta; Pre-Eclampsia; Pregnancy; Proteinuria; Rats; Rats, Wistar | 2003 |
Evidence for the absence of an intestinal adaptive mechanism to compensate for C. parvum-induced amino acid malabsorption in suckling rats.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Suckling; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Duodenum; Excitatory Amino Acid Transporter 3; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ileum; Intestinal Mucosa; Leucine; Malabsorption Syndromes; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Symporters | 2003 |
Calpain inhibitors, a treatment for Alzheimer's disease: position paper.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calpain; Cysteine Proteinase Inhibitors; Disease Models, Animal; Hippocampus; Leucine; Long-Term Potentiation; Maze Learning; Membrane Proteins; Memory Disorders; Mice; Mice, Transgenic; Organ Culture Techniques; Presenilin-1; Treatment Outcome; Up-Regulation | 2003 |
Status of the "protein kinase CK2-HMG14" system in age-related amnesia in rats.
Topics: Aging; Amnesia; Animals; Avoidance Learning; Behavior, Animal; Brain; Casein Kinases; Cell Nucleus; Disease Models, Animal; DNA-Binding Proteins; Etimizol; HMGN1 Protein; Leucine; Male; Phosphorylation; Protein Kinases; Rats; Retention, Psychology; Synaptosomes; Transcription, Genetic; Tritium; Uridine Monophosphate | 2003 |
The Leishmania chagasi proteasome: role in promastigotes growth and amastigotes survival within murine macrophages.
Topics: Acetylcysteine; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Leishmania; Leishmaniasis, Visceral; Leucine; Macrophages, Peritoneal; Male; Mice; Multienzyme Complexes; Oligopeptides; Phenylmethylsulfonyl Fluoride; Proteasome Endopeptidase Complex | 2004 |
Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Glycogen Synthase; Isoleucine; Leucine; Liver Cirrhosis; Male; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Rats, Sprague-Dawley | 2005 |
Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.
Topics: Animals; Animals, Newborn; Arginine; Blotting, Western; Brain; Cells, Cultured; Cerebellum; Cricetinae; Cricetulus; Detergents; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Gene Expression; Glial Fibrillary Acidic Protein; Golgi Apparatus; Golgi Matrix Proteins; Immunoprecipitation; Leucine; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurodegenerative Diseases; Neurons; Octoxynol; Prion Diseases; Protein Structure, Tertiary; PrPSc Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfur Isotopes; Time Factors; Type C Phospholipases; Valine | 2005 |
Evaluation of the mechanisms involved in leucine-induced oxidative damage in cerebral cortex of young rats.
Topics: Animals; Antioxidants; Brain; Catalase; Cerebral Cortex; Chromans; Disease Models, Animal; Enzyme Inhibitors; Fluoresceins; Free Radicals; Glutathione; Glutathione Peroxidase; Humans; Isoleucine; Leucine; Male; Maple Syrup Urine Disease; Mitochondria; Neurons; NG-Nitroarginine Methyl Ester; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Valine | 2005 |
Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse.
Topics: Age Factors; Animals; Autoradiography; Cerebral Cortex; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; Leucine; Mice; Mice, Knockout; Organ Size; Protein Biosynthesis; Time Factors; Tritium | 2005 |
Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis.
Topics: Animals; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Fasciola hepatica; Fascioliasis; Fertility; Injections, Intraperitoneal; Leucine; Liver; Mice; Parasite Egg Count; Survival Analysis | 2006 |
Rpe65 as a modifier gene for inherited retinal degeneration.
Topics: Age Factors; Animals; Carrier Proteins; cis-trans-Isomerases; Disease Models, Animal; Eye Proteins; Gene Expression Regulation, Developmental; Genetic Variation; Leucine; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Retina; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA, Messenger; Time Factors | 2006 |
Characterization of cationic amino acid transport systems in rat erythrocytes: lack of effect of uraemia on L-arginine influx.
Topics: Amino Acid Transport System y+; Amino Acid Transport System y+L; Animals; Arginine; Citrulline; Disease Models, Animal; Erythrocytes; Kinetics; Leucine; Lysine; Male; Nephrectomy; Ornithine; Rats; Rats, Wistar; Uremia | 2006 |
Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Cardiomegaly; Disease Models, Animal; Half-Life; Hypertension; Imidazoles; Kinetics; Leucine; Male; Mice; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Renin | 2007 |
Leucine-rich diet alters the eukaryotic translation initiation factors expression in skeletal muscle of tumour-bearing rats.
Topics: Animals; Cachexia; Carcinoma 256, Walker; Dietary Supplements; Disease Models, Animal; Eukaryotic Initiation Factors; Insulin; Leucine; Muscle, Skeletal; Protein Biosynthesis; Random Allocation; Rats; Rats, Wistar; Reference Values | 2007 |
Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cathepsin H; Cathepsins; Crystallins; Cysteine Endopeptidases; Disease Models, Animal; Gene Deletion; Gene Expression; Gene Expression Regulation; Heat-Shock Proteins; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Chaperones; mu-Crystallins; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Peptide Initiation Factors; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2007 |
Enterococcal leucine-rich repeat-containing protein involved in virulence and host inflammatory response.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Disease Models, Animal; Enterococcus faecalis; Female; Gram-Positive Bacterial Infections; Interleukin-6; Leucine; Mice; Mice, Inbred ICR; Molecular Sequence Data; Peritonitis; Virulence | 2007 |
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.
Topics: Age Factors; Analysis of Variance; Animals; Antibodies; Behavior, Animal; Brain; Cell Line, Tumor; Dementia; Disease Models, Animal; Humans; Immunotherapy; Leucine; Mice; Mice, Transgenic; Motor Activity; Neuroblastoma; Proline; Psychomotor Performance; Recognition, Psychology; Sex Factors; tau Proteins | 2007 |
Effects of antenatal glucocorticoids on cerebral substrate metabolism in the preterm ovine fetus.
Topics: Animals; Betamethasone; Brain; Cerebrovascular Circulation; Disease Models, Animal; Female; Gestational Age; Glucocorticoids; Injections, Intramuscular; Leucine; Maternal Exposure; Oxygen Consumption; Pregnancy; Random Allocation; Reference Values; Sheep, Domestic | 2008 |
Rad GTPase deficiency leads to cardiac hypertrophy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Humans; Leucine; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; ras Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Tritium | 2007 |
Mitochondrial changes in motor neurons of homozygotes of leucine 126 TT deletion SOD1 transgenic mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Homozygote; Humans; Leucine; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Mitochondria; Motor Neurons; Oligopeptides; Peptides; Sequence Deletion; Superoxide Dismutase; Superoxide Dismutase-1 | 2008 |
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cathepsin B; Cattle; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Humans; Leucine; Maze Learning; Memory; Mice; Mice, Transgenic | 2008 |
Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Diet, Protein-Restricted; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Malnutrition; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction | 2008 |
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Indoles; Kainic Acid; Leucine; Membrane Proteins; Mice; Mice, Transgenic; Mutation; Neurons; Plant Lectins; Seizures; Stress, Physiological; Valine | 2008 |
Metachromatic leukodystrophy: genetics, pathogenesis and therapeutic options.
Topics: Animals; Disease Models, Animal; Hematopoietic Stem Cell Transplantation; Humans; Leucine; Leukodystrophy, Metachromatic; Mice; Mice, Transgenic; Mutation, Missense; Phenotype; Proline | 2008 |
Chronic bacterial infection models for BRM screening.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Bacterial Infections; Disease Models, Animal; Drug Evaluation, Preclinical; Escherichia coli Infections; Female; Leucine; Listeriosis; Macrophages; Mice; Salmonella Infections; Urinary Tract Infections | 1984 |
Disturbances of amino acid transport in rats with experimental hyperphenylalaninaemia.
Topics: Amino Acids; Animals; Cerebral Cortex; Disease Models, Animal; Fenclonine; Glycine; Humans; Leucine; Liver; Phenylalanine; Phenylketonurias; Rats; Tryptophan | 1981 |
Aminoacid incorporation into polyribosomes of ischaemic and reperfused gerbil brain.
Topics: Amino Acids; Animals; Brain Ischemia; Cell-Free System; Cerebrovascular Circulation; Disease Models, Animal; Female; Gerbillinae; In Vitro Techniques; Leucine; Male; Nerve Tissue Proteins; Polyribosomes | 1980 |
Cathepsin B inhibition in two models of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Cathepsin B; Ceruletide; Disease Models, Animal; Leucine; Lipase; Male; Pancreatitis; Rats; Rats, Sprague-Dawley | 1993 |
Opsin synthesis in the C57BL/6-mivit/mivit mouse model of retinal degeneration.
Topics: Aging; Animals; Dark Adaptation; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Leucine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Photoreceptor Cells; Retinal Degeneration; Rod Opsins | 1993 |
NPC 15669 reduces mortality associated with sepsis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Feces; Gentamicins; Leucine; Leukocyte Count; Leukocytes; Male; Peritonitis; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Additive effects of a bradykinin antagonist, NPC 17761, and a leumedin, NPC 15669, on survival in animal models of sepsis.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bradykinin Receptor Antagonists; Disease Models, Animal; Drug Synergism; Endotoxins; Leucine; Male; Mice; Molecular Sequence Data; Peritonitis; Rats; Rats, Sprague-Dawley; Shock, Septic; Survival Rate | 1993 |
The leukocyte recruitment inhibitor, NPC 15669 accelerates healing in acetic acid-induced colitis.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Leucine; Male; Peroxidase; Rats; Rats, Sprague-Dawley | 1993 |
Effect of platelet on protein degradation in rat skeletal muscle.
Topics: Animals; Disease Models, Animal; Disseminated Intravascular Coagulation; Humans; In Vitro Techniques; Leucine; Male; Muscle Proteins; Muscles; Platelet Activation; Rats; Rats, Sprague-Dawley; Thrombin; Tyrosine | 1993 |
A comparative study on protein incorporation of L-[methyl-3H]methionine, L-[1-14C]leucine and L-2-[18F]fluorotyrosine in tumor bearing mice.
Topics: Animals; Brain; Carbon Radioisotopes; Disease Models, Animal; Fluorine Radioisotopes; Hydrogen-Ion Concentration; Leucine; Lipid Metabolism; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Inbred C3H; Neoplasm Proteins; Nerve Tissue Proteins; Nucleic Acids; Solubility; Tissue Distribution; Tomography, Emission-Computed; Tritium; Tyrosine | 1993 |
Synthesis of proteoglycans in tissue explants derived from aortas of rabbits with experimentally induced atherosclerosis.
Topics: Animals; Aorta; Arteriosclerosis; Culture Techniques; Disease Models, Animal; Leucine; Male; Proteoglycans; Rabbits; Sulfates; Sulfur Radioisotopes; Tritium | 1993 |
Guinea pig ileitis is attenuated by the leumedin N-(fluorenyl-9- methoxycarbonyl)-leucine (NPC 15199).
Topics: Animals; Disease Models, Animal; Fluorenes; Guinea Pigs; Ileitis; Intestines; Leucine; Peroxidase; Trinitrobenzenesulfonic Acid | 1993 |
Chronic low protein intake reduces tissue protein synthesis in a pig model of protein malnutrition.
Topics: Amino Acids; Animals; Blood Proteins; Diet, Protein-Restricted; Disease Models, Animal; Female; Intestinal Mucosa; Leucine; Liver; Male; Muscle, Skeletal; Nitrogen; Protein Biosynthesis; Protein-Energy Malnutrition; Proteins; Skin; Swine; Tritium; Urea; Weight Gain | 1996 |
Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis.
Topics: Animals; Colitis; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Injections, Intravenous; Intestinal Mucosa; Leucine; Leukotriene B4; Male; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thromboxane B2 | 1996 |
Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antithrombin III; Blood Proteins; Disease Models, Animal; Endothelin-1; Female; Fibronectins; Hemostasis; Leucine; Macrophage-1 Antigen; Myocardial Stunning; Protein C; Protein S; Reperfusion Injury; Swine; Thromboxane B2; Up-Regulation | 1996 |
Pretreatment with an inhibitor of mac-1 alters regional and systemic platelet function during ischemia-reperfusion in swine.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Coronary Disease; Disease Models, Animal; Leucine; Macrophage-1 Antigen; Platelet Aggregation; Reperfusion Injury; Swine; Up-Regulation | 1996 |
A rabbit model for metabolic studies after burn injury.
Topics: Animals; Blood Glucose; Burns; Disease Models, Animal; Energy Metabolism; Leucine; Male; Rabbits; Rest | 1998 |
Chronic early leucine administration induces behavioral deficits in rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Chronic Disease; Disease Models, Animal; Exploratory Behavior; Female; Humans; Leucine; Male; Maple Syrup Urine Disease; Pregnancy; Rats; Rats, Wistar; Time Factors | 1999 |
Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Benzyl Compounds; Cell Survival; Dexamethasone; Disease Models, Animal; Drug Combinations; Gliosis; HIV-1; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Leucine; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, SCID; Microglia; Neurons; Pentoxifylline; Platelet Activating Factor; Protease Inhibitors; Succinates; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2001 |
Leucine and protein metabolism in rats with chronic renal insufficiency.
Topics: Acidosis; Animals; Body Weight; Cholesterol; Creatinine; Disease Models, Animal; Eating; Isoleucine; Kidney Failure, Chronic; Leucine; Male; Muscle, Skeletal; Nephrectomy; Proteins; Rats; Rats, Wistar; Urea; Uremia; Valine | 2001 |
Effects of dipeptide bestatin on Porphyromonas gingivalis and epithelial cells.
Topics: Abscess; Amino Acids; Aminopeptidases; Animals; Anti-Bacterial Agents; Bacteroidaceae Infections; Carbon Radioisotopes; Cell Line; Cell Movement; Cell Survival; Collagen; Colony Count, Microbial; Culture Media; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Gelatinases; Guinea Pigs; Humans; Keratinocytes; Leucine; Peptides; Porphyromonas gingivalis; Protease Inhibitors; Radiopharmaceuticals | 2001 |
Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Disease Models, Animal; Female; Imidazoles; Interleukin-1; Leucine; Lung; Mice; Pancreatitis; Peroxidase; Platelet Activating Factor; Tumor Necrosis Factor-alpha | 2001 |
Impairment of amino-acid absorption in suckling rats infected with Cryptosporidium parvum.
Topics: Alkaline Phosphatase; Animals; Animals, Suckling; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Female; Glutamic Acid; Ileum; Intestinal Absorption; Intestinal Mucosa; Leucine; Leucyl Aminopeptidase; Microvilli; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms | 2001 |
Metabolic approach of absence seizures in a genetic model of absence epilepsy, the GAERS: study of the leucine-glutamate cycle.
Topics: Acetates; Amines; Amino Acids, Branched-Chain; Animals; Brain; Carbon Monoxide; Cells, Cultured; Cerebral Cortex; Cyclohexanecarboxylic Acids; Disease Models, Animal; Energy Metabolism; Epilepsy, Absence; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Keto Acids; L-Lactate Dehydrogenase; Leucine; Male; Neurons; Rats; Rats, Mutant Strains; Synaptic Transmission; Synaptic Vesicles; Transaminases | 2001 |
In vitro and in vivo evaluation of aminopeptidase inhibitors as antimicrosporidial therapies.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Cyclohexanes; Disease Models, Animal; Encephalitozoon cuniculi; Encephalitozoonosis; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Leucine; Mice; Mice, Nude; O-(Chloroacetylcarbamoyl)fumagillol; Parasitic Sensitivity Tests; Peptides; Sesquiterpenes | 2001 |
Brain uptake and protein incorporation of amino acids studied in rats subjected to prolonged hyperphenylalaninaemia.
Topics: Amino Acids; Animals; Brain; Disease Models, Animal; Female; Fenclonine; Glycine; Humans; Leucine; Lysine; Male; Nerve Tissue Proteins; Phenylalanine; Phenylketonurias; Rats | 1975 |
Medical progress. Biologic concomitants of alcoholism.
Topics: Aggression; Alcoholic Intoxication; Alcoholism; Aminobutyrates; Anxiety; Depression; Disease Models, Animal; Drug Tolerance; Ethanol; Female; Humans; Leucine; Liver Diseases, Alcoholic; Male; Pituitary Hormones; Sexual Behavior; Social Behavior; Testosterone; Vasodilation | 1979 |
[The antigranuloma effect of fluocinolone acetonide by paper disk granuloma in rats (author's transl)].
Topics: Adrenalectomy; Animals; Disease Models, Animal; DNA; Female; Fluocinolone Acetonide; Granuloma; In Vitro Techniques; Leucine; Methods; Orotic Acid; Paper; Protein Biosynthesis; Puromycin; Rats; RNA; Thymidine; Uridine | 1977 |
Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat.
Topics: Animals; Brain; Disease Models, Animal; Fatty Acids; Histidine; Hydroxyindoleacetic Acid; Hypothalamus; Isoleucine; Leucine; Liver Cirrhosis; Phenylalanine; Portacaval Shunt, Surgical; Rats; Serotonin; Tryptophan; Tyrosine; Valine | 1976 |
3H leucine incorporation into myofibrils of normal and dystrophic mouse skeletal muscle.
Topics: Animals; Disease Models, Animal; Glycerol; Leucine; Mice; Mice, Inbred Strains; Muscles; Muscular Dystrophy, Animal; Myofibrils; Sarcoplasmic Reticulum | 1975 |
Neuronal damage after repeated 5 minutes of ischemia in the gerbil is preceded by prolonged impairment of protein metabolism.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Cell Death; Disease Models, Animal; Female; Gerbillinae; Ischemic Attack, Transient; Leucine; Protein Biosynthesis; Reperfusion Injury | 1992 |
Parenteral nutrition with short- and long-chain triglycerides: triacetin reduces atrophy of small and large bowel mucosa and improves protein metabolism in burned rats.
Topics: Animals; Atrophy; Burns; Disease Models, Animal; DNA; Energy Intake; Energy Metabolism; Fluid Therapy; Intestinal Mucosa; Leucine; Male; Nitrogen; Parenteral Nutrition, Total; Proteins; Random Allocation; Rats; Rats, Inbred Strains; Triacetin; Triglycerides; Weight Loss | 1992 |
Effect of ischemia on protein synthesis in the septic liver.
Topics: Acute-Phase Proteins; Alanine Transaminase; Albumins; Animals; Aspartate Aminotransferases; Complement C3; Disease Models, Animal; Evaluation Studies as Topic; Infections; Interleukin-1; Ischemia; Lactates; Leucine; Ligation; Liver; Liver Diseases; Male; Orosomucoid; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Cysteine protease inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal.
Topics: Animals; Body Water; Calcium; Calpain; Cataract; Crystallins; Cysteine Proteinase Inhibitors; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Injections, Intraperitoneal; Lens, Crystalline; Leucine; Organ Culture Techniques; Rats; Rats, Inbred Strains; Selenious Acid; Selenium | 1991 |
Spontaneous neurodegeneration in transgenic mice with mutant prion protein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Brain Diseases; Codon; Disease Models, Animal; DNA; Endopeptidase K; Gerstmann-Straussler-Scheinker Disease; Leucine; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Pedigree; Prions; PrPSc Proteins; Serine Endopeptidases; Transfection; Vacuoles; Viral Proteins | 1990 |
Different resorption modes on living and devitalized bones by isolated osteoclasts in vitro. The effects of TIMP, E-64, and TGF-alpha.
Topics: Animals; Bone Resorption; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Glycoproteins; Indomethacin; Leucine; Metalloendopeptidases; Mice; Microscopy, Electron, Scanning; Osteoclasts; Prostaglandins; Rabbits; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor alpha | 1990 |
[Application of neuronal cell culture in human degenerative brain disorders].
Topics: Age Factors; Animals; Cathepsin H; Cathepsins; Cells, Cultured; Cysteine Endopeptidases; Disease Models, Animal; Humans; Leucine; Leukodystrophy, Globoid Cell; Mice; Neuronal Ceroid-Lipofuscinoses; Neurons; Oligodendroglia; Psychosine; Rats | 1989 |
The thiol proteinase inhibitors improve the abnormal rapid down-regulation of protein kinase C and the impaired natural killer cell activity in (Chediak-Higashi syndrome) beige mouse.
Topics: Animals; Calpain; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Disease Models, Animal; Killer Cells, Natural; Killer Factors, Yeast; Leucine; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Protein Biosynthesis; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate | 1989 |
Scrapie: concept of a virus-induced amyloidosis of the brain.
Topics: Amyloidosis; Animals; Brain Diseases; Cricetinae; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Leucine; Nerve Tissue Proteins; Prions; PrP 27-30 Protein; RNA, Viral; Scrapie; Uridine | 1985 |
Effects of phenylalanine loading on protein synthesis in the fetal heart and brain of rat: an experimental approach to maternal phenylketonuria.
Topics: Animals; Brain; Carbon Radioisotopes; Disease Models, Animal; Female; Fenclonine; Fetal Heart; Fetus; Leucine; Maternal-Fetal Exchange; Phenylalanine; Phenylketonurias; Polyribosomes; Pregnancy; Protein Biosynthesis; Rats; Rats, Inbred Strains; Urea | 1986 |
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase.
Topics: Animals; Captopril; Disease Models, Animal; Ferrets; In Vitro Techniques; Influenza A virus; Leucine; Leupeptins; Metalloendopeptidases; Muscle Contraction; Muscle, Smooth; Neprilysin; Orthomyxoviridae Infections; Thiorphan; Tiopronin; Trachea | 1988 |
The cysteine proteinase inhibitor, E-64, reduces proteinuria in an experimental model of glomerulonephritis.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Endopeptidases; Glomerulonephritis; Kidney Cortex; Kidney Glomerulus; Leucine; Protease Inhibitors; Proteinuria; Rabbits; Rats | 1988 |
Chemotherapeutics: a questionable or a promising project.
Topics: Adjuvants, Immunologic; Animals; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Immunotherapy; Infections; Leucine; Lymphocytes; Macrophage Activation; Neoplasms, Experimental | 1986 |
A rat model for evaluating leucine oxidation after skeletal trauma.
Topics: Animals; Body Weight; Disease Models, Animal; Eating; Femoral Fractures; Fractures, Bone; Leucine; Male; Nitrogen; Rats; Rats, Inbred Strains; Time Factors | 1985 |
The wobbler mouse mutant: an animal model of hereditary motor system disease.
Topics: Animals; Atrophy; Axonal Transport; Brain Stem; Chromosome Aberrations; Chromosome Disorders; Disease Models, Animal; Homozygote; Leucine; Lysosomes; Mice; Microscopy, Electron; Movement Disorders; Mutation; Nerve Tissue Proteins; Neurons; Spinal Cord; Tritium | 1971 |
Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies.
Topics: Acrylamides; Animals; Axonal Transport; Cats; Central Nervous System Diseases; Cresols; Disease Models, Animal; Leucine; Nerve Tissue Proteins; Organophosphorus Compounds; Sciatic Nerve; Spinal Cord; Spinal Nerve Roots; Tibial Nerve; Tritium; Vincristine | 1973 |
Tritiated leucine incorporation by Sertoli cells in scrotal and cryptorchid rat testes.
Topics: Animals; Autoradiography; Cell Nucleus; Cryptorchidism; Disease Models, Animal; Haplorhini; Histocytochemistry; Leucine; Male; Sertoli Cells; Spermatogenesis; Testis; Tritium | 1973 |
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.
Topics: Acromegaly; Adenoma, Islet Cell; Adolescent; Adult; Animals; Child; Chromatography, Gel; Cricetinae; Cushing Syndrome; Diazoxide; Disease Models, Animal; Female; Glucagon; Glucose Tolerance Test; Half-Life; Humans; Hypoglycemia; Hypokalemia; Insulin; Iodine Isotopes; Leucine; Male; Middle Aged; Myotonic Dystrophy; Neoplasms, Experimental; Obesity; Proinsulin; Radioimmunoassay; Stimulation, Chemical; Tolbutamide | 1971 |
Talc injury: changes in glucosamine and leucine incorporation into liver and plasma proteins.
Topics: Animals; Blood Proteins; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glucosamine; Glycoproteins; Granuloma; Injections, Subcutaneous; Leucine; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Perchlorates; Protein Biosynthesis; Solubility; Talc; Time Factors | 1973 |
Experimental disciform serous retinal detachment. II. Autoradiography of photoreceptor protein metabolism.
Topics: Animals; Autoradiography; Disease Models, Animal; Eye Proteins; Female; Hyaluronoglucosaminidase; Leucine; Male; Microbial Collagenase; Phenylalanine; Photoreceptor Cells; Rabbits; Retinal Detachment; Time Factors; Tritium | 1974 |
Protein synthesis in vitro by the rat brain in course of experimental cyanide encephalopathy.
Topics: Animals; Brain; Brain Diseases; Cyanides; Demyelinating Diseases; Disease Models, Animal; Female; Hypoxia; Leucine; Male; Myelin Sheath; Nerve Tissue Proteins; Poisoning; Proline; Rats | 1974 |
Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
Topics: Animals; Depression; Dihydroxyphenylalanine; Disease Models, Animal; Dose-Response Relationship, Drug; Glycine; Haplorhini; Humans; Injections, Intraperitoneal; Leucine; Mice; Oligopeptides; Pargyline; Proline; Reserpine; Secologanin Tryptamine Alkaloids | 1973 |
Retinal dystrophy in the pigmented rat.
Topics: Animals; Autoradiography; Disease Models, Animal; Epithelium; Fundus Oculi; Humans; Leucine; Ophthalmoscopy; Phagocytosis; Phenylalanine; Photoreceptor Cells; Rats; Rats, Inbred Strains; Retinal Degeneration; Retinitis Pigmentosa; Time Factors; Tritium | 1974 |
Alterations in cardiac protein metabolism in rats force-fed a threonine-devoid diet.
Topics: Actomyosin; Animal Nutritional Physiological Phenomena; Animals; Carbon Radioisotopes; Deficiency Diseases; Disease Models, Animal; DNA; Female; Glycogen; Kwashiorkor; Leucine; Lipid Metabolism; Liver; Mitochondria; Muscle Proteins; Myocardium; Myofibrils; Organ Size; Polyribosomes; Protein Biosynthesis; Rats; RNA; Threonine | 1974 |
Studies on mRNA of the livers of rats force-fed a threonine-devoid or complete diet.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carbon Radioisotopes; Dactinomycin; Deficiency Diseases; Deoxycholic Acid; Diet; Disease Models, Animal; Female; Kwashiorkor; Leucine; Liver; Orotic Acid; Polyribosomes; Protein Biosynthesis; Rats; Ribonucleases; Ribosomes; RNA, Messenger; RNA, Ribosomal; Subcellular Fractions; Threonine | 1974 |
Protein synthesis in neurons and glial cells by extrahepatic cholestasis in rats.
Topics: Animals; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Centrifugation, Density Gradient; Cholestasis; Disease Models, Animal; In Vitro Techniques; Injections, Intraperitoneal; Leucine; Male; Nerve Tissue Proteins; Neuroglia; Neurons; Rats; Tritium | 1974 |
Inhibition of cerebral protein synthesis by epileptic seizures without motor manifestations.
Topics: Animals; Atropine; Brain; Brain Damage, Chronic; Brain Stem; Cerebellum; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Electroshock; Epilepsy; Leucine; Male; Nerve Tissue Proteins; Paralysis; Rats; Tritium | 1974 |
Metabolic abnormalities in the pancreatic islets and livers of the diabetic Chinese hamster.
Topics: Acidosis; Animals; Blood Glucose; Carbon Isotopes; Cricetinae; Diabetes Mellitus; Disease Models, Animal; Glucokinase; Gluconeogenesis; Hexokinase; Insulin; Insulin Secretion; Islets of Langerhans; L-Lactate Dehydrogenase; Leucine; Liver; Liver Glycogen; Organ Size; Phosphogluconate Dehydrogenase; Pyruvate Kinase; Pyruvates | 1970 |
Aspermatogenesis. Exploration as a nodel for auto-allergic diseases.
Topics: Acid Phosphatase; Aminopeptidases; Animals; Antigens; Autoimmune Diseases; Cathepsins; Deoxyribonucleases; Disease Models, Animal; Glucuronidase; Guinea Pigs; Hyaluronoglucosaminidase; L-Lactate Dehydrogenase; Leucine; Lysosomes; Male; Organ Size; Oxidoreductases; Ribonucleases; Sorbitol; Spermatogenesis; Spermatozoa; Testis | 1972 |
Degenerative changes of neurocytes in the light of autoradiographic investigations.
Topics: Adenine; Amino Acids; Animals; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Disease Models, Animal; Female; Glycine; Leucine; Male; Nerve Degeneration; Nerve Tissue Proteins; Nervous System Diseases; Neurons; Nucleoproteins; Phenylalanine; Radiation Injuries, Experimental; Rats; Rats, Inbred Strains; Sciatic Nerve; Thymidine; Tritium | 1971 |
[Autoradiographic and biochemical investigations of the rat liver in the acute stage of aminonucleoside nephrosis].
Topics: Analysis of Variance; Animals; Autoradiography; Carbon Isotopes; Disease Models, Animal; DNA; Epithelium; Female; Histocytochemistry; Injections, Subcutaneous; Leucine; Liver; Liver Glycogen; Liver Regeneration; Nephrosis; Nucleosides; Protein Biosynthesis; Rats; Thymidine; Tritium | 1969 |
Skeletal muscle protein metabolism changes in rats force-fed a diet inducing an experimental Kwashiorkor-like model.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Disease Models, Animal; Kwashiorkor; Leucine; Muscle Proteins; Rats; Threonine; Tritium | 1970 |
Pulmonary artery ligation. Effect on in vitro protein systhesis.
Topics: Animals; Autoradiography; Carbon Isotopes; Culture Techniques; Disease Models, Animal; DNA; Dogs; Female; Leucine; Ligation; Lung; Male; Protein Biosynthesis; Pulmonary Artery; Pulmonary Circulation; Pulmonary Embolism; RNA | 1971 |