leucine and Deficiency of GP 2b 3a Complex

leucine has been researched along with Deficiency of GP 2b 3a Complex in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Einav, Y; Hauschner, H; Koren, A; Mansour, W; Rosenberg, N; Seligsohn, U1
Basani, RB; Bennett, JS; Brown, DL; Poncz, M; Vilaire, G1
Chen, F; Coller, BS; French, DL; Grimaldi, CM; Weiss, HJ; Wu, C1
Jackson, DE; Jennings, LK; Newman, PJ; White, MM1
Kestin, AS; Newman, PJ; Ward, CM1
Combrié, R; Gauthier, B; Kunicki, T; Nurden, AT; Nurden, P; Pasquet, JM; Ruan, J1

Other Studies

6 other study(ies) available for leucine and Deficiency of GP 2b 3a Complex

ArticleYear
An αIIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the β-propeller (Asn2Asp) disrupts a calcium binding site in blade 6.
    Journal of thrombosis and haemostasis : JTH, 2011, Volume: 9, Issue:1

    Topics: Adolescent; Amino Acid Sequence; Animals; Arabs; Asparagine; Aspartic Acid; Binding Sites; Blood Platelets; Calcium; Cell Line; Child; Child, Preschool; Cricetinae; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Glutamine; Hemostasis; Heredity; Humans; Hydrogen Bonding; Integrin alpha2; Integrin beta3; Israel; Leucine; Male; Models, Molecular; Molecular Sequence Data; Mutation; Pedigree; Phenotype; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Thrombasthenia; Transfection

2011
A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface.
    Blood, 1997, Oct-15, Volume: 90, Issue:8

    Topics: Alleles; Amino Acid Sequence; Animals; Blood Platelets; COS Cells; Flow Cytometry; Humans; Infant; Leucine; Molecular Sequence Data; Mutation; Oligopeptides; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Conformation; Surface Properties; Thrombasthenia; Tryptophan

1997
Glycoprotein IIb Leu214Pro mutation produces glanzmann thrombasthenia with both quantitative and qualitative abnormalities in GPIIb/IIIa.
    Blood, 1998, Mar-01, Volume: 91, Issue:5

    Topics: Animals; Bleeding Time; Blood Platelets; CHO Cells; Cricetinae; Dual Specificity Phosphatase 2; Fibrinogen; Humans; Immunosorbent Techniques; Leucine; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Thrombasthenia; Transfection

1998
A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia.
    Thrombosis and haemostasis, 1998, Volume: 80, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Antigens, CD; Child; Humans; Integrin beta3; Integrins; Leucine; Male; Molecular Sequence Data; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Thrombasthenia

1998
A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen.
    Blood, 2000, Jul-01, Volume: 96, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Cell Line; Child, Preschool; COS Cells; Female; Fibrin; Fibrinogen; Humans; Integrin beta3; Kidney; Leucine; Male; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Pedigree; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Point Mutation; Polymerase Chain Reaction; Proline; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thrombasthenia; Transfection; Xenopus

2000
A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia.
    Platelets, 2002, Volume: 13, Issue:2

    Topics: Aged; Amino Acid Substitution; DNA Mutational Analysis; Family Health; Fibrinogen; Genetic Variation; Humans; Leucine; Male; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Proline; Protein Binding; Protein Subunits; Thrombasthenia

2002